• 대한의용생체공학회:의공학회지
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• 제41권5호
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• pp.173-178
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• 2020

Remote control intervention surgery robotic system improves treatment effect on cardiovascular patients and reduces X-ray exposure. However, at the time of the first procedure, CT (computerized tomography) and other ultrasound diagnostic equipment should be used because the operator must insert the cannula directly into the patient's leg. Improvements to this have been un-met-needs of hospitals. In this paper, we developed a system that can insert the cannula intuitively and quickly by displaying blood vessels at a glance through the system using smart wearable glasses. The core development method is as follows. In order to project augmented reality onto the surgical image, CT scan angiography image is extracted and processed. In the process, three CT-Markers are used to create a coordinate system of blood vessel images. Additionally, a reference marker is photographed on a single camera to obtain a camera coordinate system. Since the CT marker and the reference marker are in the same position, 3D registration is performed. In the text, a detailed explanation will be given.

• 대한의용생체공학회:의공학회지
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• 제41권1호
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• pp.42-47
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• 2020

A personal authentication system based on biosignals has received increasing attention due to its relatively high security as compared to traditional authentication systems based on a key and password. Electrocardiography (ECG) measured from the chest or wrist is one of the widely used biosignals to develop a personal authentication system. In this study, we investigated the feasibility of using similar ECG measured behind the ears to develop a personal authentication system. To this end, similar ECGs were measured from thirty subjects using a pair of three electrodes attached behind each of the ears during resting state during which the standard Lead-I ECG was also simultaneously measured from both wrists as baseline ECG. The three ECG components, Q, R, and S, were extracted for each subject as classification features, and authentication accuracy was estimated using support vector machine (SVM) based on a 5×5-fold cross-validation. The mean authentication accuracies of Lead I-ECG and similar ECG were 90.41 ± 8.26% and 81.15 ± 7.54%, respectively. Considering a chance level of 3.33% (=1/30), the mean authentication performance of similar ECG could demonstrate the feasibility of using similar ECG measured behind the ears on the development of a personal authentication system.

• 대한의용생체공학회:의공학회지
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• 제26권6호
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• pp.357-363
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• 2005

Active contour models have been extensively used to segment, match, and track objects of interest in computer vision and image processing applications, particularly to locate object boundaries. With conventional methods an object boundary can be extracted by controlling the internal energy and external energy based on energy minimization. However, this still leaves a number of problems, such as initialization and poor convergence in concave regions. In particular, a contour is unable to enter a concave region based on the stretching and bending characteristic of the internal energy. Therefore, this study proposes a method that controls the internal energy by moving the local perpendicular bisector point of each control point on the contour, and determines the object boundary by minimizing the energy relative to the external energy. Convergence at a concave region can then be effectively implemented as regards the feature of interest using the internal energy, plus several objects can be detected using a multi-detection method based on the initial contour. The proposed method is compared with other conventional methods through objective validation and subjective consideration. As a result, it is anticipated that the proposed method can be efficiently applied to the detection of the pulmonary parenchyma region in medical images.

• 문화기술의 융합
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• 제10권2호
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• pp.35-42
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• 2024

의공학은 의학 및 생물학적 이해를 바탕으로 공학적 기술을 이용하여 인체 질병을 진단하고 치료하는 학문이다. 올바른 의공학 교육을 위해서는 교육과정에 의학용어, 인체해부학, 인체 생리학 등의 교육이 필요하지만 학생들은 이들 의학 기초 과목들을 암기 과목이라는 선입견을 가지고 있다. 이러한 학생들의 선입견을 해소시키기 위해서는 다양한 교육방법을 개발하여 학생들이 기초의학 과목들에 쉽게 접근할 수 있도록 해야 한다. 본 논문에서는 의학용어 과목에 인체 반신 해부 모형의 관찰 실습을 도입하여 학습 효과를 높이는 방법을 제시한다. 인체 반신 모형은 여러가지 장기가 조립되어 있는 형태이며 하나씩 분해하면서 관찰할 수 있다. 본 관찰 실습은 머리, 목, 가슴, 복부 부위의 장기들에 대한 질문으로 구성하여 학생들이 조별로 답을 찾아가도록 구성하였다. 학생들은 실습 후 이 실습이 학습동기를 유발하고 강의의 이해를 쉽게 해 주었다고 평가하였다.

• Journal of Microbiology and Biotechnology
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• 제23권2호
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• pp.274-277
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• 2013

The unique properties of graphene have earned much interest in the fields of materials science and condensedmatter physics in recent years. However, the biological applications of graphene remain largely unexplored. In this study, we investigate the cell culture conditions, which are exposed to graphene onto glass and $SiO_2$/Si using human nerve cell line, SH-SY5Y. Cell viability was 84% when cultured on glass and $SiO_2$/Si coated with graphene as compared to culturing on polystyrene surface. Fluorescence data showed that the presence of graphene did not influence cell morphology. These findings suggest that graphene may be used for biological applications.

