• 셀메드
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• 제5권2호
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• pp.12.1-12.3
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• 2015

Adolescent menorrhagia is defined as excessive menstrual bleeding from menarche to adolescents. It is a distressing condition both for the patient as well as for her parents. If it is not managed in time itmay pose significant health problems that may leads to blood transfusion. We determined the efficacy of Geru (Red ochre) in controlling the amount and duration of blood flow in patients of Adolescent menorrhagia. This study included 40 teenage girls, who presented with heavy bleeding during menstruation to Outpatient Department, Sameena Maternity Nursing Home, Hyderabad during the year of 2013. Assessment of each case was done by history and Pictorial Blood loss Assessment Chart (PBAC) score. Geru powder was given for 2 cycles and results were assessed. The data was analyzed statistically. The mean PBAC score before treatment was $497.04{\pm}389.92$ and after trial in $1^{st}$ and $2^{nd}$ it was found to be $471.13{\pm}162.18$ and $310.13{\pm}142.15$ respectively. On basis of results it was concluded that single unani drug Geru is enough in controlling bleeding and was found effective by its astringent and styptic properties.

• 동아시아식생활학회지
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• 제19권3호
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• pp.369-374
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• 2009

This study analyzed and examined the anti-oxidant properties of Saengmaegsan chocolate, and blood glucose levels were examined according to the Saengmaegsan chocolate intake. The total carbohydrate content of the chocolate was 57.8%, crude fat was 31.5%, crude ash was 1.6%, and crude protein was 4.0%. In Saengmaegsan chocolate. Furthermore, total polyphenol content of Saengmaegsan chocolate was 191.52 mg/100 g and DPPH scavenging activity was 87.06%. The radical scavenging activity of the Saengmaegsan chocolate was higher than that of normal milk chocolate. Also, blood glucose levels were significantly lower, by Saengmaegsan chocolate intake, than by normal milk chocolate intake. These results indicate that Saengmaegsan chocolate can be used as a safe and is clinically applicable as a supplementation of in diet therapy for both healthy and diabetic persons.

• Journal of Digestive Cancer Research
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• 제11권1호
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• pp.21-29
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• 2023

Despite recent advancements in the diagnosis and treatment of pancreatic cancer, clinical results remain dismal. Furthermore, there are no reliable biomarkers or alternatives beyond carbohydrate antigen 19-9. Circulating tumor cells (CTCs) may be a potential biomarker, but their therapeutic application is constrained by their rarity in peripheral venous blood. Theoretically, the portal vein can be a more appropriate location for the detection of CTCs, because the first venous drainage of pancreatic cancer is portal circulation. According to several studies, the number and detection rate of CTCs may be higher in the portal blood than in the peripheral blood. CTC counts in the portal blood are strongly correlated with several prognostic parameters such as hepatic metastasis, recurrence after surgery, and survival. The phenotypic and genotypic properties analyzed in the captured portal CTCs can assist us to comprehend tumor heterogeneity and predicting the prognosis of pancreatic cancer. The investigations to date are limited by small sample sizes and varied CTC detection techniques. Therefore, a large number of prospective studies are required to confirm portal CTCs as a valid biomarker in pancreatic cancer.

• 한국수산과학회지
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• 제56권5호
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• pp.651-659
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• 2023

The effect of bio-logger tagging location on blood characteristics and bio-logger attachment efficiency in spotted sea bass (mean body weight 2356.7 g) was investigated. The fish were tagged at four different tagging locations: no-tag (control), operculum attachment (OA), dorsal muscle attachment (DA), and cauda peduncle muscle attachment (CA). The blood properties and bio-logger attachment efficiencies were examined on days 1, 7, 14, and 35 after tagging the bio-logger at each tagging location. During the experimental periods, the concentrations of hematocrit and hemoglobin in whole blood, and GOT (glutamic oxaloacetic transaminase), GPT (glutamic pyruvic transaminase), total protein (TP), glucose, total cholesterol, cortisol, and superoxide dismutase in plasma were not affected by the attachment location of the bio-logger, however, the TP concentration was significantly lower in OA than in the control group on day 7. After tagging for 35 days, the efficiencies of bio-logger attachment in the OA, DA, and CA after tagging for 35 days were 33.3%, 100.0%, and 33.3%, respectively. These results indicate that, in our experimental condition, the most appropriate bio-logger attachment location is DA, providing basic information on bio-logger utilization methods for ecological and biological biotelemetry surveys of the spotted sea bass.

