• Biomolecules & Therapeutics
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• 제5권2호
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• pp.211-214
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• 1997

In the present study, we investigated the mechanisms of antinociceptive effect and thermoregulatory action of capsaicin in guinea pigs. The administration of capsaicin (5 mg/kg, s.c.) caused a significant decrease in frequency of eye wiping, an indicative of nociceptive threshold. This antinociceptive effect of calsaicin was abolished by co-administration of capsazepine (30 mg/kg, s.c.) with capsaicin, suggesting the involvement of a vanilloid receptor in the antinociceptive action of capsaicin. The administration of capsaicin (1 mg/kg, s.c.) produced a significant decrease in body temperature of guinea pigs. The maximum decrease in body temperature by 2 degrees was shown 1 hour after the treatment, and this decrease was not reversed by coadministration of capsazepine. In conclusion, it is suggested that the mechanism of action of capsaicin-induced thermoregulation involves different pathways from that of capsaicin-induced antinociception.

• 한국의류산업학회지
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• 제22권2호
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• pp.240-249
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• 2020

This study reviews studies that used skin temperature in order to establish an emotion evaluation protocol based on skin temperature for home appliances. A survey of skin temperature evaluation papers was conducted by the following five stages: (1) keyword search, (2) title screening, (3) abstract screening, (4) full paper screening, and (5) relevance evaluation. Selected papers were reviewed for: purpose, recruitment criteria of participants, the number of participants, apparatus, procedure, measures, analysis methods, and major findings. Thermistor sensors and thermography are used for the measurement of skin temperature. Skin temperature sensors are attached to 4 - 10 locations on the body and their mean of skin temperature is calculated by Ramanatan's 4-point or Hardy & Dubois's 7-point method. Semantic differential (SD) method and thermography measuring facial surface temperature have been used for emotion evaluation. The SD method provides a set of adjective pairs related to a product and evaluates changes in emotion from the use of the product. The range of facial surface analyzed is defined in the thermal image and temperature changes before and after the evaluation are analyzed. The evaluation items of home appliances include form, color, material, aesthetics, satisfaction, novelty, convenience, pleasantness, and excellence. Many existing emotion studies using skin temperature do not apply physiological and psychological methods. This study provides basic data to establish a skin temperature and emotion evaluation protocol by examining literature for skin temperature and evaluation of sensitivity.

• Journal of the Optical Society of Korea
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• 제9권4호
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• pp.157-161
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• 2005

Medical infrared imaging is obtained by measuring the self-emitted infrared radiance from the human body. Infrared emission is related to surface temperature and temperature is one of the most important physiological parameters related to health. Though recent applications such as security identification and oriental medicine have provided new fields of biomedical applications, infrared thermography has had ups and downs in its usages in cancer detection. Some of the main difficulties include finding proper applications and efficient diagnostic algorithms. In this study, infrared thermal imaging was used to detect regional metastasis of breast cancer. Our measurements were done for 110 women. From 63 individuals of a Healthy Group and a Benign Breast Disease Group, we developed algorithms for differentiating malignant regional metastasis based on temperature difference and asymmetry of temperature distribution. Testing with 47 cancer patients, we achieved a positive predictive value of $87.5\%$ and a negative predictive value of $95.6\%$. The results were better than for mammogram examination. A proper analysis of infrared imaging proved to be a highly informative and sensitive method for differentiating regional cancer metastasis from normal regions.

• 한국생산제조학회지
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• 제22권2호
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• pp.248-255
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• 2013

The objective of this study is to optimize the Metal Injection Molding(MIM) process with design of experiments(DOE) and numerical analysis. To derive the optimal process condition, experiment or numerical analysis was performed under various process conditions. To analyze the interaction among influential factors contributing to the temperature at flow front and response surface in MIM, both central point and axial point were added to the full factorial design with 2 levels and 5 factors and then their impacts on response variable in 43 experimental conditions were analyzed and the significance was evaluated. As a result, sprue, runner, and gate were completely filled in about 0.247 seconds after injection, the front part of the green body was filled in about 0.3344 seconds, the green body except gate, etc changed to almost solid state in about 3.29 seconds, the Packinging pressure was completed in about 6.29 seconds, and the green body inside and outside and sprue, etc became solid in 13.2 seconds. The impact of individual or reciprocal action of factors on the temperature at flow front was analyzed through regular probability, test statistics, main effect, and interaction effect. As a result, of a total of 31 combinations of factors, 9 unit factors and reciprocal actions were significant, and the screening was also possible. A proper regression equation was drawn with regression analysis and response surface design on the response variable of temperature at flow front, and the applicability could be verified.

