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Anti-inflammatory Activity of Codium fragile in Macrophages Induced by Peptidoglycan  

Han, Sin-Hee (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumsung)
Kim, Young-Guk (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumsung)
Lee, Su-Huan (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumsung)
Park, Chung-Berm (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA, Eumsung)
Han, Seung-Won (Urban Agriculture Research Division, National Institute of Horticultural & Herbal Science, RDA)
Jang, Hye-Jin (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Wonkwang Oriental Medicines Research Institute)
Lee, Hyo-Jeong (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Wonkwang Oriental Medicines Research Institute)
Park, Seong-Cheol (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Wonkwang Oriental Medicines Research Institute)
Kim, Hye-Sung (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Wonkwang Oriental Medicines Research Institute)
Lee, Young-Seob (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Wonkwang Oriental Medicines Research Institute)
Kwon, Dong-Yeul (Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Wonkwang Oriental Medicines Research Institute)
Publication Information
Natural Product Sciences / v.16, no.3, 2010 , pp. 153-158 More about this Journal
Abstract
To fine out the anti-inflammatory activities of the C. fragile. and its mechanism were investigated in macrophages induced by Peptidoglycan (PGN). Treatments of macrophages with 100 ug/ml of ethanol extract of Codium fragile (EECF) inhibited PGN-induced IL-6, NO and PGE2 production in a dose-dependent manner as well as expression of iNOS and COX-2. EECF inhibited PGN-induced extracellular signal-regulated kinase (ERK) 1/2, JNK 1/2 and p38 MAPK phosphorylation, which suggests that EECF inhibits IL-6 and NO secretion by blocking MAPKs phosphorylation. These findings may help elucidate the mechanism by which EECF modulates RAW 264.7 cell activation under inflammatory conditions.
Keywords
Ethanol extract of Codium fragile (EECF); anti-inflammatory activities;
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