• 한국축산식품학회지
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• 제37권5호
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• pp.743-751
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• 2017

During slaughtering, animal blood is typically discarded, resulting in water pollution. However, this discarded blood has valuable components, such as immunoglobulin (Ig). Although several studies have been conducted to develop methods for effective recycling of slaughterhouse blood, they have not been commercially utilized in Korea. Here, we extracted an Ig-rich fraction from porcine blood that was then subjected to various in vitro tests, including pathogen growth inhibition, antigenic cross-reactivity, and anti-toxin activity. The porcine immunoglobulin concentrate (PIC) was effectively purified by eliminating other components, such as albumin, and consisted of approximately $63.2{\pm}2.9%$ IgG and $7.2{\pm}0.4%$ IgM on a protein basis. The results showed that it significantly suppressed the growth of pathogenic bacteria, and bound to all tested pathogens, including both gram-positive and gram-negative species, although the degree of activity differed according to strain. The PIC bound to two types of lipopolysaccharide (LPS) obtained from Escherichia coli O111:B4 and Salmonella enterica serotype typhimurium in a concentration-dependent manner. In addition, the PIC restored the proliferation activity of the lymphoblast K-562 cells when co-incubated with pathogenic LPS. These results confirm that the PIC prepared in this study is a potentially valuable functional food material or diet supplement as an alternative to antibiotics that can protect animals from pathogenic bacteria.

• 한국자기공명학회논문지
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• 제17권1호
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• pp.40-46
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• 2013

For a case study of suspected paraquat intoxication, we developed a simple and rapid method of $^1H$ qNMR to determine the mili-molar amount of paraquat in postmortem blood samples. There were no interfering signals from endogenous compounds in the chemical shift of paraquat and diquat (internal standard). The amount of sample used ranged from 0.25 mM to 10.0 mM. Diquat, which has similar physicochemical properties with paraquat, was chosen as an internal standard. The NMR experimental conditions, relaxation delay time and CPMG spin-echo pulse sequence were optimized. The developed method was validated in terms of specificity, accuracy, precision, matrix effect, recovery, limit of detection (LOD), and low limit of quantification (LLOQ). The proposed qNMR method provided a simple and rapid assay for the identification and quantification of the quaternary ammonium herbicide, "paraquat" in postmortem blood samples. This method was tested by using the blood from the heart of a man who was intoxicated with paraquat. In this particular case, the level of paraquat was 1.07 mM in the blood. For the determination of quaternary ammonium herbicides, qNMR could also be used to provide a better understanding of the currently available techniques.

• 한국식품조리과학회지
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• 제15권2호
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• pp.191-196
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• 1999

본 연구에서 순대 제조의 표준화를 위하여 돈혈의 최적 함량을 구하고, 돈혈을 혈장과 난백으로 대체했을 때의 조리 특성을 연구한 결과를 요약하면 다음과 같다. 순대에 사용된 재료는 관능검사 결과, 돈육 27%, 찹쌀 15%, 채소류(배추:순주=3:2) 35%, 양념류가 8%이며 돈혈의 첨가량이 15%일 때 가장 좋았다. 결착제를 달리한 순대의 특성에서 순대의 조리수율은 79.4%이었으나 혈장과 난백을 돈혈과 대체하였을때 조리수율이 각각71.2%, 75.0% 혈장과 난백의 첨가로 조리 수율이 낮아졌다. 수분 흡수 능력은 돈혈장 순대(P15)가 11.5%, 돈혈순대 (control)가 22.0%, 난백 순대 (E15)가 41.9%이었고 유화 안정도는 control이 49.3%로 가장 높았으며 돈혈 또는 난백 첨가 비율에 따라 감소하였다. 순대의 pH는 모든 처리군에서 유의적인 차이가 없었다. 색도는 혈장과 난백 첨가에 따라 L 값과 b 값이 증가하였으며 적색을 나타내는 a 값은 감소하였다. 기계적인 방법으로 텍스쳐를 측정한 결과 혈장 혹은 난백이 돈혈과 대체될수록 경도와 부착력, 씹힙성이 저하되었다. 순대는 돈혈을 첨가한 것이 수분 흡수 능력, 유화 안정도 등에서 높은 수치를 보여 텍스쳐가 우수하였고 돈혈장, 난백을 대체할수록 가공 적성이 기대한 것보다 낮았으나 관능검사 결과 혈액순대와 유의적인 차이를 보이지 않아 순대에서 돈혈장과 난백의 대체 가능성을 엿볼 수 있었다.

