• Journal of Biomedical Engineering Research
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• v.27 no.6
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• pp.343-350
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• 2006

Medical magnetic stimulator generates strong magnetic field pulses. Clinical applications of the magnetic pulse are the stimulation of nervous system and the contraction of muscle. The unique source of the strong magnetic pulse is a capacitor-inductor resonator and this inductor generates a strong sinusoidal magnetic pulse by discharging the capacitor with high initial voltage. Continuous muscle contraction needs sequential generation of the magnetic pulses. However, to keep the magnitude of sequential pulses identical, an expensive high-voltage power supply have to support voltage drop of the capacitor between the pulses. A protection circuit between the supply and the resonator is necessary to protect the supply from reverse current caused by capacitor voltage reversal. In this paper, a new circuit structure of the magnetic stimulator adopting a low-frequency fly-back switching is proposed. The new circuit supports sequential pulse generation and allows the reverse current without damage. Performance of the new circuit is examined and a low-cost magnetic stimulator for urinary incontinence therapy is being developed using the presented method.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.7
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• pp.1252-1256
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• 2016

Internet of Things(IoT)-devices are now expanding inter-connecting networking technologies to invent healthcare monitoring system especially for assessing physiological conditions of the chronically-ill patients those with cardiovascular diseases. Hence, IoT system is expected to be utilized for home healthcare by dedicating the original usage of IoT devices to collect the biomedical data such as electrocardiogram(ECG) and photoplethysmography(PPG) signal. The aim of this work is to implement health monitoring system by integrating IoT devices with Raspberry-pi components to measure and analyze ECG and the multi-channel PPG signals. The acquired data and fiducial features from our system can be transmitted to mobile devices via wireless networking technology to support the concept of tele-monitoring services based on IoT devices.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2001.10a
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• pp.1-9
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• 2001

scale genomic and postgenomic data means that many of the challenges in biomedical research are now challenges in computational sciences and information technology. The informatics revolutions both in clinical informatics and bioinformatics will change the current paradigm of biomedical sciences and practice of clinical medicine, including diagnostics, therapeutics, and prognostics. Postgenome informatics, powered by high throughput technologies and genomic-scale databases, is likely to transform our biomedical understanding forever much the same way that biochemistry did a generation ago. In this talk, 1 will describe how these technologies will in pact biomedical research and clinical care, emphasizing recent advances in biochip-based functional genomics. Basic data preprocessing with normalization and filtering, primary pattern analysis, and machine teaming algorithms will be presented. Issues of integrated biochip informatics technologies including multivariate data projection, gene-metabolic pathway mapping, automated biomolecular annotation, text mining of factual and literature databases, and integrated management of biomolecular databases will be discussed. Each step will be given with real examples from ongoing research activities in the context of clinical relevance. Issues of linking molecular genotype and clinical phenotype information will be discussed.

• Journal of Biomedical Engineering Research
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• v.29 no.5
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• pp.364-370
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• 2008

Recent development in large area flat-panel x-ray detector technology enables clinical application of digital tomosyntesis. Unlike conventional motion tomography using x-ray films, flat-panel x-ray detectors provide projection images in digital formats so that tomographic images can be synthesized in a more flexible way. For the digital tomosynthesis, precise movements of the x-ray source and the x-ray detector with respect to a fulcrum point are necessary. In this study, we apply the digital tomosynthesis technique to the flat-panel detector based micro-CT in which the flat-panel detector and the x-ray source rotate together on a circular arc. The experimental results suggest that flat-panel detector based 3D CTs can be used for digital tomosynthesis in the clinical environment.

