• Journal of Chest Surgery
• /
• 제4권2호
• /
• pp.69-80
• /
• 1971

Total body perfusion using Rygg-Kyvsgaard Heart-Lung-Machine, Mark IV, Polystan was attempted in the dogs by the hemodilution method with total prime of buffered Hartman's solution and under hypothermia. The first of all, the functions of Rygg--Kyvsgaard Heart-Lung-Machine and the effects of the hemodilution perfusion by buffered Hartman's solution was studied. At the same time the changes of blood pressure, oxygen consumption, and influence on the blood pictures were observed before, during, and in 1-3 days after perfusion. Hemodilution rates were the average 74. 22cc/Kg(the ranges of 67 to 81 cc/Kg) and perfusion flow rates were maintained in the mean 62. 6cc/Kg/min., Although it was possible to check up to 87 cc/ Kg/min. The total body perfusion continued for 60-80 minutes. Hypothermia was employed between $36^{\circ}C$ and $32^{\circ}C$ of the rectal temperature. Arterial pressure was ranged approximately between 68mmHg and 149mmHg, but generally, it was maintained over 80mmHg. Venous pressure was measured between 6.5cm $H_2O$and 11.5cm $H_2O$. Optimum oxygenation can be expected when oxygen flow into the disposable bubble oxygenator was maintained approximately at 3.5 L/min .. Inthis way, the oxygen contents were measured in the mean value of 13.11${\pm}$O.56 vol. % of arterial blood and 8.67+1.08 vol.% of venous blood(P${\pm}$0.86 vol.% in arteriovenous oxygen difference and 2. 97${\pm}$0.62cc/Kg in oxygen consumption were calculated. According to these dates, it is as plain as pikestaff that excellent oxygenation and good tissue perfusion was accomplished. Erythrocyte, hemoglobin and hematocrit were decreased about 38% during extracorporeal circulation and these were not recovered until 1-3 days after perfusion. These decrease was resulted from relatively high degree of hemodilution rate and no blood transfusion to compensate during these experimental studies. The platelets were also decreased about 76% during perfusion, but on the contrary, it was increased progressively after perfusion and in 1-3 days after perfusion was returned to the control level. Leucocyte were also decreased during perfusion, but it was increased progessively after perfusion and in 1-3 days after perfusion exceed the control level. This increase was resulted from postoperative infection of the wound, but its analysis were not changed significantly.

• 대한약리학회지
• /
• 제11권2호
• /
• pp.55-59
• /
• 1975

Safety study of the continuous releasing dichlorvos-resin insecticide $(Mopari^{\circledR})$ was conducted in human volunteers and domestic fowls. For the purpose, the potential hazards in using the insecticide were observed in terms of the inhibition of plasma cholinesterase activity and the changes in the liver function (GOT, GPT, Alkaline phosphatase, Bilirubin, Thymol turbidity), the blood picture (RBC, WBC with differential count, Hemoglobin, Hematocrit and ESR) and the urine picture (sugar, albumin, pH and microscopic findings) in 40 healthy adult volunteers and 60 leghorn domestic fowls. In case of the human study the observation was continued for 2 months during the application of the insectiside ($1{\sim}3$ solid formulations/$30m^3$) in the living rooms of ordinary Korean dwelling houses or in the office. In the animal test, however, 1 to 5 solid formulations of the insecticide were applied in the fowl cage of $9.2m^3$ for 5 weeks. Any significant inhibition of the plasma cholinesterase activity was not observed in both the human volunteer and the fowl throughout the experimental period. And the liver function as well as the blood and urine pictures were also not changed after exposure to the vaporizing insecticide. It is considered from the result that the amount of dichlorvos released into the air by the continuous vaporizing dichlorvos-resin insecticide presents no significant hazardous effect on humans or animals in the present experimental condition.

• 대한수의학회지
• /
• 제29권3호
• /
• pp.223-229
• /
• 1989

These studies were carried out to investigate the changes of blood pictures, hitological findings and testosterone concentrations after orchidectomy in ageing rat. The results obtained were summarized as follows: 1. The total W.B.C. counts were $9.27{\pm}12{\times}10^3/mm^3$ in the control group, $9.54{\pm}34{\times}10^3/mm^3$ in the sham-operation group and $12.08{\pm}28{\times}10^3/mm^3$ in the orchidectomy group when it was checked 50days after the operation. 2. The number of lymphocytes after orchidectomy began to increase gradually as time passes, thereafter markedly increased $10.12{\pm}03{\times}10^3/mm^3$ at 50days after orchidectomy. 3. The concentration of testosterone in serum began to decrease gradually after orchidectomy showed lowest level $1.68{\pm}0.61pg/ml$ at 50days after orchidectomy while it was $5.82{\pm}0.39pg/ml$ in control group. 4. The histological findings of thymus after orchidectomy were marked increase of thymic lymphocyte, disapearance of fat cells and appearance of mitotic figures.

