• Animal Bioscience
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• 제34권3_spc호
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• pp.321-337
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• 2021

The global population has increased with swift urbanization in developing countries, and it is likely to result in a high demand for animal-derived protein-rich foods. Animal farming has been constantly affected by various stressful conditions, which can be categorized into physical, environmental, nutritional, and biological factors. Such conditions could be exacerbated by banning on the use of antibiotics as a growth promoter together with a pandemic situation including, but not limited to, African swine fever, avian influenza, and foot-and-mouth disease. To alleviate these pervasive tension, various immunomodulants have been suggested as alternatives for antibiotics. Various studies have investigated how stressors (i.e., imbalanced nutrition, dysbiosis, and disease) could negatively affect nutritional physiology in chickens. Importantly, the immune system is critical for host protective activity against pathogens, but at the same time excessive immune responses negatively affect its productivity. Yet, comprehensive review articles addressing the impact of such stress factors on the immune system of chickens are scarce. In this review, we categorize these stressors and their effects on the immune system of chickens and attempt to provide immunomodulants which can be a solution to the aforementioned problems facing the chicken industry.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2001년도 ICCAS
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• pp.115.1-115
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• 2001

According as many people use a computer newly, damage of computer virus and hacking is rapidly increasing by the crucial users. A computer virus is one of program on computer and has abilities of self reproduction and destruction like a virus of biology. And hacking is to rob a person´s data in a intruded computer and to delete data in a person´s computer from the outside. To block hacking that is intrusion of a person´s computer and the computer virus that destroys data, a study for intrusion-detection of system and virus detection using a biological immune system is in progress. In this paper, we make a mood of positive selection and negative selection of self-recognition process that is ability of ...

• 대한전기학회논문지:시스템및제어부문D
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• 제52권8호
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• pp.471-481
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• 2003

The acts of biological immune system are similar to the navigation for autonomous mobile robots under dynamically changing environments. In recent years, many researchers have studied navigation algorithms using artificial immune networks. Conventional artificial immune algorithms consist of an obstacle-avoidance behavior and a goal-reaching behavior. To select a proper action, the navigation algorithm should combine the obstacle-avoidance behavior with the goal-reaching behavior. In this paper, the neural network is employed to combine the behaviors. The neural network is trained with the surrounding information. the outputs of the neural network are proper combinational weights of the behaviors in real-time. Also, a velocity control algorithm is constructed with the artificial immune network. Through a simulation study and experimental results for a autonomous mobile robot, we have shown the validity of the proposed navigation algorithm.

• 한국지능시스템학회논문지
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• 제11권2호
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• pp.127-131
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• 2001

생체 면역시스템은 바이러스나 병원균 등의 외부 침입자로부터 자신을 보호한다. 본 논문에서는 이러한 기능을 컴퓨터 면역시스템에 적용하기 위하여 생체 면역시스템의 기본 요소인 T세포를 모델링 하였다. 모델링한 T세포는 MHC 인식부와 항원 인식부를 가지고 있으며, 매칭을 통하여 컴퓨터내의 랜덤 파일로부터 자기 파일과 비자기 파일을 구분할 수 있다. 모델링한 T세포의 유효성을 보이기 위해서 컴퓨터 바이러스의 문제에 적용하여 자기-비자기 구분이 가능함을 보인다.

• 전자공학회논문지CI
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• 제41권4호
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• pp.51-58
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• 2004

본 논문에서는 fault tolerant 하드웨어에서 가장 기본이 되는 온라인 하드웨어 테스트 시스템 구현을 위하여 새로운 인공면역 알고리즘을 제안한다. 인공 면역 알고리즘은 알려진 자기(self) 정보만을 이용하여 항체 즉 tolerance condition을 가장 최적으로 생성하는 알고리즘이다. 이를 위하여 본 논문에서는 생체 면역 시스템의 중요한 원리인 antibody diversity 원리를 적용한 새로운 tolerance condition 생성 알고리즘을 제안한다. 또한 생체 면역 시스템에서의 중요한 세포인 APC (Antigen Presenting Cell)를 Quine-McCluskey 방법으로 구현한 후 유전자 알고리즘을 통해 tolerance condition을 자동 생성하는 알고리즘을 구현한다. 이렇게 제안된 알고리즘은 FSM(Finite State Machine)의 가장 전형적인 예인 십진카운터에 적용한 후 컴퓨터 모의 실험을 통해 그 성능을 확인한다.

