• Korean journal of food and cookery science
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• v.16 no.6
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• pp.644-651
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• 2000

This study was carried out to evaluate the effects of fractions of methanol(MeOH) extracts of Lycopus lucidic Turcz on hyperglycemia and energy metabolites in streptozotocin(STZ) diabetic rats. Diabetes mellitus was induced in male Sprague-Dawley rats weighing 200-220 g by an injection of STZ dissolved in a citrate buffer into the tail vein at a dose of 45 mg/kg of body weight, and the rats were divided into 7 groups, that is, one normal group and 6 diabetic groups: STZ-control, hexane, chloroform(CHCl$\sub$3/). ethylacetate(EtOAc), butanol(BuOH) and H$\sub$2/O fraction-fed groups. All groups were fed an AIN-93 diet and the fractions of Lycopus lucidic Turcz were administered orally with 2 % Tween 80 for 14 days after the STZ injection. Body weight, diet intake and organ weights were monitored. The plasma levels of blood glucose, insulin and protein were determined. The plasma concentrations of cholesterol, HDL-cholesterol, triglycerides and free fatty acid were assayed. The plasma activities of aspartate aminotransferase (AST) and alanine aminotransferase(ALT) were also measured. Body weight losses were observed by feeding the fractions of Lycopus lucidic Turcz in STZ experimental groups, and the kidney weight was increased. The extent of blood glucose decrement was significantly greater in the hexane and BuOH fraction-fed groups than STZ-control group. The plasma protein level was significantly lower in the H$\sub$2/O fraction-fed group. The plasma cholesterol level was decreased in BuOH and H$\sub$2/O fraction-fed groups compared with the STZ-control group. The levels of free fatty acids in the CHC1$\sub$3/ and H$\sub$2/O fraction-fed groups were significantly decreased(p<0.05). ALT activitiy of BuOH fraction-fed group was lower than control but it was not significantly different. These results suggest that the fractions of Lycopus lucidic Turcz are capable of lowering blood glucose and fat metabolites concentrations when administered to STZ-treated rats, and AST/ALT activity and insulin levels show the possibility of therapeutic use to diabetes mellitus.

• Journal of the Korean Applied Science and Technology
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• v.3 no.1
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• pp.23-31
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• 1986

Several authors reported that vegetable proteins cause to decrease serum cholesterol and reported the effect of limiting amino acid balance in dietary protein on the blood component. This study was designed to observe growth rate and blood component in 1% cholesterol-fed male rats intake pure isolated soy proteins and methionine for 4 weeks. The diets were supplemented with either 20% casein or isolated soy protein as dietary protein sources and methionine as limiting amino acid of isolated soy protein and casein protein. The results were as follows; 1) The body weight gain was the greatest in casein groups. 2) Serum total cholesterol concentration was significantly increased by casein groups and slightly decreased by isolated soy protein groups. 3) Serum HDL-cholesterol concentration was significantly increased by isolated soy protein groups than control group. 4) Serum total lipid and triglyceride concentrations were significantly decreased by isolated soy protein groups than control group. 5) Serum glucose concentration was significantly increased by isolated soy protein plus 0.8% methionine than control group. 6) Serum total protein and albumin concentrations were significantly increased by all experimental diets groups than control group. Especially, casein groups were the most increased in all experimental diets groups.

• Journal of Nutrition and Health
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• v.36 no.1
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• pp.75-82
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• 2003

It has been considered that high Na intake, and low Ca/K intake are related to the incidence of hypertension. In this preliminary study, dietary Na, K, and Ca intake and their urinary excretion in rural area in Kyungpook province were measured to recognize the relationship between those blood pressure-related minerals and blood pressure regulation in elderly people in rural area of South Korea. Sixty eight subjects (male 39, female 29) aged over 60 were randomly selected in rural area in South Korea. Blood pressure and soup saltness were measured, and dietary intake using 24 hours recall and urinary excretion of Na, K and Ca were measured. Depending on the blood pressure level, the data were analyzed using non-parametric ANOVA of Kruskal Wallis analysis on the basis of categorizing of one of four blood pressure groups, such as normal, high normal, hypertension I and hypertension II. Mean systolic (124.2$\pm$15.1 mmHg) and diastolic (79.0$\pm$10.2 mmHg) blood pressures were within the normal range. Soup saltiness and systolic pressure was positively correlated (p < 0.05). Even without statistical significance, dietary Na intake was higher in the upper systolic blood pressure groups then in the lower ones, which suggested higher Na intake caused the increase of blood pressure. No consistency was shown between the urinary concentration of Na, K, Ca level and blood pressure level, respectively. From the results of this study, it is assumed that high Na intake might be related to the incidence of hypertension. Further study with large sample size is needed to supplement the limitation of this preliminary study. (Korean J Nutrition 36 (1) : 75-82, 2003)

