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http://dx.doi.org/10.5352/JLS.2014.24.7.804

In vivo Micronucleus Test of Cyclohexanone and Mutagenicity Classification According to a Globally Harmonized System  

Kim, Soo-Jin (Chemicals Safety and Health Center, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
Rim, Kyung-Taek (Chemicals Safety and Health Center, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
Lim, Cheol-Hong (Chemicals Safety and Health Center, Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency)
Publication Information
Journal of Life Science / v.24, no.7, 2014 , pp. 804-811 More about this Journal
Abstract
A micronucleus test of cyclohexanone has not yet been conducted. To classify the chemical hazard posed by cyclohexanone according to a globally harmonized system of classification and labeling of chemicals (GHS), we investigated its mutagenicity by micronucleus induction in ICR bone marrow cells of 7-weeek-old male mice. The mice were administered three dosages of the chemical for 24 hr via the oral route. After 24 hr, the mice were sacrificed, and their bone marrow cells were prepared for smearing slides. Based on counts of micronucleated polychromatic erythrocytes (MNPCEs) of 2,000 polychromatic erythrocytes, cyclohexanone did not inhibit bone marrow cell proliferation in any of the treated groups, but it resulted in micronucleus induction. According to the results of the mammalian bone marrow micronucleus test, this chemical is mutagenic and classified as category 2 in the GHS.
Keywords
Cyclohexanone; GHS (globally harmonized system of classification and labeling of chemicals); micronucleus; mutagenicity;
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Times Cited By KSCI : 1  (Citation Analysis)
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