• 대한본초학회지
• /
• 제24권4호
• /
• pp.149-157
• /
• 2009

Objectives : This study was designed to investigate the effects of Cheunggyeongsamul-tang extract on the growth of longitudinal bone in adolescent female rats. Methods : Longitudinal bone growth was measured by fluorescent microscopy. To examine the effects on the growth plate metabolism, the total height of growth plate, the induction of local insulin-like growth factor-1 (IGF-1), IGF-1 receptor, bone morphogenetic protein-2 (BMP-2), BMPR-1A, indian hedgehog (IHH), and parathyroid hormone-related protein (PTH-rP) were measured. Results : Cheunggyeongsamul-tang extract enhanced longitudinal bone growth and total height of the growth plate. Also, it promoted the induction of local IGF-1, BMP-2, IHH and PTH-rP of the growth plate. Conclusions : This study shows that the Cheunggyeongsamul-tang extract effects longitudinal bone growth in adolescent rats and might be used for both stunted adolescents and inherent growth failure patients.

• Biomolecules & Therapeutics
• /
• 제7권4호
• /
• pp.329-334
• /
• 1999

Recently, cellular signal transduction mechanisms are greatly understood. However, bone cell signaling is not completely characterized. Interestingly, bone cells synthesize a number of growth factors such as IGF-I PDGF, IGF-II etc., suggesting these growth factors play important roles in bone cell signaling. In the present study, potential roles of nitric oxide (NO) and protein kinases in osteoblast signal transduction are proposed.

• 대한기계학회논문집A
• /
• 제30권6호
• /
• pp.722-727
• /
• 2006

Bone fracture healing is one of the important topics in biomechanics, demanding computation simulations due to the difficulty of obtaining experimental or clinical results. In this study, we adopt the design space optimization method which was established by the authors as a tool for the simulation of bone growth using its evolutionary characteristics. As the mechanical stimulus, strain energy density is used. We assume that bone tissues over a threshold strain energy density will be differentiated and bone tissues below another threshold will be resorbed. Under compression and torsion as loadings, the filling process of the defect is well illustrated following the given mechanical criterion. It is shown that the design space optimization is an excellent tool for simulating the evolutionary process of bone growth, which has not been possible otherwise.

• Archives of Plastic Surgery
• /
• 제35권1호
• /
• pp.92-95
• /
• 2008

Purpose: Heterotopic ossification in pressure sore patients is reported to rarely develop, but once it occurs, it frequently causes joint stiffness and mobilization restriction. The aim of this article is to report our experience of atypical bone growing at femur neck fracture site with chronic, extensive pressure sore in patient with paraplegia secondary to spinal injury. Methods: A 28-year-old male patient presented with atypical bone growth at femur neck fracture site with pressure sore. He had undergone atypical growth bone removal and separation of united iliac bone and femur, and then pressure sore was covered by advanced rotation flap. Results: The patient mobilized hip joint and rode in a wheelchair. Complications such as dehiscence, infection, hematoma and flap necrosis did not occur. Conclusion: We experienced successful correction of atypical bone growth removal and recovery of pressure sore. We report our experience of atypical bone growth of fracture site and the related literature was reviewed.

• International Journal of Oral Biology
• /
• 제44권2호
• /
• pp.37-42
• /
• 2019

Oral squamous cell carcinoma (OSCC) is the most common oral malignancy and an increasing global public health problem. OSCC frequently invades the jaw bone. OSCC-induced bone invasion has a significant impact on tumor stage, treatment selection, patient outcome, and quality of life. A number of studies have shown that osteoclast-mediated bone resorption is a major step in the progression of bone invasion by OSCC; however, the molecular mechanisms involved in OSCC bone invasion are not yet clear. In this review, we present the clinical types of OSCC bone invasion and summarize the role of key molecules, including proteases, cytokines, and growth factors, in the sequential process of bone invasion. A better understanding of bone invasion will facilitate the discovery of molecular targets for early detection and treatment of OSCC bone invasion.

• Archives of Plastic Surgery
• /
• 제33권1호
• /
• pp.1-4
• /
• 2006

Cryopreserved fibroblast implants represent a major advancement for healing of chronic wounds. Bone marrow stromal cells, which include the mesenchymal stem cells, have a low immunity-assisted rejection and are capable of expanding profoundly in a culture media. Therefore, they have several advantages over fibroblasts in clinical use. The ultimate goal of this study was to compare the wound healing accelerating growth factor secretion of the bone marrow stromal cells with that of the fibroblasts and this pilot study particularly focuses on the growth factor secretion to accelerate wound healing. Bone marrow stromal cells and fibroblasts were isolated from the same patients and grown in culture. At 1, 3, and 5 days post-incubating, secretion of basic fibroblast growth factor(bFGF), vascular endothelial growth factor (VEGF), and transforming growth factor beta(TGF-${\beta}$) were compared. In TGF-${\beta}$ secretion fibroblasts showed 12~21% superior results than bone marrow stromal cells. In contrast, bFGF levels in the bone marrow stromal cells were 47~89% greater than that in fibroblasts. The VEGF levels of the bone marrow stromal cells was 7~12 fold greater than that of the fibroblasts. Our results suggest that the bone marrow stromal cells have great potential for wound healing accelerating growth factor secretion.