• 대한의용생체공학회:의공학회지
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• 제23권4호
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• pp.281-286
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• 2002

심혈관계에서 자주 발생하는 죽상경화증과 혈전의 발생 및 성장에 관한 복잡한 기전을 이해하기 위하여 뇌의 혈액공급을 담당하는 경동맥을 2차원 축대칭으로 모사하여 수치해석하였다. 박동유동 상태에서 경동맥 내에 25%. 50%, 75%의 협착이 형성된 경우에 대하여 혈관내의 속도분포 및 혈류역학적 벽 파라미터들이 고찰되었다. 혈액은 뉴턴유체 및 전단변형률에 따라 점성이 변화하는 비뉴턴유체로 간주되었으며 비뉴턴모델로는 혈액과 유사한 점성치를 나타내는 Carraeu-Yasuda 모델이 적용되었다. 해석 결과 혈관내벽에 작용하는 벽전단응력은 협착이 커질수록 크게 증가하였으며 비뉴턴유체보다 뉴턴유체의 경우에서 벽전단응력이 크게 평가되었다. 벽전단응력 진동지표(OSI)에 의해 시간평균 재부착점이 예측되었는데 비뉴턴유체보다 뉴턴유체의 경우에서 협착 영역으로부터 멀리 떨어진 곳에서 관찰되었다. 시간평균 벽전단응력구배(WSSG)도 협착이 큰 경우에 상당히 크게 나타났는데 비뉴턴유체보다 뉴턴 유체의 경우에 더 큰 값이 나타났다.

• 혜화의학회지
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• 제29권2호
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• pp.22-29
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• 2020

Objectives: This study aims to investigate the effects of diabetes mellitus care mixture (DCM) on blood glucose and lipid metabolism in type 2 diabetic mellitus mice. DCM consisted of lagerstroemia speciose, allium hookeri, momordica charantia, amaranthus tricolor, and boesenbergia rotunda, which have been proven to have antidiabetic properties. Methods: In this study, we researched the effects of DCM in type 2 diabetic mellitus mice. C57BLKS/J mouse groups had no treatment, db/db mouse randomly assigned to 2 groups, and treated with distilled water and DCM (200 mg/kg/day). Blood glucose levels and body weight were checked every week. After 4 weeks of treatment, liver function indicators (AST, ALT, and LDH) and lipid metabolites (triglyceride, total cholesterol, LDL-cholesterol, HDL-cholesterol) were measured with a biochemistry analyzer. Diabetic factors (insulin, resistin, and leptin) were measured with ELISA. Results: DCM was decreased blood glucose, diabetic factors, liver function indicators, triglyceride, total cholesterol, and LDL-cholesterol significantly. Also, HDL-cholesterol was significantly increased in DCM group. The bodyweight of DCM group decreased but, no significant difference with the control group. DCM may have the potential to improved diabetes mellitus by regulating blood glucose levels and diabetic factors. Also protecting from diabetic complications by adjusting liver function indicators and lipid metabolites. Conclusions: These results suggest that DCM to be used as an oriental medicine for diabetes, the results of clinical trials are needed.

• 한국약용작물학회지
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• 제28권4호
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• pp.287-297
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• 2020

Background: Type II diabetes is considered as one of the common diseases. Bangpungtongseongsan (BPS) has been used as a traditional medicine for treating obesity and hypertension in Korea. According to previous reports, it has anti-obesity, anti-chronic asthma, anti-oxidant, and anti-inflammatory properties. However, the effects of BPS on type II diabetes have not yet been elucidated. Thus, in this sutudy, we evaluated the water extracts of BPS using type II diabetes animal models. Methods and Results: Each group was orally administered with BPS (170, 850 and 1,700 mg/kg) for approximately 13 weeks. A mixture of 150 mg/kg metformin and 10 mg/kg sitagliptin (MS) was used as a positive control. The glycated hemoglobin (HbA1c) and glucose levels, and hematological parameters including blood urine nitrogen, creatinine, low density lipoprotein and total cholesterol, were measured using blood samples. Treatment with 170 mg/kg BPS decreased the HbA1c and glucose levels in blood without affecting the weights of the animals. However, threatment with 1,700 mg/kg BPS reduced the weights and fatty liver, and increased the blood glucose level in type II diabetes animal models Conclusions: These results indicate that a low dose of BPS for 13 weeks, which reduces HbA1c and blood glucose levels, could be used for the treatment of type II diabetes. However, further studies are required to elucidate how active ingredients of BPS influence HbA1c and glucose levels in blood.