• Journal of the Korean Society of Physical Medicine
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• v.3 no.4
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• pp.261-268
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• 2008

Purpose : This study was to investigate the effects of aerobic exercise and resistive exercise program on hypertension in the elderly. Methods : Subjects were allocated into one of three groups (aerobic exercise group, resistive exercise group, control group). Blood pressure was measured pre- and post-exercise in each exercise group. Data were analyzed with paired t-test and one-way ANOVA to determine blood pressure differences. Results : The results of this study were as follows. 1) The systolic blood pressure of the aerobic exercise group decreased significantly after exercise (p<.05). 2) The diastolic blood pressure of the resistive exercise group decreased significantly after exercise (p<.05). 3) There was a significant decrease in systolic blood pressure of aerobic exercise group compared with control group following the exercise. 4) There was no significant differences in diastolic blood pressure among three groups following the exercise (p>.05). Conclusion : Aerobic exercise and resistive exercise program were effective in reducing systolic blood pressure and diastolic blood pressure of the hypertension in the elderly. Thus, this program can be recommended as an effective intervention for the elderly. Therefore, regular and continued those exercises will be the solution for decreasing systolic blood pressure and diastolic blood pressure.

• Nutrition Research and Practice
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• v.7 no.1
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• pp.34-42
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• 2013

This study investigated the effects of magnetized water supplementation on blood glucose, DNA damage, antioxidant status, and lipid profiles in streptozotocin (STZ)-induced diabetic rats. There were three groups of 4-week-old male Sprague-Dawley rats used in the study: control group (normal control group without diabetes); diabetes group (STZ-induced diabetes control); and magnetized water group (magnetized water supplemented after the induction of diabetes using STZ). Before initiating the study, diabetes was confirmed by measuring fasting blood glucose (FBS > 200 dl), and the magnetized water group received magnetized water for 8 weeks instead of general water. After 8 weeks, rats were sacrificed to measure the fasting blood glucose, insulin concentration, glycated hemoglobin level, degree of DNA damage, antioxidant status, and lipid profiles. From the fourth week of magnetized water supplementation, blood glucose was decreased in the magnetized water group compared to the diabetes group, and such effect continued to the 8th week. The glycated hemoglobin content in the blood was increased in the diabetes group compared to the control group, but decreased significantly in the magnetized water group. However, decreased plasma insulin level due to induced diabetes was not increased by magnetized water supplementation. Increased blood and liver DNA damages in diabetes rats did significantly decrease after the administration of magnetized water. In addition, antioxidant enzyme activities and plasma lipid profiles were not different among the three groups. In conclusion, the supplementation of magnetized water not only decreased the blood glucose and glycated hemoglobin levels but also reduced blood and liver DNA damages in STZ-induced diabetic rats. From the above results, it is suggested that the long-term intake of the magnetized water over 8 weeks may be beneficial in both prevention and treatment of complications in diabetic patients.

• Journal of the Korean Dietetic Association
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• v.13 no.1
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• pp.30-37
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• 2007

The purpose of this study was to compare the nutrient intakes, blood pressure, and blood lipids in Korean adults according to BMI. Subjects were recruited and divided into three groups according to BMI, which included normal group (18.5$\leq$BMI<23), overweight group (23$\leq$BMI<25), obese group (25$\leq$BMI). The average age, height, weight, BMI of the subjects were 53.1years, 159.2cm, 54.5kg, 21.4kg/$m^2$ for normal group, 52.3years, 159.4cm, 61.4kg, 24.1kg/$m^2$ for overweight group, 55.9years, 158.7cm, 68.5kg, 27.2kg/$m^2$ for obese group, respectively. There were not significant differences in energy and food intakes by BMI groups. The blood pressure, serum cholesterol, serum triglyceride, serum LDL-cholesterol, and AI were significantly increased and serum HDL-cholesterol decreased with increment of BMI. The age and BMI were significantly positively correlated with blood pressure and serum lipids except HDL-cholesterol. There was significantly negative correlation between percentage of protein energy intake and AI. To summarize these results, energy, nutrient, and food intakes were not significantly correlated with BMI, and blood pressure and blood lipids increased with increment of BMI. Further systematic study of relation among nutrient intakes including various life factors, BMI, blood pressure, and blood lipid profile is needed.

