• Journal of Biomedical Engineering Research
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• v.37 no.5
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• pp.195-207
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• 2016

This study examined the effectiveness of micro-current stimulation (MCS) to improve the facial skin qualities by performing clinical test. The MCS is generally known that provide healing response in the damaged tissue and pain relief through activating the adenosine triphosphate (ATP) and protein synthesis. In here, we can hypothesize that the improvement of facial skin qualities may occur due to MCS, since the induction of micro-current from outside may enhance the cellular activity according to ATP activation. From the clinical test, our results showed that a variety of evaluating categories, which is able to assess the skin qualities, significantly enhanced due to stimulation of micro-current after 7 and 14 days. Therefore, we can estimate that MCS in human facial skin may be effective to improve the skin qualities.

• Journal of Biomedical Engineering Research
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• v.36 no.3
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• pp.69-78
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• 2015

Ultrasonic physiotherapy systems should comply with IEC 60601-2-5(particular requirements for safety of ultrasonic physiotherapy equipment) standard for safety of patients and clinical performances. One of the most important parameters in the standard is the effective radiating area ($A_{ER}$). It has to be measured in accordance with IEC 61689 (field specifications and methods of measurement in the frequency range 0.5MHz to 5MHz). Typical ultrasonic physiotherapy system works in the frequency range 1MHz ~ 3MHz to comply with the IEC 61689. However, ultrasonic physiotherapy system using frequencies over 5MHz is out of the IEC 61689's scope. That is, even if such ultrasonic physiotherapy systems are developed by demands of the market, there is no standard to apply. It is the motivation for this study. Whereas there are other parameters to be considered, this study focuses on the effective radiating area and shows effectiveness of applying IEC 61689 in measuring effective radiating area of ultrasonic physiotherapy systems using frequency range over 5MHz by comparing the results of computer simulation and experiment. Results of this study shows that applying the IEC 61689 standard to ultrasonic physiotherapy system using frequency range over 5MHz is possible.

• Korean Journal of Cleft Lip And Palate
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• v.14 no.1_2
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• pp.37-44
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• 2011

Amniotic fluid is a complex and biological reservoir that provides mechanical cushioning and has many nutrients required for fetal growth and development. During our main research works about the fetal surgery of congenital facial defects, we reviewed several recent articles about the effectiveness and composition of amniotic fluid. Among these review processes, amniotic fluid, as the convenient medium to store sking grafts, was focused especially for its growth factors and rich nutrients, and we summarized some experimental investigations of skin grafts stored in amniotic fluid in rats. We reviewed mainly the article, "Turhan-haktanir N. et al. Histological assessment of skin grafts in amniotic fluid and saline. J Plast Surg Hand Surg 2010;44:226-30."

• 보존과학연구
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• s.30
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• pp.125-136
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• 2009

Stone cultural heritages in Korea have a severe damages from chemical and biological weathering because most of them have been situated in outdoors without any suitable protection systems, and this in turn causes deformation and structural damage. To counteract these problems and increase durability, various kinds of conservation materials are used in the conservation and restoration treatments. However until now there are not many practical and technological experiments on this subject. This paper attempts quantitative evaluation of effectiveness about chemical of ethylsilicate based resin for sandstone in Yeongyang-gun. It takes a long time to evaluate durability and side effect after conservation materials treatment. So we use artificial weathering through freezing§ thawing experimental method. As a result of this experiment, porosity and absorptance increased, and elastic wave speed, elastic modules, unconfined compression strength and tensile strength decreased more than before. This study plans to make a scientific method study about weathering factor and mechanism, and to deduce correlation between artificial weathering and natural weathering.

• Korean Journal of Environmental Agriculture
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• v.33 no.1
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• pp.30-36
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• 2014

BACKGROUND: Best management practices are often implemented to control nonpoint source pollutants. Best management practices need to be simulated and analyzed for effective Best management practices implementations. Filter strip is one of effective Best management practices in agricultural areas. METHODS AND RESULTS: Soil and Water Assessment Tool model was selected to explore the effectiveness of filter strip to control total phosphorous in Golji watershed. Soil and Water Assessment Tool model was calibrated for flow and total phosphorous by Sequential Uncertainty Fittin ver.2 algorithm provided in Soil and Water Assessment Tool-Calibration and Uncertainty Procedures. Three scenarios defined by filter strip width were applied. The filter strip width of 5 m was able to reduce the most amount of total phosphorous. In other words, the total phosphorous reduction by filter strip of 5 m was 28.0%, while the reduction was 17.5% by filter strip of 1 m. However, the reduction per unit filter strip width were 17.4%, 8.0%, and 4.5% for 1 m, 3 m, and 5 m of filter strips, respectively. CONCLUSION: Best management practices need to be simulated and analyzed so that the BMP scenario can be cost-effective. A large size of BMP might be able to control large amount of pollutants, however it would not be indicated as a cost-effective strategy.