• Journal of Engineering Education Research
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• v.23 no.1
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• pp.59-64
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• 2020

The purpose of this study is to develop capstone design model of gender analysis methods suitable for engineering education field and examine improvements and effects by applying it to actual lessons for biomedical engineering students. Case study was performed to achieve the purpose of the study. Twelve gender analysis methods were applied to 'biomedical engineering capstone design' which was major course offered by department of biomedical engineering at J university. After the students understood how to analyze gender analysis methods and cases, they decided project topics and presented what gender analysis methods were applied for each project. Additionally, the results of analysis showed that the students were more able to understand the differences between men and women of all ages and try to narrow down the differences. They also found that they could contribute to development of new added value of knowledge and technology that reflected the needs of both men and women by applying gender analysis methods in system development.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.57-60
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• 1996

A medical image management system was implemented using WWW(world wide web) technology. The Httpd server was designed using PC with Linux operating system. The client used Netscape as its network browser. The image processing module of the client part was programmed in Java. The database was constructed with Bicom3 format images and programmed using Perl. The present technique can be used to standardize the network and user environment of PACS and teleradiology.

• Journal of Sensor Science and Technology
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• v.21 no.3
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• pp.223-228
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• 2012

In this study, a fiber-optic pH sensor based on a pH sol-gel film is fabricated. The sol-gel film is made by co-polymerizing tetramethoxysilane, trimethoxymethylsilane, ethanol and distilled water. As a pH indicator, a neutral red is immobilized in a thin porous film formed by the sol-gel process. The pH change in a sensing probe gives rise to a change in the color of the pH sol-gel film, and the absorbance of reflected light through the pH sol-gel film is also changed. By using a spectrometer, therefore, the spectra of reflected lights in the sensing probe with different pH values are measured. Also, the relationships between the pH values and the absorbance are analyzed on the basis of the color variations of the pH sol-gel films. In repeated experiments, the fiber-optic pH sensor shows that it has reversibility, a high reproducibility and a wide absorbance change in a pH range from pH 5 to 9. Also, we confirmed that the fabricated pH sol-gel film exhibits a fast response time, little or no pH indicator leaching and a dynamic range of 2.04 dB from pH 5 to 9. Based on the results of this study, a fiber-optic pH sensor can be developed for the pH monitoring in the harsh environments.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.35 no.2
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• pp.150-150
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• 2024

• Food Science and Biotechnology
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• v.17 no.2
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• pp.367-372
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• 2008

Cellular protection against carcinogens could be achieved by the induction of phase 2 detoxifying and antioxidant enzymes such as glutathione S-transferase (GST), NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO1). Nuclear transcription factor E2-related factor 2 (Nrf2) binds to antioxidant response element (ARE) in the promoter region of these genes and the resulting transactivation occurs. In the present study the effect of gujeolcho (Chrysanthemum zawadskii) roots on the Nrf2-ARE pathway were investigated. C. zawadskii root extract was fractionated with a series of organic solvents and their ability to induce Nrf2-ARE pathway was examined. We separated the most potent dichloromethane (DCM) fraction into 12 sub-fractions and found several sub-fractions with strong effects on the Nrf2-ARE pathway. Fraction 4 strongly induced the ARE-reporter gene activity as well as Nrf2 expression. Sitosterol was isolated as a major compound in fraction 4 although its activity was not as potent as its mother fraction. These results indicate that C. zawadskii roots might be used as a potential natural chemopreventive source.

• Progress in Medical Physics
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• v.28 no.3
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• pp.77-82
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• 2017

We proposed the objective ROC analysis method based on the setting of threshold value for evaluation of single photon emission computed tomography (SPECT) image. This proposed ROC analysis method uses the quantification computational threshold value to each signal on the SPECT image. The SPECT images for this study were acquired by using Monte Carlo n-particle extended simulation code (MCNPX, Ver. 2.6.0, Los Alamos National Laboratory, USA). The basic SPECT detectors and specific water phantom were realized in the simulation, and we could get the simulation results by the simulation operation. We tried to analyze the reconstructed images using threshold value application based objective ROC method. We can get the accuracy information of reconstructed region in the image. This proposed ROC technique can be helpful when we have to evaluate the weak signal for the NM image. In this study, the proposed threshold value based computational ROC analysis method can provide better objectivity than the conventional ROC analysis method.