• The Korean Journal of Food And Nutrition
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• v.17 no.4
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• pp.356-367
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• 2004

This study was performed to evaluate the effectiveness of a nutritional education program conducted by public health center in Jinju city for obese women. The subjects of this study consisted of 27 obese women(BMI $\geq$ 25) aged 35∼55 years in Jinju area, and the educational period was 6 weeks. We evaluated the anthropometric parameters and biochemical indices, dietary habits, dietary behaviors, nutritional attitude of obese women before and after the nutritional education. And also daily intake during the educational period were measured. Weight, obesity index, BMT, waist circumferences and hip circumferences of obese women were significantly decreased(p<0.001) after nutritional education, but changes of WHR, systolic blood pressure and diastolic blood pressure were not significant. There were no significant difference in total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, LDH and blood glucose level in serum before and after the nutritional education, but the indices tend to decrease after the nutritional education. There was significantly different change of dietary behaviors in 3 items among the dietary behavior after the nutritional education. Their dietary habit, dietary behavior and nutritional attitude scores were significantly improved after the nutritional education. Mean daily energy intakes was low compared with the RDA as 78.88%. The average carbohydrates, protein, fat ratio on the energy intakes was 63 : 17 : 20. The proportion of energy intake from snacks the was 12.91${\pm}$6.15%.

• Journal of Animal Science and Technology
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• v.64 no.5
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• pp.863-870
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• 2022

This study was conducted to investigate the effect of dietary supplementation of octacosanol (OCT) extracted from triticale sprout on laying performance, egg quality, and blood parameters of laying hens. A total of 192, Hyline brown laying hens aged 43 weeks were divided into 4 dietary groups of 48 birds each and they were randomly subjected to one of the experimental diets containing OCT at the levels of none, 10, 20, and 30 mg/kg of diet. All birds were fed with isoenergetic and isonitrogenous mash diets for 6 weeks. The result showed that hens supplemented with 20 and 30 mg/kg OCT in diet significantly increased (p < 0.05) egg production than those fed with the basal diet. OCT concentration in the egg yolk of hens fed with 20 and 30 mg/kg OCT was significantly higher than in those fed the control diet. Hens fed 20 and 30 mg/kg OCT exhibited greater high-density lipoprotein (HDL) cholesterol and interleukin (IL) concentrations and reduced serum concentrations of cholesterol and triglyceride compared to those fed with 0 and 10 mg/kg OCT. This study indicates that supplementing the diet of laying hens with 20 and 30 mg/kg of OCT can improve the performance, egg quality, and health status of laying hens.

• Journal of Biomedical Engineering Research
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• v.16 no.2
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• pp.223-230
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• 1995

This study investigates a combined mathematical model for the quantitative estimation of regional myocardial blood flow in experimental canine coronary artery occlusion and in patients with ischemic myocardial diseases using Rb-82 dynamic myocardial positron emission tomography. The coronary thrombosis was induced using the new catheter technique by narrowing the lumen of coronary vessel gradually, which finally led to partial obstruction of coronary artery. Thirty four Rb-82 dynamic myocardial PET scans were performed sequentially for each experiment using our 5, 10 and 20 second acquisition protocol, respectively, and six to seven regions of interest were drawn on each transaxial slices, one on left ventricular chamber for input function and the others on normal and decreased perfusion myocardial segments for the flow estimation in those regions. Two compartment model and graphical analysis method have been applied to the measured sets of regional PET data, and the rate constants of influx to myocardial tissue were calculated for regional myocardial flow estimates with the two parameter fits of raw data by the Levenberg-Marquardt method. The results showed that, (I) two compartment model suggested by Kety-Schmidt, with proper modification of the measured data and volume of distribution, could be used for the simple estimation of regional myocardial blood flow, (2) the calculated regional myocardial blood flow estimates were dependent on the selection of input function, which reflected partial volume effect and left ventricular wall motion in previously used graphical analysis, and (3) mathematically fitted input and tissue time activity curves were more suitable than the direct application of the measured data in terms of convergence.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.2
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• pp.675-678
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• 2015