• Toxicological Research
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• 제30권2호
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• pp.77-81
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• 2014

In contrast to animals, plants do not have a circulatory system as well as mobile immune cells that allow them to protect themselves against pathogens. Instead, plants exclusively depend on the innate immune system to defend against pathogens. As typically observed in the animal innate immunity, plant immune responses are composed of pathogen detection, defense signaling which includes transcriptional reprogramming, and secretion of antimicrobial compounds. Although knowledge on recognition and subsequent signaling of pathogen-derived molecules called elicitors is now expanding, the mechanisms of how these immune molecules are excreted are yet poorly understood. Therefore, current understandings of how plants secrete defense products especially via exocytosis will be discussed in this review.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 하계학술대회 논문집 G
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• pp.3036-3038
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• 1999

The conventional structure for an action selector of an Autonomous Mobile Robot (AMR) has been criticized for a repeated action. To overcome this problem recently many researches have been focused on the reactive planning systems such as the biological immune system. In this paper, we propose a learning aritificial immune network, the learning method is to use Genetic Algorithm (GA). The computer simulation show that the usefulness of the learning immune network.

• BMB Reports
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• 제55권6호
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• pp.259-266
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• 2022

Recent studies have revealed that the immune system plays a critical role in various physiological processes beyond its classical pathogen control activity. Even under a sterile condition, various cells and tissues can utilize the immune system to meet a specific demand for proper physiological functions. Particularly, a strong link between immunity and metabolism has been identified. Studies have identified the reciprocal regulation between these two systems. For example, immune signals can regulate metabolism, and metabolism (cellular or systemic) can regulate immunity. In this review, we will summarize recent findings on this reciprocal regulation between immunity and metabolism, and discuss potential biological rules behind this interaction with integrative perspectives.

• 전자공학회논문지CI
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• 제42권5호
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• pp.59-68
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• 2005

본 논문에서는 하드웨어 오류 검출을 위하여 공생 진화(symbiotic evolution)에 기반을 둔 새로운 immunotronic 알고리즘을 제안한다. 면역학(immunology)과 전자공학(Electronics)을 결합한 immunotronic 시스템에서 가장 중요한 점은 포용 조건 (tolerance condition)을 생성하는 방식이다. 여기서 포용 조건 생성은 생체 면역 시스템에서의 항체 생성을 의미한다. 본 논문에서는 생체 면역 시스템에서 매우 중요한 개념인 항체의 다양성 원리(principle of antibody diversity)를 포용 조건 생성에 적용한 후 공생 진화를 통하여 이를 구현한다. 공생 진화는 기존의 유전자 알고리즘(standard genetic algorithm, SGA)에 비해서 더욱 더 생체 면역 시스템이 항체를 생성하는 방식과 유사하며 이러한 방식은 이전의 immunotronic 방식에 비해서 더 향상된 비자기 검출 율을 보여 준다. 이렇게 제안된 알고리즘을 FSM(Finite State Machine)의 가장 전형적인 예인 십진 카운터와 MCNC benchmark FSM에 적용한 후 컴퓨터 모의 실험을 통해 그 성능을 확인한다.

• BMB Reports
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• 제55권10호
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• pp.473-480
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• 2022

Neutrophils, the most abundant innate immune cells, play essential roles in the innate immune system. As key innate immune cells, neutrophils detect intrusion of pathogens and initiate immune cascades with their functions; swarming (arresting), cytokine production, degranulation, phagocytosis, and projection of neutrophil extracellular trap. Because of their short lifespan and consumption during immune response, neutrophils need to be generated consistently, and generation of newborn neutrophils (granulopoiesis) should fulfill the environmental/systemic demands for training in cases of infection. Accumulating evidence suggests that neutrophils also play important roles in the regulation of adaptive immunity. Neutrophil-mediated immune responses end with apoptosis of the cells, and proper phagocytosis of the apoptotic body (efferocytosis) is crucial for initial and post resolution by producing tolerogenic innate/adaptive immune cells. However, inflammatory cues can impair these cascades, resulting in systemic immune activation; necrotic/pyroptotic neutrophil bodies can aggravate the excessive inflammation, increasing inflammatory macrophage and dendritic cell activation and subsequent T_H1/T_H17 responses contributing to the regulation of the pathogenesis of autoimmune disease. In this review, we briefly introduce recent studies of neutrophil function as players of immune response.