Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
권호 표지
DOI QR코드

DOI QR Code

Skin-Mimicking Phantom for Measurment of Cosmetic Transdermal Absorption and Temperature Changes by Sonophoresis

  • Kim, Gahee (Department of Biomedical Engineering, College of Software and Digital Healthcare Convergence, Yonsei University) ;
  • Jang, Hwijin (Department of Biomedical Engineering, College of Software and Digital Healthcare Convergence, Yonsei University) ;
  • Choi, Seonmin (Department of Biomedical Engineering, College of Software and Digital Healthcare Convergence, Yonsei University) ;
  • Park, Sanghyo (Department of Biomedical Engineering, College of Software and Digital Healthcare Convergence, Yonsei University) ;
  • Kim, Woo Cheol (Department of Biomedical Engineering, College of Software and Digital Healthcare Convergence, Yonsei University) ;
  • Key, Jaehong (Department of Biomedical Engineering, College of Software and Digital Healthcare Convergence, Yonsei University)
  • Received : 2022.08.08
  • Accepted : 2022.08.23
  • Published : 2022.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

Functional cosmetics containing various ingredients that improve skin health are currently being developed. In addition, technologies that help increase the absorption rate of such cosmetics have recently gained significant attention. Sonophoresis is a method to increase the transdermal absorption of cosmetics using ultrasound. A skin-mimicking phantom was fabricated using polydimethylsiloxane, Strat-MTM membrane, and thermochromic pigments. Gel-type cosmetics used in skin mask packs and epidermal-growth-factor-based nano-cosmetics were tested for their absorption rates at ultrasound frequencies of 1, 3, and 10 MHz in the single frequency mode, and 1/3 and 3/10 MHz in the dual frequency mode. The gel-type cosmetics and epidermal-grow-factor-based nano-cosmetics showed the highest absorption rate at 3/10MHz dual frequency. The size of the cosmetic particles decreased by 5-9 %. Furthermore, the temperature rise caused by ultrasound could be visually recognized by the thermochromic pigment in the phantom turning white. We presented a skin-mimicking phantom. The device can be customized according to the size of the ultrasound probe and has the advantage of quantitatively evaluating the transdermal permeability of cosmetics at a low cost. The development of the skin-mimicking phantom will be useful for determining the suitable conditions required to increase the absorption rate of cosmetics using ultrasound.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (grant no. 2022RIS-005, and 2022R1F1A1069516).

