• 대한한의학방제학회지
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• 제25권2호
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• pp.193-207
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• 2017

Objectives : This study was designed to investigate anti-obesity effects of DF in a ob/ob mouse model. Methods : Fifteen-week-old ob/ob mice were divided into four groups: a normal lean group given a standard diet, an ob/ob control group given a standard diet, and DF(1) and DF(2) groups given a standard diet with DF(1) (300 mg/kg), and DF(2) (600 mg/kg), respectively. After 10 weeks of treatment, body weight gain, feeding efficiency ratio, blood lipid markers, fat weight and histology were examined. Results : Body weight gain and fat mass were significantly decreased in DF(1) and DF(2) groups compared with control. The extent of decreases was eminent in DF(2) group. Feeding efficiency ratio were significantly decreased in DF(2) group compared with control. Consistent with their effects on body weight gain and fat mass, circulating concentrations of LDL, total cholesterol, free fatty acid, and insulin were decreased in DF(2) group compared with control. The size of adipocytes were significantly decreased by DF(2) compared with control. Consistent with their effects on body weight gain, hepatic lipid accumulation and liver weights were reduced in DF compared with control. Conclusions : In conclusion, these results suggest that DF not only decrease feeding efficiency ratio, and blood anti-obesity biomarkers, but also reduce fat mass, contributing to the improvement of obesity. DF also inhibits hepatic lipid accumulation.

• 혜화의학회지
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• 제13권2호
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• pp.327-335
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• 2004

Using aged Wistar rat living body change by aging Dokhwaljihwang was each orally administrated and achieved research about aging control. In Wistar rat 10, 30, 50 week and 40 week Dokhwaljihwang between 10 weeks form condition change of weight, change of intestine weight, hematology, blood chemistry, research result about serum content following conclusion get. 1. Observed gain in weight than control group form of Dokhwaljihwang to aged Wistar rat. 2. Is thought to promote activation of living body action gaining intestine weight along with gain in weight. 3. Displayed decrease of MDA's content of serum than control group form of Dokhwaljihwang to aged Wistar rat. 4. Change that is Wistar rat's hematological value by aging according to 10, 30, 50 week WBC, RBC, Hgb, monocytes, eosinophil etc. increase, and HCT, PLT etc. showed tendency that decrease according to old-week, and observed improvement that is hematological value than control group form of Dokhwaljihwang 5. Change that is Wistar rat's biochemical value by aging was measured highest in 50 week because ALT, AST, BUN, CRN, T-bili., T-chol, TG, TP, ALB, A/G, P etc. increase according to 10, 30, 50 week, and observed improvement that is biochemical value than control group form of Dokhwaljihwang. Is considered by being effect that Dokhwaljihwangimprove living body function decline by aging by this result.

• Asian-Australasian Journal of Animal Sciences
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• 제24권10호
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• pp.1329-1334
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• 2011

The Hinai-dori is a breed of chicken native to Akita Prefecture, Japan. An $F_2$ resource population produced by crossing low- and high-growth lines of the Hinai-dori breed was analyzed to detect quantitative trait loci (QTL) for growth traits. Highly significant QTLs for body weight at 10 and 14 weeks of age and average daily gain between 4 and 10 weeks and between 10 and 14 weeks of age were accordingly mapped in a common region between ADL0198 and ABR0287 on chromosome 1 and between MCW0240 and ABR0622 on chromosome 4, respectively. A significant QTL for body weight at 4 weeks of age and a significant QTL for average daily gain between 0 and 4 weeks of age were mapped for the first time to the same region flanking ABR0204 and ABR0284 on chromosome 1. These QTLs are good candidates for application in the development of marker-assisted selection strategies for increasing growth efficiencies in the Hinai-dori breed and native breeds of chickens in Asia.

• 대한화학회지
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• 제10권3호
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• pp.109-113
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• 1966

By the micro-bioassay method, quantitative studies were made on the increment of body weight and changes in free-lysine and threonine contents in the liver and plasm of rats, when they were fed on sucrose diet added with 0.3% DL-methionine, 0.36% DL-threonine and 0.1% L-tryptophane. The results of the experiment were as follows: (1) The weight gain and growth gain of rats decreased more when they were fed on 0.36% DL-threonine diet (Sth-group) than 0.3% DL-methionine diet (Sm-group). But those gain were increased when they were fed on 0.1% L-tryptophane diet (Str-group). (2) The contents of free-lysine and threonine in plasm and liver of rats were decreased more when they were fed on 0. 36% DL-threonine diet than 0.3% DL-methionine diet. And, those free amino acids were increased greatly when they were fed on 0.1% L-tryptophane diet. (3) The increment of body weight was the biggest when the free amino acid pattern showed that the contents of free-lysine decreased and threonine increased in the plasm and liver of rats being fed on 0.l% L-tryptophane diet.