• 한국초전도저온공학회지:초전도와저온공학
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• 제11권2호
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• pp.23-29
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• 2009

The unique features of HTS offer opportunities and challenges to a number of applications. In this paper we focus on NMR and MRI magnets, illustrating them with the NMR/MRI magnets that we are currently and will shortly be engaged: a 1.3 GHz NMR magnet, an "annulus" magnet, and an $MgB_2$whole-body MRI magnet. The opportunities with HTS include: 1) high fields (e.g., 1.3 GHz magnet); 2) compactness (annulus magnet); and 3) enhanced stability despite liquid-helium-free operation ($MgB_2$whole-body MRI magnet). The challenges include: 1) a large screening current field detrimental to spatial field homogeneity (e.g., 1.3 GHz magnet); 2) uniformity of critical current density (annulus magnet); and 3) superconducting joints ($MgB_2$magnet).

• 한국초전도ㆍ저온공학회논문지
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• 제11권4호
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• pp.1-7
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• 2009

The unique features of HTS offer Opportunities and challenges to a number of applications. In this paper we focus on NMR and MRI magnets, illustrating them with the NMR/MRI magnets that we are currently and will shortly be engaged: a 1.3GHz NMR magnet, an "annulus" magnet, and an $MgB_2$ whole-body MRI magnet. The opportunities with HTS include: 1) high fields (e.g., 1.3GHz magnet); 2) compactness (annulus magnet); and 3) enhanced stability despite liquid-helium-free operation ($MgB_2$ whole-body MRI magnet). The challenges include: 1) a large screening current Beld detrimental to spatial field homogeneity (e.g., 1.3 GHz magnet); 2) uniformity of critical current density (annulus magnet); and 3) superconducting joints ($MgB_2$ magnet).

• Biomolecules & Therapeutics
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• 제10권1호
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• pp.19-24
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• 2002

The effects of a newly synthesized $H^+/K^+$ ATPase inhibitor,1-(2-methyl-4-methoxypheny)-4-[(3-hy-droxypropyl)amino] -6-methyl-2,3-dihydropyrrolo (3,2-c) quinoline (DBM-819) , on the central nervous system, isolated smooth muscle, cardiovascular and digestive systems and renal function were investigated in various experimental animals. Oral administration of DBM-819 had no effect on the central nervous system except body temperature of mice slightly decreased at doses of 15 and 50 mg／kg. DBM-819 produced a moderate analgesic effect in acetic acid-induced writhing test in mice at 50 mg／kg (p.o.). In conscious rats, DBM-819 (15 and 50 mg／kg, p.o.) showed a slight increase in blood pressure and a small decrease in heart rate. DBM-819 had an significant effect on agonist-induced contraction of guinea pig ileum at $1.5{\times}10^{-5}g/ml.$ No significant effect of DBM-819 (5 and 15 mg／kg, i.p) on urinary volume or urinary excretion of $Na^+,\;K^+$ and Cl- was observed in rats. DBM-819 had no significant effect on intestinal transport of a semisolid meal in mice at 15 and 50 mg／kg (p.o.). These findings suggest that DBM-819 exerts no significant pharmacological effects on the central nervous system and renal function at 15 mg／kg (p.o.), but produces some effects on the smooth muscle and circulatory system.

• 대한약침학회지
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• 제7권1호
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• pp.15-26
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• 2004

Background : This study was conducted to evaluate the effects of wild ginseng herbal acupuncture developed for the intravenous use. Healthy male and female volunteers(n=57) went through Randomized Control Trials(RCT). Methods : For those who are under a medication due to common cold or other illnesses were excluded in the primary stage and the subjects with possible abnormalities in the pre-screening process were also excluded in the secondary stage. Then the examination groups were determined by random sampling. Experiment groups were divided into Normal saline injection group(control group), cultivated wild ginseng herbal acupuncture group(experiment group 1) and natural wild ginseng herbal acupuncture group(experiment group 2) Blood tension, body temperature, pulse, and other criteria were measured and analyzed. Results : 1. Intravenous injection of cultivated wild ginseng herbal acupuncture and natural wild ginseng herbal acupuncture didn't cause significant changes in the blood tension, pulse, body temperature, and etc. 2. No significant differences were witnessed in CBC, ESR, biochemistry of blood test and UA between the experiment groups. 3. No significant changes were noted in the thermography before and after the test in the experiment groups. 4. Some of the common physical changes occurring during and after the administration were fatigue, chest distension, and headache in all of the experiment groups. 5. Comparing general condition after one week from the termination of administration, the control group showed worst condition while as the natural wild ginseng herbal acupuncture group displayed best condition. Conclusion : From the above results, we can carefully deduce that the intravenous injection of the wild ginseng herbal acupuncture didn't show significant differences compared to injection of the normal saline. We can infer it is safe on the human body and further studies and reports must be followed.

