• 생명과학회지
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• 제24권7호
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• pp.804-811
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• 2014

Cyclohexanone의 GHS 분류 기준에 따른 화학물질의 변이원성 구분을 위해, 다른 연구에서는 아직까지 수행된 바 없는 ICR계 마우스의 골수세포를 이용하는 in vivo 소핵시험을 수행하였다. 7주령의 수컷 ICR계 마우스에 동 시험물질의 3가지 농도를 투여하였으며, 경구투여 24시간 후에 도살, 골수세포를 채취하여 슬라이드 표본을 제작하였고, 2,000개의 다염성적혈구 중 소핵을 갖는 다염성 적혈구(MNPCE)를 계수하였다. 모든 투여군에서 cyclohexanone은 골수세포의 증식을 억제하지 않았으며, 소핵을 유발하였다. 이 골수세포를 이용한 소핵시험의 결과로 동 시험물질(cyclohexanone)은 GHS 분류기준에 의거, 변이원성 구분2로 분류하였다.

• Journal of Korean Dental Science
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• 제6권1호
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• pp.13-21
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• 2013

Purpose: To report the successful results of using chin bone graft and autogenous tooth bone graft material (AutoBT) in alveolar cleft patients. Materials and Methods: Five patients with alveolar cleft defects underwent alveolar bone grafting. Three patients were treated using chin bone graft, and the other two patients underwent AutoBT graft. After implant site development using chin bone graft in the fi rst three cases, endosseous implant restorations were placed. In case #4 and 5, AutoBT graft material was placed to guide the normal eruption of partially impacted maxillary right canine and to the upper docking site after distraction osteogenesis. Result: Successful implant restorations with closure of the oronasal fistula were achieved in alveolar cleft defect reconstruction using either chin bone graft (Case #1, 2, 3) or AutoBT graft material (Case #4, 5). Case #4 showed enlarged follicle of the right maxillary canine, indicating a normal eruption guide pattern. Conclusion: Both chin bone graft and AutoBT graft showed favorable outcomes in reconstructing alveolar cleft defects. Autogenous tooth bone graft opens up the possibility of avoiding harvesting autogenous bone graft with complications and morbidities.

• Journal of Nutrition and Health
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• 제24권1호
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• pp.30-39
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• 1991

This study was designed to investigate the effects of dietary calcium. serum estrogen level and physical activity on the bone status of 116 healthy elderly women living in urban area. Current calcium intake was assessed by convenient method(refered to as Ca intake) and calcium containing food frequency method(refered to as Ca index) Daily activity record was used for the estimation of physical activity level, and serum estrogen level was measured from fasting blood of subjects. The rate of bone resorption was evaluated by the determination of hydroxyproline(Hpr) in fasting urine with correction for creatinine excretion. The results of this study are summarized as follows : 1) Average daily Ca intake of subjects was 621.4$\pm$155.8mg, which is above the Korean recommended dietary allowances. However 44.8% of the subjects consumed Ca below RDA level. Ca index score was significantly correlated with the bone status(P<0.05), Ca intake did not show significant correlation with the bone status although a positive trend of influence was evident. 2) Average serum estrogen level of subjects was 18.7$\pm$9.8pg Contrary to our anticipation. estrogen level did not show any significant relation to age and bone status. 3) Daily physical activity was classified into four categories by activity intensity : sedentary. moderate, active and severe. The average physical activity of subjects belong to moderate level. and the bone status was significantly related to the physical activity(P<0.01) 4) Among other influential factors such as age, pocket-money. family type. drinking, smoking and BMI, there was a significant difference between bone status and BMI(P<0.05). 5) Multiple regression analysis of variables showed that physical activity has greater effect than other variables when the entire subjects were taken into account. However. eliminating the subjects whose bone status rated as excellent(Hpr/cr<0.009), Ca index showed higher correlation than physical activity. These results have demonstrated that dietary calcium intake is the primary important factor for keeping good bone health and that bone status of subjects with a sufficient calcium intake is affected by various factors such as physical activity, age, smoking. BMI and others.

• Journal of Nutrition and Health
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• 제30권3호
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• pp.266-276
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• 1997

To investigate the effects of dietary protein and calcium levels on calcium and bone metabolism Sprague-Dawley male growing rats weighting approximately 91.4g were divided into four groups and fed one of the following four experimental diets-15% protein 0.2% calcium ; 15% protein 0.5% calcium ; 30% protein 0.2% calcium ; 30% protein 0.5% calcium-for five weeks. Calcium intake and excretion, apparent calcium absorption were measured and bone densities and mineral contents of femur and scapula were analyzed. Calcium excretion through feces and urine was significantly greater in animals receiving diets of higher calcium. Fecal calcium but not urinary calcium excretion was greater when the protein level was increased from 15% to 30%. Apparent calcium absorption rate was significantly higher with lower calcium intakes. Serum alkaline phosphatase activity was significantly higher in 0.2% calcium group than in 0.5% calcium group, while urinary hydroxyproline excretion was essentially same among all experimental groups. Weights and mineral contents or protein. Bone weights were greater, but calcium and ash contents of femur and scapula were lower in animals on the diet containing low calcium and high protein, which suggests that bone metabolism may be affected by the interaction between calcium and protein intake. These results indicate that during growth high protein intake might be beneficial to bone health if the diet is sufficient in calcium, however, if the diet fails to provide an optimum amount of calcium, such practice might be detrimental.

