• KSII Transactions on Internet and Information Systems (TIIS)
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• v.5 no.5
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• pp.1049-1068
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• 2011

In this paper a simple and effective call admission control (CAC) scheme is proposed for the emerging interleave-division multiple-access (IDMA) systems, supporting a variety of traffic types and offering different quality of service (QoS) requirements and priority levels. The proposed scheme is signal-to-interference-plus-noise ratio (SINR) evolution based CAC (SE-CAC). The key idea behind the scheme is to take advantage of the SINR evolution technique in the process of making admission decisions, which is developed from the effective chip-by-chip (CBC) multi-user detection (MUD) process in IDMA systems. By virtue of this semi-analytical technique, the MUD efficiency can be estimated accurately. Additionally, the computational complexity can be considerably reduced. These features make the scheme highly suitable for IDMA systems, which can combat intra-cell interference efficiently with simple CBC MUD. Analysis and simulation results show that compared to the traditional CAC scheme considering MUD efficiency as a constant, the proposed SE-CAC scheme can guarantee high power efficiency and throughput for multimedia traffic even in heavy load conditions, illustrating the high efficiency of CBC MUD. Furthermore, based on the SINR evolution, the SE-CAC can make accurate estimation of available resource considering the effect of MUD, leading to low outage probability as well as low blocking and dropping probability.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.6247-6251
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• 2014

Background: The aim of the present study was to investigate the involvement of emodin on the growth of human breast cancer MCF-7 and MDA-MB-231 cells and the estrogen (E2) signal pathway in vitro. Materials and Methods: MTT assays were used to detect the effects of emodin on E2 induced proliferation of MCF-7 and MDA-MB-231 cells. Flow cytometry (FCM) was applied to determine the effect of emodin on E2-induced apoptosis of MCF-7 cells. Western blotting allowed detection of the effects of emodin on the expression of estrogen receptor ${\alpha}$, cyclin D1 and B-cell lymphoma-2 (Bcl-2), mitogen-activated protein kinases (MAPK) and phosphatidylinostiol 3-kinases (PI3K). Luciferase assays were emplyed to assess transcriptional activity of $ER{\alpha}$. Results: Emodin could inhibit E2-induced MCF-7 cell proliferation and anti-apoptosis effects, and arrest the cell cycle in G0/G1 phase, further blocking the effect of E2 on expression and transcriptional activity of $ER{\alpha}$. Moreover, Emodin influenced the ER ${\alpha}$ genomic pathway via downregulation of cyclin D1 and Bcl-2 protein expression, and influenced the non-genomic pathway via decreased PI3K/Akt protein expression. Conclusions: These findings indicate that emodin exerts inhibitory effects on MCF-7 cell proliferation via inhibiting both non-genomic and genomic pathways.

• Biomedical Science Letters
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• v.11 no.3
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• pp.319-326
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• 2005

It is well known that oxidative stress of reactive oxygen species (ROS) may be a causative factor in the pathenogenesis of bone disorder on osteoblast or osteoclast. The purpose of this study was to evaluate the cytotoxicity of oxidative stress, protective effect of glutamate receptor antagoinst against ROS-induced osteotoxicity, secretion of tumor necrosis factor $(TNF)-\alpha$ and the expression of c-fos gene in the cultured rat osteoblasts and osteoclasts. Cell viability by MTS assay or !NT assay, activity of glutathione peroxidase (GPx), lipid peroxidation (LPO) activity, protein synthesis by sulforhodamine B (SRB) assay, alkaline phosphatase (ALP) activity, lactate dehydrogenase (LDH) activity, MTS assay for NMDA (N-methyl-D-aspartate) receptor antagonist or AMPA/kainate receptor antagonist, measurement for $TNF-\alpha$, and c-fos gene expression were performed after these cells were treated with or without various cocentrations of xanthine oxidase (XO), hypoxanthine (HX), D-2-amino-5-phosphonovaleric acid (APV), 7-chlorokynurenic acid (CKA), 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and 6,7-dinitroquinoxaline-2,3-dione (DNQX), respectively. In this study, XO/HX showed decreased cell viability and glutathione peroxidase (GPx) activity, but it showed increased LPO activity, $TNF-\alpha$ secretion and c-fos expression. APV and CKA incresed protein sythesis and ALP activity. While, CNQX or DNQX did not show any protective effect in LDH activity or cell viability. From these results, XO/HX showed cytotoxic effect in cultured rat osteoblast or osteoclast, and also NMDA receptor antagonist such as APV or CKA was effective in blocking XO/HX-induced osteotoxicity in these cultures.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.3
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• pp.1077-1082
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• 2015