• Toxicological Research
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• 제12권1호
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• pp.93-99
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• 1996

The effect of KTC-1, a new semisynthetic rifamycin antituberculous drug, on general toxicity, reproductive capability and fetal development was investigated in Sprague-Dawley rats. Male rats were administered KTC-1 with mashed feed from 63 days before mating to the end of mating period, and female rats were given from 14 days before mating to day 7 of gestation at dose levels of 0, 375, 750, and 1,500 ppm. The females were sacrificed on day 21 of gestation for examination of their fetuses. At 1,500 ppm, a reduction in body weight gain and testis atrophy were observed in male rats. Histological examination revealed testicular atrophy, absence or decrease of germinal cells, and vacuolization of Sertoli cells in testis. A reduction in body weight gain, a decrease in food consumption were found in female rats. In addition, decreases in the number of corpora lutea, iraplantations, and the litter size of live fetuses were seen. Mating, fertility, and pregnancy performances were also affected. There were no external abnormalities observed by examination of fetuses. At 750 ppm, a reduction in the body weight gain of male and female rats and decreases in the number of implantations and litter size were found. At 375 ppm, no treatment-related effects were observed. The results suggest that the no-effect dose levels (NOELs) of KTC-1 are 375 ppm for males and females on general toxicity, 750 ppm for males and females on reproductive capability, and 375 ppm for fetuses on embryonic development.

• Asian-Australasian Journal of Animal Sciences
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• 제29권10호
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• pp.1451-1457
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• 2016

A comparative study was performed to investigate the efficacy of KiFAY as a feed additive on performance parameters, thyroid, and pancreatic hormone levels in broilers. Ninety birds (Vencobb 400) were randomly divided into three groups viz., Control (no DL-methionine supplementation), Treatment1 (containing added DL-methionine) and Treatment 2 (containing KiFAY and without DL-methionine supplementation). The performance parameters (weekly body weight, body weight gain, feed intake, and feed consumption ratio) were recorded and calculated during the whole study of 4 weeks. Analyses of insulin and insulin-like growth factor (IGF 1), triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) were performed at the end of the study. The results show that birds on supplementation of KiFAY performed significantly (p<0.001) better than other treatments. The weekly body weight, body weight gain, feed in-take and feed consumption ratio improved in KiFAY treated birds. The study found an increase in insulin and IGF1 levels (p<0.001) in KiFAY compared with the other treatments. Serum T3, T4, and TSH levels in the Treatment 2 were higher than other treatments (p<0.001). The KiFAY supplementation was able to improve performance with associated responses at a hormonal level in broilers.

• 농업과학연구
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• 제48권1호
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• pp.1-9
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• 2021

A total of twenty-four multiparous sows (Landrace × Yorkshire) and their litters were used in this 21-day experimental trial. Based on their body weight, sows were randomly allocated into one of three treatments with eight replicates. The dietary betaine supplementation contained three levels: (i) CON (Basal diet + 0% Bet), (ii) Bet 0.05% (CON + 0.05% Betaine), and (iii) Bet 0.15% (CON + 0.15% Betaine). The supplementation of betaine had no effect (p > 0.05) on body weight and feed intake of lactating sow. Moreover, no significant response was observed on backfat thickness, body condition score, and weaning of the estrus interval with the dietary supplementation of betaine. In addition, the litter weaning weight, litter weight gain, average litter daily gain, and survivability rate at birth showed no significant difference with the dietary betaine supplementation of the sow diet. Fecal scores of the lactating sows and suckling piglets were not affected (p > 0.05) with the dietary betaine supplementation compared with the control diet during the experimental periods. The findings of this study showed that betaine supplementation does not boost growth performance, feed intake, body conditions, and fecal score in lactating sows and suckling piglets fed a corn-soybean meal-based diet.

