• Nutrition Research and Practice
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• 제4권6호
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• pp.507-514
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• 2010

Vitamin K intake has been reported as an essential factor for bone formation. The current study was conducted under the hypothesis that insufficient vitamin K intake would affect inflammatory markers and bone mineral density in young adult women. The study was a cross-sectional design that included 75 women in their 20s. Physical assessments, bone mineral density measurements, 24-hr dietary recalls, and biochemical assessments for high sensitivity C-reactive protein (hs-CRP) and percentages of undercarboxylated osteocalcin (%ucOC) were performed. An analysis of vitamin K nutritional status was performed comparing first, second, and third tertiles of intake based on %ucOC in plasma. Vitamin K intake levels in the first, second, and third tertiles were $94.88{\pm}51.48\;{\mu}g$, $73.85{\pm}45.15\;{\mu}g$, and $62.58{\pm}39.92\;{\mu}g$, respectively (P < 0.05). The T-scores of the first and third tertiles were 1.06 and -0.03, respectively, indicating that bone mineral density was significantly lower in the group with lower vitamin K intake (P < 0.05). There was a tendency for different serum hs-CRP concentrations between the first ($0.04{\pm}0.02$) and third tertiles ($0.11{\pm}0.18$), however this was not statistically significant. Regression analysis was performed to identify the correlations between vitamin K nutritional status, inflammatory markers, and bone mineral density after adjusting for age and BMI. Serum hs-CRP concentrations were positively correlated with vitamin K deficiency status (P < 0.05). And bone mineral density, which was represented by speed, was negatively correlated with vitamin K deficiency status (P < 0.05). In conclusion, status of vitamin K affects inflammatory status and bone formation. Therefore, sufficient intake of vitamin K is required to secure peak bone mass in young adult women.

• 한국산학기술학회논문지
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• 제10권11호
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• pp.3405-3411
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• 2009

본 논문은 일개 농촌주민들을 대상으로 신체구성, 운동(과거 운동여부), 체력상태, 골밀도를 조사하고, 골밀도와의 관련된 요인을 파악하여 농촌 주민들의 골다공증 예방을 위한 기초자료를 제시하고자 143명을 대상으로 연구하였고, 결과로서 조사대상자들 연령이 증가할수록, 교육수준이 낮을수록 골밀도가 낮았으며(p<0.05), 만성질환이 있는 경우는 없는 경우보다 골밀도가 낮았다(p<0.05). 그리고, 체중 BMI 체지방량 제지방량이 많이 나가는 경우가 낮은 경우보다 골밀도가 유의하게 높았으며(p<0.01), 과거 운동을 했던 경우와 기초 대사량이 높은 경우, 근육량이 많은 경우 골밀도가 높았다(p<0.01). 또한, 악력 윗몸일으키기 팔굽혀펴기 등 체력이 좋은 경우 골밀도가 높았으며(p<0.01), 골밀도 수치를 종속변수로 한 다중 회귀분석결과 연령, 만성질환 유무, 과거 운동유무가 유의한 변수로 나타났다.

• Journal of Nutrition and Health
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• 제37권2호
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• pp.100-107
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• 2004

This study was performed to evaluate the effect of dietary protein source and sulfur amino acid content on bone metabolism in ra. Thirty male rats (body weight 145$\pm$2g) were divided into three groups. The rats in the first group were fed on casein 20% diet as animal protein source and those in the second group were fed on soy 20% diet as plant protein source. Sulfur amino acid ratio of these group was 1.07:1. The rats in the third group were fed on soy 20% diet and the sulfur amino acid were supplemented with the amount contained as much in the soy 20% diet. All rats were fed on experimental diet and deionized water ad libitum for 9 weeks, The total body, spine, femur bone mineral density and bone mineral content were measured using Dual Energy X-ray Absorptiometry Calcium, phosphate, pyridinoline, creatinine in urine and calcium, phosphate, alkaline phosphatase, osteocalcin in serum were measured. During the experimental period, plant protein (soy protein) group had a lower urinary Ca excretion, urine pyridinoline ＆ crosslinks value and had a higher Ca efficiency in total bone and femur bone mineral density than animal protein (casein) group. There were no significant differences in serum calcium, phosphate, alkaline phosphatase and osteocalcin among the three groups of the rats. The findings from this study demonstrated that plant protein (soy protein) is beneficial of bone mineral density because it had a higher Ca efficiency in total bone and femur bone mineral density than animal protein (casein). However, the supplementation of sulfur amino acid on soy results were consistent with prior studies that dietary sulfur amino acid load had a negative effect on calcium balance. The rats fed sulfur amino acid supplementation diet increased urinary calcium excretion and decreased calcium efficiency for total and femur mineral density. Therefore, dietary protein source and sulfur amino acid content influence bone metabolism. (Korean J Nutrition 37(2): 100-107, 2004)

