• Macromolecular Research
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• 제17권6호
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• pp.403-410
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• 2009

Cytotoxicity is a severe problem of cadmium sulfide nanoparticles(CSNPs) for use in biological systems. In the present study, mercaptoacetic acid-coated CSNPs were conjugated with bovine serum albumin (BSA) to improve biocompatibility. The surface properties of the CSNPs and albumin-conjugated CSNPs (ACSNPs) were characterized by XRD, UV, FTIR, EA, TEM and DLS. Human breast cancer cells (KB cells) were then cultured in the presence of the nanoparticles to evaluate the cytotoxicity of CSNPs and ACSNPs. Finally, the fluorescence intensity of the nanoparticles' aqueous solution was examined using a fluorescence spectrometer. The results showed that the cell compatibility and fluorescence intensity of ACSNPs were higher than those of CSNPs. The strongly luminescent features of the biocompatible ACSNPs are promising for use in biological fields such as cellular labeling, intracellular tracking and molecular imaging.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제44회 동계 정기학술대회 초록집
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• pp.107-107
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• 2013

Many nanomaterials are being harnessed as critical components in various systems for biomedical applications including diagnosis, imaging, and drug delivery. Those systems necessitate biocompatibility and low toxcity within effective dose range while achieving enough efficacy. Even though many nanomaterials enjoy successful demonstrations in bioapplications, lack of biocompatibility and high cytotoxicity often become hurdles for practical bioapplications. On the other hand, it is important to achieve enough efficiency based on chemically well-defined systems with efforts to understand mechanism at molecular level. Here, we developvarious biocompatible nanomaterials based on simple procedure using dextran as both reducing agent and surface coating. Dextran is one of the popular biocompatible polymers that have been used for drug delivery and biosensors. Dextran coated nanomaterials showed excellent colloidal stability, flexible surface chemistry for conjugation of bioactive molecules and low cytotoxicity with successful demonstrations in various bioapplications.

• BMB Reports
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• 제49권1호
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• pp.26-36
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• 2016

Emerging trends for cardiac tissue engineering are focused on increasing the biocompatibility and tissue regeneration ability of artificial heart tissue by incorporating various cell sources and bioactive molecules. Although primary cardiomyocytes can be successfully implanted, clinical applications are restricted due to their low survival rates and poor proliferation. To develop successful cardiovascular tissue regeneration systems, new technologies must be introduced to improve myocardial regeneration. Electrospinning is a simple, versatile technique for fabricating nanofibers. Here, we discuss various biodegradable polymers (natural, synthetic, and combinatorial polymers) that can be used for fiber fabrication. We also describe a series of fiber modification methods that can increase cell survival, proliferation, and migration and provide supporting mechanical properties by mimicking micro-environment structures, such as the extracellular matrix (ECM). In addition, the applications and types of nanofiber-based scaffolds for myocardial regeneration are described. Finally, fusion research methods combined with stem cells and scaffolds to improve biocompatibility are discussed. [BMB Reports 2016; 49(1): 26-36]

• Bulletin of the Korean Chemical Society
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• 제33권12호
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• pp.4137-4140
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• 2012

A novel bioabsorbable suture material, poly(glycolide-caprolactone) (PGLCL) monofilament, was prepared by spinning of the PGLCL copolymer. The physical properties, strength retention, biocompatibility, and organism resolvability of the PGLCL monofilament were investigated. The results showed that the knot pull strength of the monofilament was higher than that stated in European Pharmacopoeia. The in vivo retention strength following implantation was 64%, 23%, 7%, and 0% after one, two, three, and four weeks, respectively. Mortality, clinical signs, validation, and sterility tests indicated that all items had passed. Organism resolvability tests showed that the PGLCL monofilament, as a suture, was absorbed within 91 days.

• KSBB Journal
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• 제25권5호
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• pp.409-420
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• 2010

Biopolymer-based materials recently have garnered considerable interest as they can decrease dependency on fossil fuel. Biopolymers are naturally obtainable macromolecules including polysaccharides, polyphenols, polyesters, polyamides, and proteins, that play an important role in biomedical applications such as tissue engineering, regenerative medicine, drug-delivery systems, and biosensors, because of their inherent biocompatibility and biodegradability. However, the insolubility of unmodified biopolymers in most organic solvents has limited the applications of biopolymer-based materials and composites. Ionic liquids (ILs) are good solvents for polar organic, nonpolar organic, inorganic and polymeric compounds. Biopolymers such as cellulose, chitin/chitiosan, silk, and DNA can be fabricated from ILs into films, membranes, fibers, spheres, and molded shapes. Various biopolymer/biopolymer and biopolymer/synthetic polymer composites also can be prepared by co-dissolution of polymers into IL mixtures. Heparin/biopolymer composites are especially of interest in preparing materials with enhanced blood compatibility.