• 한국간호교육학회지
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• 제12권2호
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• pp.214-223
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• 2006

Purpose: This study is to find the significant symptoms related to bone density, from which a cost-effective nursing diagnosis and intervention can be derived. Method: The research sample was 102 women, the sampling was designed by the researcher's convenience, and the subjects of the sample voluntarily participated in a questionnaire survey and measurements. The questionnaire asked socio-demographics, women' reproductive health symptoms, and the life style of the subject. Osteometer DTX-200 for bone density measure and a ruler for measuring spinal curvature were used. All the data were collected at the two public health clinics in a city in Korea. Result: The subjects' current and completed menopause ages, duration of menopause, degree of spinal curvature, BMI, frequency of parity and etc. showed significant correlations with bone density. However, only the degree of spinal curvature(p<.001, r=-.22) was found to be meaningful as a predicted factor for self diagnosis of bone density level. Conclusions: Since most of the subjects have not recognized the relationships between changes in spinal curvature and lowered bone densities, nurse needs to educate clients to get medical assistance to prevent from further bone density reduction by earlier finding of spinal curvature.

• 식품보건융합연구
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• 제8권2호
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• pp.15-27
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• 2022

This study aims to analyze the relative importance of bone age and chronological age in physique according to gender and to identify the relative importance of bone age, chronological age, and physique in physical fitness and motor coordination according to gender in order to alleviate the imbalance between physique and physical fitness in children. A total of 666 children(346 males, 320 females) between the ages of 11-14 were enrolled as subjects, and the skeletal maturation The skeletal maturation were measured by taking hand-wrist. Physical fitness were measured through a total of 4 components: muscular strength. The results of this study. First, physique variables for both males and females aged 11-14 were found to be more significant predictors of bone age than chronological age. Second, for physical fitness in males, in the order of %fat, body water, waist-hip ratio, weight, fat-free mass, and chronological age were more significant predictor variables; and in females, in the order of %fat, fat-free mass, height, chronological age, weight, bone age, fat mass, and body water were more significant predictor variables. For bone age and chronological age in physical fitness, bone age in males and chronological age in females found to be the more representative variables respectively.

• International Journal of Oral Biology
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• 제44권2호
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• pp.37-42
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• 2019

Oral squamous cell carcinoma (OSCC) is the most common oral malignancy and an increasing global public health problem. OSCC frequently invades the jaw bone. OSCC-induced bone invasion has a significant impact on tumor stage, treatment selection, patient outcome, and quality of life. A number of studies have shown that osteoclast-mediated bone resorption is a major step in the progression of bone invasion by OSCC; however, the molecular mechanisms involved in OSCC bone invasion are not yet clear. In this review, we present the clinical types of OSCC bone invasion and summarize the role of key molecules, including proteases, cytokines, and growth factors, in the sequential process of bone invasion. A better understanding of bone invasion will facilitate the discovery of molecular targets for early detection and treatment of OSCC bone invasion.

• Journal of Preventive Medicine and Public Health
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• 제51권4호
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• pp.215-216
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• 2018

• 대한디지털의료영상학회논문지
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• 제13권2호
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• pp.59-62
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• 2011

In this experiment, how DEXA(Dual-energy X-ray Absorptiometry) bone mineral density was measured using the equipment. In order to maintain the same measurement conditions, bone mineral density measurements of 10 cm thick phantom, with an actual patient at a point when examining the same conditions(100 kVp, 1 mA) and then out to the five doses of radiation and its average was calculated by dividing measured. X-ray dose rate measured at the Research Institute, Sword of the gamma survey meters calibrated MEDCOM Ltd. (Inspector GM counter tube) was used, calibration factor is 1.15. On a horizontal plane around the patient, depending on the distance was significantly reduced dose rate. In addition, orientation $0^{\circ}$ head end was higher in the direction of the highest dose rate, $0^{\circ}$ $180^{\circ}$ direction from the direction towards the higher dose rate reduced to some extent in the direction of all the $120^{\circ}$ were able to identify.

• 근관절건강학회지
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• 제15권1호
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• pp.88-95
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• 2008

Purpose: This study was to evaluate and compare the effectiveness of the Resistance Exercise Program on pain, stiffness, ADL and bone mineral density in Arthritis Patients at home. Methods: Forty-two patients participated in this study and they were divided randomly into two groups (exercise and control group). Two subjects dropped during the study period. The exercise group had a structured training which was 50 minutes in duration, five times per week for a period of 16 weeks and the control group without any scheduled treatment. Data were gathered for 16 weeks (May 21, 2007- September 10, 2007) and were analyzed by using SPSS Win 12.0. Results: The pain, stiffness, ADL, balance and bone mineral density in the exercise group were improved significantly after the Resistance Exercise Program. However, a significant improvement on the above mentioned variables was not observed in the control group.