• 제목/요약/키워드: Bone china

검색결과 79건 처리시간 0.027초

Variability of Osteocalcin Status in Chinese Holstein Cattle: Do Phylogeny, Vitamin D or Gene Polymorphisms Matter?

  • Ferreri, Miro;Gao, Jian;Ren, Gaixian;Chen, Liben;Su, Jingliang;Han, Bo
    • Asian-Australasian Journal of Animal Sciences
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    • 제24권2호
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    • pp.173-180
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    • 2011
  • Osteocalcin (OC), a marker of bone turnover, displays patterns in relation to physiological and genetic factors. Here, we present an association study in a population of Chinese Holstein cattle (n = 24) with OC serum concentration as a phenotypic trait. We hypothesised that OC status is associated with phylogeny, vitamin D serum level and single nucleotide polymorphisms (SNPs). Mitochondrial DNA (mtDNA) was used as an unlinked marker to examine phylogeny and linkage to measured phenotypic traits of vitamin D and OC status. Following an association study with OC serum variability as the trait, genotyping of SNPs (n = 27) in OC-related genes was performed. Candidate SNPs were chosen in genes with an emphasis on the vitamin D and vitamin K pathways. Multivariant factor analysis revealed a correlation between vitamin D serum concentration and a SNP in the gene GC (rs43338565), which encodes a vitamin D-binding protein, as well as between a SNP in NFATc1 (rs42038422) and OC concentration. However, univariate analysis revealed that population structure, vitamin D serum levels and SNPs were not significant determinants of OC status in the studied group.

Selective blockade of spinal D2DR by levo-corydalmine attenuates morphine tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner

  • Dai, Wen-Ling;Liu, Xin-Tong;Bao, Yi-Ni;Yan, Bing;Jiang, Nan;Yu, Bo-Yang;Liu, Ji-Hua
    • Experimental and Molecular Medicine
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    • 제50권11호
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    • pp.6.1-6.12
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    • 2018
  • Morphine tolerance remains a challenge in the management of chronic pain in the clinic. As shown in our previous study, the dopamine D2 receptor (D2DR) expressed in spinal cord neurons might be involved in morphine tolerance, but the underlying mechanisms remain to be elucidated. In the present study, selective spinal D2DR blockade attenuated morphine tolerance in mice by inhibiting phosphatidylinositol 3 kinase (PI3K)/serine-threonine kinase (Akt)-mitogen activated protein kinase (MAPK) signaling in a ${\mu}$ opioid receptor (MOR)-dependent manner. Levo-corydalmine (l-CDL), which exhibited micromolar affinity for D2DR in D2/CHO-K1 cell lines in this report and effectively alleviated bone cancer pain in our previous study, attenuated morphine tolerance in rats with chronic bone cancer pain at nonanalgesic doses. Furthermore, the intrathecal administration of l-CDL obviously attenuated morphine tolerance, and the effect was reversed by a D2DR agonist in mice. Spinal D2DR inhibition and l-CDL also inhibited tolerance induced by the MOR agonist DAMGO. l-CDL and a D2DR small interfering RNA (siRNA) decreased the increase in levels of phosphorylated Akt and MAPK in the spinal cord; these changes were abolished by a PI3K inhibitor. In addition, the activated Akt and MAPK proteins in mice exhibiting morphine tolerance were inhibited by a MOR antagonist. Intrathecal administration of a PI3K inhibitor also attenuated DAMGO-induced tolerance. Based on these results, l-CDL antagonized spinal D2DR to attenuate morphine tolerance by inhibiting PI3K/Akt-dependent MAPK phosphorylation through MOR. These findings provide insights into a more versatile treatment for morphine tolerance.