• 대한간호학회지
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• 제36권6호
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• pp.933-941
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• 2006

Objective: The purpose of this study was to evaluate the effects of soybean intake on bone mineral density and bone turnover markers in postmenopausal rural Korean women. Method: This study was carried out during nine months from Oct. 25 2004 to Aug. 31 2005. The subjects of this study were female patients over 50 living in rural areas diagnosed with osteoporosis. There were 18 women in the experimental group and 20 in the control group. In this study, the experimental group received 100 mg of isoflavone (soybean) and calcium 1,500 mg for nine months while the control group received 1,500mg of calcium only. Results: After the soybean intake, the change of bone mineral density between the experimental group and control group was statistically significant. However, the bone turnover markers of osteocalcin and deoxypyridinoline between the experimental group and control group were not significantly different statistically. In the Pearson Correlation between bone mineral density and bone turnover markers, the osteocalcin and deoxypyridinoline of the experimental group had a positive correlation, and osteocalcin and DPD/osteocalcin ratio had anegative correlation. In the control group, osteocalcin and DPD/osteocalcin ratio had a negative correlation. Conclusions: This result showed that soybean intake changed bone mineral density in postmenopausal woman.

• 보건의료산업학회지
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• 제11권4호
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• pp.145-155
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• 2017

Objectives : To investigate the factors affecting bone mineral density in across stratified postmenopausal ages. Methods : Data from 1,698 subjects who completed the 2010-2011 National Health and Nutrition Survey were analyzed using SPSS Statistics 21.0 The $x^2$ test and one way (ANOVA) were used to verify the relationship between general characteristics and health behaviors and the prevalence of osteoporosis. Logistic regression analysis was used to verify the factors Influencing bone mineral density. Results : The bone mineral density distribution was the highest among those with osteopenia, with proportions of 21.8% in healthy subjects, 58.1% in osteopenia, and 20.0% in those with osteoporosis. The distribution of osteoporosis by age group was 5.2% among subjects in their 50s, 15.4% among those in their 60s, and 42.4% among those in their 70s. In multivariate logistic regression analysis, the prevalence of osteoporosis according to ages was significantly correlated with age, educational level, body mass index(BMI), and parity 4 of more than 1-2 babies. Conclusions : Although age is an uncontrollable factor in the prevention of osteoporosis, educational level and BMI are correctable factors to maintain bone mineral density. There is a need to maintain healthy BMI and expand osteoporosis prevention education.

• Clinical and Experimental Pediatrics
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• 제56권2호
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• pp.60-67
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• 2013

As chemotherapy and other sophisticated treatment strategies evolve and the number of survivors of long-term childhood cancer grows, the long-term complications of treatment and the cancer itself are becoming ever more important. One of the most important but often neglected complications is osteoporosis and increased risk of fracture during and after cancer treatment. Acquisition of optimal peak bone mass and strength during childhood and adolescence is critical to preventing osteoporosis later in life. However, most childhood cancer patients have multiple risk factors for bone mineral loss. Cancer itself, malnutrition, decreased physical activity during treatment, chemotherapeutic agents such as steroids, and radiotherapy cause bone mineral deficit. Furthermore, complications such as growth hormone deficiency and musculoskeletal deformity have negative effects on bone metabolism. Low bone mineral density is associated with fractures, skeletal deformity, pain, and substantial financial burden not only for childhood cancer survivors but also for public health care systems. Thus, it is important to monitor bone health in these patients and minimize their risk of developing osteoporosis and fragility fractures later in life.

• 농촌의학ㆍ지역보건
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• 제48권4호
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• pp.275-284
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• 2023

Objectives: This study aimed to assess hand grip strength and femoral neck bone mineral density levels among Korean fishery workers and investigate their association. Methods: Hand grip strength and femoral neck bone mineral density were measured in a survey and health examination conducted in 2021 among fishery workers in a southern region of South Korea. Covariates including gender, age, education level, income level, smoking behavior, drinking behavior, family history of hip fractures, use of calcium and vitamin D supplements, hypertension, diabetes, regular exercise, and body mass index were investigated. Multiple regression analysis was employed to assess the association between hand grip strength and femoral neck bone mineral density. Results: Among 147 fishery workers, 8.16% exhibited low hand grip strength levels indicative of possible sarcopenia, and a significant association was found between low hand grip strength and decreased femoral neck bone mineral density (β = -89.14, 95% CI = -160.50, -17.78). Additionally, factors such as women gender, advanced age, family history of hip fractures, and a body mass index below 25 kg/m² were associated with decreased femoral neck bone mineral density. In the subgroup analysis by gender, a correlation between low hand grip strength and decreased femoral neck bone mineral density was observed only in men. Conclusions: Further research is needed to explore various determinants and intervention strategies to prevent musculoskeletal disorders among fishery workers, ultimately enhancing their quality of life and well-being.

