• Journal of Biomedical Engineering Research
• /
• v.32 no.2
• /
• pp.144-150
• /
• 2011

The primary purpose of this study was to analyze the motion of the scaphoid, capitate, and lunate during dart-throwing motion by three-dimensional modeling. Five series of CT images of five normal right wrists were acquired from five motion steps from radial extension to ulnar flexion in the dart-throwing motion plane. Segmentation and three-dimensional modeling of bones from CT images was performed using Analyze. Distances among centroids of the scaphoid, capitate and lunate and angles between principal axes of three carpal bones were calculated to analyze the motion by using MATLAB. As the wrist motion changed from radial extension to ulnar flexion, the distance between two adjacent bones decreased. The scaphoid and lunate rotated less than the capitates during dart-throwing motion. This study reports the Three-dimensional in vivo measurement of carpal motion using CT images.

• Journal of Biomedical Engineering Research
• /
• v.43 no.4
• /
• pp.271-279
• /
• 2022

Functional cosmetics containing various ingredients that improve skin health are currently being developed. In addition, technologies that help increase the absorption rate of such cosmetics have recently gained significant attention. Sonophoresis is a method to increase the transdermal absorption of cosmetics using ultrasound. A skin-mimicking phantom was fabricated using polydimethylsiloxane, Strat-M^TM membrane, and thermochromic pigments. Gel-type cosmetics used in skin mask packs and epidermal-growth-factor-based nano-cosmetics were tested for their absorption rates at ultrasound frequencies of 1, 3, and 10 MHz in the single frequency mode, and 1/3 and 3/10 MHz in the dual frequency mode. The gel-type cosmetics and epidermal-grow-factor-based nano-cosmetics showed the highest absorption rate at 3/10MHz dual frequency. The size of the cosmetic particles decreased by 5-9 %. Furthermore, the temperature rise caused by ultrasound could be visually recognized by the thermochromic pigment in the phantom turning white. We presented a skin-mimicking phantom. The device can be customized according to the size of the ultrasound probe and has the advantage of quantitatively evaluating the transdermal permeability of cosmetics at a low cost. The development of the skin-mimicking phantom will be useful for determining the suitable conditions required to increase the absorption rate of cosmetics using ultrasound.

• Korean Journal of Radiology
• /
• v.22 no.12
• /
• pp.2073-2081
• /
• 2021

Deep learning-based applications have great potential to enhance the quality of medical services. The power of deep learning depends on open databases and innovation. Radiologists can act as important mediators between deep learning and medicine by simultaneously playing pioneering and gatekeeping roles. The application of deep learning technology in medicine is sometimes restricted by ethical or legal issues, including patient privacy and confidentiality, data ownership, and limitations in patient agreement. In this paper, we present an open platform, MI2RLNet, for sharing source code and various pre-trained weights for models to use in downstream tasks, including education, application, and transfer learning, to encourage deep learning research in radiology. In addition, we describe how to use this open platform in the GitHub environment. Our source code and models may contribute to further deep learning research in radiology, which may facilitate applications in medicine and healthcare, especially in medical imaging, in the near future. All code is available at https://github.com/mi2rl/MI2RLNet.

• Journal of Biomedical Engineering Research
• /
• v.36 no.1
• /
• pp.16-21
• /
• 2015

Indocyanine green(ICG) and 5-aminolevulinic acid(5-ALA) have been widely used to mark blood vessels or tumors. However, fluorescent dye detection systems were designed to use one type of dyes only. In this study, we proposed a detection system capable of detecting Indocyanine green and 5-aminolevulinic acid. Multiple filters and light sources are integrated into a single system. In this study, we performed analysis of fluorescent dyes and configured a detection system. During the analysis, it was found that Indocyanine green and 5-aminolevulinic acid have the maximum intensity at $40{\mu}M$. We designed light source for fluorescent dyes and conducted compatibility test using a commercial surgical microscope. The fluorescent dye detection system was configured based on the experimental results. The developed system successfully detects Indocyanine green and 5-aminolevulinic acid. Therefore, more efficient surgical operations can be achieved using both fluorescent dyes at the same time. We expect that the developed system can increase the survival rate of patients.

• Journal of Biomedical Engineering Research
• /
• v.34 no.2
• /
• pp.55-62
• /
• 2013

Wrist joints consist of irregularly shaped carpal bones and other complicated structures. Thus, evaluating the motion of a wrist joint is a challenging task. In this study, we used an infrared camera to perform a kinematic analysis of a dart-throwing motion. We measured the difference between the movement of a normal wrist and constrained wrist (wrist with a wrist glove) in the dart-throwing motion with thirty six healthy participants. We measured the ulna flexion - radial extension motion using the attached passive marker and analyzed it using Polygon software and SPSS. The pitch and yaw motions with a glove was bigger than the ones without a glove by 20 and 15 degrees, respectively. On the other hand, the roll motion without a glove was bigger than the one with a glove by 7 degree. Wilcoxon signed rank test (p<0.05) confirmed that there are significant differences between the motion with and without a glove. It was found that the magnitude of the pitch and yaw motion with a constrained wrist joint toward radial extension in dart-throwing motion is smaller than the one with a normal wrist joint. However, a normal wrist joint showed a bigger movement in the roll direction.