• 정보처리학회논문지:컴퓨터 및 통신 시스템
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• 제12권2호
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• pp.85-92
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• 2023

코로나바이러스감염증-19와 같은 호흡기 감염병은 주로 밀집/밀폐/밀접 공간인 실내에서 일어난다. 호흡기 감염병 이상징후의 존재 여부는 발열, 기침, 재채기 및 호흡곤란 등의 초기 증상을 통해 판단되고 있으며, 이러한 초기 증상에 대한 상시 모니터링이 요구된다. 열화상 온도 스크리닝 시스템은 개인의 피부 온도 상승의 징후가 있는지 초기에 선별하는 빠르고 쉬운 비접촉 스크리닝 방법을 제공하지만, 측정 타겟, 주변 온도 등의 측정 환경과 피 측정대상과의 측정 거리에 따른 오차로 인해 정확한 온도측정이 어렵다. 그리고 국제표준 IEC 80601-2-59 에서는 내안각(Inner Canthus) 인접한 영역에 대한 안면 열화상 촬영을 권고하고 있다. 본 논문에서는 가시광 카메라 모듈과 열화상 카메라 모듈에 대해서 이미지 일치화 보정을 수행하였으며, 흑체(Blackbody)를 이용해 측정 환경에 대한 열화상 카메라 모듈 온도를 보정하였다. 표준에서 권고하는 측정 타겟을 인식하기 위해 딥러닝 기반 객체 인식 알고리즘과 내안각 인식 모델을 개발하였으며, 100명의 실험자군에 대한 데이터셋을 적용하여 인식 모델 정확도를 도출하였다. 또한 라이다 모듈을 이용한 객체 거리 측정과 선형회귀 보정 모듈을 통해 측정 거리에 따른 오차를 보정하였다. 제안한 모델의 성능 측정을 위해 모터 스테이지, 열화상 온도 스크리닝 시스템, 흑체로 구성된 실험환경을 구축하였으며, 1m에서 3.5m 사이 가변 거리에 따른 온도측정 결과 0.28℃ 이내의 오차 정확도를 확인하였다.

• 대한정형도수물리치료학회지
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• 제1권1호
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• pp.9-14
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• 1995

인체에서 발생하는 체열을 과학적으로 이용하여 질병을 진단하고 치료과정을 관찰하고 예후를 추측할 수 있는 Thermography는 현대의학의 임상 여러분야에서 응용할 수 있는 유용한 진단장비에 속한다 하겠다. 인체의 피부온도는 좌우 대칭적으로 온도분포를 나타내며 여러가지 생리학적인 원인에 의하여 온도는 변화할 수 있으며, 그러한 온도변화는 여러 질병과의 연관성을 갖게 된다. Thermography는 유방암세포의 증식에 따른 유방체표면의 초기온도 상승을 screening 함으로서 조기에 유방암을 발견할 수 있으며, 척추의 신경근 자극에 따른 체열분포를 파악함으로서 신경근의 이상유무 및 척추질환을 진단할 수 있으며, 말초 혈액순환 장애 등으로 인한 질환에 있어서도 뚜렷한 체표면 온도분포를 나타내 줌으로서 혈액순환의 장애분포를 시각적으로 관찰할 수 있는 이점을 지니고 있다. 또한 정형 물리치료 분야에 속하는 근-골격계 질환에 있어서의 근육통, 압통점, 염좌, 염증질환 등을 구별할 수 있고 나아가 치료 전후에 적외선 체열검사를 실시해 봄으로서 치료전이나 치료결과에 대한 객관적인 평가를 할 수 있다는데 큰 의의가 있다고 하겠다.