• Journal of Radiopharmaceuticals and Molecular Probes
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• v.2 no.1
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• pp.3-8
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• 2016

Molecular imaging technologies have been used to provide a new pathway for therapies and diagnosis of human disease. Especially, imaging probes have been much development in the molecular imaging field. Combining imaging probes for positron emission tomography (PET) and magnetic resonance imaging (MRI) have suggested the potential of multiple methods in living body. This review discusses the cancer or lymph node-targeting probes that are suitable for PET/MRI based diagnosis.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2013.10a
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• pp.769-772
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• 2013

When developing engine mount, interm mount bracket 1st resonance is critical to make sound quality better or worse. So, at the initial stage of development, we need to consider some design parameter to setup the target of interm bracket 1st resonance. Especially, 3cylinder interm bracket guideline is not well known. So, this paper deals with some important sensitivity which should be considered during the development of vehicle. From source to interior side, we should know the component sensitivity like body sensitivity p/F or bracket gain etc. Through this paper, we could get the knowledge of design guideline and key consideration points.

• Journal of Magnetics
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• v.21 no.4
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• pp.599-602
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• 2016

Fluoride (F) is an important element for the mineralization of body tissues. The purpose of this study was to administer fluoride prenatally to rats to evaluate its beneficial concentration for rat bone using microstructural analysis, to analyze its effect on the bone structure, and to evaluate the effect of its transfer through rat placenta. Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance spectrometry (NMR) were performed. The $^{19}F$ NMR and $^{31}P$ NMR signals suggested the existence of fluoride ions in the apatite lattice because the signals were caused by the fluoride ions that were coupled to the phosphate atoms and were affected in the phosphate phases other than the element phases in the apatite. Consequently, if it was not affected too much, the desirable concentration of prenatal fluoride treatment could have a helpful effect on the bone crystal structure through placental fluoride transfer.

• Investigative Magnetic Resonance Imaging
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• v.23 no.2
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• pp.148-156
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• 2019

Hyperglycemia-induced hemichorea (HGHC) is a rare but characteristic hyperkinetic movement disorder involving limbs on one side of the body. In a 75-year-old woman with a left-sided HGHC, conventional brain MR imaging showed very subtle T1-hyperintensity and unique gadolinium enhancement in the basal ganglia contralateral to movements. Multi-parametric MRI was acquired using pulse sequence with quantification of relaxation times and proton density by multi-echo acquisition. Myelin map was reconstructed based on new tissue classification modeling. In this case report of multi-parametric MRI, quantitative measurement of myelin change related to HGHC in brain structures and its possible explanations are presented. This is the first study to demonstrate myelin loss related to hyperglycemic insult in multi-parametric quantitative MR imaging.

• Investigative Magnetic Resonance Imaging
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• v.23 no.1
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• pp.17-25
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• 2019

We discuss recent advances in Gd-based $T_1$-weighted MR contrast agents for the mapping of cellular pH. The pH plays a critical role in various biological processes. During the past two decades, several MR contrast agents of strategic importance for pH-mapping have been developed. Some of these agents shed light on the pH fluctuation in the tumor microenvironment. A pH-responsive self-assembled contrast agent facilitates the visualization of tumor size as small as $3mm^3$. Optimization of various parameters is crucial for the development of pH-responsive contrast agents. In due course, the new contrast agents may provide significant insight into pH fluctuations in the human body.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.21 no.5
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• pp.410-418
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• 2009

Based on a linear potential theory, the boundary element method(BEM) is developed and applied to analyze the hydrodynamic forces and the motion responses of a floating body with a partially reflective sidewall. The hydrodynamic forces (added mass and damping coefficients) are dependent on not only the submergence of a floating body and the reflection of a sidewall, but also the gap between body and sidewall. In particular, the partial reflection of a sidewall plays an importance role in the motion responses of a floating body at resonant frequencies. It reduces the resonant peaks caused by resonance phenomenon due to the wave trapping in an enclosed fluid domain between body and sidewall. Developed predictive tools can be used to assess the motion performance of a floating body for various combinations of configuration of a floating body, wave heading, sidewall properties, and wave characteristics and applied to supply the basic informations for the harbour design considering the motion characteristics of a moored ship.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.05a
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• pp.110-113
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• 2006