Recent studies have suggested that the RAS protein activator like-1 (RASAL1) functions as a tumor suppressor in vitro and may play an important role in the development of gastric cancer. However, whether or not RASAL1 suppresses tumor growth in vivo remains to be determined. In the present study, we investigated the role of RASAL1 in gastric carcinogenesis using an in vivo xenograft model. A lentiviral RASAL1 expression vector was constructed and utilized to transfect the human poorly differentiated gastric adenocarcinoma cell line, BGC-823. RASAL1 expression levels were verified by quantitative real-time RT-PCR and Western blotting analysis. Then, we established the nude mice xenograft model using BGC-823 cells either over-expressing RASAL1 or normal. After three weeks, the results showed that the over-expression of RASAL1 led to a significant reduction in both tumor volume and weight compared with the other two control groups. Furthermore, in xenograft tissues the increased expression of RASAL1 in BGC-823 cells caused decreased expression of p-ERK1/2, a downstream moleculein the RAS/RAF/MEK/ERK signal pathway. These findings demonstrated that the over-expression of RASAL1 could inhibit the growth of gastric cancer by inactivation of the RAS/RAF/MEK/ERK pathway in vivo. This study indicates that RASAL1 may attenuate gastric carcinogenesis.

• Journal of Astronomy and Space Sciences
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• v.29 no.4
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• pp.343-349
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• 2012

The solar proton telescope (SPT) is considered as one of the scientific instruments to be installed in instruments for the study of space storm (ISSS) which is determined for next generation small satellite-1 (NEXTSat-1). The SPT is the instrument that acquires the information on energetic particles, especially the energy and flux of proton, according to the solar activity in the space radiation environment. We performed the simulation to determine the specification of the SPT using geometry and tracking 4 (GEANT4). The simulation was performed in the range of 0.6-1,000 MeV considering that the proton, which is to be detected, corresponds to the high energy region according to the solar activity in the space radiation environment. By using aluminum as a blocking material and adjusting the energy detection range, we determined total 7 channels (0.6~5, 5~10, 10~20, 20~35, 35~52, 52~72, and >72 MeV) for the energy range of SPT. In the SPT, the proton energy was distinguished using linear energy transfer to compare with or discriminate from relativistic electron for the channels P1-P3 which are the range of less than 20 MeV, and above those channels, the energy was determined on the basis of whether silicon semiconductor detector (SSD) signal can pass or not. To determine the optimal channel, we performed the conceptual design of payload which uses the SSD. The designed SPT will improve the understanding on the capture and decline of solar energetic particles at the radiation belt by measuring the energetic proton.

• International Journal of Highway Engineering
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• v.14 no.3
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• pp.87-96
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• 2012

This research overcomes limit of prevention of disasters connection manual that was stopping in existing administrative formality presentation, and allowed purpose in substantial prevention of disasters countermeasure presentation through powerful engineering access. Did operation plan manual Tuesday in contiguity crossing that can reduce confusion by vehicleses that detour by contiguity IC of disaster point to do unusualness ashes in freeway section for this and solve jam-up phenomenon that occur by processing way insufficiency for roundabout way vehicles when happen. Metropolitan areas to target type classification in the highway along the highway adjacent to the intersection at Main Line Blocking optimum operating point analysis and an analysis of countermeasures in case of disaster, the lower the road entering the highway depending on the type of operating at the intersection were different. Depending on the results of analysis, while each point of a disaster, according to the characteristics of geometric conditions, traffic conditions, identify and determine the operating room and the adjacent intersection of media, and building systems to promote the driver if the quick initial response from the impending disaster situations and the safety of drivers can be considered secure.

