• Asian Pacific Journal of Cancer Prevention
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• 제15권12호
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• pp.4753-4758
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• 2014

In recent times, a number of studies have provided evidence that biotoxins present great potential as antitumor agents, such as snake venom, bee venom, some bacteria toxins and plant toxins, and thus could be used as chemotherapeutic agents against tumors. The biodiversity of venoms and toxins make them a unique source from which novel anticancer agent may be developed. Biotoxins, also known as natural toxins, include toxic substances produced by plants, animals and microorganisms. Here, we systematically list representative biological toxins that have antitumor properties, involving animal toxins, plant toxins, mycotoxins as well as bacterial toxins. In this review, we summarize the current knowledge involving biotoxins and the active compounds that have anti-cancer activity to induce cytotoxic, antitumor, immunomodulatory, and apoptotic effects in different tumor cells in vivo or in vitro. We also show insights into the molecular and functional evolution of biotoxins.

• 한국식품위생안전성학회지
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• 제36권6호
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• pp.455-473
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• 2021

이 총설에서는 해양 연체동물 내 독소 분석을 하는 연구자들의 이해를 돕기 위하여, 국내에서 생산되거나 유통되는 수산물 중 해양 생물독소에 오염될 수 있는 이매패류와 복족류 종들의 공식 명칭과 생태학적 특성을 소개하였다. 또한 대표적인 생물군의 해부도를 통한 각 기관들의 위치와 공식적인 명칭을 알리고자 하였다. 향후 해양생물독소 분석 관련 식품공전, 학술논문 및 보고서에 실험생물의 정확한 종명과 분석 기관의 명칭에 대한 통일 및 규격화가 필요하다.

• 한국식품위생안전성학회지
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• 제35권5호
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• pp.411-418
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• 2020

본 연구에서는 제외국 관리 해양생물독소인 YTXs의 원인조류, 독화생물, 국내·외 관리현황 및 분석법에 대해 리뷰하였다. 현재까지 YTXs에 의한 국내 수산물 오염이 보고된 사례는 없지만 기후변화로 인한 국내 연안 해역의 아열대화로 독성조류의 국내 유입 가능성이 있을 뿐 아니라 외국의 경우 YTXs에 의한 오염이 빈번하게 발생하고 있기 때문에 해당 국가로부터 수입되는 수산물의 경우 잠재적인 오염가능성이 있어 이에 대한 선제적 대응이 필요하다. YTXs는 와편모조류인 Protecratium reticulatum, Gonyaulax polygramma, Gonyaulax spinifera과 Lingulodinium polyedrum에 의해 생성되는 것으로 알려져 있으며, 이들은 국내 연안에도 출현한다. 현재 패류 내 YTXs는 메탄올 추출, SPE 카트리지 정제 후 LC-MS/MS를 이용하여 분석하고 있다. YTXs, pectenotoxins, azaspiracids와 같은 지용성 패독은 추출 및 정제 등의 전처리 과정이 유사하여 동시분석이 가능할 것으로 보이며, 이에 대한 분석법 최적화가 필요하다. 향후 국내 해역의 YTXs의 원인조류 출현 및 국내 유통(국내산 및 수입산) 수산물의 오염에 대한 지속적인 모니터링이 필요하다.

• 식품과학과 산업
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• 제42권2호
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• pp.2-19
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• 2009

• ALGAE
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• 제26권4호
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• pp.317-325
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• 2011

Five benthic species of the genus Gambierdiscus (Dinophyceae) were observed for the first time in the coastal waters of Pakistan, Northern Indian Ocean. The morphology of the epiphytic, ciguatera-related toxic species G. toxicus, G. belizeanus, G. polynesiensis, G. australes and G. cf. yasumotoi are presented here, described by the Kofoid system of thecal plates Po, 3', 7", 6c, 8s, 5"', 1p, 2"" with differences in cell shape, cell size, plates, pores around the apical pore plate by using light and scanning electron microscopy. The occurrence of these potentially toxic dinoflagellate species in Pakistani coastal areas of Manora Channel and Balochistan during high temperatures of 28-$32^{\circ}C$ is cause of concern for human health impacts from ciguatera fish poisoning.

• Journal of Microbiology and Biotechnology
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• 제13권1호
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• pp.50-56
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• 2003

A freshwater bloom-forming cyanobacterium, Microcystis aeruginosa, and local soil isolate Scytonema sp. strain BT 23 were demonstrated to contain biotoxic secondary metabolites with pesticidal and mosquito larvicidal activities. A purified toxic constituent from M aeruginosa showed an absorption maximum at 230 nm and its toxicity symptoms, Rf value on TLC, and retention time observed ill an HPLC analysis were similar to those of the hepatotoxic heptapeptide microcystin-LR. The bioactive constituent of the Scytonema sp. was less polar in nature and exhibited two peaks at 240 and 285 m. When applied to two cruciffrous pests, Pieris brassicae and Plutella flostella, the crude extracts and toxic principles from the two cyanobacteria showed significant antifeedant activity in a no-choice bioassay, and at higher concenuations exhibited contact toxicity to the insect larvae. The purified toxin from M. aeruginosa was found to be more effective and produced 97.5 and $92.8\%$ larval mortality in the two pests, fo11owing 2 h of toxin treatment at a concentration of $25{\mu}g$ Per leaf disc (2.5 cm dia.). Meanwhile, similar treatment with the purified toxin from Sytonema sp. stain BT 23 only produced 73 and $78\%$ mortality in the two pests. The cyanobacterial constituents also showed significant activity against Culex and Anopheles larvae. The M. aeruginosa toxin ($20{\mu}g\;ml^-1$) caused 98.2 and $88.1\%$ mortality in the Culex and Anopheles larvae, respectively, while the purified toxin from the Sytonema sp. was less toxic and only produced a 96.3 and $91.2\%$ mortality, respectively, at a much higher concentration ($40{\mu}g\;ml^-1$). Accordingly, the current results point to certain hitherto unknown biological properties of cyanobacterial biotoxins.