• 한국식품영양학회지
• /
• 제34권6호
• /
• pp.568-575
• /
• 2021

The purpose of this study was to investigate the effects of extract mixture of C. wilfordii and P. umbrosa (IPLUS-CWPU) on bone growth in 4-week old young male SD rats. To confirm the effect of IPLUS-CWPU, we measured the length of bone growth plate, the ratio of proliferative zone to the length of growth plate and the expression level of insulin-like growth factor, IGF-1. The IPLUS-CWPU treatment shows a significant increase of tibial and femoral growth plate and the ratio of proliferative zone in growth plate. Especially, the length increased by 13.9% and 25.3% in the tibia and femur, respectively, in the high-dose group compared to the normal group. Moreover, the expression of IGF-1 gene in liver was upregulated in IPLUS-CWPU treated groups. These results indicated that IPLUS-CWPU administration could increase the proliferative zone of bone growth plate in early developmental stage by upregulation of IGF-1 gene.

• 동국한의학연구소논문집
• /
• 제9권
• /
• pp.1-23
• /
• 2000

Osteoporosis is a common disorder characterized by reduced bone mineral density, deterioration of the microarchitecture of bone tissue and increased risk of fracture. The aim of treatment of osteoporosis is to maintain and, ideally, to restore bone strength safely. In recent years the role of polypeptide growth factors in bone metabolism has begun to appear. It has been proposed that alterations in the expression or production of growth factor can modulate the proliferation and activity of bone forming cells. Thus, the role of structurally diverse peptides for the management and diagnosis of osteoporosis has attracted the attention of many investigators. This paper reviews numerous findings concerning the use of polypeptides, hormones, and growth factors, for the management of osteoporosis. Many of the compounds mentioned here are experimental prototypes of new therapeutic classes. Though it is unlikely that some of the compounds may ever be used clinically, development of safe and efficacious agents in each class will define the future course of therapy for osteoporosis.

• 생명과학회지
• /
• 제29권5호
• /
• pp.614-620
• /
• 2019

본 연구는 성장 유도 인자가 포함된 여러 가지의 한약재의 조성물을 활용하여 성장기 흰쥐에서 골성장판 길이, 대퇴부 길이, 골밀도(Bone mineral density) 및 혈액분석을 통해 키 성장 효과를 검증하고자 한다. 먼저, 골성장판 길이 분석 결과, N군에 비해 PC군과 Gh-199군 및 Sh-188군의 골성장판 길이가 전반적으로 증가하였고, 특히 Gh-199군의 경우 PC군보다 더 우수한 골성장판 길이 성장률을 보였다. 대퇴부 길이 및 골밀도 경우 Gh-199군에서 보다 긍정적인 효과를 나타내었다. 반면에 황기분말을 급여한 PC군의 경우, Gh-199군 및 Sh-188군과 달리 높은 혈중 AST 및 ALT 수치를 나타내었다. 성장호르몬 인자 중 하나인 IGF-1의 결과, PC군과 Sh-188군은 비슷한 경향이었으며, Gh-199군에서 보다 증가한 것으로 나타났다. 따라서, 이상의 결과 골성장판, 대퇴부길이, 골밀도 및 혈액분석 결과 모두 Gh-199군에서 긍정적인 결과를 나타내어 본 실험에 사용한 한약재 조성물은 키 성장에 효과가 있을 것으로 기대된다.

• Journal of Korean Dental Science
• /
• 제6권2호
• /
• pp.50-57
• /
• 2013

Purpose: Autogenous tooth bone graft is proven to be efficient. We evaluated the bone healing effect and clinical capabilities of autogenous tooth bone materials as a scaffold when growth factor is used together with this material. Materials and Methods: Subjects were those who needed implant placement and bone graft because of missing tooth or alveolar bone defect and who kept their autogenous tooth or needed extraction of other tooth. Group I included autogenous tooth bone graft with growth factor, whereas Group II had only autogenous tooth bone graft. We investigated the bone healing state through computed tomography taken just before surgery and 3 to 4 months after surgery to evaluate the effectiveness of bone graft. Group I had 9 patients, whereas Group II had 5 patients. We compared the pre- and post-operative increase of the Hounsfield unit and bone height by analyzing the computed tomography images. Result: Sinus bone grafts numbered 8 cases, and vertical ridge augmentation was performed together with 3 cases of these. Vertical ridge augmentation was performed in 2 cases, and horizontal ridge augmentation in 1 case alone. Socket graft was done in 3 cases. The post-operative mean value of the Hounsfield unit was 960 in Group I and 836.7 in Group II, but the increase was almost similar, i.e., 636.9 in Group I and 634.7 in Group II on the average. Increase of bone height was 7.6 mm in Group I and 11.1 mm in Group II on the average. This difference was attributable to the fact that most of the cases were sinus bone graft in Group II. Conclusion: In this study, we suggest the possibility of autogenous tooth bone graft materials as a scaffold besides their bone healing ability.