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Prevention of Arthritic Inflammation Using an Oriental Herbal Combination BDX-1 Isolated from Achyranthes bidentata and Atractylodes japonica  

Han Sang-Bae (Korea Research Institute of Bioscience and Biotechnology(KRIBB))
Lee Chang Woo (Korea Research Institute of Bioscience and Biotechnology(KRIBB))
Yoon Yeo Dae (Korea Research Institute of Bioscience and Biotechnology(KRIBB))
Lee Jong-Ho (BIORADIX Co., Ltd)
Kang Jong Soon (Korea Research Institute of Bioscience and Biotechnology(KRIBB))
Lee Ki Hoon (Korea Research Institute of Bioscience and Biotechnology(KRIBB))
Yoon Won Kee (Korea Research Institute of Bioscience and Biotechnology(KRIBB))
Lee Kiho (Korea Research Institute of Bioscience and Biotechnology(KRIBB))
Park Song-Kyu (Korea Research Institute of Bioscience and Biotechnology(KRIBB))
Kim Hwan Mook (Korea Research Institute of Bioscience and Biotechnology(KRIBB))
Publication Information
Archives of Pharmacal Research / v.28, no.8, 2005 , pp. 902-908 More about this Journal
Abstract
An oriental herbal combination (BDX-1) was isolated from Achyranthes bidentata and Atractylodes japonica. We previously tested the clinical effectiveness of BDX-1 in rheumatoid arthritis (RA) patients and found that it has a beneficial therapeutic effect. Here, we provide experimental evidence for the effectiveness of BDX-1 on RA in murine models. The oral administration of BDX-1 was found to markedly inhibit collagen-induced arthritis, adjuvant-induced arthritis, and zymosan-induced inflammation. It also inhibited carrageenan-induced acute edema and acetic acid-induced writhing response. In addition, the biological activity of BDX-1 was found to be strongly increased by fermentation. Our results suggest that BDX-1 could be useful for the treatment of rheumatoid arthritis.
Keywords
BDX-1; Atractylodes japonica; Achyranthes bidentata; Rheumatoid arthritis;
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