• 한국임상수의학회지
• /
• 제6권1호
• /
• pp.217-225
• /
• 1989

In order to develop the effective methods of electroacupuncture anesthesia to bovine species. eight animals of Korean native cow, which are healthy and have ordinary perception response. were examined to study on the acupuncture prescription. In the present study, six kinds of acupuncture prescription methods were applied with four kinds of meridian points which consist of Sam Yang Rack, Keuk Moon, Boo Yang and Sam Eum Kyo. The results are summarized as follows. 1. All kinds of methods applied here were simple in needling technique but considerably effective on analgesia. It was also confirmed that the methods could be applied to the all clinical signs, because these were not depended to vary on the position of operation area and the body restrain. 2. The results, which were obtained by applying to all meridian points at both legs selected by diagonal lines(e. g., right foreleg and left hind leg, and vice versa) and to all meridian points at the all legs, were revealed the same analgesia effect. However, the result applied to meridian points at one side of body did not show the good effect for analgesia. 3. When the acupuncture prescription was applied to Sam Yang Rack and Keuk Moon at both forelegs, and Boo Yang and Sam Eum Kyo at both hind-legs, the good effects of regional analgesia appeared at the anterior body and both forelegs, and the posterior body and both hind-legs, respectivery. 4. There was no sognificant difference in changing biochemical pictures of blood and serum during the experiment.

• Journal of Chest Surgery
• /
• 제25권5호
• /
• pp.458-468
• /
• 1992

With the aid of extracorporeal circulation, nine dogs underwent orthotopic cardiopulmonary transplantation after preservation of the donor heart in a hypothermic amino acid[glutamate, aspartate] enriched high potassium extracellular solution, and preservation of the donor lung with hypothermic low potassium dextran solution from June 1990 to May 1991. The mean body weights of dogs were 20kg and the recipients` preoperative hematologic and hemodynamic pictures were within normal range except slightly decreased level of albumin and total protein, which was supposed to be due to malnutrition. The following modifications of the original Stanford technique were emphasized: [1] the posterior mediastinum is dissected as little as possible with meticulous hemostasis; [2] the surgical procedure is kept away from the phrenic and vagus nerves; [3] the tracheal anastomosis may be wrapped with recipient`s pulmonary artery flap or surrouding soft tissues. A combination of Cyclosporine, Azathioprine, corticosteroid was used as perioperative immunosuppressive therapy. Postoperatively all recipients could be weaned from extracorporeal circulation, showing favorable vital signs, but within 24 hours, irreversible congetive heart failure, ascites, arrhythmias developed with a mean survival time 13.6$\pm$6.6[n=9, range=6~26] hours. Hemoglobin and platelet counts were significantly[p<0.05] decreased postoperatively, which is thought to be attributed to blood damage by cardiopulmonary bypass and hemodilution. Postmortem finding included multiple subendocardial patch hemorrhage in both atrial and ventricular cavities, pulmonary and liver congestion, and all tracheal anastomoses were intact. Further consideration about quality control of the animal, infection, rejection, the effect of cardiopulmonary bypass on the experimental animal is required to improve the results.

• 대한수의학회지
• /
• 제12권1호
• /
• pp.7-14
• /
• 1972

Hemogram and serum composition of pregnant rabbits were studied and the results obtained were as follows: 1. Erythrocyte, hemoglobin concentration and hemotocrit value of pregnant rabbits decreased at the late stage of gestation, and 1 week after delivery the values were recovered to the normal levels. Number of erythrocyte and hematocrit value were not found to be significant, but hemoglobin concentration showed significant differences at the third and fourth week of pregnancy. 2. Total leucocytes of pregnant rabbits increased continuously as gestation progresses and 1 week postpartum the values were returned to normal. Highly significant changes were observed in the third and the fourth week of pregnancy. Neutrophil was revealed highly significant rise at the third and the fourth week of gestation and 1 week postpartum, but lympocyte was decreased highly significantlly. 3. Serum calcium of pregnant rabbits revealed the tendency of decrease as gestation progresses and 1 week after delivery the value was returned to normal, and highly significant decrease was abserved at the fourth week. Serum inorganic phosphorus of pregnant rabbits showed highly significant decrease at the fourth week of gestation, but no differences were observed at the other period of gestation and 1 week postpartum. 4. Serum protein of pregnants rabbits showed the tendency of decrease continuously pregnancy progresses, and 1 week after delivery showed the normal values. Highly significant decrease was found at the fourth week of gestation. the levels of serum lipids in pregnant rabbits was unchanged untill the third week of pregnancy, but at the fourth week and 1 week postpartum, the rise was highly significant. The level of total serum cholesterol in pregnants rabbis was shown the tendency of decrease untill the end of the second week of gestation and significantly dropped at the third week, thereafter, the value was rose significantly at the fourth week of gestation and 1 week postpartum.