Background: There are several validated risk factors for breast cancer. However the legitimacy of elevated fasting blood glucose (FBG) is not well established. This study was designed to assess this parameter as a risk factor for breast cancer among pre- and post-menopausal women. Materials and Methods: This case-control study was conducted at Department of Biochemistry, University of Karachi from June 2010 to August 2014. Simple random sampling technique was used to collect data of study subjects comprising 175 diagnosed breast cancer patients with positive histopathology from Breast Clinic, surgical unit-1, Civil Hospital, Karachi and 175 healthy controls from various screening programs. Blood samples were analyzed for FBG and serum insulin. Results: FBG, HOMA-IR, systolic and diastolic blood pressure were significantly raised in breast cancer cases when compared to control subjects. Cases and controls were further categorized in to two groups using cutoff value of 110mg/dl to distinguish subjects into normal fasting glucose (<110mg/dl) and having impaired fasting glucose (${\geq}110-{\leq}125mg/dl$) or diabetes (${\geq}126mg/dl$). Odds ratios were found to be 1.57, 2.15 and 1.17 in overall, pre-menopausal and post-menopausal groups, respectively. (all p < 0.05). Conclusions: A statistically significant risk of breast cancer exists in women having elevated fasting blood glucose levels, corresponding to prediabetes and diabetes, among pre and postmenopausal ages, with comparatively greater effects in the premenopausal group.

• Current Optics and Photonics
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• v.3 no.6
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• pp.555-565
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• 2019

Development of a biomarker for predicting tumor-treatment efficacy is a matter of great concern, to reduce time, medical expense, and effort in oncology therapy. In a preclinical study, we hypothesized that the blood-flow parameter based on laser speckle flowmetry (LSF) could be a potential indicator to estimate the efficacy of breast-cancer treatment. To verify this hypothesis, a 13762-MAT-B-III rat breast tumor was grown in a dorsal skinfold window chamber applied to a nude mouse, and the change in blood flow rate (BFR) - or the speckle flow index (SFI) is used together as the same meaning in this manuscript - was longitudinally monitored during tumor growth and metronomic cyclophosphamide treatment. Based on the daily LSF angiogram, several BFR parameters (baseline SFI, normalized SFI, and △rBFR) were compared to tumor size in the normal, treated, and untreated tumor groups. Despite the incomplete tumor treatment, we found that the daily changes in all BFR parameters tended to have partially positive correlation with tumor size. Moreover, we observed that the changes in baseline SFI and normalized SFI responded one day earlier than the tumor shrinkage during chemotherapy. However, daily variations in the hypercapnia-induced △rBFR lagged tumor shrinkage by one day. This study would contribute not only to evaluating tumor vascular response to treatment, but also to monitoring blood-flow-mediated diseases (in brain, skin, and retina) by using LSF in preclinical settings.

• Proceedings of the Korea Environmental Mutagen Society Conference
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• 2003.10a
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• pp.148-148
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• 2003

• Toxicological Research
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• v.7 no.1
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• pp.51-59
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• 1991

The purpose of the present study was to investigate the effects of non-watering, fasting and non-watering fasting for 16-17 hrs on haematological and biochemical parameters in SD rats. 1. Liver weight was decreased in the order of in the fasting group, non-watering fasting group and non-watering group in both sexes. 2. In fasting group and non-watering fasting group, haematologic parameters of male (HGB and MCH) and femal (MCHC) were trends to decrease compared with normal feeding & watering group. 3. In the differential leucocyte counts, there were no significant differences compared with noraml feeding % watering group.

