• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.7
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• pp.4310-4317
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• 2014

The HACCP (Hazard Analysis Critical Control Point) system was applied to Handmade Rice Cakes. The main ingredients of rice cakes, work facilities and workers were provided from the KB company located in Seogye-dong Yongsan-gu, Seoul between September 12, 2012 and February 13, 2013. The manufacturing process chart was prepared by referring to the manufacturing process of rice cake manufacturers in general. Microbiological hazard analysis of the raw materials and after the steaming process of rice-cakes showed a safe result. On the other hand, the microorganism test on the manufacturing environment and workers suggested that the microbiological hazard can be reduced through systematic cleaning and disinfection, accompanied by improved personal hygiene based on hygienic education for workers on the management of microorganisms in the working area.

• Journal of the Korea Society for Simulation
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• v.33 no.3
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• pp.13-26
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• 2024

The CBRN(Chemical, Biological, Radiological, and Nuclear) hazard prediction model is a system that supports commanders in making better decisions by creating contamination distribution and damage prediction areas based on the weapons used, terrain, and weather information in the events of biochemical and radiological accidents. NBC_RAMS(Nuclear, Biological and Chemical Reporting And Modeling S/W System) developed by ADD (Agency for Defense Development) is used not only supporting for decision making plan for various military operations and exercises but also for post analyzing CBRN related events. With the NBC_RAMS's core engine, we introduced a CBR hazard assessment scenario analysis system that can generate contaminant distribution prediction results reflecting various CBR scenarios, and described how to apply it in specific purposes in terms of input information, meteorological data, land data with land coverage and DEM, and building data with pologon form. As a practical use case, a technology development case is addressed that tracks the origin location of contaminant source with artificial intelligence and a technology that selects the optimal location of a CBR detection sensor with score data by analyzing large amounts of data generated using the CBRN scenario analysis system. Through this system, it is possible to generate AI-specialized CBRN related to training and analysis data and support planning of operation and exercise by predicting battle field.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.1
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• pp.438-444
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• 2015

The aim of this research was to apply a HACCP system (Hazard Analysis Critical Control Point) to fermented milk. The main ingredients of fermented milk, work facilities and workers were obtained from a company named YD, which is located in Seobuk-gu, Cheonan-si between November 5 2013 to April 13, 2014. A manufacturing process chart was prepared by referring to the manufacturing process of fermented milk manufacturers in common. The manufacturing process chart was made with raw materials; Raw milk, High Fructose Corn Syrup, Oligosaccharides, Lactic Acid bacteria and Subsidiary ingredients, Warehousing of packaging materials, Storage, Input, Preheating, Mixing, Homogeneity, Sterilization, Precooling, Culture, Filtration, In packaging, Out packaging, Storage, and Consignment, as listed Table 1. The results of the microbiological hazard analysis on the raw materials was safe after sterilization($90^{\circ}C{\pm}5^{\circ}C$, $35{\pm}3min.$) On the other hand,a microorganism test of an environment and workers suggested that the microbiological hazard should be reduced through systematic cleaning and disinfection accompanied by improved personal hygiene based on hygienic education on workers and the management of microorganisms in air.

• Journal of agriculture & life science
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• v.44 no.6
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• pp.121-132
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• 2010

Soybean farms in Changnyeong were selected for hazard analysis to establish the Good Agricultural Practices (GAP) model of soybean, and physical, chemical(heavy metal) and biological(sanitary indications, foodborne pathogens) hazard analysis for cultivation environment (soil, water) was carried out. First, bow which is able to be mixed in soil and water was confirmed as physical hazard. Levels (Cd:0.01~0.103, Cu:0.001~6.036, As:0.006~3.045, Hg:ND~0.041, Pb:0.003~3.952, $Cr^{+6}$:0.007~0.496, Zn:0.001~66.500, Ni:0.003~18.010) of heavy metals in soil and water were appropriate for GAP criteria. In biological hazard, APC and coliform in soil were detected at the levels of $6.0{\pm}0.3$ and $3.6{\pm}1.6$ log CFU/g, and levels of water were $3.5{\pm}0.7$ and $1.9{\pm}0.7$ log CFU/mL, while E. coli wasn't detected in all sample. However, coliform in water wasn't appropriate for criteria, and E. coli O157 was detected about 22% in some farms, so it needs ways to prevent contamination by human and animals excrements. In conclusion, it needs proper management to prevent cross-contamination of hazards although physical and chemical hazard level were appropriate for GAP criteria while biological hazard wasn't.

• 대한예방의학회:학술대회논문집
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• 2003.04a
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• pp.30-37
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• 2003

o Cohort study became the major approach to study of chronic diseases such as CVD and cancer o Cohort can be population-based or volunteer-based o Types of be population-be categorized by source population and selection mechanism o More and more cohort studies involve biological specimens, such as blood, urine, toenail, cheek cells, etc. o Multi-center and multi-national collaboration is an effective way to increase sample size. o Current statistical method typically use time-to-event analysis by Cox proportional hazard model.

• Journal of Biomedical Engineering Research
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• v.45 no.4
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• pp.187-194
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• 2024

In this study, text network analysis was performed using PMS(Post-Marketing Surveillance) data collected from the FDA's MAUDE(Manufacturer and User Facility Device Experience) database to evaluate the usability of the central monitoring system. Based on the data reported from January 1, 2021 to June 30, 2023, keywords related to the central monitoring system were extracted and visualized with a text network. By analyzing the eigenvector centrality of text network, we identified hazards and types of hazardous situations related to usability of the central monitoring system. Eigenvector centrality was chosen because it is relatively more accurate than other centralities. In addition, we derived an appropriate use scenario to evaluate the usability of the central monitoring system. The research results provide more realistic and valuable insights through data derived based on actual adverse event cases, and are expected to contribute to improving safety and reliability by identifying user requirements for improved usability and reducing use errors in the future.