References

  1. Jang, Min Ah, and Jung Min Lee. Research on domestic and international industrial trends of functional cosmetics. Journal of the Korean Applied Science and Technology. 2021;38.2:618-627. https://doi.org/10.12925/JKOCS.2021.38.2.618
  2. Kim B, Cho HE, Moon SH, Ahn HJ, Bae S, Cho HD, An S. Transdermal delivery systems in cosmetics. Biomedical Dermatology. 2020;4(1):1-12. https://doi.org/10.1186/s41702-019-0053-z
  3. Naik, Aarti, Yogeshvar N. Kalia, and Richard H. Guy. Transdermal drug delivery: overcoming the skin's barrier function. Pharmaceutical science & technology today. 2000;3.9:318-326. https://doi.org/10.1016/S1461-5347(00)00295-9
  4. Kim, Eun-Ju, Hyun-Ki Jung, and Sung-Jun Kim. Technology for Skin Rejuvenation and Homeostasis by Fermented Product with Micro-needle Therapy System. KSBB Journal. 2010;25.2:116-122.
  5. Mitragotri, Samir, Daniel Blankschtein, Robert Langer. Transdermal drug delivery using low-frequency sonophoresis. Pharmaceutical research. 1996;13:411-420. https://doi.org/10.1023/A:1016096626810
  6. TANG Hua, MITRAGOTRI Samir, BLANKSCHTEIN Daniel, LANGER Robert. Theoretical description of transdermal transport of hydrophilic permeants: Application to low-frequency sonophoresis. Journal of pharmaceutical sciences. 2001;90.5:545-568. https://doi.org/10.1002/1520-6017(200105)90:5<545::AID-JPS1012>3.0.CO;2-H
  7. Lee SJ, Lee SH, Park SI. A study on skin permeability enhancement of active substances in cosmetics using nanobubble technique. Journal of the Korean Applied Science and Technology. 2020;37:1041-1051. https://doi.org/10.12925/JKOCS.2020.37.4.1041
  8. Park DH, Park HJ, Seo JB, Lee SH. Sonophoresis in transdermal drug deliverys. Ultrasonics 2014;54:56-65. https://doi.org/10.1016/j.ultras.2013.07.007
  9. Byl Nancy N. The use of ultrasound as an enhancer for transcutaneous drug delivery: phonophoresis. Physical therapy. 1995;75:539-553. https://doi.org/10.1093/ptj/75.6.539
  10. Robinson MK, Cohen C, de Fraissinette A. D.B, Ponec M, Whittle E, Fentem JH. Non-animal testing strategies for assessment of the skin corrosion and skin irritation potential of ingredients and finished products. Food Chem Toxicol. 2002;40:573-592. https://doi.org/10.1016/S0278-6915(02)00005-4
  11. Franz, Thomas J. Percutaneous absorption. On the relevance of in vitro data. Journal of Investigative Dermatology. 1975;64:190-195. https://doi.org/10.1111/1523-1747.ep12533356
  12. Franz, Thomas J. The finite dose technique as a valid in vitro model for the study of percutaneous absorption in man. Current problems in dermatology. 1978;7:58-68. https://doi.org/10.1159/000401276
  13. Vasefi F, Saager R, Durkin AJ, MacKinnon N, Gussakovsky E, Chave R, Farkas DL. Quantifying the optical properties and chromophore concentrations of turbid media using polarization sensitive hyperspectral imaging: optical phantom studies. In Proceedings of the Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XI. 2013;p. 8587.
  14. Baxi J, Calhoun III, WR, Sepah YJ, Hammer DX, Ilev, I, Pfefer TJ, Agrawal A. Retina-simulating phantom for optical coherence tomography. Journal of biomedical optics. 2013;19:021106.
  15. Fredriksson I, Saager RB, Durkin AJ, Stromberg T. Evaluation of a pointwise microcirculation assessment method using liquid and multilayered tissue simulating phantoms. Journal of Biomedical Optics 2017,22(11):115004.
  16. Kim JH, Ko JA, Kim JT, Cha DS, Cho JH, Park HJ, Shin GH. Preparation of a capsaicin-loaded nanoemulsion for improving skin penetration. Journal of agricultural and food chemistry. 2014;62(3):725-732. https://doi.org/10.1021/jf404220n
  17. Li J, Lee IW, Shin GH, Chen X, Park HJ. Curcumin-Eudragit® E PO solid dispersion: a simple and potent method to solve the problems of curcumin. European Journal of Pharmaceutics and Biopharmaceutics. 2015;94:322-332. https://doi.org/10.1016/j.ejpb.2015.06.002
  18. Nallagundla, Sumalatha, Srinivas Patnala, and Isadore Kanfer. Comparison of in vitro release rates of acyclovir from cream formulations using vertical diffusion cells. AAPS PharmSciTech. 2014;15.4:994-999. https://doi.org/10.1208/s12249-014-0130-y