Repair of sports bone injury based on multifunctional nanomaterial particles

  • Dongbai Guo
    • Structural Engineering and Mechanics
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    • 제86권4호
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    • pp.487-501
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    • 2023
  • Nanoparticles have lower size and larger specific surface area, good stability and less toxic and side effects. In recent years, with the development of nanotechnology, its application range has become wider and wider, especially in the field of biomedicine, which has received more and more attention. Bone defect repair materials with high strength, high elasticity and high tissue affinity can be prepared by nanotechnology. The purpose of this paper was to study how to analyze and study the composite materials for sports bone injury based on multifunctional nanomaterials, and described the electrospinning method. In this paper, nano-sized zirconia (ZrO2) filled micro-sized hydroxyapatite (HAP) composites were prepared according to the mechanical properties of bone substitute materials in the process of human rehabilitation. Through material tensile and compression experiments, the performance parameters of ZrO2/HAP composites with different mass fraction ratios were analyzed, the influence of filling ZrO2 particles on the mechanical properties of HAP matrix materials was clarified, and the effect of ZrO2 mass fraction on the mechanical properties of matrix materials was analyzed. From the analysis of the compressive elastic modulus, when the mass fraction of ZrO2 was 15%, the compressive elastic modulus of the material was 1222 MPa, and when 45% was 1672 MPa. From the analysis of compression ratio stiffness, when the mass fraction of ZrO2 was 15%, the compression ratio stiffness was 658.07 MPa·cm3/g, and when it was 45%, the compression ratio stiffness is 943.51MPa·cm3/g. It can be seen that by increasing the mass fraction of ZrO2, the stiffness of the composite material can be effectively increased, and the ability of the material to resist deformation would be increased. Typically, the more stressed the bone substitute material, the greater the stiffness of the compression ratio. Different mass fractions of ZrO2/HAP filling materials can be selected to meet the mechanical performance requirements of sports bone injury, and it can also provide a reference for the selection of bone substitute materials for different patients.

三國史記의 服飾硏究 Ⅵ -色服의 服飾 附屬品을 中心으로- (A Study on the Costume Accessories of Shilla in Sam Kuk Sa Ki(三國史記))

  • 김진구
    • 복식문화연구
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    • 제7권3호
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    • pp.1-16
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    • 1999
  • This study in concerned with the costume accessories appeared in Sam Kuk Sa ki. The accessories of both sexes were analized. Results of this research can be summarized as follows : It was appeared that names of accessories of men were fewer in number than those of women. Men\`s accessories such as a hat, bok-du, a belt,boots, shoes, and sock were mentioned in Sam Kuk Sa Ki. Women\`s accessories appeared such as a hat, a comb, a hair pin, a belt, shoes, and sock. A bok-du, boots, and a hared belt were used exclusively by men, while a hat, kwan(冠), a comb, a hair pin, a scarf, pyo( ) were worn exclusively by women. All men from different classes including true bone class as well as the common class wore bok-du, a hat, a hard belt, boots, sock ; however, class distinctions were made from materials used for those items. Also women\`s accessories were used as means of differentiating social status of the wearer by means of materials employed for each item. Especially, woman\`s hat and scarf were a symbol of the noble class. Only two classes of women from the true-bone class and women from the sixth du-pum class entited to wear hats. Wearing a scarf was not allowed to women from the common class. Class dirrernetiations were made by the materials used for hats and scarves. Materials for a scarf such as gold and silver leaf, pecock tail, and king fisher fly feather were restricted to women from true-bone class. Such as man\`s hat bok-du( 頭), use of women\`s comb and hair pin, scarf, leggings were items drived from Tang China. It clearly showed that costume accessories of Silla were heavily influenced by the Chinese. At the same time the costume accessories were sued to make sex difference among the people of Silla. Woman wore a soft belt made of cloth while man wore a hard belt. Woman\`s hat, a scarf, a comb, a hair pin, a belt or sash for a shirt, and leggings were woman\`s sex symbol. Thus, costume accessories of Silla appeared in Sam Kum Sa Ki functioned as means of differentiating social status of the wearer such as sex,class and rank in the society. Also, they showed that Silla kingdom had close cultural relationship with Tang China.

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Study on the Health-related Quality of Life in Patients after Surgery for Malignant Bone Tumors