• 대한방사선기술학회지:방사선기술과학
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• 제28권3호
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• pp.235-239
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• 2005

청소년기에 형성된 골밀도는 25세에서 35세 전후로 최고치가 되며, 형성된 골밀도는 중년기와 노년기에 감소된다. 골밀도 감소는 골다공증의 발생과 골절 위험성 증가 등을 유발하여 사회적인 건강문제로 대두되고 있다. 골다공증은 사전 예방이 매우 중요하며, 골밀도가 감소되는 중년기 이후보다 골밀도가 형성되고 최고로 발달되는 시기인 청년기에 적극적인 관리와 예방이 중요하다. 따라서 본 연구는 대학생의 골밀도 상태와 생활습관 및 신체활동과의 관계를 파악하여 골밀도 향상을 위한 자료 개발에 도움이 되는 시사점을 도출하고자 일부 대학생 119명을 대상으로 골밀도 측정과 생활습관에 대한 설문을 실시하여 다음과 같은 결론을 도출하였다. 첫째, 대상자의 일반적 골밀도 상태는 정상 88명(73.9%), 골감소증 29명(24.4%), 골다공증 2명(1.7%)으로 정상이 가장 높게 나타났으나 골감소증도 다소 높게 나타났다. 둘째, 성별에 따른 생활습관과의 관계에서는 음주 경험, 흡연경험, 운동 경험이 통계적으로 유의하게 나타났다. 음주경험, 흡연경험, 운동경험이 있는 경우는 남학생 군이 모두 높게 나타났다. 셋째, 일반적 특성에 따른 골다공증 상태와의 관계에서는 성별과 흡연경험이 집단 내에서 통계적으로 유의한 차이를 나타냈다. 성별에서는 남학생에게서는 골감소증이 가장 높게 나타났고, 여학생은 정상이 높게 나타났으며 이는 통계적으로 유의하였다. 흡연경험에 따른 골다공증 상태에서는 흡연경험이 없는 군에서는 정상이 가장 높게 나타났고, 흡연경험이 있는 군에서는 골감소증이 가장 높게 나타났으며 통계적으로 유의하였다.

• 대한간호학회지
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• 제38권5호
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• pp.667-675
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• 2008

Purpose: The aim of this study was to compare the relation between differently measured sports activities (metabolic equivalent [MET] and peak strain score) and distal radius bone mineral density in college-aged women. Methods: lifetime sports activity was scored in two different ways: 1) a sports activity score by multiplying the intensity (METs) and duration and 2) a sports activity score by adding up physical strain scores based on the ground reaction force of each sports activities. Bone mineral density was measured using dual energy x-ray densitometry (DTX-200) in the distal radius site. Results: In stepwise multiple regression analysis, body weight and sports activities during the college period were significant positive predictors for distal radius bone mineral density. The explained variance of sports activity measured with a peak strain score (8.8%) for distal radius bone mineral density was higher than one measured with the MET score (3.3%). Conclusion: It can be concluded that sports activity scores based on MET and peak strain scores during college are very important for determining the bone mineral density in the distal radius site in women under 30.

• Journal of Community Nutrition
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• 제7권2호
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• pp.93-99
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• 2005

This study investigated associations between exercise habit and bone mineral density (BMD) and bone mineral content (BMC) in postmenopausal women. The BMD and BMC of the spinal skeleton was measured by dual energy x-ray absorptiometry. Exercise and energy expenditure of physical activity were estimated by questionnaire. For exercise activities, subjects were asked to identify all exercises they have participated in. The subjects were further asked to estimate the number of years of participation, the number of weeks per year, the number of times per week, and the number of hours per time. Subjects were then categorized into exercise (more than 3 times/wk, more than 30min per session exercise (n = 47) and nonexercise group (n = 72). Results indicated that there were no significant differences in BMD and BMC when comparisons were made between subjects in exercise habit, a general exercise group and a nonexercise control group. However, when exercise subjects were divided into weight-bearing and nonweight-bearing groups, significant differences were found. These results suggest that weight-bearing exercise positively influences bone mineral density and bone mineral content in postmenopausal women. Sedentary women should be encouraged to adopt a weight-bearing exercise to maintain the health of their skeletons. Exercise interventions are practical and feasible for healthy women and should be encouraged at the earliest possible age. Our findings lend support to recommendations for physical activity and weight-bearing exercise as a means of osteoporosis prevention.