• Asian-Australasian Journal of Animal Sciences
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• v.21 no.9
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• pp.1330-1338
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• 2008

This study was conducted to investigate the effects of Acanthopanax senticosus extract (ASE) as a dietary additive on gut microflora in weaned piglets. A total of sixty pigs were weaned at 21 d of age (BW = $5.64{\pm}0.23kg$) and allocated on the basis of BW and litter to three dietary treatments in a randomized complete block design. The dietary treatments were: control group (basal diet), antibiotics group (basal diet+0.02% colistin), and ASE group (basal diet+0.1% ASE). On d 7, 14 and 28 after consuming the experimental diets, five piglets per group were sacrificed and then the contents from the jejunum, ileum and cecum were collected to determine changes in the microbial community by using a polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) technique and estimating the contents of Lactobacillus and E. coli by in vitro culturing methods. The results showed that the ASE promoted the microflora diversity in the cecum. Enumeration of bacteria in the gut contents showed that the number of Lactobacillus increased (p<0.05), while that of E. coli decreased (p<0.05) when compared with the other 2 groups as the days of age progressed post-weaning. These findings suggested that the ASE, as a substitute for dietary antimicrobial products, could improve the development of the normal gut microflora and suppress bacterial pathogens, and effectively promote a healthy intestinal environment.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.3
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• pp.24-31
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• 2020

Centralized systems in computing environments have various problems, such as privacy infringement due to hacking, and the possibility of privacy violations in case of system failure. Blockchain, one of the core technologies for the next generation of converged information, is expected to be an alternative to the existing centralized system, which has had various problems. This paper proposes a blockchain-based user authentication system that can identify users using EID in an online environment. Existing identification (ID)/password (PW) authentication methods require users to store personal information in multiple sites, and receive and use their respective IDs. However, the proposed system can be used without users signing up at various sites after the issuing of an EID. The proposed system issues an EID with a minimum of information, such as an e-mail address and a telephone number. By comparing the stability and efficiency of a centralized system, the proposed integrated authentication system proved to be excellent. In order to compare stability against existing systems, we chose attack methods and encroachments on the computing environment. To verify efficiency, the total throughput between the user's app, the issuance and certification-authority's servers, and the service provider's servers was compared and analyzed based on processing time per transaction.

• Journal of Chest Surgery
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• v.32 no.9
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• pp.813-817
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• 1999

Background: Conventional thoracoscopic thoracic sympathectomy or sympathicotomy is an effective method in treating localized hyperhidrosis; however, this may result in a postoperatively embarrassing compensatory hyperhidrosis or facial anhidrosis in the treatment of palmar hyperhidrosis. We modified the conventional sympathicotomy by limiting the extent of nerve transection. The purpose of this study was to assess the result of the limited thoracoscopic sympathetic nerve transection in hyperhidrosis. Material and Method: From May to August 1998, 17 patients underwent limited transection of the sympathetic nerve. For 9 patients with facial hyperhidrosis, we transected only the interganglionic fiber between the first and the second ganglion, whereas the conventional method cuts two interganglionic fibers. Eight patients with palmar hyperhidrosis underwent limited transection of the interganglionic fiber between the second and third ganglion. Result: Sixteen patients had improved symptom postoperatively. There was a recurred facial sweating in 1 patient 1 month after the operation. Among the 9 facial hyperhidrosis patients, postoperative compensatory hyperhidrosis was severe in 4, moderate in 4 and minimal in 1. But in 8 cases of palmar hyperhidrosis compensatory hyperhidrosis was moderate in 3, and minimal in 1, none in 4. Facial sweating was not disturbed postoperatively in all of the palmar hyperhidrosis patients. Conclusion: Limited sympathetic nerve transection is a practical and less invasive method for the treatment of localized hyperhidrosis and may reduce the incidence of compensatory truncal hyperhidrosis and facial anhidrosis in case of palmar hyperhidrosis.

• Journal of the Korea Convergence Society
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• v.10 no.3
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• pp.49-57
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• 2019

The core technology development of the Fourth Industrial Revolution is linked to the development of other core technologies, which will change the industrial structure in the future and create a new smart business model. In this paper, tried to analyze the technology maturity level and analyze the technology maturity. To do this, used technology trend information to investigate and integrate the market, policy, etc. Of core technology of the 4th Industrial Revolution to achieve a comprehensive maturity level. Because technology maturity measures are scored by technology developers, prejudices may be acted upon according to a person's tendency, which may be a subjective evaluation. It is also a measure of the maturity of individual technologies, and thus is not suitable for evaluating the overall system integration perspective. However, it is possible to evaluate the maturity before integrating the core element technologies constituting the whole system and to use it as a means to compare the effect of the whole system and its feasibility and play an important role in the planning of technology development.

• Journal of Digital Convergence
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• v.17 no.6
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• pp.219-227
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• 2019

This study aims to examine Blockchain research trend using bibliometrics-based network analysis. The data were collected from WoS, Scopus, Korea Citation Index and National science & Technology Information Service, from 2009 to 2018. As results, the number of publications has started increasing rapidly from 2017 and it showed the initial stage of formation of coauthor network. Words often used in the title of the publications were related to application development, controversy and technology development. In addition, the majority of domestic papers are in the subject of social science, while international papers tend to focus on engineering issues. The results of the temporal analysis show that Korean researchers' block chain 3.0 started in 2017 and are rapidly increasing in 2018. The number of citations was associated with publication year in a statistically signifiant way. By examining these research trends, we hope that this paper can be a useful basis for the development of blockchain. Future research is expected to reveal more clearly the knowledge structure and characteristics of blockchain around the world.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.11
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• pp.287-294
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• 2018