• Korean Journal of Organic Agriculture
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• v.27 no.2
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• pp.193-204
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• 2019

The aim of this study was to investigate the effect of hazard analysis and critical control point (HACCP) system application on microbial hazard management levels of pork and manufacturing environments. In this study, we compared and analyzed microbial levels in raw meat, finished products, and manufacturing environments (knifes, gloves, and cutting boards) of HACCP and non-HACCP meat markets. In addition, we surveyed the hygiene statuses of HACCP and non-HACCP meat markets. The general bacterial counts in raw meat, finished products, and manufacturing environments were lower in HACCP meat markets than in non-HACCP meat markets. Particularly, non-HACCP meat markets exceeded the Ministry of Food and Drug Safety microbiological recommendation criteria for raw meats (8.7%) and finished products (8.7%). Escherichia coli and coliform counts in raw meat, finished products, and manufacturing environments were also lower in HACCP meat markets than in non-HACCP meat markets. The biological hazard levels of finished products from non-HACCP meat markets were affected by raw meat and manufacturing environment. Moreover, according to questionnaire survey results, personal hygiene, manufacturing environment, and facility standards were lower in non-HACCP meat markets than in HACCP meat markets. Implementation of HACCP at meat markets is expected to minimize food poisoning by reducing the biological hazard levels to provide safe livestock products to consumers.

• Culinary science and hospitality research
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• v.23 no.6
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• pp.20-26
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• 2017

To guarantee the safety of rice cake production, the Hazard Analysis Critical Control Points system was applied to the production process. The purpose of this study was to analyze the microbiological hazards of the manufacture of rice cakes, and establish critical limits in the process of the manufacturing rice cakes. To control the microbiological hazards, the sterilization process was set to a critical limit. The process of manufacturing rice cakes can reduce these microbiological hazards during the steaming process. A microorganism test for each specimen was conducted three times and compared with before and after steaming processes. The finished product was conducted by microbiology experiment and the validity of the steaming process was verified. The results were determined to be capable of reducing the biological element of Critical Control Point via the steaming process. Microbiology such as aerobic plate count, coliform, Escherichia coli(E. coli), Listeria monocytogenes, Enterohemorrhagic E. coli, Salmonella spp., Bacillus cereus, Staphylococcus aureus and Clostridium perfringens was evaluated by the experimental method of Korean Food Standards Codex. Aerobic plate count was reduced by steaming process, and no microorganism were detected. All rice cakes in the finished product were judged to be safe for both the Escherichia coli and general bacteria. In conclusion, it suggested that a HACCP plan was necessary for management standard and systematic approach in the establishment of critical limit, problem resolution, verification method, education, and records management. Based on this study, it is intended to provide a baseline for improving quality control standards and improving hygiene levels for small manufacturers.

• Journal of Environmental Health Sciences
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• v.39 no.3
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• pp.268-278
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• 2013

Objectives: The purpose of this study was to apply the Hazard Analysis Critical Control Point (HACCP) system to the production of seasoned laver products. The hazard analysis examined microbial evaluations and developed a HACCP management plan through the heating process. Methods: In this study we chose three companies and performed the analysis thrice. During this study, general bacteria along with other food poisoning bacteria such as Salmonella spp., Staphylococcus aureus, Listeria monocytogenes, Bacillus cereus, E.coil, O157:H7, Vibrio parahaemolyticus, were studied at varying temperatures from 100 to $300^{\circ}C$. Results: The presence of general bacteria was detected in raw laver in the samples analyzed from all the three companies, and the number ranged from $10^5-10^7$. Bacillus cereus was detected in samples from only two of the three companies analyzed. However, Salmonella spp., Staphylococcus aureus, Listeria monocytogenes, E.coil, O157:H7, and Vibrio parahaemolyticus were all negative. General bacteria was reduced to $10^5$ after being subjected to temperatures of $100-250^{\circ}C$, but heating to over $270^{\circ}C$ reduced the number to below $10^3$, and the other microbes such as Bacillus cereus were not detected. Conclusions: In conclusion, the heating process ($270-280^{\circ}C$) along with RPM of 100-1200 were identified as CCP to reduce biological hazards.

• Environmental Analysis Health and Toxicology
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• v.2 no.1_2
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• pp.43-53
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• 1987

Among the environmental toxic metals, cadmium and lead compounds are very hazard for human health because these may affect the biological function of human body and furthermore enhance the cause of various disease. In recent years, as the view of environmental toxicology, the combination of toxic metals suffering human health is especially significant cadmium chloride (10 mg/kg P. 0., 1 mg/kg I.P.) and lead acetate (20 mg/kg P.O., 2 mg/kg I.P.) were administered to rats for 4 weeks on alternate days and then examined the effect of these on body weight, tissue weight and also biochemical function in blood and tissue were investigated and comparision of the two experimental groups such as single and combined administration. According to the results of this experiment, accumulation of heavy metals increased and biological metabolic function grew worse but, in tissue, toxic effect decreased by combined administration and intraperitoneal administration was more toxic than per OS.