• 한국표면공학회:학술대회논문집
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• 한국표면공학회 2003년도 추계학술발표회초록집
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• pp.136-137
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• 2003

In this study, in order to fabricate sintered dental implant, the effects of HA, Ti and TiN on corrosion and biocompatibility, cell toxicity, osseointegration of electroless Cu-plated and sintered stainless steel implant were investigated using various characteristics. The effects of Ti/TiN/HA coating on the interface activation and surface characteristics of sintered stainless steels(SSS) by electron-beam physical vapor deposition(EB-PVD) method have been studied. Stainless steel compacts containing 2, 4, and 10 wt%Cu were prepared by electroless Cu-plating method which results in the increased homogenization in alloying powder. The specimens were coated with HA, Ti and TiN with few $\mu\textrm{m}$ thickness respectively by EB-PVD method. The microstructures and phase analysis were conducted by using SEM. Biocompatibility were investigated in experimental dog. The corrosion behaviors were investigated using potentiosat in 0.9% NaCl solution and corrosion surface was observed using SEM and XPS.

• 대한치과보존학회:학술대회논문집
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• 대한치과보존학회 2003년도 제120회 추계학술대회 제 5차 한ㆍ일 치과보존학회 공동학술대회
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• pp.592-593
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• 2003

I. Objectives The purpose of this study was to compare in vivo the biocompatibility of new calcium phosphate-based root canal sealers(CAPSEAL I, CAPSEAL II) with another type of commercially available calcium phosphate sealer (Apatite Root Sealer type I, Apatite Root Sealer type II) and zinc oxide-eugenol-based sealer (Pulp Canal Sealer EWT) after implantaion in rat subcutaneous tissue. II. Materials and Methods 64 Sprague-Dawley rats were used. There were five groups of three animals each for experimental period of 1, 2, 4, and 12 weeks. The teflon tubes, 5mm in length with an inner diameter of 1.5mm, were washed with ethanol and distilled weter and autoclaved.(omitted)

• 한국표면공학회지
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• 제39권1호
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• pp.43-48
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• 2006

The oxidation behavior and Biocompatibility of pure Ti and Ti-8Ta-3Nb alloy were studied in dry air atmosphere. The specimens showed that Ti-8Ta-3Nb alloy had higher oxidation resistance than pure Ti at $650^{\circ}C$. Cytotoxicity test also revealed that moderate oxidation treatment lower cell toxicity and Ti-8Ta-3Nb alloy showed better results compared with pure Ti. The weight gains during the oxidation increase rapidly at temperature above $600^{\circ}C$.

• 대한금속재료학회지
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• 제50권9호
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• pp.691-695
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• 2012

Calcium phosphate ceramic composites, consisting of hydroxyapatite(HA) and tricalcium phosphate (TCP), were fabricated by solid state sintering in order to investigate the effect of their initial compositions on microstructural evolutions and biocompatibility. All the sintered calcium phosphate ceramics exhibited almost full densification, while the grain growth of the composites increased with an increasing TCP content in the green body. The TCP phase transformed into a Ca-deficient HA phase during sintering via the diffusion of calcium ions from the HA phase into the TCP phase. The phases formed in the composites significantly affected the biocompatibility of the composites. The HA-matrix ceramic composites with TCP had a better cellular response than the pure HA ceramics, presumably due to the newly formed Ca-deficient HA.

• Bulletin of the Korean Chemical Society
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• 제8권3호
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• pp.158-161
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• 1987

A Series of hydrophilic-hydrophobic copolymeric surfaces of 2-hydroxyethyl methacrylate (HEMA) and various alkyl methacrylate (RMA) have been prepared by in-situ solution copolymerization using a redox radical initiator. Contact angles of various probing fluids on the polymeric surfaces were determined in air (hydrophobic environment) and under water (hydrophilic environment). From contact angle data, the dispersive interaction contribution (${\gamma}^d_s$) and the polar contribution (${\gamma}^p_s$) to the total surface free energy (${\gamma}^d_s$) and interfacial energetic quantities (e.g., water-polymer, liquid-polymer interface, etc.) were estimated by surface and interface physicochemical theory. From the comparison of surface energetic components between hydrophobic and hydrophilic media, it is found that surface and interface energetic components of polymeric surface as a representative low-energy surface are highly dependent on environmental fluids. Also, from the correlation between interfacial energetic results and surface energetic criterion of biocompatibility, we found that HEMA/BMA, HEMA/HMA copolymer systems are in the region of biocompatibility.