Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Gangjihwan Reduces Body Weight Gain in a ob/ob Female Mice

Ob/Ob 비만마우스 모델에서 강지환(降脂丸)의 체중감량 효과

  • Baek, Song Young (Department of Formula Sciences and Research Center of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University) ;
  • Lee, Hye Rim (Department of Formula Sciences and Research Center of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University) ;
  • Park, Ju Hye (Department of Formula Sciences and Research Center of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University) ;
  • Yoon, Michung (Division of Medical Engineering and Health Management, Mok-Won University) ;
  • Yoon, Yoosik (Department of Microbiology, College of Medicine, Chung-Ang University) ;
  • Yang, Heejung (College of Pharmacy, Kangwon National University) ;
  • Choi, Yung Hyun (Department of Biochemistry, College of Korean Medicine, Dong-Eui University) ;
  • Shin, Soon Shik (Department of Formula Sciences and Research Center of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University)
  • 백송영 (동의대학교 한의과대학 방제학교실 및 한방당뇨비만연구소) ;
  • 이혜림 (동의대학교 한의과대학 방제학교실 및 한방당뇨비만연구소) ;
  • 박주혜 (동의대학교 한의과대학 방제학교실 및 한방당뇨비만연구소) ;
  • 윤미정 (목원대학교 의생명.보건학부) ;
  • 윤유식 (중앙대학교 의과대학 미생물학교실) ;
  • 양희정 (강원대학교 약학대학) ;
  • 최영현 (동의대학교 한의과대학 생화학교실) ;
  • 신순식 (동의대학교 한의과대학 방제학교실 및 한방당뇨비만연구소)
  • Received : 2017.05.22
  • Accepted : 2017.05.26
  • Published : 2017.05.31
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Abstract

Objectives : This study was designed to investigate anti-obesity effects of DF in a ob/ob mouse model. Methods : Fifteen-week-old ob/ob mice were divided into four groups: a normal lean group given a standard diet, an ob/ob control group given a standard diet, and DF(1) and DF(2) groups given a standard diet with DF(1) (300 mg/kg), and DF(2) (600 mg/kg), respectively. After 10 weeks of treatment, body weight gain, feeding efficiency ratio, blood lipid markers, fat weight and histology were examined. Results : Body weight gain and fat mass were significantly decreased in DF(1) and DF(2) groups compared with control. The extent of decreases was eminent in DF(2) group. Feeding efficiency ratio were significantly decreased in DF(2) group compared with control. Consistent with their effects on body weight gain and fat mass, circulating concentrations of LDL, total cholesterol, free fatty acid, and insulin were decreased in DF(2) group compared with control. The size of adipocytes were significantly decreased by DF(2) compared with control. Consistent with their effects on body weight gain, hepatic lipid accumulation and liver weights were reduced in DF compared with control. Conclusions : In conclusion, these results suggest that DF not only decrease feeding efficiency ratio, and blood anti-obesity biomarkers, but also reduce fat mass, contributing to the improvement of obesity. DF also inhibits hepatic lipid accumulation.

Keywords

References

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