• Journal of Sensor Science and Technology
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• v.14 no.5
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• pp.322-330
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• 2005

A new type of transducer, piezoelectric floating mass transducer (PFMT) which has advantages of piezoelectric and electromagnetic transducer has been proposed and implemented for the implantable middle ear hearing devices. By the uneven bonding of piezoelectric material to the inner bottom of transducer case, the PFMT can vibrate back-and-forth along the longitudinal axis of the transducer even though the piezoelectric material within the cylindrical case produces only the bilateral expansion and contraction according to the applied electrical signal. To improve efficiency of the PFMT, the multi-layered piezoelectric material has been adapted. The small number of components in the PFMT enables the simple manufacturing and the easy implanting into the middle ear. In order to examine the characteristics of vibration, mechanical modeling and finite element analyses of the proposed transducer have been performed. From the result of theoretical analyses and the measured data from the experiment, it is verified that the implemented PFMT can be used in implantable middle ear hearing devices.

• Molecules and Cells
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• v.38 no.1
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• pp.26-32
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• 2015

Toll-like receptors (TLR) 7 and 9 transduce a cellular signal through the MyD88-dependent pathway and induce the production of inflammatory mediators against microbial nucleotide components. The repeated stimulation of TLR4 leads to endotoxin tolerance, but the molecular mechanisms of tolerance induced through the costimulation of individual TLR has not yet been established, although endosomal TLRs share signaling pathways with TLR4. In the present study, mouse macrophages were simultaneously stimulated with the TLR7 agonist, gardiquimod (GDQ), and the TLR9 agonist, CpG ODN 1826, to examine the mechanism and effector functions of macrophage tolerance. Compared with individual stimulation, the costimulation of both TLRs reduced the secretion of TNF-${\alpha}$ and IL-6 through the delayed activation of the NF-${\kappa}B$ pathway; notably, IL-10 remained unchanged in costimulated macrophages. This tolerance reflected the early induction of suppressor of cytokine signaling-1 (SOCS-1), according to the detection of elevated TNF-${\alpha}$ secretion and restored NF-${\kappa}B$ signaling in response to the siRNA-mediated abrogation of SOCS-1 signaling. In addition, the restimulation of each TLRs using the same ligand significantly reduced the expression of both TLRs in endosomes. These findings revealed that the costimulation of TLR7 and TLR9 induced macrophage tolerance via SOCS-1, and the restimulation of each receptor or both TLR7 and TLR9 downregulated TLR expression through a negative feedback mechanisms that protects the host from excessive inflammatory responses. Moreover, the insufficient and impaired immune response in chronic viral infection might also reflect the repeated and simultaneous stimulation of those endosomal TLRs.

• Journal of Biomedical Engineering Research
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• v.21 no.4
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• pp.339-344
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• 2000

The mucociliary system is one of the most important airway defense mechanisms in human body and impairment of ciliary movement results in various diseases in respiratory tract. In this study, we have developed a system that can measure ciliary movement in vivo and quantified ciliary beat frequency (CBF) through autoregressive (AR) power spectrum. To measure the frequency in vivo, we applied a photoelectric method that was composed of a laser light and a fiber optic probe. Scattered signals are transferred to a PC in which they are displayed on the monitor and its CBF is determined by the AR method in were acquired. For 8 normal subjects, the analyzed CBFs ranged from 5 to 10Hz and its mean was 7.3${\pm}$1.1Hz. This result showed similar aspects to the reported results of CBFs to data. We expect that this result will be applied in various clinical studies such as analysis of CBF changes by drugs or by diseaes.

• Journal of Biomedical Engineering Research
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• v.27 no.1
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• pp.30-37
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• 2006

Injecting currents into an electrically conducting subject, we may measure the induced magnetic flux density distributions using an MRI scanner. The measured data are utilized to reconstruct cross-sectional images of internal conductivity and current density distributions in Magnetic Resonance Electrical Impedance Tomography (MREIT). Injection currents are usually provided in a form of mono-polar or bi-polar pulses synchronized with an MR pulse sequence. Given an MRI scanner performing the MR phase imaging to extract the induced magnetic flux density data, the current source becomes one of the key parts determining the signal-to-noise ratio (SNR) of the measured data. Since this SNR is crucial in determining the quality of reconstructed MREIT images, special care must be given in the design and implementation of the current source. This paper describes a current source design for MREIT with features including interleaved current injection, arbitrary current waveform, electrode switching to discharge any stored charge from previous current injections, optical isolation from an MR spectrometer and PC, precise current injection timing control synchronized with any MR pulse sequence, and versatile PC control program. The performance of the current source was verified using a 3T MRI scanner and saline phantoms.