• Journal of Animal Science and Technology
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• v.50 no.2
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• pp.209-216
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• 2008

This study was conducted to investigate the effects of selenium feeding and supplementation in diet on the concentration of selenium in blood and velvet antler of spotted deer(Sika deer). Three spotted deer were fed high selenium concentration(6mg/kg DM). Absorption and retention rates of selenium were examined by evaluating selenium concentrations in feces and urine. Stress-related hormones and serum biochemical parameters in blood were also evaluated for the purpose of detecting any negative effect by the high level of selenium feeding. Eight spotted deers were randomly assigned to two groups and were fed with one of two diets for 20 days, which were with or without the addition of 6mg selenium /kg diet. Concentration of selenium in velvet antler was evaluated. Selenium concentration in blood of spotted deer fed high level selenium for 30 days was significantly increased(p<0.05), retention rate of selenium reached 59.15%. No differences in level of stress-related hormone and biochemical parameters(NEFA, ALT, AST) in blood were observed by feeding high level selenium. The diet with selenium significantly increased concentrations of selenium in top(0.11 vs 0.45ppm; p<0.001), middle(0.08 vs 0.21ppm; p<0.01) and basepart(0.08 vs 0.15ppm; p<0.05) of velvet antler.

• Korean Journal of Poultry Science
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• v.35 no.1
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• pp.57-62
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• 2008

The study was conducted to evaluate the effects of dietary organic acid mixture(lactic acid 12%, formic acid 9%, citric acid 5%, butyric acid 5% and phosphoric acid 6%) on growth performance, organ weight, blood immunological parameter and intestinal villi morphology in broilers. Dietary treatments included 1) CON (basal diet), 2) OA1 (basal diet + 0.1% organic acid mixture) and 3) OA2 (basal diet + 0.2% organic acid mixture). Four hundred eighty hatched Arbor Acre broiler chickens were housed in 24 pens of 20 birds each. Eight replicate pens were allotted into each treatment by completely randomized design. Daily weight gain, feed intake and feed/gain were not significantly different among the treatments. In organ weight, that of gizzard was significantly heavier in OA2 than CON (Linear effect = 0.034). However, those of spleen and intestine were not significantly different among the treatments. Blood immunological parameters such as RBC, WBC and lymphocyte were not significantly difference. In intestinal villi morphology, villi length was increased in OA1 compared to CON (Quadratic effect = 0.050). In conclusion, 0.2% organic acid mixture was effective to improve gizzard weight of broilers.

• Journal of Acupuncture Research
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• v.28 no.4
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• pp.49-55
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• 2011

Objectives : The purpose of this study was 1) to investigate the possibility of taking blood stasis pattern as a clinical parameter of frozen shoulder, using blood stasis pattern questionnaire (BSPQ) to frozen shoulder group comparing with normal group, and 2) to find out the relationship of the severity of main frozen shoulder symptoms (pain and limited range of motion of shoulder) and the level of blood stasis pattern through BSPQ analysis. Methods : During the period of January 2010 to July 2010, fifty five frozen shoulder patients who visited outpatient clinic of department of acupuncture and moxibustion in East-West Neo Medical Center, Kyung Hee University and fifty five normal people without shoulder pain nor limited ROM in shoulder joint were evaluated through BSPQ, and to the frozen shoulder group, also evaluated three different visual analogue scales (VAS) of pain (pain on average, pain at night, and pain on motion) and active / passive range of motion (ROM) of shoulder joint. Results : Mean blood stasis pattern score of frozen shoulder patients group was significantly higher than the score of normal group (patients vs normal group : $4.85{\pm}1.68$ vs $3.49{\pm}1.54$). Three different types of pain VAS (on average, at night and on motion) showed low to very low positive correlation with BSPQ scores when analyzed with Pearson's correlation coefficient. ROM levels in shoulder joint were not significantly related to BSPQ scores, though active external rotation range showed low positive correlation with BSPQ scores. Conclusions : Patients with frozen shoulder showed higher blood stasis pattern score in BSPQ but the level of blood stasis pattern is not significantly related to the severity of pain or limitation of ROM in shoulder joint.