• Food Science and Biotechnology
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• v.14 no.5
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• pp.566-571
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• 2005

Process of screw-pumping system (SPS) was optimized for mass production of encapsulated bifidus. SPS entrapment device was composed of feeding component, with optimized nozzle size and length of 18G (0.91 cm) and 4 mm, respectively, screw pump, and 37-multi-nozzle. Screw component had five wing turns [radius (r)=26 to 15 mm] from top to bottom of axis at 78-degree angle from middle of the screw, and two wings were positioned at screw edge to push materials toward nozzle. For nozzle component, 37 nozzles were attached to 20-mm round plate. Air compressor was attached to SPS to increase productivity of encapsulated bifidus. This system could be operated with highly viscous (more than 300 cp) materials, and productivity was higher than $1128\;{\pm}\;30\;beads/min$. Viability of encapsulated bifidus was $5.45\;{\times}\;10^8\;cfu$/bead, which is superior to that of encapsulated bifidus produced by other methods ($2.51{\times}10^8\;cfu$/bead). Average diameter of produced beads was $2.048\;{\pm}\;0.003\;mm$. Survival rate of SPS-produced encapsulated bifidus was 90% for Simulator of the Human Intestinal Microbial Ecosystem test and 88% in fermented milk (for 14 days). These results show SPS is effective for use in development of economical system for mass production of viable encapsulated bifidus.

• Journal of Korean Biological Nursing Science
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• v.10 no.2
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• pp.131-140
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• 2008

Purpose: This study is about safety of the expressed human milk by investigating its bacterial contamination and antibiotic resistance of the microbes in the expressed milk. Methods: The data are collected from the 156 mothers and their newborn infants in NICU of U University Hospital from January 2004 to September 2005. Results: 1) The expressed human milk was contaminated by Staphylococcus epidermidis for 66.7%, Two mixed bacterial strain for 11.5%, Acinetobacter species for 8.0%, Klebsiella species for 4.6%, Staphylococcus aureus for 4.6%. 2) The microbes in the human milk had high resistance to the Antimicrobial agents: 77.5% for Penicillin-G, 66.6% for Oxacillin, and 63.7% for Cephalothin. 3) The distribution of microbes showed a significant depending on the place of the milk expression (p=.020). In particular, mixed bacterial strain was found more in the milks expressed at home than the milk expressed at the hospital. Conclusion: This study shows the importance of systematic education of feeding process in expressed milk: poor management of a breast pump, inadequate hand washing and imperfect breast cleaning explain the reasons of contamination 156 cases.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.11
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• pp.22-24
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• 1996

Small size DC motor control method for portable drug delivery system has been developed to be used for the actuator of insulins pump. The control method gives the controllabilities both in high speed(40-50 revolution per second(rps)) DC motor drive and also in low speed(0.5-1rps). In low speed mode DC motor is controlled to act like stepping motor and in high speed to optimize power consumption. To control both mode modified bang bang control is suggested. Using this method small size DC motor(spec.) speed is controlled from 0.2 rps to 50 rps. Experimental setup is developed using micro-processor(PIC16C73, Micro Chips co., USA), motor turns checking circuitry, small size DC motor for pager(SM1012, Samhong co., Korea) and gear box. Results from experiment meet need for vailable load condition which is require for portable drug delivery system.

• Korean Chemical Engineering Research
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• v.54 no.1
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• pp.108-113
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• 2016

A miniaturized lab-scale Cu plating cell for the metallization of electronic devices was fabricated and its deposit uniformity and profile were investigated. The plating cell was composed of a polypropylene bath, an electrolyte ejection nozzle which is connected to a circulation pump. In deposit uniformity evaluation, thicker deposit was found on the bottom and sides of substrate, indicating the spatial variation of deposit thickness was governed by the tertiary current distribution which is related to $Cu^{2+}$ transport. The surface morphology of Cu deposit inside photo-resist pattern was controlled by organic additives in the electrolyte as it led to the flatter top surface compared to convex surface which was observed in the deposit grown without organic additives.

