• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1989년도 춘계학술대회
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• pp.5-6
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• 1989

Polyurethane surface was chemically modified to have different hydrophilic polyethyleneoxide(PEO)/hydrophobic dodecanediol(DDO) groups and negatively charged sulfonate group to investigate the effect to the antithrombogenicity. The hydrophilicity of the surface was significantly increased after PEO grafting or sulfonation. Lowering in-vitro platelet adhesion led to a prologation in the ex-vivo occlusion time. Especially, the sulfonated PU-PEO surface showed most enhanced blood compatibility due to the synergistic effects of PEO and $SO_3$ groups.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1998년도 추계학술대회
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• pp.227-228
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• 1998

Lumbrokinase, potent fibrinolytic enzyme purified from earthworm, was immobilized onto polyurethane valves using photoreaction, photoreactive polyallyl-amino as a photoreactive linker. For evaluation of blood compatibility, lumbrokinase immobilized polymer valves were assembled into the total artificial heart (TAH). This TAH was implanted to 60kg healthy lamb for 1-3 days with the cardiac output 5 L/min. In the control lamb, the valves were untreated, in ore other, only valves on the right were treated, and in the remaining animal, only those on the left. To facilitate the thrombus formation, low doses of heparin were administered. For evaluation of the immobilized lumbrokinase, thrombus formation, proteolytic and fibrinolytic activity was measured. This data shows that lumbrokinase-treated polyurethane valves lead to decreased thrombus formation in vivo, and that their biocompatibility is therefore higher than that of untreated valves.

• 공업화학
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• 제4권1호
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• pp.188-195
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• 1993

생체의료용 재료로서 응용 가능한 고분자 전해질복합체와 그라프트 공중합체를 수용성 고분자 유도체로부터 제조하였다. 고분자 전해질 복합체들은 카르복시메틸 셀룰로오즈(CMC)와 젤라틴으로부터 제조하였다. 그라프트 공중합체는 메틸셀룰로오즈(MC)에 아크릴산을 그라프트반응시켜 합성하였고, 이 그라프트 공중합체와 젤라틴의 고분자 전해질 복합체도 제조하였다. 그라프트 공중합체와 고분자 전해질 복합체들을 화학가교법과 열처리법으로 제조시 최적조건들을 조사하였다. 예비실험 결과 이들 재료들이 생체의료용 재료로서의 응용 가능성이 있는 것을 알았다.

• 한국임상약학회지
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• 제31권2호
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• pp.125-135
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• 2021

Background: Generally, pharmacokinetics (PK) models could be stratified into two models. The compartment PK model uses the concept of simple compartmentalization to describe complex bodies, and the physiologically based pharmacokinetic (PBPK) model describes the body using multi-compartment networking. Notwithstanding sharing a theoretical background in both models, there was still a lack of knowledge to enhance compatibility in both models. Objective: This study aimed to evaluate the compatibility among PBPK, lumping model and compartment PK model with voriconazole PK case study. Methods: The number of compartments and blood flow on each tissue in the PBPK model were modified using the lumping method, considering physiological similarities. The concentration-time profiles and area under the concentration-time curve (AUC) parameters were simulated at each model, assuming taken voriconazole oral 400 mg single dose. After that, those mentioned PK parameters were compared. Results: The PK profiles and parameters of voriconazole in the three models were similar that proves their compatibility. The AUC of central compartment in the PBPK and lumping model was within a 2-fold range compared to those in the 2- compartment model. The AUC of non-eliminating tissues compartment in the PBPK model was similar to those in the lumping model. Conclusion: Regarding the compatibility of the three PK models, the utilization of the lumping method was confirmed by suggesting its reliable PK parameters with PBPK and compartment PK models. Further case studies are recommended to confirm our findings.

• 대한의용생체공학회:의공학회지
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• 제13권4호
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• pp.269-274
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• 1992

In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO2 with Plethysmograph.raph.

• Macromolecular Research
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• 제16권7호
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• pp.596-603
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• 2008

To improve the mechanical properties, dimensional stability and blood compatibility, the biomedical material $Pellethene^{(R)}$ was blended with multiblock polyurethane (MPU) containing phospopholipid/long alkyl chain (C-18) at the various MPU contents and crosslinked using dicumyl peroxide as a crosslinking agent. The maximum MPU content for stable $Pellethene^{(R)}$/MPU blended films was approximately 30 wt%. The optimum crosslinking agent content and crosslinking time with respect to the mechanical properties were 4 wt% and 3 h, respectively. The mechanical properties (tensile strength and elongation at break) and water absorption of the crosslinked blend film increased with increasing MPU content. The test of platelet adhesion on the surfaces of the crosslinked blend film showed a decrease in the level of platelet adhesion from 70% to 6% with increasing MPU content from 0 to 30 wt%. These results suggest that the crosslinked $Pellethene^{(R)}$/MPU-30 (MPU content: 30 wt%) sample has strong potential as a novel material for blood compatible material applications.

• 폴리머
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• 제35권1호
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• pp.40-46
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• 2011

The synthesis of well-defined poly(styrene-b-isobutylene-b-styrene) (SIBS) triblock copolymers was accomplished by cationic sequential block copolymerization of isobutylene (IB) with styrene (St) using 1,4-di(2-chloro-2-propyl) benzene (DCC) /$TiCl_4$/2,6-di-tert-butylpyridine(DtBP) as an initiating system in methyl chloride ($CH_3Cl$)/methylcyclohexane(MeChx) (50/50 v/v) solvent mixture at $-80^{\circ}C$. The triblock copolymers exhibited excellent thermoplastic and elastomeric characteristics. Tensile strengths and Shore hardness increased with increasing polystyrene (PS) content, while elongation at break decreased. The blood-compatibility of SIBS was assessed by SEM observation of the platelet adhesion, blood clotting time and haemolysis ratio. The haemolysis ratios were below 5% which met the medical materials standard. The platelet adhesion test further indicated that SIBS block copolymers had a good blood compatibility.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1991년도 추계학술대회
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• pp.101-102
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• 1991

• 한국막학회:학술대회논문집
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• 한국막학회 1992년도 추계 총회 및 학술발표회
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• pp.47-48
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• 1992

Polymer containing monomers with pendant phospholipid polar group, 2-(metha-cryloyoxy) ethyl-2-(trimethylammonium) ethyl phosphate(MTP) were synthesized and blood compatibility of the copolymers was evaluated. Good permeability of biocomponents of molecular weight below 10$^4$ through cellulosic membrane coated with the copolymer of 2-(methacryloyoxy) ethyl-2-(tri-methylammonium)ethyl phosphate, butylmethacrylate(BMA), and glycidyl methacrylate(GMA) was observed, (Fig.1).

• 한국염색가공학회지
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• 제6권4호
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• pp.40-45
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• 1994

To improve the blood compatibility of cellulose membrane, 2-(methacryloyloxy)ethyl-2-(trimethylammonium)ethyl phosphate(MTP), which is a methacrylate with phospholipid polar group, and glycidyl methacrylate(GMA) were grafted simultaneously on the surface of membrane and the biocompatibility of grafted membrane was investigated. There was no difference of permeability between the MTP and GMA-grafted and the original cellulose membrane. The permeation pathway for a solute whose molecular weight was above 10$^{4}$ is maintained after grafting on the surface of membrane. The cellulose membrane grafted with MTP and GMA effectively suppressed thrombogenicity for the rabbit blood. This effect became more clear with increasing the surface distribution of phospholipid polar groups.