• Journal of Biomedical Engineering Research
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• v.26 no.3
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• pp.157-161
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• 2005

Direct injection of a fibrinolytic agent to the intraarterial thrombosis may increase the effectiveness of thrombolysis by enhancing the permeation of thrombolytic agents into the blood clot. Permeation of fibrinolytic agents into a clot is influenced by the surface pressure, which is determined by the injection velocity of fibrinolytic agents. In order to calculate the pressure distribution on the clot surface for different jet velocities (1, 3, 5 m/sec) and nozzle arrangements (1, 9, 17 nozzles), computational fluid dynamic methods were used. Thrombolysis of a clot was mathematically modeled based on the pressure and lysis front velocity relationship. Direct injection of a thrombolytic agent increased the speed of thrombolysis significantly and the effectiveness was increased as the ejecting velocity increased. The nine nozzles model showed about $20\%$ increase of the lysed volume, and the one and seventeen nozzles models did not show significant differences. The wall shear stress decreased as the number of nozzles increased, and the wall shear stress in most vessel wall was lower than 25 Pa. The results implied that thrombolysis could be accelerated by direct injection of a drug with the moderate velocity without damaging the blood vessel wall.

• Archives of Pharmacal Research
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• v.28 no.8
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• pp.902-908
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• 2005

An oriental herbal combination (BDX-1) was isolated from Achyranthes bidentata and Atractylodes japonica. We previously tested the clinical effectiveness of BDX-1 in rheumatoid arthritis (RA) patients and found that it has a beneficial therapeutic effect. Here, we provide experimental evidence for the effectiveness of BDX-1 on RA in murine models. The oral administration of BDX-1 was found to markedly inhibit collagen-induced arthritis, adjuvant-induced arthritis, and zymosan-induced inflammation. It also inhibited carrageenan-induced acute edema and acetic acid-induced writhing response. In addition, the biological activity of BDX-1 was found to be strongly increased by fermentation. Our results suggest that BDX-1 could be useful for the treatment of rheumatoid arthritis.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.157-160
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• 1996

We have developed the prototype Multi-leaf Collimator(MLC) for medical linear acclerator. In this study, we have examined the clinical effectiveness of our newly developed MLC by analysing treatment pattern of radiation therapy and studied the radiation safety by measuring the transmitted radiation and the leakage radiation. Over 81% patients can be treated with new MLC(20 pairs of leaves) and 98% with 30 pairs of leafed-MLC, while 95% with commercial MLC. New MLC showed superior properties of radiation leakage and transmission to commercially available MLC.

• Transactions on Control, Automation and Systems Engineering
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• v.4 no.1
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• pp.49-55
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• 2002

A decrease in the birthrate and aging are progressing in Japan and several countries. In that society, it is important that physically weak persons such as elderly persons are able to take care of themselves. We have been developing exoskeletal robots for human (especially for physically weak persons) motion support. In this study, the controller controls the angular position and impedance of the exoskeltal robot system using multiple fuzzy-neuro controllers based on biological signals that reflect the human subject's intention. Skin surface electromyogram (EMG) signals and the generated wrist force by the human subject during the elbow motion have been used as input information of the controller. Since the activation level of working muscles tends to vary in accordance with the flexion angle of elbow, multiple fuzzy-neuro controllers are applied in the proposed method. The multiple fuzzy-neuro controllers are moderately switched in accordance with the elbow flexion angle. Because of the adaptation ability of the fuzzy-neuro controllers, the exoskeletal robot is flexible enough to deal with biological signal such as EMG. The experimental results show the effectiveness of the proposed controller.

• Journal of Applied Biological Chemistry
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• v.50 no.1
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• pp.6-12
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• 2007

Feasibility of laboratory-synthesized zerovalent iron was investigated to remove arsenic from leachates of tailings taken from an Au-Ag abandoned mine. The tailings were seriously contaminated with arsenic, and its potential adverse effect on the ecosystems around the mine seems to be significantly high. Long-term column experiments were conducted for about 3.5 months to evaluate the effectiveness of the synthesized zerovalent iron for removal of arsenic. Over than 95% removal efficiency of As was observed in the zerovalent iron mediated tests. In addition, the XRD data suggest that the corrosion products of ZVI were identified magnetite, maghemite, goethite, and lepidocrocite, all of which support Fe(II) oxidation as an intermediate step in the zerovalent iron corrosion process. The results indicate that arsenic can be removed from the tailing-leachate by the mechanism of coprecipitation and/or adsorption onto those iron oxides formed from ZVI corrosion.