This thesis covers legal aspects of the crypto-currency exchange and the legal rights of crypto-currencies holders. Unlike financial markets in which central authorities or intermediaries determine the validity of transactions and manage records, crypto-currency markets utilize a decentralization system based on block chain technology. Such distinct characteristics distinguish crypto-currency from currency, notes, or financial instruments. Therefore, we need to check closely the legal principles that are applicable to crypto-currency. Crypto-currency users possess rights indirectly through the crypto-currency exchange. However, we should look at whether crypto-currency can be an object of ownership. This research found that legal protection for crypto-currency exchanges are limited. Domestic laws have many shortcomings to protect users' rights. This study found that users who incurred damages due to internet computation errors at exchanges require a protective system like stock markets. Therefore, studies on the legal controls and system regulations are required to protect users' rights. Also, crypto-currency information exchanges keep inside and protections for users' private information need to be further examined.

• Journal of Science and Technology Studies
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• v.18 no.3
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• pp.217-255
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• 2018

Bitcoin, which appeared in 2008, was merely a conceptual virtual currency, but it now enjoys the status as actual money. Bitcoin is an electronic money system that can be traded directly without a central trust institution. Thanks to the popularization of Bitcoin, blockchain technology has become a widespread concern. That technology is expanding not only the currency mechanism, but also a variety of other services. The possibility of a blockchain in relation to actual currency is ongoing. This paper investigates the technological characteristics and social construction of the blockchain by comparing the cases of Bitcoin, Namecoin, and MediBloc among blockchain applications. Namecoin emerged in 2013 is an attempt to replace the centralized Internet Domain Name System(DNS). There has been controversy over that current system for a long time, but replacing the already established system is not easy. Nevertheless, Namecoin has potential as an alternative. Meanwhile, MediBloc is an application that involves distributed management of medical data in South Korea. MediBloc claims that the key producers of medical data are patients themselves. This is to challenge to the question who is a knowledge producer of medical data. Through these three cases, it has discussed that blockchain technology does supports to form more democratic decision-making or simply provide a technical solution as automation. As a citizen, we can intervene in the realization of blockchains by presenting social agenda. This will be a method of the social construction of technology.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.25 no.3
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• pp.346-354
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• 2021

Since 2015, Blockchain has experienced rapid development throughout the world, institutions including Central Banks, Government Departments, Commercial Banks, IT Giants are all accelerating their exploration on Blockchain, and investment on Blockchain related R&D departments and start-up companies also shows explosive growth. This paper studies the impact of blockchain technology on banks' conventional trade settlement methods and describes blockchain technology in term of its concepts, advantages, and disadvantages. It also studies the application processes of blockchain technology combined with conventional trade settlement methods (remittance, collection, and L/C), and analyzes the positive and negative impacts of blockchain technology on the conventional trade settlement methods. In addition, this paper lists the blockchain application cases, analyzes the technology development status and existing problems, and puts forward suggestions and measures for the development of blockchain finance in China based on the case analysis and impact research.

• Smart Media Journal
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• v.10 no.1
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• pp.88-98
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• 2021

As blockchain technology has emerged as a security issue for IoT, technology which integrates block chain into IoT is being studied. In this paper is a research concerning token-based IoT service access control technology for data sharing, which propose a possessor focused data sharing technic by using the permissioned blockchain. To share IoT health data, a Hyperledger Fabric Network consisting of three organizations was designed to provide a way to share data by applying different access control policies centered on device owners for different services. In the proposed system, the device owner issues access control tokens with different security levels applied to the participants in the organization, and the token issue information is shared through the distributed ledger of the HFN. In IoT, it is possible to lightweight the access control processing of IoT devices by granting tokens to service requesters who request access to data. Furthmore, by sharing token issuance information among network participants using HFN, the integrity of the token is guaranteed and all network participants can trust the token. The device owners can trust that their data is being used within their authorized rights, and control the collection and use of data.

• The Korean Journal of Physiology and Pharmacology
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• v.26 no.4
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• pp.239-253
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• 2022

Epithelial-mesenchymal transition (EMT) is known to be involved in airway remodeling and fibrosis of bronchial asthma. However, the molecular mechanisms leading to EMT have yet to be fully clarified. The current study was designed to reveal the potential mechanism of microRNA-21 (miR-21) and poly (ADP-ribose) polymerase-1 (PARP-1) affecting EMT through the PI3K/AKT signaling pathway. Human bronchial epithelial cells (16HBE cells) were transfected with miR-21 mimics/inhibitors and PARP-1 plasmid/small interfering RNA (siRNA). A dual luciferase reporter assay and biotin-labeled RNA pull-down experiments were conducted to verify the targeting relationship between miR-21 mimics and PARP-1. The migration ability of 16HBE cells was evaluated by Transwell assay. Quantitative real-time polymerase chain reaction and Western blotting experiments were applied to determine the expression of Snail, ZEB1, E-cadherin, N-cadherin, Vimentin, and PARP-1. The effects of the PI3K inhibitor LY294002 on the migration of 16HBE cells and EMT were investigated. Overexpression of miR-21 mimics induced migration and EMT of 16HBE cells, which was significantly inhibited by overexpression of PARP-1. Our findings showed that PARP-1 was a direct target of miR-21, and that miR-21 targeted PARP-1 to promote migration and EMT of 16HBE cells through the PI3K/AKT signaling pathway. Using LY294002 to block PI3K/AKT signaling pathway resulted in a significant reduction in the migration and EMT of 16HBE cells. These results suggest that miR-21 promotes EMT and migration of HBE cells by targeting PARP-1. Additionally, the PI3K/AKT signaling pathway might be involved in this mechanism, which could indicate its usefulness as a therapeutic target for asthma.