• Journal of Biomedical Engineering Research
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• v.20 no.5
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• pp.559-566
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• 1999

환자의 기능평가를 위하여 중요한 자세균형의 유지는 압력중심(COP) 의 동요 신호를 직접 연속적으로 계측함으로써 가능하다. COP 신호로부터 다양한 종류의 자세안정도지표를 산출할 수 있으나 임상적으로 유용한 최소한의 지표종류로는 규명된 바 없다. 이에 본 연구에서는 인체가 서있는 상태의 정적자세를 유지할 때 압력중심 신호로부터 자세안정도지표를 산출하여 분석함으로써 임상적 유용성이 가장 큰 지표의 종류를 결정하고자 하였다. 양발을 편안히 벌리거나 (FS), 모두 모으거나(FT), 한쪽발 만으로(RL, LL)서있는 자세에 대해서 양쪽 눈을 뜨거나(EO) 감은(EC)8가지 정적자세를 취하며 30초간 자세균형을 유지시켰다. 자세형태에 따른 안정도의 척도로서 신체가 지면을 차지하는 면적(S)을 사용하였다. 자세안정도지표로서 1)position deviation, 2) position turn 3) velocity의 3가지로 분류할 수 있는 18가지 지표를 설정하였다. 피검자는 20, 30, 40 ,50 대 정상인을 연령대 별로 각각 남·녀 5명씩 고르게 총 40명을 선정하여 실험하였다. 자세안정도지표 모두가 S와 비교적 높은 유의한 상관관계를 보인 바 인을 연령대 별로 각각 남·녀 5명씩 고르게 총 40명을 선정하여 실험하였다. 자세안정도지표 모두가 S와 비교적 높은 유의한 상관관계를 보인바 (상관계수=0.6∼0.8, P<0.0001), S가 자세형태를 정량화 할 수 있음을 입증하였다. 모든 지표들에 있어서 시각의 영향이 뚜렷하였으며 특히 자세가 불안해질수록 상대적으로 시각의 영향이 두드러졌다. 그러나 시각의 영향의 지표들간의 차이는 없었다. 반면 노화(연령증가)에 따른 안정도지표의 변화는 미미하였으며 위의 3가지 안정도지표분류 중 position deviation 지표만이 통계적으로 유의한(P<0.05) 상관관계를 보였다. 따라서 정적자세유지시 안정도지표로는 position deviation 지표들이 가장 예민함을 알 수 있었다. 그러나 position deviation 지표들과 연령과의 상관계수는 0.5이하로서 매우 느슨한 상관관계를 보였으며, 연령증가에 따른 자제불안정도의 증가도 매우 작아서 그 임상적 응용가능성은 의문시되었다. 또한 위에서 제시한 3가지의 분류의 지표중 position turn 과 velocity 지표의 의미에 관해서는 향후 심층적인 연구가 필요한 것으로 판단되었다.

• Proceedings of the KACD Conference
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• 2003.11a
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• pp.545-545
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• 2003

Chitosan is applied as a dressing for oral mucous wound and a tampon following radical treatment of maxillary sinus. Furthermore, it is being investigated as an absorbing membrane for endodontic and periodontic surgeries. A few studies have reported osteoconduction and osteogenesia at the site of chitosan implant in vivo. However, compared with soft tissue healing processes, the mechanisms concerning effects of chitosan for biological mineralization have not yet been resoil In the present study, we studied the gene expression pattern using cDNA microarray and RT-PCR analyses in hard tissue forming osteoblasts cultured with water-soluble and low molecular weight chitooligosaccharide. cDNA microarray analysis revealed that 16 genes were expressed at 〉1.5-fold higher signal ratio levels in the experimental group compared with the control group after 3 days. RT-PCR analysis showed that chitosan oligomer induced an increase in the expression of two genes, CD56 antigen and tissue-type plasminogen activator. Furthermore, the expression of mRNAs for BMP-2 was almost identical in the experimental and control groups after 3 days of culture, but slightly increased after 7 days of culture with chitosan oligomer. These results suggest that a super-low concentration of chitooligosaccharide could modulate the activity of osteoblastic cells through mRNA levels and that the genes concerning cell proliferation and differentiation can be controlled by water-soluble chitosan.

