Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Anti-hyperglycemic Effect of Bangpungtongseong-san on Type II Diabetes Animal Models

제2형 당뇨 동물모델을 이용한 방풍통성산의 고혈당 개선효과

  • Ko, Moon Hee (Department of Preventive Medicine, Chonnam National University Medical School) ;
  • Cho, Hyun Woo (National Development Institute of Korean Medicine) ;
  • Nho, Jong Hyun (National Development Institute of Korean Medicine)
  • 고문희 (전남대학교 의과대학 예방의학교실) ;
  • 조현우 (한국한의약진흥원) ;
  • 노종현 (한국한의약진흥원)
  • Received : 2020.01.30
  • Accepted : 2020.07.16
  • Published : 2020.08.30
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Abstract

Background: Type II diabetes is considered as one of the common diseases. Bangpungtongseongsan (BPS) has been used as a traditional medicine for treating obesity and hypertension in Korea. According to previous reports, it has anti-obesity, anti-chronic asthma, anti-oxidant, and anti-inflammatory properties. However, the effects of BPS on type II diabetes have not yet been elucidated. Thus, in this sutudy, we evaluated the water extracts of BPS using type II diabetes animal models. Methods and Results: Each group was orally administered with BPS (170, 850 and 1,700 mg/kg) for approximately 13 weeks. A mixture of 150 mg/kg metformin and 10 mg/kg sitagliptin (MS) was used as a positive control. The glycated hemoglobin (HbA1c) and glucose levels, and hematological parameters including blood urine nitrogen, creatinine, low density lipoprotein and total cholesterol, were measured using blood samples. Treatment with 170 mg/kg BPS decreased the HbA1c and glucose levels in blood without affecting the weights of the animals. However, threatment with 1,700 mg/kg BPS reduced the weights and fatty liver, and increased the blood glucose level in type II diabetes animal models Conclusions: These results indicate that a low dose of BPS for 13 weeks, which reduces HbA1c and blood glucose levels, could be used for the treatment of type II diabetes. However, further studies are required to elucidate how active ingredients of BPS influence HbA1c and glucose levels in blood.

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References

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