• Title/Summary/Keyword: Biological systems

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Computational Study on the Hemodynamics of Cardiovascular System Including Short-term Auto-regulation Functions (단기적 자율조절기능을 포함하는 심혈관계 혈류역학 모델링에 관한 수치적 연구)

  • 심은보;정찬일;최한고
    • Journal of Biomedical Engineering Research
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    • v.22 no.5
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    • pp.393-402
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    • 2001
  • A computational model representative of cardiovascular circulation was built using 12 standard lumped compartments. Especially, both the baroreceptor reflex and the cardiopulmonary reflex control model were implemented to explain the auto-regulation of cardiovascular system. Another important aspect of this model is to utilize the impulse-response curve of the nerve system in transferring the impulse error signals to autonomous nerve system. For the verification of this model, we have computed the normal hemodynamic conditions and compared those with the clinical data. Then. hemodynamic shock of 20% hemorrhage to cardiovascular system was simulated to test the effects of the control system model. The results of these two simulations were well matched with the experimental ones. The steady state LBNP simulation was also performed. The transient changes of hemodynamic variables due to ramp increase of bias pressure of LBNP showed good agreement with the physiological experiments. Numerical solution using only the baroreflex model showed relatively a larger deviation from the experimental data. compared with the one using the control model haying both the baroreflex and the cardiopulmonary reflex systems, which shows an important role of the cardiopulmonary reflex system for the simulation of the hemodynamic behavior of the cardiovascular system .

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Investigation of Radiation Effects on the Signal and Noise Characteristics in Digital Radiography (디지털 래디오그라피의 신호 및 잡음 특성에 대한 방사선 영향에 관한 연구)

  • Kim, Ho-Kyung;Cho, Min-Kook;Graeve, Thorsten
    • Journal of Biomedical Engineering Research
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    • v.28 no.6
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    • pp.756-767
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    • 2007
  • For the combination of phosphor screens having various thicknesses and a photodiode array manufactured by complementary metal-oxide-semiconductor (CMOS) process, we report the observation of image-quality degradation under the irradiation of 45-kVp spectrum x rays. The image quality was assessed in terms of dark pixel signal, dynamic range, modulation-transfer function (MTF), noise-power spectrum (NPS), and detective quantum efficiency (DQE). For the accumulation of the absorbed dose, the radiation-induced increase both in dark signal and noise resulted in the gradual reduction in dynamic range. While the MTF was only slightly affected by the total ionizing dose, the noise power in the case of $Min-R^{TM}$ screen, which is the thinnest one among the considered screens in this study, became larger as the total dose was increased. This is caused by incomplete correction of the dark current fixed-pattern noise. In addition, the increase tendency in NPS was independent of the spatial frequency. For the cascaded model analysis, the additional noise source is from direct absorption of x-ray photons. The change in NPS with respect to the total dose degrades the DQE. However, with carefully updated and applied correction, we can overcome the detrimental effects of increased dark current on NPS and DQE. This study gives an initial motivation that the periodic monitoring of the image-quality degradation is an important issue for the long-term and healthy use of digital x-ray imaging detectors.

Biological Treatment of Dyeing Wastewater Using Jet Loop Reactor with Activated Carton Supports (활성탄 담체가 포함된 Jet-Loop Reactor를 이용한 종합염색폐수처리)

  • 조무환;박종탁;이길호;류원률
    • KSBB Journal
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    • v.17 no.3
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    • pp.241-246
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    • 2002
  • Today, many problems of dye-processing wastewaters were raised due to industry of dyeing and textiles. It is difficult to treat them perfectly because they contain many poorly degradable matters, such as surfactants, ethylene glycol, polyvinyl alcohol, and so on. To improve the performances of conventional physicochemical treatment and activated sludge process, new systems of combining jet-loop reactor (JLR) with physicochemical treatment were developed. Volumetric oxygen transfer coefficient ($k_{L}a$) of JLR was significantly larger than that of air-lift reactor. Also, for the effective treatment of dye-processing wastewater, JLR with active carbon supports (JLRAS) were investigated. Removal efficiency of BOD, $COD_{Mn}$, $COD_{Cr} and color were found as 99, 86, 84, 83%, respectively, when HRT was 8 hrs. And performance of JLRAS was rapidly restored after step change of $COD_{Mn}$ loading late. The optimal coagulant and dosage of second physicochemical treatment after JLRAS were polyferric sulfate and 130 mg/L, respectively, when removal efficiencies of $COD_{Mn} and color were 85 and 73%, respectively. In conclusion, this system enables the reduction of operation cost, and the effective removal of many organics.