• Journal of Biomedical Engineering Research
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• v.24 no.1
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• pp.45-53
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• 2003

Based on the 4-compartmental pharmacokinetic model developed in PART1, target-controlled infusion(TCI) pump system was designed and evaluated. The TCI system consists of digital board including microcontroller and digital signal process(DSP), analog board, motor-driven actuator, user friendly interface, power management and controller. It provides two modes according to the drugs: plasma target concentration and effect target concentration. Anaesthetist controls the depth of anaesthesia for patients by adjusting the required concentration to maintain both plasma and effect site in drug concentration. The data estimated in DSP include infusion rate, initial load dose, and rotation number of motor encoder. During TCI operation, plasma concentration. effect site concentration, awaken concentration, context-sensitive decrement time and system error information are displayed in real time. Li-ion battery guarantees above 2 hours without power line failure. For high reliability of the system, two microprocessors were used to perform independent functions for both pharmacokinetic algorithm and motor control strategy.

• Journal of Biomedical Engineering Research
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• v.12 no.1
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• pp.29-34
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• 1991

Ventricular assist device(VAD) has been clinically applied as a temporary circulatory sup- porting system in the patients with severe heart failure, but small sized VAD for infant is not available. The purpose of tilis paper is to introdIAce small sized VAD and presents the result of in vitro test. Sejong VAD is diaphragmatic type of pneumatic pump and stroke volume is 11cc. Cardiac outputs of the Sejong VAD were measured by overflow tank under variable conditions of driving parameters. The cardiac output was 1.3 1/min at the heart rate of 120 per minute, left atrial pressure of $15cmH_2O$, percent systole of 43%, driving pressure of 240 mmHg, vacuum pressure of -40 mmHg, and mean aortic pressure of 70 mmHg. No mechanical problem was developed during the continuous in vitro test for 3 months.

• Journal of Biomedical Engineering Research
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• v.3 no.1
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• pp.43-48
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• 1982

Ventricular assist device(VAD) has been clinically applied as a temporary circulatory sup- porting system in the patients with severe heart failure, but small sized VAD for infant is not available. The purpose of this paper is to introduce small sized VAD and presents the result of in vitro test. Sejong VAD is diaphragmatic type of pneumatic pump and stroke volume is 11cc. Cardiac outputs of the Sejong VAD were measured by overflow tank under variable conditions of driving parameters. The cardiac output was 1.3 1/min at the heart rate of 120 per minute, left atrial pressure of 15cmH2O, percent systole of 43%, driving pressure of 240 mmHg, vacuum pressure of -40 mmHg, and mean aortic pressure of 70 mmHg. No mechanical problem was developed during the continuous in vitro test for 3 months.

• Proceedings of the KOSOMBE Conference
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• v.1997 no.11
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• pp.428-431
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• 1997

This study is the basic research on esophageal balloon dialation with automatic detection of the pressure change in the balloon and analysis using personal computer. In conventional method, the esophageal stricture is cured by surgically. Recently, balloon dialation method has been proposed and is popularized. In balloon dialation, detecting esophageal rupture is very important. When using radiological investigation, the leak of contrast medium is very dangerous. In proposed method, the detection of esopageal rupture can be peformed by detecting and analyze the pressure change of dialation balloon. Experimental system is composed of balloon catheter, pressure pump, pressure sensor, A/D converter and PC.

• Journal of Biomedical Engineering Research
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• v.18 no.1
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• pp.51-64
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• 1997

A dynamic model of the Korean total artificial heart(TAH) which contains a brushless DC motor, all of mechanical components, the pump system with integrated variable volume space(WS) and the circulatory system model including the bronchial circulation were established Two different sets of seven differential equations were separately derived for the left and right systolic period of the Korean TAH operation. Throughout the computer simulation, a full-state fEedback optimal controller that minimizes the power consumption of the Korean TAH and drives the end stage velocity of the energy converter to zero was developed based upon the optimal control theory. Robustness of the controller were also analyzed with the dynamic model of the Korean TAH.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.143-146
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• 1996

An adaptive digital filtering of the electroencophalogram(EEG) is a successful way of suppressing mains interference, but it affects some of the frequency components of the signal, an artifact which not be acceptable in some cases of automatic EEG processing. The types of electrical artifact seen on EEG records is described. Those are the EOG and the PVC roller pump noise. And we study the method for cancelling these artifacts. The method does not need the reference channel, and are obtained by cascading the linear predictor and the noise canceller. The simulation results illustrate the performances of the presented method in terms of the capability of interferences suppression.