• BMB Reports
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• 제51권9호
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• pp.462-467
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• 2018

A previous study of ours indicated that Drosophila flightless-1 controls lipid metabolism, and that there is an accumulation of triglycerides in flightless-1 (fliI)-mutant flies, where this mutation triggers metabolic stress and an obesity phenotype. Here, with the aim of characterizing the function of FliI in metabolism, we analyzed the levels of gene expression and metabolites in fliI-mutant flies. The levels of enzymes related to glycolysis, lipogenesis, and the pentose phosphate pathway increased in fliI mutants; this result is consistent with the levels of metabolites corresponding to a metabolic pathway. Moreover, high-throughput RNA sequencing revealed that Drosophila FliI regulates the expression of genes related to biological processes such as chromosome organization, carbohydrate metabolism, and immune reactions. These results showed that Drosophila FliI regulates the expression of metabolic genes, and that dysregulation of the transcription controlled by FliI gives rise to metabolic stress and problems in the development and physiology of Drosophila.

• International journal of advanced smart convergence
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• 제6권4호
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• pp.19-25
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• 2017

After 40 years of age, the saliva glands are aged and the saliva is not made enough to cause xerostomia symptoms. Side effects such as hypertension medication or diuretics that the elderly take mainly can cause xerostomia syndrome. In addition, autoimmune diseases, diabetes, anemia, depression and other common diseases that cause xerostomia symptoms. If the saliva secretion is insufficient, tooth decay and gum disease are likely to occur, and the digestive ability of the saliva is also reduced due to the lack of amylase, which is a digestive element. Once the degenerated salivary gland is restored to its normal state, it is difficult to recover. In this paper, we give electrical stimulation to the masseter which is in contact with the large pituitary gland, and stimulate the salivary gland to the utmost by using speech recognition using words corresponding to oral gymnastics. Use the STM32F407VG to implement a system to relieve xerostomia.

• International journal of advanced smart convergence
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• 제5권4호
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• pp.10-14
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• 2016

Among the methods of treating tinnitus, the transcutaneous clectrical nerve stimulation (TENS) method of treating by electrical stimulation is common. However, there is a problem that surgical operation is required to stimulate the vagus nerve (VN) main trunk near most of the bronchus. Alternatively, we found that the same effect could be achieved by electrically stimulating the vagus nerve VN branch (Arnold's nerve) distributed in the outer ear. The TENS system for stimulation of vagus nerve has been developed, but it has not been able to implement to stimulate as a parameter optimized for the patient by simultaneously playing the sound of eliminating the tinnitus frequency. Therefore, in this paper, it is important to develop a safe and practical TENS device for tinnitus treatment based on a 32-bit microprocessor that simultaneously applies non-invasive and notched sounds and to develop optimal treatment methods for treating tinnitus.

• 한국건설순환자원학회논문집
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• 제7권4호
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• pp.323-332
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• 2019

건설 방수재로 사용되는 고무아스팔트 씰재에 대한 한국 및 중국의 공동 품질관리 규정 제정을 위해 양국의 재료 및 품질기준 현황을 조사하고, 향후 방향을 제시한 연구다. 고무아스팔트 씰재에 대한 한중 무역교류가 추진되고 있 있으나, 국가 간에 제시된 품질기준이 달라 제품에 대한 품질 검증의 어려움이 있고, 이를 해소하기 위해 양국의 현황을 파악하여 공동 품질관리 규정 제정의 필요성을 제시하였다 .한국과 중국의 고무아스팔트 씰재에 대한 구성 재료 비교, 품질관리 기준(성능평가 항목)의 비교 결과, 구성 재료에 있어서 방수 성능을 발현하는 주성분 원료인 "아스팔트와 고무"의 사용 비율에 차이가 있고, 부원료(충전제, 증점제, 접착제 등)의 사용 소재 종류도 다르게 나타났으며, 성능평가 항목에 있어서도 양국의 요구 성능 항목이 크게 다르다는 것을 파악되었다. 이러한 문제을 해소하기 위하여 일반적으로 ISO(국제표준기구 : International Organization for Standardization)에서 제시한 표준 기준을 활용하는 등의 대안이 있으나 고무 아스팔트 씰재에 대한 방수재 ISO 표준은 전무하며, 한중간 무역 교류를 위하여 ISO 규격을 제정하기에는 소모되는 시간이나 비용에 따른 경제적 여건이 불합리한 상황이다. 이에 본 연구에서는 한중 양국 간에 공동으로 적용할 수 있는 품질규격을 제정하여 상호 무역 교류 시 이를 적용함으로써 제품에 대한 물성파악이 용이한 국제공동규격 제정을 위한 성능평가 요소로써 주요 성능 항목으로 "화학저항성능, 투수저항성능, 온도안정성능, 습윤면 부착성능"을, 부가 성능 항목으로 "균열 거동 대응성능", "점도", "고형분" 등 7가지 항목을 제시하였다.

• 대한의용생체공학회:의공학회지
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• 제38권4호
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• pp.211-217
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• 2017

During the emergency situation such as cardiac arrest, cardiopulmonary resuscitation(CPR) is the most important treatment to maintain patient's blood circulation. Since the quality of CPR can not be easily measured or evaluated by the eye, an assistive device with an accelerometer can help to assess the pressure depth of CPR. In this study, we propose a single frequency analysis method to reduce the error of the accelerometer by extracting only one frequency component from the Fourier transform process. To verify the effectiveness of the single frequency analysis, acceleration data at CPR conditions were measured at a sampling rate of 50 / sec using a wristband equipped with an acceleration sensor. Then, We compared the existing distance estimation method and the single frequency analysis method using the measured data. The amplitude value proportional to the compression depth was obtained by applying the single frequency analysis method.