Dyeabilities with Various Fabrics and Chemical Composition of Brown Colorants from Pine Bark (적송수피 색소 성분의 화학적 조성과 섬유 염색성)

  • Kim, Yong-Sook;Bae, Soon Ei
    • Fashion & Textile Research Journal
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    • v.15 no.1
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    • pp.138-146
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    • 2013
  • Chemical compositions and biological functions of brown colorants extracted from pine bark(Pinus densiflora) have been studied. Dyeing test using multifiber fabrics with extracted colorants were preliminary carried out. Dyeing conditions and fastness tests of selected fabrics have been also studied. The brown colorants were produced 1.5% concentrations by solvent extraction from milled pine bark using methanol. The colorants were extracted with 80% methanol as best choice by a criteria of solid quantity and dyeability on fabrics. The chemical compositions were identified as mixtures of taxifolin epicatechin and procyanidin by LC/MS analysis. The brown colorants could be dyed not only natural fibers such as cotton, silk and wool but also synthetic fiber as nylon and semi-synthetic fiber as viscose rayon. Maximum K/S values was shown at 400 nm according to different fiber with color appearance of redish brown. Optimum pH and temperature of dyeing conditions was 4 and above $80^{\circ}C$, respectively. The brown colorants had a strong antioxidant activity compared to Butylated hydroxyanisole as standard and weak antimicrobial activity against E. coli. compared to kanamycin. Washing, rubbing, perspiration, dry cleaning and light fastness for cotton, nylon and silk dyed with the brown colorants were carried out by KS K method. Most of color fastness such as washing, rubbing, perspiration, and dry cleaning were represented as 4-5 grade. However, light fastness was reported as 2-3 grade. From this studies, brown colorants produced pine bark have a high potentials for natural dyeing on fabrics with antioxidant activity.

Identification of Putative MAPK Kinases in Oryza minuta and O. sativa Responsive to Biotic Stresses

  • You, Min Kyoung;Oh, Seung-Ick;Ok, Sung Han;Cho, Sung Ki;Shin, Hyun Young;Jeung, Ji Ung;Shin, Jeong Sheop
    • Molecules and Cells
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    • v.23 no.1
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    • pp.108-114
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    • 2007
  • The mitogen-activated protein kinase (MAPK) signaling cascade is critical for regulating plant defense systems against various kinds of pathogen and environmental stresses. One component of this cascade, the MAP kinase kinases (MAPKK), has not yet been shown to be induced in plants following biotic attacks, such as those by insects and fungi. We describe here a gene coding for a blast (Magnaporthe grisea)- and insect (Nilaparvata lugens)-responsive putative MAPK kinase, OmMKK1 (Oryza minuta MAPKK 1), which was identified in a library of O. minuta expressed sequence tags (ESTs). Two copies of OmMKK1 are present in the O. minuta genome. They encode a predicted protein with molecular mass 39 kDa and pI of 6.2. Transcript patterns following imbibition of plant hormones such as methyl jasmonic acid (MeJA), ethephone, salicylic acid (SA) and abscisic acid (ABA), as well as exposure to methyl viologen (MV), revealed that the expression of OmMKK1 is related to defense response signaling pathways. A comparative analysis of OmMKK1 and its O. sativa ortholog OsMKK1 showed that both were induced by stress-related hormones and biotic stresses, but that the kinetics of their responses differed despite their high amino acid sequence identity (96%).