• Journal of the Korea Convergence Society
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• v.10 no.11
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• pp.95-100
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• 2019

In this paper, autonomous vehicles of service with existing vehicle accident for the prevention of the vehicle communication technology, self-driving techniques, brakes automatic control technology, artificial intelligence technologies such as well and developed the vehicle accident this occur to death or has been techniques, can prepare various safety cases intended to minimize the injury. In this paper, it is a study to secure safety in autonomous vehicles. This is determined according to spatial factors such as chip signals for general low-power short-range wireless communication and micro road AI. On the other hand, in this paper, the safety of boarding is improved by checking the signal from the electronic chip, up to "recognition of the emotion from residence time in the sensing area" to the biological electronic chip. As a result of demonstrating the reliability of the world countries the world, inducing safety autonomous system of all passengers in terms of safety. Unmanned autonomous vehicle riding and commercialization will lead to AI systems and biochips (Verification), linked IoT on the road in the near future, and the safety technology reliability of the world will be highlighted.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.13 no.4
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• pp.1765-1794
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• 2019

Genetic Programming (GP) is an intelligence technique whereby computer programs are encoded as a set of genes which are evolved utilizing a Genetic Algorithm (GA). In other words, the GP employs novel optimization techniques to modify computer programs; imitating the way humans develop programs by progressively re-writing them for solving problems automatically. Trial programs are frequently altered in the search for obtaining superior solutions due to the base is GA. These are evolutionary search techniques inspired by biological evolution such as mutation, reproduction, natural selection, recombination, and survival of the fittest. The power of GAs is being represented by an advancing range of applications; vector processing, quantum computing, VLSI circuit layout, and so on. But one of the most significant uses of GAs is the automatic generation of programs. Technically, the GP solves problems automatically without having to tell the computer specifically how to process it. To meet this requirement, the GP utilizes GAs to a "population" of trial programs, traditionally encoded in memory as tree-structures. Trial programs are estimated using a "fitness function" and the suited solutions picked for re-evaluation and modification such that this sequence is replicated until a "correct" program is generated. GP has represented its power by modifying a simple program for categorizing news stories, executing optical character recognition, medical signal filters, and for target identification, etc. This paper reviews existing literature regarding the GPs and their applications in different scientific fields and aims to provide an easy understanding of various types of GPs for beginners.

• Biomedical Engineering Letters
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• v.8 no.4
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• pp.365-371
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• 2018

Uninterrupted monitoring of multiple subjects is required for mass causality events, in hospital environment or for sports by medical technicians or physicians. Movement of subjects under monitoring requires such system to be wireless, sometimes demands multiple transmitters and a receiver as a base station and monitored parameter must not be corrupted by any noise before further diagnosis. A Bluetooth Piconet network is visualized, where each subject carries a Bluetooth transmitter module that acquires vital sign continuously and relays to Bluetooth enabled device where, further signal processing is done. In this paper, a wireless network is realized to capture ECG of two subjects performing different activities like cycling, jogging, staircase climbing at 100 Hz frequency using prototyped Bluetooth module. The paper demonstrates removal of baseline drift using Fast Fourier Transform and Inverse Fast Fourier Transform and removal of high frequency noise using moving average and S-Golay algorithm. Experimental results highlight the efficacy of the proposed work to monitor any vital sign parameters of multiple subjects simultaneously. The importance of removing baseline drift before high frequency noise removal is shown using experimental results. It is possible to use Bluetooth Piconet frame work to capture ECG simultaneously for more than two subjects. For the applications where there will be larger body movement, baseline drift removal is a major concern and hence along with wireless transmission issues, baseline drift removal before high frequency noise removal is necessary for further feature extraction.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2014.10a
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• pp.484-487
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• 2014

In this paper, We describe antenna characteristics for efficiently detecting human signs using small, planar and low power antenna. Then we can measure biological signals including respiration, heart rate, blood pressure, and blood sugar, using UWB (Ultra Wide Band) pulses, while does not contact the human body. The antenna need stable and wideband impedance characteristic, because it use gaussian pulse signal. Usually it has trade-off between wideband impedance and gain. But we don't considered array type antennas because we want to need small size. Generally the antennas that classified as frequency independent satisfy our requirements. Frequency independent antennas include spiral, log-periodic, sinuous, and etc. These antennas are possible to have shape planar type. In this paper, We tested these kind antenna's characteristics in center frequency 5 GHz, Especially circular patch and sinuous antenna designed and analyzed.