• 한국가금학회지
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• 제27권1호
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• pp.43-50
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• 2000

Two experiments were conducted to investigate the effect of dietary supplemental lincomycin at different food waste supplements on performance of broiler chicks. Diets were based corn, soybean meal and contained 3,078, 3,089 ㎉/kg ME, 21% CP for the first three weeks and 3,116 ㎉/kg and 19% CP for the rest two weeks. Three levels of lincomycin(LM; 0, 2.2, 4.4mg/kg) and food waste (FW;0, 5, 10%) were differently used for both experiments. Weight gain, feed intake, feed conversion ratio were weekly measured for five weeks. Blood components, liver and abdominal fat were sampled at the end of experiments. In experiment, 1 weight gain of birds fed 4.4mg/kg LM was significantly higher than that of no LM treatments (p<0.05). It was tended to decrease in 10% food waste treatment compared to that of control but was not significantly different. FCR of chocks fed LM supplement tended to improve as dietary LM level increased. It was not superior in 10% food waste treatment to that of control, but tended to improve compared to that of other treatments. Weight gain and FCR of birds fed 2.2mg/kg LM without food waste tended to improve compared to those of other treatments, but were not significantly different. Liver to body weight ratio birds fed LM supplements regardless of FW decreased significantly compared to that of control (p<0.05), but was not consistency in FW treatments. There was no significance in blood components except blood protein. In experiment 2, weight gain of chicks fed no FW showed quadratic, but increased as dietary supplemental LM increased. Birds fed 5% FW was not superior weight gain to that of other FW treatments. It also decreased in no LM treatment with 10% FW compared to that of control. However, the birds fed 4.4 mg/kg LM with 10% FW exhibited significantly higher weight gain the trend of weight gain. It tended to increase up to 10% FW combined with 4.4 mg/kg LM, but was not significantly different. Liver to body weight ratio of chicks fed LM was significantly decreased more than the control(p<0.05).The results of these experiments indicated that chicks fed 10% FW with 4.4 mg/kg LM supplements maximized growth rate of all treatments, but was not improve FCR in both experiments.

• Asian-Australasian Journal of Animal Sciences
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• 제16권12호
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• pp.1782-1788
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• 2003

A mathematical model has been constructed to estimate the amino acid requirements for growing Taihe silky fowls in early stage. A requirement was taken as the sum of the needs for maintenance, for gain in carcass weight without feathers, and for the feathers. The maintenance requirement was considered to be the sum of the needs for replacing skin and intestinal losses and for the obligatory creatinine excretion in the urine. A comparative slaughter trial and nitrogen balance trials with growing and adult Taihe silky fowls, respectively, were conducted to estimate the parameters in the model. The amino acid requirements were then calculated with the constructed models. The results showed as following: the replacement needs for skin nitrogen loss was determined at 213.41 mg/d for adult male fowls (body weight 1.60 kg); creatinine excretion in these birds was 4.04 mg/d. when fed an nitrogen-free diets, the adult male fowls with body weight 1.60 kg excreted a total of 246.10 mg/d endogenous nitrogen. The net protein requirement for maintenance was estimated at $11.24mg/w_g{^{0.75}}/d$Per gram of body weight gain contained 27.18 mg carcass nitrogen for growing birds in early stage, but feathers nitrogen in per gram of body weight gain increased with age. The amino acid requirements for growing Taihe silky fowls were slightly higher than for starting and growing pullets, but lower than that of broiler chicks. The amino acid requirements patterns changed with weeks of age.

• 생약학회지
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• 제33권1호통권128호
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• pp.21-28
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• 2002

Antidiabetic effects of the acid hydrolysate of silk fibroin were investigated by oral administration to animal models for diabetes mellitus, Fibroin protein was extracted from cocoon and digested to peptides of low-molecular weight range (mainly below 3,000) and amino acids by acid hydrolysis, Feeding of the fibroin hydrolysate resulted in a significant recovering effect on reduction of body weight gain and a lowering effect on blood glucose gain in streptozotocin-induced diabetic Sprague Dawley rats (STZ rats) which were used as an insulin-dependent diabetic animal model. But the body weight and blood glucose level in C57BL/KsJ-db/db mice (db/db mice), an non-insulin-dependent diabetic animal model, were not changed significantly by the feeding, On the other hand, plasma leptin levels increased according to increased feeding amount of the hydrolysate in STZ rats and db/db mice in common, It was concluded from the results that the fibroin hydrolysate might stimulate the insulin secretion by recovering or activating pancreatic ${\beta}$ cells and result in the increased plasma leptin level. It was also deduced that the antidiabetic improvements in body weight and blood glucose gain in STZ were thought to be due to the increased insulin secretion, but in db/db mice of which the diabetic symptoms were caused by insulin resistance, the stimulated secretion of insulin was unlikely to be able to change body weight and blood glucose level significantly.