  • Han, Gang;Wang, Yan;Bi, Wen-Zhi
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권1호
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    • pp.127-130
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    • 2012
  • Aim: We conducted a study in China to assess the health-related quality of life (HRQoL) in patients treated on for malignant bone tumors after surgery, and investigate the possible determinants. Methods: The subjects were 120 patients surgically treated by amputation and limb-salvage for bone tumors during the period of June 2008 to June 2010. The Medical Outcomes Study Short Form 36 (SF-36) was employed to measure the HRQoL of all the patients before and after surgery. Results: With regard to the results of the general quality of life tool (SF-36), we observed a significant improvement of all the indexes of HRQoL after 6 months (p<0.05). PF, RP and BP scores showed significant increase between surgery after 6 and 12 months (p<0.05). The means of the HRQoL of bone tumor patients in our study were still much lower than those of general population in every domain, even 12 months after surgery. Logistic regression showed that female patients were found to have lower scores in physical component summary (PCS) than males (OR=0.64, 95% CI=0.35-0.89). Patients older than 15 years had lower scores in mental component summary (MCS) (OR=0.60, 95% CI=0.32-0.86). Ablative surgery was related to both lower MCS and PCS scores (For MCS, OR=0.54, 95% CI=0.31-0.83; for PCS, OR=0.43, 95% CI=0.25-0.73). Conclusion: Our study showed the treatment for bone tumor could greatly alter the HRQoL of patients. Age, sex and type of surgery were associated with physical or mental HRQoL after surgery.

Effect of Titanium Prosthesis on Computed Tomography Measurements of Bone Mineral Density

  • Han, S.M.;Zude Feng
    • 대한의용생체공학회:의공학회지
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    • 제19권2호
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    • pp.177-182
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    • 1998
  • 본 연구에서는 체내의 티타늄, 보철물, malalignment, 측정범위, 그리고 보철물 distal flare등이 전산화단층(CT) 촬영으로 골밀도를 축정할때에 미치는 영향을 조사하였다. 8구의 남성 사체로부터 대퇴골과 경골을 각각 8개씩 얻었으며 경골의 상부에 위치해있는 해면골 부분에서 15개의 평행사변형 시편을 만들었다. 평행사변형 시편과 대퇴골을 CT 스캔받침대의 중앙에 바로 놓았을때와 조금 떨어져 놓았을 때 그리고 티타늄 보철물을 체내에 넣었을 경우와 그렇지 않았을 경우 모두에 대해서 각각 스캔하였다. 이때 얻어진 CT 영상자료는 측정범위를 10cm와 30cm로 해서 재구성 하였다. 그리고 골밀도는 영상분석 소프트웨어을 사용하여 측정하였다. 그 결과 시편을 CT 스캔받침의 중앙에 놓았을 경우에는 그렇지 않았을 경우에 비해 골밀도 평균값의 상대차이가 피질골과 해면골 모두에 대해서 1% 미만이었다. 그러나 보철물의 malalignment와 distal flare는 골밀도의 측정값에 상당히 영향을 미쳤다. 체내에 티타늄 보철물의 존재여부는 시편을 CT 스캔받침대의 중앙에 놓았을 경우에는 피질골 뿐만 아니라 해면골 골밀도 측정값에 영향을 미치지 않았다. 그러나 체내에 티타늄 보철물의 존재가 malalignment 효과와 합쳐졌을때에는 골밀도 측정값이 많은 차이를 드러내었다.

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Radiotherapy Alone is Associated with Improved Outcomes Over Surgery in the Management of Solitary Plasmacytoma

  • Li, Qi-Wen;Niu, Shao-Qing;Wang, Han-Yu;Wen, Ge;Li, Yi-Yang;Xia, Yun-Fei;Zhang, Yu-Jing
    • Asian Pacific Journal of Cancer Prevention
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    • 제16권9호
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    • pp.3741-3745
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    • 2015
  • Background: A moderate dose of radiation is the recommended treatment for solitary plasmacytoma (SP), but there is controversy over the role of surgery. Our study aimed at comparing different treatment modalities in the management of SP. Materials and Methods: Data from 38 consecutive patients with solitary plasmacytoma, including 16 with bone plasmacytoma and 22 with extramedullary plasmacytoma, were retrospectively reviewed. 15 patients received radiotherapy alone; 11 received surgery alone, and 12 received both. The median radiation dose was 50Gy. All operations were performed as radical resections. Local progression-free survival (LPFS), multiple myeloma-free survival (MMFS), progression-free survival (PFS) and overall survival (OS) were calculated and outcomes of different therapies were compared. Results: The median follow-up time was 55 months. 5-year LPFS, MMFS, PFS and OS were 87.0%, 80.9%, 69.8% and 87.4%, respectively. Univariate analysis revealed, compared with surgery alone, radiotherapy alone was associated with significantly higher 5-year LPFS (100% vs 69.3%, p=0.016), MMFS (100% vs 51.4%, p=0.006), PFS (100% vs 33.7%, p=0.0004) and OS (100% vs 70%, p=0.041). Conclusions: Radiotherapy alone can be considered as a more effective treatment for SP over surgery. Whether a combination of radiotherapy and surgery improves outcomes requires further study.