• 대한한의학회지
• /
• 제20권2호
• /
• pp.187-197
• /
• 1999

To assess the usefulness of tongue inspection for evaluating the Pattern identification in oriental medicine, we observed stroke patient's tongue and tongue coat and compared it with Pattern identification. The test group was composed of 85 acute stroke stage patients(within 72 hours of onset). Subjects were randomly selected from stroke patients admitted in the KyungHee University, Hospital of Oriental Medicine from December 1 1998 to June 30 1999. We took pictures of patient's tongue and tongue coat within 72hours from onset and checked Pattern identification at the same time. Tongues colored pale rose or red greatly outnumbered other colors. Tongue shape tended to be prickly or fissured, and tongue condition tended to be unflexible or deviated. Regarding tongue coat color, there were great amounts of yellow or clark yellow tongue coats, which were moist, thick or greasy in substance. The red tongue was significantly related to Fire-heat and deficiency of Yin syndrome, while faint white tongue to Damp syndrome(P=0.006). In terms of tongue coat, thin coat was related to Wind and Fire-heat syndromes, thick coat to Damp and Blood stasis syndrome, respectively (P=0.002). In conclusion, we thought that tongue inspection could be a useful Oriental medicine diagnosis in stroke.

• 대한영양사협회학술지
• /
• 제16권4호
• /
• pp.369-377
• /
• 2010

This study was conducted to investigate the effects of food consumption monitoring based on a digital photography method using a mobile phone on food consumption and weight reduction. Eighteen female college students (>30% body fat) participated in the weight control program using a mobile-phone for 4 wks. The energy intake was reduced significantly after 3 wks compared to baseline (P<0.05, baseline: 1,453.0 kcal, 3rd wk: 1,171.1 kcal, 4th wk: 1,130.8 kcal). The subjects lost 2.8 kg of body weight, 1.4% of % body fat, and 1.1 $kg/m^2$ of body mass index (BMI) after 4 wks. There were also significant differences in blood pressure (P<0.001) and serum cholesterol (total cholesterol: P<0.05, LDL-cholesterol: P<0.01) before and after the self-regulated diet program. In this study, the digital photography method using a mobile-phone influenced weight control through trained consumption monitoring, which helps individuals reduce discrepancies between perceived and actual consumption levels. Therefore, effective monitoring by taking food pictures using a mobile-phone can lead individuals to rely more heavily on easy-to-monitor visual cues.

• 대한한의학회지
• /
• 제16권1호통권29호
• /
• pp.271-280
• /
• 1995

Effects of aqua-acupuncture with soshiho-tang at Kansu(BL_{18}$) and Tamsu(BL_{19}$) on the Glutamic Oxaloacetic Transaminase(GOT), Glutamic Pyruvic Transaminase(GPT), Lactic dehydrogenase(LDH) and blood pictures in rat with $CCI_4$ were determined. In the group with $CCI_4$ the activity of GOT, GPT and LDH showed a tendency to increase, however these values showed a tendency to decrease by the aqua-acupuncture with soshiho-tang throughout experimental days and these values were recovered to those of control group on the last experimental days. Counts of RBC and Hemoglobin showed a tendency to decrease in rat with $CCI_4$, however these decreased values were recovered by the aqua-acupuncture with soshiho-tang and on the last experimental days, these values were similar to those of control group. In the $CCI_4$ group, counts of WBC and the proportion of Lymphocytes showed a tendency to increase and the proportion of Neutrophils showed a tendency to decrease, however these values showed a rapid recovery by the aqua-acupuncture with soshiho-tang. In the meridian point of Kansu and Tamsu, the effects of aqua-acupuncture with soshiho-tang on recovery of liver function showed no difference. Results from this study indicate that the aqua-acupuncture with soshiho-tang can improve the liver function in rat with $CCI_4$.

• 한방안이비인후피부과학회지
• /
• 제35권4호
• /
• pp.209-218
• /
• 2022

Objective : This study assessed the effect of a combination of Korean medicine on a chronic nipple eczema patient complaining of stress and immunodeficiency due to long-term steroid use. Methods : Herbal medicine, moxibustion and acupuncture were performed for a year. Treatment outcomes were evaluated with DLQI(Dermatology Life Quality Index), EQ-5D-5L(The 5 level of EuroQol 5 Dimensio scale), EQ-VAS(EuroQol-Visual Analog Scale), ADSI(Atopic Dermatitis Severity Index), pruritus NRS(Numeral Rating Scale), pictures and patient's statements. Results : After the treatment, symptoms have been alleviated, the quality of life has increased, and it has been maintained without further nipple eczema for three months. Conclusion : We suggest that Korean medicine is effective for chronic nipple eczema patient.