This paper describes the development process of body and full vehicle for reduced idle vibration through the data level of frequency and sensitivity. The vibration mode map is used to separate body structure modes from resonance of engine idle nm and steering system. This paper describes the analysis approach process to reduce the variation of uncertainties for idle vibration performance at initial design stage. The robust design method is performed to increase the stabilization performance under vehicle vibration. It is used to predict the effects of the stiffness deviation according to the spot welding condition of the body structure. The tolerance associated with hood over slam bumper is analyzed for the quality deviation of the moving system in full vehicle. And the glass sealant stiffness and weight difference is considered for the deviation characteristic. The design guideline is suggested considering sensitivity about body and full vehicle by using mother car at initial design stage. It makes possible to design the good NVH performance and save vehicles to be used in tests. These improvements can lead to shortening the time needed to develop better vehicles.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.29 no.2
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• pp.84-89
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• 2016

We present the results of a study of a piezoelectric generator that generates electricity by the application of tension to an element. A device is named "EYE-type generator". The EYE-type generator consists of a rectangular ceramic and two elastic body plates that are attached to upper and lower surfaces of a ceramic. If tension is applied to both ends of the elastic body, that tension is transformed to pressure on the ceramic through a change in the form of the elastic body, causing a piezoelectric effect whereby electricity is generated by the ceramic. This generator is relatively durable because a forces are not applied directly to the ceramic. We examined dependencies of the generator's output characteristics on the size of the ceramic and elastic body. A resonance and output characteristics were analyzed by using a finite element method. The generator was fabricated based on results of the analysis, and this was attached to a frequency-controllable vibrator to measure the output characteristics. The measured results were compared with results of the simulation, and the results pointed to the practicality of the design.

• Korean Journal of Digital Imaging in Medicine
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• v.14 no.1
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• pp.21-29
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• 2012

The purpose of this study is to evaluate the mutual relations by measuring SNR from T2 weighted image and ADC values on the basis of the stiffness values from liver tissues. This study was conducted that total 37 people(23 of males and 11 of females) were taken the liver MRI examination and average age was $54.5{\pm}12.7$ years old. The equipment was MAGNETOM Skyra 3.0T (SIEMENS, Erlangen, Germany) and 32 channel body-array coil. The examination were conducted with HASTE T2 weighted image by axial plane, Spin-echo EPI (echo planner image) DWI (b-value = 800) and Magnetic resonance elastography. The ROIs (region of interest: 200-300 $mm^2$) were established on the basis of the first axial stiffness image corresponded 95% confidence interval from axial stiffness image and then were measured values. After drawing the grid lines, signals were measured SNR from T2 weighted image and ADC values on the same locations that were analysed other 3 planes respectively. The results were showed correlation (0.057) that were increased to SNR from T2 weighted image by increasing stiffness value that no significant difference statistically p = 0.003. Other results were showed correlations (-0.301) that were decreased to ADC values by increasing stiffness values that no significant difference statistically p = 0.088. In the 3.0T equipment, the results may be error in much the same fashion as the 1.5T from ADC values by evaluation of fibrosis stage. However, Magnetic resonance elastography would be useful method that is used to diagnose exactly liver fibrosis stages in the 3.0T.

• Journal of Korean Neurosurgical Society
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• v.56 no.6
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• pp.504-508
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• 2014

A 59-year-old male patient had 5-month history of gait disturbance and memory impairment. His initial brain computed tomography scan showed $3.5{\times}2.8cm$ sized mass with high density in the pineal region. The tumor was hypointense on T2 weighted magnetic resonance images and hyperintense on T1 weighted magnetic resonance images with heterogenous enhancement of central portion. The tumor was totally removed via the occipital transtentorial approach. Black mass was observed in the operation field, and after surgery, histopathological examination confirmed the diagnosis of malignant melanoma. Whole spine magnetic resonance images and whole body 18-fluoro-deoxyglucose positron emission tomography could not demonstrate the primary site of this melanoma. Scrupulous physical examination of his skin and mucosa was done and dark pigmented lesion on his left leg was found, but additional studies including magnetic resonance images and skin biopsy showed negative finding. As a result, final diagnosis of primary pineal malignant melanoma was made. He underwent treatment with the whole brain radiotherapy and extended local boost irradiation without chemotherapy. His preoperative symptoms were disappeared, and no other specific neurological deficits were founded. His follow-up image studies showed no recurrence or distant metastasis until 26 weeks after surgery. Primary pineal malignant melanomas are extremely rare intracranial tumors, and only 17 cases have been reported since 1899. The most recent case report showed favorable outcome by subtotal tumor resection followed by whole brain and extended local irradiation without chemotherapy. Our case is another result to prove that total tumor resection with radiotherapy can be the current optimal treatment for primary malignant melanoma in the pineal region.