Bone-level implants placed in the anterior maxilla: an open-label, single-arm observational study

  • Gao, EnFeng;Hei, Wei-Hong;Park, Jong-Chul;Pang, KangMi;Kim, Sun Kyung;Kim, Bongju;Kim, Soung-Min;Lee, Jong-Ho
    • Journal of Periodontal and Implant Science
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    • 제47권5호
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    • pp.312-327
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    • 2017
  • Purpose: This study assessed marginal bone remodeling and soft tissue esthetics after the loading of single bone-level implants in the anterior maxilla. Methods: An open, single-arm observational clinical trial with 3 years of follow-up was performed, including 22 implants. The patients presented with a single tooth gap in the anterior maxilla (tooth positions 14-24), with natural or restored adjacent teeth. An implant was placed at least 8 weeks post-extraction and healed submerged for 6 weeks. After the second-stage operation, a fixed provisional prosthesis was provided. The final restoration was placed 6 months after the provisional restoration. The time of the provisional crown connection was considered to be the baseline in this study. Esthetic parameters and the marginal bone level were assessed at 6, 12, 24, and 36 months. Results: All implants were well integrated in the bone. A statistically significant increase was found in the mean implant stability quotient between the time of the provisional prosthesis and the time of the final prosthesis. Most implants (95.5%) revealed marginal bone resorption (<0.5 mm), and just 1 implant (4.5%) showed a change of 2.12 mm from baseline to 36 months (mean $0.07{\pm}0.48mm$), while the crestal bone level decreased significantly, from $2.34{\pm}0.93mm$ at baseline to $1.70{\pm}1.10mm$ at 36 months. The facial gingival margin and papilla were stable and the esthetic scores indicated high patient and dentist satisfaction. Conclusions: Platform-switching bone-level implants placed in maxillary single-tooth gaps resulted in successful osseointegration with minimal marginal bone resorption. The peri-implant soft tissue was also esthetically satisfying and stable.

An updated review on probiotics as an alternative of antibiotics in poultry - A review

  • Yaqoob, Muhammad Umar;Wang, Geng;Wang, Minqi
    • Animal Bioscience
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    • 제35권8호
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    • pp.1109-1120
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    • 2022
  • Antibiotics used to be supplemented to animal feeds as growth promoter and as an effective strategy to reduce the burden of pathogenic bacteria present in the gastro-intestinal tract. However, in-feed antibiotics also kill bacteria that may be beneficial to the animal. Secondly, unrestricted use of antibiotics enhanced the antibiotic resistance in pathogenic bacteria. To overcome above problems, scientists are taking a great deal of measures to develop alternatives of antibiotics. There is convincing evidence that probiotics could replace in-feed antibiotics in poultry production. Because they have beneficial effects on growth performance, meat quality, bone health and eggshell quality in poultry. Better immune responses, healthier intestinal microflora and morphology which help the birds to resist against disease attack were also identified with the supplementation of probiotics. Probiotics establish cross-feeding between different bacterial strains of gut ecosystem and reduce the blood cholesterol level via bile salt hydrolase activity. The action mode of probiotics was also updated according to recently published literatures, i.e antimicrobial substances generation or toxin reduction. This comprehensive review of probiotics is aimed to highlight the beneficial effects of probiotics as a potential alternative strategy to replace the antibiotics in poultry.

골회자기 소지의 제물성에 미치는 첨가제의 영향 (A Study on Effect of Physical Proeprteis of Additives to Bone China Body)

  • 이응상;이성희
    • 한국세라믹학회지
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    • 제26권2호
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    • pp.289-295
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    • 1989
  • The properteis of the composition of second reports with Al2O3 and CaO have been investigated. The amount of Al2O3 addition was 5-20w/o, the composition ranges of maximum strength and the microstructure have been studied. In the same method, the effects of CaO on the theoretical composition of tricalcium phosphate have been studied.

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