• Journal of Korean Academy of Nursing
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• v.32 no.5
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• pp.673-683
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• 2002

This study was conducted to evaluate the effects of SaSang constitutional diet for essential hypertension on blood pressure, fat, and serum lipid on the subjects with aerobic exercise and low salt diet at the same time. Method: A non-equivalent control group time-series design was used. For the experimental group, aerobic exercise and SaSang constitutional diet were taught by researcher at health center. Test for hypothesis was done by repeated measured ANOVA. Result: There was significant decrease in systolic, diastolic, and MAP between the experimental group and control group over three different times. There was significant decrease in body weight, BMI, and body composition over three different times. But, there was no significant difference between groups and interaction by groups or over time. There was significant decrease in T/G and cholesterol over three different times. But, there was no significant difference in T/G, HDL, LDL, and total cholesterol between groups and interaction by groups or over time. Conclusion: Findings indicate that this study will contribute to develop nursing strategies for the regulation of the blood pressure as a means of alternative- complementary nursing intervention.

• Archives of Plastic Surgery
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• v.48 no.1
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• pp.133-143
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• 2021

Background Extensive research has been conducted on islet transplantation as a possible cure for diabetes. Islet transplantation in the liver via the portal vein has shown remarkable results, but numerous other recipient sites are currently being investigated. We aimed to show the effectiveness of using a muscle flap as a recipient site for islet transplantation. Methods Islet cells were harvested from 12 isogenic Lewis rats, and then diabetes was induced in another 12 isogenic Lewis rats by streptozotocin injection. In six rats, 3,000 islets were transplanted into gastrocnemius muscle flaps, and in the other six rats, the same number of islets were transplanted into the gastrocnemius muscle. The transplanted islet cell function between the two groups was compared by means of blood glucose tests, glucose tolerance tests, immunohistochemistry, and real-time reverse transcription polymerase chain reaction. Results In the muscle flap group, blood glucose levels significantly decreased after islet transplantation. Blood glucose levels were significantly different between the two groups at 3 weeks after transplantation. The muscle flap group showed nearly normoglycemic results upon the glucose tolerance test, whereas the muscle group was hyperglycemic. Immunohistochemical evaluation showed positive results against insulin and glucagon in biopsies of both groups, and the islet cell density was higher in the muscle flap group. There were no statistically significant differences between the two groups in real-time reverse transcription polymerase chain reaction results. Conclusions Our results suggest that muscle flaps are promising candidates for islet cell transplantation.

• Journal of Environmental Science International
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• v.30 no.7
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• pp.537-545
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• 2021

This study aimed to investigate the improvement effect of 5% (w/w) mung bean (Phaseolus aureus L.) on lipid composition and protein concentration in hyperlipidemic rats. Seven-week-old male (Sprague-Dawley) rats were divided into four groups (n=6, each), and fed experimental diets containing mung bean meal [basal diet+5% (w/w) mung bean (BM), basal-hyperlipidemic diet+5% (w/w) mung bean (BHM)], basal-hyperlipidemic diet (BH), and control (basal diet, BD). Lipid composition in the mung bean diet groups (BM and BHM) evidenced significant reductions in serum total cholesterol, low-density lipoprotein cholesterol, atherosclerotic index, cardiac risk factor, triglyceride, phospholipid, free cholesterol, cholesteryl ester, blood glucose, nonesterified fatty acid, and an elevation in high-density lipoprotein cholesterol. The serum albumin/globulin ratio was increased in mung bean diet-supplemented rats compared to that in hyperlipidemic rats (p < 0.05). Total calcium, phosphorus and potassium concentrations in sera were higher in the BM, BHM and BD groups than in the BH group. Concentrations of sodium and chlorine in sera were lower in the mung bean diet-supplemented groups than in the hyperlipidemic group. The in vivo experiments showed that ingestion of mung bean was effective in improving lipid composition, protein concentration, and blood glucose.

• The Korean Journal of Food And Nutrition
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• v.36 no.1
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• pp.50-57
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• 2023

This study was designed to evaluate antihyperglycemic and antihyperlipidemic effects of ethanol extracts of Taraxacum mongolicum(T.m.) on streptozotocin (STZ)-induced diabetic rats. Sprague-Dawley rats were randomly assigned to five groups: normal (NC), STZ-control (DC), and three experimental groups. Diabetes was induced in Sprague-Dawley rats with a single intravenous injection [45 mg/kg body weight (b.w.)] of STZ. An ethanol extract of T.m. was orally given to diabetic rats for 14 days. Three experimental groups were additionally treated with T.m. extract at doses of 1 g/kg b.w./day for T.m.-1, 2 g/kg b.w./day for T.m.-2, and 3 g/kg b.w./day for T.m.-3. Oral administration of T.m.-2 significantly increased their body weights. T.m.-1 and T.m.-2 significantly decreased aspartate aminotransferase (AST) levels than DC. T.m.-1 and T.m.-2 group significantly decreased blood glucose levels. Total cholesterol, triglycerides, and free fatty acids were significantly decreased whereas high-density lipoprotein cholesterol was significantly increased in groups treated with T.m. extract than those in the DC group. These results support the fact that administration of T.m. extract can reduce hyperglycemia and hyperlipidemia risk in diabetic rats.