  19. Pan TL, Wang PW, Aljuffali Ibrahim A., Hung YY, Lin CF, Fang JY. Dermal toxicity elicited by phthalates: evaluation of skin absorption, immunohistology, and functional proteomics. Food and chemical toxicology. 2014;65:105-114. https://doi.org/10.1016/j.fct.2013.12.033
  20. Flaten GE, Palac Z, Engesland A, Filipovic-Grcic J, Vanic Z, Skalko-Basnet N. In vitro skin models as a tool in optimization of drug formulation. European journal of pharmaceutical sciences. 2015;75:10-24. https://doi.org/10.1016/j.ejps.2015.02.018
  21. Uchida T, Kadhum W.R, Kanai S, Todo H, Oshizaka T, Sugibayashi K. Prediction of skin permeation by chemical compounds using the artificial membrane, Strat-MTM. European Journal of Pharmaceutical Sciences. 2015;67:113-118. https://doi.org/10.1016/j.ejps.2014.11.002
  22. Beriro D.J, Cave M.R, Wragg J, Thomas R, Wills G, Evans F. A review of the current state of the art of physiologicallybased tests for measuring human dermal in vitro bioavailability of polycyclic aromatic hydrocarbons (PAH) in soil. Journal of hazardous materials. 2016;305:240-259. https://doi.org/10.1016/j.jhazmat.2015.11.010
  23. Lee WR, Shen SC, Aljuffali I.A, Li YC, Fang JY. Impact of different vehicles for laser-assisted drug permeation via skin: full-surface versus fractional ablation. Pharmaceutical research. 2014;31:382-393. https://doi.org/10.1007/s11095-013-1167-4
  24. Haq A, Dorrani M, Goodyear B, Joshi V, Michniak-Kohn B. Membrane properties for permeability testing: Skin versus synthetic membranes. International journal of pharmaceutics. 2018;539:58-64. https://doi.org/10.1016/j.ijpharm.2018.01.029
  25. Haq A, Goodyear B, Ameen D, Joshi V, Michniak-Kohn, B. Strat-M® synthetic membrane: Permeability comparison to human cadaver skin. International journal of pharmaceutics 2018;547:432-437. https://doi.org/10.1016/j.ijpharm.2018.06.012
  26. Neupane R, Boddu S.H, Renukuntla J, Babu R.J, Tiwari A.K. Alternatives to biological skin in permeation studies: Current trends and possibilities. Pharmaceutics. 2020;12.2:152.
  27. Gutierrez J, Gonzalez C, Maestro A, Sole I, Pey C, Nolla J. Nano-emulsions: New applications and optimization of their preparation. Current opinion in colloid & interface science. 2008;13:245-251. https://doi.org/10.1016/j.cocis.2008.01.005
  28. Sonneville-Aubrun O, Simonnet J.T, L'Alloret F. Nanoemulsions: a new vehicle for skincare products. Advanced in colloid and interface science. 2004;108:145-149. https://doi.org/10.1016/j.cis.2003.10.026
  29. Damianou C.A, Sanghvi N.T, Fry F.J, Maass-Moreno R. Dependence of ultrasonic attenuation and absorption in dog soft tissues on temperature and thermal dose. The journal of the acoustical society of america. 1997;102:628-634. https://doi.org/10.1121/1.419737
  30. Park JH, Lee HW, Lim GS, Kim NY, Kim DW, Kim YC. Enhanced Transdermal Drug Delivery by Sonophoresis and Simultaneous Application of Sonophoresis and Iontophoresis. AAPS PharmSciTech 2019;20(3):1-7. https://doi.org/10.1208/s12249-018-1201-2
  31. Azagury A, Khoury L, Enden G, Kost J. Ultrasound mediated transdermal drug delivery. Advanced Drug Delivery Reviews. 2014;72:127-143. https://doi.org/10.1016/j.addr.2014.01.007
  32. Kruglikov I. Sehr hochfrequenter ultraschall. Der Hautarzt. 2015;66:829-833. https://doi.org/10.1007/s00105-015-3676-z
  33. Jambrak A.R, Mason T.J, Lelas V, Paniwnyk L, Herceg Z. Effect of ultrasound treatment on particle size and molecular weight of whey proteins. Journal of Food engineering 2014;121:15-23. https://doi.org/10.1016/j.jfoodeng.2013.08.012
  34. Alberti M., Dancik Y., Sriram G., Wu B., Teo Y. L., Feng Z., Bigliardi-Qi M., Wu R. G., Wnag Z. P., Bigliardi P. L. Multichamber microfluidic platform for high-precision skin permeation testing. Lab on a Chip 2017;17(9):1625-1634. https://doi.org/10.1039/C6LC01574C
  35. Lukacs B., Bajza, A., Kocsis, D., Csorba, A., Antal, I., Ivan, K., Jozsef Laki, A., Erdo, F. Skin-on-a-chip device for ex vivo monitoring of transdermal delivery of drugs-design, fabrication, and testing. Pharmaceutics 2019;11(9):445.