Textile Coloration and Finishing (한국염색가공학회지)

The Korean Society of Dyers and Finishers (한국염색가공학회)
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Development and Application of Biocompatible Polymers( I ) ―Biocompatibility of Cellulose Graft Copolymer with Phosphoryl Choline Groups―

생체적합성 고분자의 개발과 응용(I) ―Phosphoryl choline기를 가진 셀룰로오즈 그래프트 공중합체의 생체적합성―

  • Lee, Mi Kyung (Dept. of Textile Eng., College of Eng., Pusan National Univ., Pusan, 609-735, Korea) ;
  • Kim, Moon Sik (Dept. of Textile Eng., College of Eng., Pusan National Univ., Pusan, 609-735, Korea) ;
  • Park, Soo Min (Dept. of Textile Eng., College of Eng., Pusan National Univ., Pusan, 609-735, Korea)
  • Published : 1994.12.01
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Abstract

To improve the blood compatibility of cellulose membrane, 2-(methacryloyloxy)ethyl-2-(trimethylammonium)ethyl phosphate(MTP), which is a methacrylate with phospholipid polar group, and glycidyl methacrylate(GMA) were grafted simultaneously on the surface of membrane and the biocompatibility of grafted membrane was investigated. There was no difference of permeability between the MTP and GMA-grafted and the original cellulose membrane. The permeation pathway for a solute whose molecular weight was above 10$^{4}$ is maintained after grafting on the surface of membrane. The cellulose membrane grafted with MTP and GMA effectively suppressed thrombogenicity for the rabbit blood. This effect became more clear with increasing the surface distribution of phospholipid polar groups.

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