• Journal of Plant Biotechnology
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• v.44 no.3
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• pp.229-234
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• 2017

Photoperiod is one of the factors affecting productivity of cucumber plant by inducing ethylene hormone production and so triggering flower sex differentiation into female flower. However, only few studies have been perfomed in order to reveal the effect of photoperiod in molecular level in relation to the flower differentiation. Therefore, in this study, Mercy cultivar of cucumber (andromonoecious) was treated with photoperiod of 8, 12, 16 hours of light, while control received no treatment of additional light. Photoperiod of 8 hours was achieved by blocking the sunlight with shade net and 16 hours by giving longer light exposure using white LEDs. Cucumber's flowers were quantified and the apical and lateral shoots were extracted to evaluate the gene profile related to the photoperiod, ethylene production, and female flower differentiation, which were CsACS2, CsETR1, CsCaN, and CsPIF4 using PCR method. Photoperiod of 8 hours affected the production of female flower with average number of 6.7 flowers in main stem and 8.0 flowers in lateral stem, compared to photoperiod of 12 and 16 hours which produced 3.7 and 2.0 flowers in main stem with 7.0 and 11.3 in lateral stem, respectively. In silico studies in this experiment resulted in proposed model of signal transduction that showed the connection between ethylene production and flower differentiation. PCR analysis confirmed the expression of CsACS2, CsETR1, and CsCaN, that was positively correlated with numbers of female flowers in cucumber, but the expression of CsPIF4 that represent photoperiod haven't been confirmed correlated with the ethylene production and flower differentiation.

• Natural Product Sciences
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• v.16 no.3
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• pp.153-158
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• 2010

To fine out the anti-inflammatory activities of the C. fragile. and its mechanism were investigated in macrophages induced by Peptidoglycan (PGN). Treatments of macrophages with 100 ug/ml of ethanol extract of Codium fragile (EECF) inhibited PGN-induced IL-6, NO and PGE2 production in a dose-dependent manner as well as expression of iNOS and COX-2. EECF inhibited PGN-induced extracellular signal-regulated kinase (ERK) 1/2, JNK 1/2 and p38 MAPK phosphorylation, which suggests that EECF inhibits IL-6 and NO secretion by blocking MAPKs phosphorylation. These findings may help elucidate the mechanism by which EECF modulates RAW 264.7 cell activation under inflammatory conditions.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.10C
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• pp.921-926
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• 2006

The Presence of a line-of-sight(LoS) blockage can degrade the UWB positioning accuracy for two reasons. Firstly, it makes estimation of the time of arrival(ToA) of the direct path signal difficult by complicating the multipath structure of the propagation channel. Secondly, the higher dielectric constant of the LoS blocking material than that of free space introduces excess propagation delay which will bias the range estimation. In this paper, methods based on ray tracing to reduce the ranging error resulting from the second reason are Posed. We take two different approaches; a statistical approach and a map-aided method. In the statistical approach, we establish a conditional distribution of the excess propagation delay caused by LoS blockages using a ray tracing technique. The lo6wer bound of the ranging performance based on this model is estimated. Ine ray tracing method is also used for the map-aided ToA positioning approach. UWB propagation measurement data taken in an office environment is used to examine the performance of this method.

• Journal of Korea Spatial Information System Society
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• v.10 no.1
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• pp.51-63
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• 2008

Previous studies for routing In USN (Ubiquitous Sensor Networks) appear to be unreliable due to the dependence on non-spatial data and the lack of map overlay analysis. Multiple spatial parameters and radio propagation modeling techniques were integrated to derive RSSI (Received Signal Strength Indicator) value between route nodes and produce a highly reliable path map. It was possible to identify area-wide patterns of USN route subject to many different Influences (e.g. the specific effects of radio blocking factors such as the visible area, road area, cell duplicated area, and building density), which cannot be acquired by traditional non-spatial modeling. The quantitative evidence concerning the USN route for individual cell as well as entire study area would be utilized as major tools to visualize paths in real-time and to select alternative path when failure or audition of route node occurs.