Development of a Rapeseed Seeder Attached to Tractors (트랙터 부착용 유채파종기 개발)

  • Lee, C.K.;Choi, Y.;Jun, H.J.;Choi, D.K.;Kim, Y.J.;Lee, S.K.;Moon, S.D.;Han, B.H.
    • Journal of Biosystems Engineering
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    • v.34 no.3
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    • pp.147-154
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    • 2009
  • Suitable rapeseed cultivation techniques of domestic agriculture are essential for stable security, supply and demand of rapeseed. This research developed a rapeseed seeder for bio-diesel and analyzed the seeding performance improving an existent granule fertilizer applicator. The relational expression of metering groove size and discharge rate per time displayed high correlation with a coefficient of determination of 0.988. Also, the scattering types were analyzed by forwarding speed and discharge rate. Validity application width was decided as 7.0 m by analyzing application uniformity at application widths of 7.6 m, 6.6 m, 5.6 m. All average coefficients of variation values were less than 20%. The best application uniformity was obtained in the condition of a work speed of 1.3 m/s and a sowing rate of 19.0 g/s. It was better average coefficient of variation values under 10% at superposition application of rapeseed seeder. Also, scattering amount rates of right and left were within 0.89${\sim}$1.0.

A Structured and Multi-cellular Model of Starch Biosynthesis in Potato

  • Saithong, Treenut;Saraboon, Piyaporn;Meechai, Asawin;Cheevadhanarak, Supapon;Bhumiratana, Sakarindr
    • Proceedings of the Korean Society for Bioinformatics Conference
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    • 2005.09a
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    • pp.151-155
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    • 2005
  • Recently, systems biology has been increasingly applied to gain insights into the complexity of living organisms. Many inaccessible biological information and hidden evidences fur example flux distribution of the metabolites are simply revealed by investigation of artificial cell behaviors. Most bio-models are models of single cell organisms that cannot handle the multi-cellular organisms like plants. Herein, a structured and multi-cellular model of potato was developed to comprehend the root starch biosynthesis. On the basis of simplest plant cell biology, a potato structured model on the platform of Berkley Madonna was divided into three parts: photosynthetic (leaf), non-photosynthetic (tuber) and transportation (phloem) cells. The model of starch biosynthesis begins with the fixation of CO$_2$ from atmosphere to the Calvin cycle. Passing through a series of reactions, triose phosphate from Calvin cycle is converted to sucrose which is transported to sink cells and is eventually formed the amylose and amylopectin (starch constituents). After validating the model with data from a number of literatures, the results show that the structured model is a good representative of the studied system. The result of triose phosphate (DHAP and GAP) elevation due to lessening the aldolase activity is an illustration of the validation. Furthermore, the representative model was used to gain more understanding of starch production process such as the effect of CO$_2$ uptake on qualitative and quantitative aspects of starch biosynthesis.

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Study on Activity, Type and Establishment of Community Supported Agriculture in USA and Japan (미국과 일본의 CSA운동의 등장, 유형 및 활동사례)

  • 정진영;손상목;김영호
    • Korean Journal of Organic Agriculture
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    • v.9 no.1
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    • pp.1-16
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    • 2001
  • With increasing global concern that intensively synthetic-chemical based farming systems accelerated the decline in environmental quality, the sustainability of modem agriculture became the subject of great concern. It is well known that the movement of Community Supported Agriculture(CSA) has been contributed significantly to the development of organic agriculture in USA and Japan. It was supposed that CSA could be one of the best way to promote the movement of organic agriculture since there is little reliability on the organically grown food by consumer. In this paper it was focussed to study the movement of CSA in USA and Europe in order to provide an idea for establishment and movement of CSA in Korea to support the organic agriculture. In a CSA system, the farmer grows food for a group of shareholders who pledge to buy a portion of the farm's crop that season. This arrangement gives growers up-front cash to finance their operation and higher prices for produce, since the middleman has been eliminated. For most shareholder for CSA saving money is a secondary consideration, but fresh safe products and environmentally sound farming system. People become shareholder of CSA since they expect an organic farming which can ; \circled1protect the environment, minimize pollution, promote health, \circled2replenish and maintain long-term soil fertility by providing optimal conditions for soil biological activity, \circled3maintain diversity within the farming system and its surroundings and protect plant and wildlife habit, \circled4recycle materials and resources to the greatest extent possible within the farm and its surrounding community, \circled5maintain the integrity of organic food and processed products through each step of the process from planting to consumption, \circled6develop and adopt new technologies with consideration for their long range social and ecological impact. In all CSAs, the farmer develops a crop plan and a budget, which details costs for a growing season, including fair wages for the farmers. Experienced Information on increasing shareholder retention, the future of CSA, and getting started such as ideas for ongoing marketing, printed materials that set realistic expectations, working members, production, pick-up and delivery, setting prices, and receiving feedback were also briefly introduced.