• Proceedings of the Korean Magnestics Society Conference
• /
• 2012.05a
• /
• pp.23-25
• /
• 2012

• Journal of Biomedical Engineering Research
• /
• v.44 no.3
• /
• pp.218-224
• /
• 2023

This study aimed to analyze the coordination of muscle and muscle fatigue between biceps, lateral deltoid, and anterior deltoid during dumbbell side lateral raise using bio-signal. One male subject performed dumbbell side lateral raise with 3% of 1RM dumbbell at the rate of 30bpm until failure (8 minutes). While performing, ECG were recorded to observe the participant's performance. EMG were recorded from biceps, lateral deltoid, and anterior deltoid for observing coordination and fatigue. ECG were analyzed in time and frequency domain to observe Heart rate, normLF, normHF. Changes in heart rate, normLF, and normHF indicate that the sympathetic nervous system is activated, while changes in median frequency (MDF) indicate the occurrence of muscle fatigue. Moreover, the coordination relationship of muscle changed. The correlation of MDF between each muscles indicated that lateral deltoid is associated with biceps and anterior deltoid. These results showed that our study can contribute to improving understanding of muscle fatigue and muscle coordination relationships.

• Current Optics and Photonics
• /
• v.7 no.5
• /
• pp.569-573
• /
• 2023

We utilized terahertz time-domain spectroscopy (THz-TDS) to measure the thickness and electrical properties of nickel-chromium (Ni-Cr) films. This technique not only aligns well with traditional methods, such as haze-meter and transmission-densitometer measurements, but it also reveals the electrical properties and thickness of films down to a few tens of nanometers. The complex conductivity of the Ni-Cr thin films was extracted using the Tinkham formula. The experimental values closely aligned with the Drude model, indicating the reliability of our Ni-Cr film's electrical and optical constants. The thickness of Ni-Cr was estimated using the complex conductivity. These findings emphasize the potential of THz-TDS in quality control of metallic nanofilms, pointing toward an efficient and nondestructive test (NDT) for such analyses.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2020.11a
• /
• pp.854-857
• /
• 2020

최근 사람형(Anthropomorphic)로봇손의 사물조작 지능을 개발하기 위하여 행동복제(Behavior Cloning) Deep Reinforcement Learning(DRL) 연구가 진행중이다. 자유도(Degree of Freedom, DOF)가 높은 사람형 로봇손의 학습 문제점을 개선하기 위하여, 행동 복제를 통한 Human Demonstration Augmented(DA)강화 학습을 통하여 사람처럼 사물을 조작하는 지능을 학습시킬 수 있다. 그러나 사물 조작에 있어, 의미 있는 파지를 위해서는 사물의 특정 부위를 인식하고 파지하는 방법이 필수적이다. 본 연구에서는 딥러닝 YOLO기술을 적용하여 사물의 특정 부위를 인식하고, DA-DRL을 적용하여, 사물의 특정 부분을 파지하는 딥러닝 학습 기술을 제안하고, 2 종 사물(망치 및 칼)의 손잡이 부분을 인식하고 파지하여 검증한다. 본 연구에서 제안하는 학습방법은 사람과 상호작용하거나 도구를 용도에 맞게 사용해야하는 분야에서 유용할 것이다.

• BMB Reports
• /
• v.55 no.3
• /
• pp.148-153
• /
• 2022

Etoposide is a chemotherapeutic medication used to treat various types of cancer, including breast cancer. It is established that pulsed electromagnetic field (PEMF) therapy can enhance the effects of anti-cancer chemotherapeutic agents. In this study, we investigated whether PEMFs influence the anti-cancer effects of etoposide in MCF-7 cells and determined the signal pathways affected by PEMFs. We observed that co-treatment with etoposide and PEMFs led to a decrease in viable cells compared with cells solely treated with etoposide. PEMFs elevated the etoposide-induced PARP cleavage and caspase-7/9 activation and enhanced the etoposide-induced down-regulation of survivin and up-regulation of Bax. PEMF also increased the etoposide-induced activation of DNA damage-related molecules. In addition, the reactive oxygen species (ROS) level was slightly elevated during etoposide treatment and significantly increased during co-treatment with etoposide and PEMF. Moreover, treatment with ROS scavenger restored the PEMF-induced decrease in cell viability in etoposide-treated MCF-7 cells. These results combined indicate that PEMFs enhance etoposide-induced cell death by increasing ROS induction-DNA damage-caspase-dependent apoptosis.