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Soybean mosaic virus Infection and Helper Component-protease Enhance Accumulation of Bean pod mottle virus-Specific siRNAs

  • Lim, Hyoun-Sub;Jang, Chan-Yong;Bae, Han-Hong;Kim, Joon-Ki;Lee, Cheol-Ho;Hong, Jin-Sung;Ju, Ho-Jong;Kim, Hong-Gi;Domier, Leslie L.
    • The Plant Pathology Journal
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    • v.27 no.4
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    • pp.315-323
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    • 2011
  • Soybean plants infected with Bean pod mottle virus (BPMV) develop acute symptoms that usually decrease in severity over time. In other plant-virus interactions, this type of symptom recovery has been associated with degradation of viral RNAs by RNA silencing, which is accompanied by the accumulation of virus-derived small interfering RNAs (siRNAs). In this study, changes in the accumulation of BPMV siRNAs were investigated in soybean plants infected with BPMV alone, or infected with both BPMV and Soybean mosaic virus (SMV) and in transgenic soybean plants expressing SMV helper component-protease (HC-Pro). In many potyviruses, HC-Pro is a potent suppressor of RNA silencing. In plants infected with BPMV alone, accumulation of siRNAs was positively correlated with symptom severity and accumulation of BPMV genomic RNAs. Plants infected with both BPMV and SMV and BPMV-infected transgenic soybean plants expressing SMV HC-Pro exhibited severe symptoms characteristic of BPMVSMV synergism, and showed enhanced accumulation of BPMV RNAs and siRNAs compared to plants infected with BPMV alone and nontransgenic plants. Likewise, SMV HC-Pro enhanced the accumulation of siRNAs produced from a silenced green fluorescent protein gene in transient expression assays, while the P19 silencing suppressor of Tomato bushy stunt virus did not. Consistent with the modes of action of HC-Pro in other systems, which have shown that HC-Pro suppresses RNA silencing by preventing the unwinding of duplex siRNAs and inhibiting siRNA methylation, these studies showed that SMV HC-Pro interfered with the activities of RNA-induced silencing complexes, but not the activities of Dicer-like enzymes in antiviral defenses.

Fish Fauna and Community Structure in Lake Paldang and its Inflows (팔당호의 어류상과 군집동태)

  • Byeon, Myeong-Seop;Park, Hae-Kyung;Lee, Wan-Ok;Kong, Dongsoo
    • Journal of Korean Society on Water Environment
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    • v.24 no.2
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    • pp.206-213
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    • 2008
  • Fish fauna and community structure were investigated at 2003, 2004 and 2006 in Lake Paldang and its inflows. In this survey, we collected 54 species belong to 14 families. Family Cyprinidae take 51.9% (28 species), Cobitidae and Gobiidae occupied 7.4% (each 4 species), respectively. E. erythropterus (11.8%) was dominant species and L. macrochirus (10.2%), designated as an ecosystem-invasive alien fish species by Ministry of Environment, M. yaluensis (9.1%), Z. platypus (7.7%) and R. brunneus (6.7%) were dominated in turn. H. molitrix, C. lutheri, P. altivelis, S. microdorsalis, L. costata. S. gracilis majimae, A. rivularis, P. koreanus. S. scherzeri and O. platycephala were rare species (less than 0.1% in relative abundance). In-lake area, 36 species of fishes belonging to 11 families were collected, and 48 species of 13 families were from inflows. The number of Korean endemic species were 19 species (35.2%), and 4 kinds of exotic species (7.4%), that is, C. cuvieri, H. molitrix, L. macrochirus and M. salmoides were found at this survey area. It was revealed by the analysis of fish community that diversity and richness indices were prominent at tributaries, and dominance index was high at the main body of Lake Paldang. Fish fauna showed rapid decline after dam construction which make the mid-Han river systems to lentic ecosystem, so many of meander-riffle fishes were disappeared dramatically. But after 1990s when installation of small scale wastewater treatment plants started in watershed, the water quality of small tributaries was improved. And also, expansion of the natural macrophytic vegetation of littoral zone should contribute to the development of diverse fish fauna in Lake Paldang.