Browse > Article

Albumin-conjugated Cadmium Sulfide Nanoparticles and their Interaction with KB Cells  

Selim, K.M. Kamruzzaman (Department a Polymer Science, Kyungpook National University)
Kang, Inn-Kyu (Department Polymer Science, Kyungpook National University)
Guo, Haiqing (College of Chemistry and Molecular Engineering, Peking University)
Publication Information
Macromolecular Research / v.17, no.6, 2009 , pp. 403-410 More about this Journal
Abstract
Cytotoxicity is a severe problem of cadmium sulfide nanoparticles(CSNPs) for use in biological systems. In the present study, mercaptoacetic acid-coated CSNPs were conjugated with bovine serum albumin (BSA) to improve biocompatibility. The surface properties of the CSNPs and albumin-conjugated CSNPs (ACSNPs) were characterized by XRD, UV, FTIR, EA, TEM and DLS. Human breast cancer cells (KB cells) were then cultured in the presence of the nanoparticles to evaluate the cytotoxicity of CSNPs and ACSNPs. Finally, the fluorescence intensity of the nanoparticles' aqueous solution was examined using a fluorescence spectrometer. The results showed that the cell compatibility and fluorescence intensity of ACSNPs were higher than those of CSNPs. The strongly luminescent features of the biocompatible ACSNPs are promising for use in biological fields such as cellular labeling, intracellular tracking and molecular imaging.
Keywords
cadmium sulfide nanoparticles; bovine serum albumin; biocompatibility; fluorescence intensity;
Citations & Related Records

Times Cited By Web Of Science : 2  (Related Records In Web of Science)
Times Cited By SCOPUS : 3
연도 인용수 순위
1 L. Chen, J. Zhu, Q. Li, S. Chen, and Y. Wang, Eur. Polym. J., 43, 4593 (2007)   DOI   ScienceOn
2 Z. Li, K. Wang, W. Tan, J. Li, Z. Fu, C. Ma, H. Li, X. He, and J. Liu, Anal. Biochem., 354, 169 (2006)   DOI   ScienceOn
3 M. E. Akerman, W. C. W. Chan, P. Laakkonen, S. N. Bhatia, and E. Ruoslahti, Proc. Natl. Acad. Sci. USA, 99, 12617 (2002)   DOI   ScienceOn
4 W. C. W. Chan and S. Nie, Science, 281, 2016 (1998)   DOI   PUBMED
5 C. C. Chen, C. P. Yet, H. N. Wang, and C. Y. Chao, Langmuir, 15, 6845 (1999)   DOI   ScienceOn
6 S. Nayar, A. Sinha, S. Das, S. K. Das, and P. R. Rao, J. Mater. Sci. Lett., 20, 2099 (2001)   DOI   ScienceOn
7 J. G Liang, X. P. Ai, Z. K He, H. Y Xie, and D. W Pang, Mater. Lett., 59, 2778 (2005)   DOI   ScienceOn
8 J. S. Bae, E. J. Seo, and I. K. Kang, Biomaterials, 20, 529 (1999)   DOI   ScienceOn
9 K. S. Chow, E. Khor, and A. C. A. Wan, J. Polym. Res., 8, 27 (2001)   DOI
10 L. E. Brus, J. Chem. Phys., 80, 4403 (1984)   DOI
11 N. Zhu, A. Zhang, P. He, and Y. Fang, Analyst, 128, 260 (2003)   DOI   ScienceOn
12 I. K. Kang, B. K. Kwon, J. H. Lee, and H. B. Lee, Biomaterials, 14, 787 (1993)   DOI   ScienceOn
13 D. Maysinger, J. Lovric, A. Eisenberg, and R. Savic, Eur. J. Pharm. Biopharm., 65, 270 (2007)   DOI   ScienceOn
14 A. C. Samia, X. Chen, and C. Burda, J. Am. Chem. Soc., 125, 15736 (2003)   DOI   ScienceOn
15 C. W. Liua and H. T. Chang, Open. Anal. Chem. J., 1, 1 (2007)
16 N. V. Smith, X-Ray Powder Data Files, American Society for Testing and Materials, Philadelphia, 1967
17 H. M. Chen, X. F. Huang, L. Xu, J. Xu, K. J. Chen, and D. Feng, Superlatt. Microstruc., 27, 1 (2000)   DOI   ScienceOn
18 A. L. Pan, J. G. Ma, X. Z. Yan, and B. S. Zou, J. Phys. Condens. Matter., 16, 3229 (2004)   DOI   ScienceOn
19 L. Spanhel, M. Haase, H. Weller, and A. Henglein, J. Am. Chem. Soc., 109, 5649 (1987)   DOI
20 K. I. Hanaki, A. Momo, T. Oku, A. Komoto, S. Maenosono, Y. Yamaguchi, and K. Yamamoto, Biochem. Biophys. Res. Commun., 302, 496 (2003)   DOI   ScienceOn
21 M. Noble, M. Mayer-Proschel, and C. Proschel, Antioxid. Redox Signal, 7, 1456 (2005)   DOI   ScienceOn
22 L. Y. Wang, Y. Y. Zhou, L. Wang, C. Q. Zhu, Y. X. Li, and F. Gao, Anal. Chem. Acta, 466, 87 (2002)   DOI   ScienceOn
23 A. Pucci, M. Boccia, F. Galembeck, C. A. P. Leite, N. Tirelli, and G. Ruggeri, Reactive & Functional Polym., 68, 1144 (2008)   DOI   ScienceOn
24 Y. L. Wu, C. S. Lim, S. Fu, A. I. Y. Tok, H. M. Lau, F. Y. C. Boey, and X. T. Zeng, Nanotechnology, 18, 1 (2007)
25 A. S. Blum, C. M. Soto, C. D. Wilson, J. L. Whitley, M. H. Moore, K. E. Sapsford, T. Lin, A. Chatterji, J. E. Johnson, and B. R. Ratna, Nanotechnology, 17, 5073 (2006)   DOI   ScienceOn
26 A. M. Derfus, W. C. W. Chan, and S. N. Bhatia, Nano Lett., 4, 11 (2004)   DOI   ScienceOn
27 S. K. Haram, B. M. Quinn, and A. J. Bard, J. Am. Chem. Soc., 123, 8860 (2001)   DOI   ScienceOn
28 W. J. Parak, T. Pellegrino, and C. Plank, Nanotechnology, 16, 9 (2005)   DOI   ScienceOn
29 Y. C. Kuo, Q. Wang, C. Ruengruglikit, H. Yu, and Q. Huang, J. Phys. Chem. C, 112, 4818 (2008)
30 C. Jiang, S. Xu, D. Yang, F. Zhang, and W. Wang, Luminescence, 22, 430 (2007)   DOI   ScienceOn
31 M. J. Meziani, P. Pathak, B. A. Harruff, R. Hurezeanu, and Y. P. Sun, Langmuir, 21, 2008 (2005)   DOI   ScienceOn
32 T. Jamieson, R. Bakhshi, D. Petrova, R. Pocock, M. Imani, and A. M. Seifalian, Biomaterials, 28, 4717 (2007)   DOI   ScienceOn
33 K. M. K. Selim, J. H. Lee, S. J. Kim, Z. Xing, Y. Chang, H. Guo, and I. K. Kang, Macromol. Res., 14, 646 (2006)
34 A. M. Smith, X. Gao, and S. Nie, Photochem. Photobiol., 80, 377 (2004)
35 N. Gomez, J. O. Winter, F. Shieh, A. E. Saunders, B. A. Korgel, and C. E. Schmidt, Talanta, 67, 462 (2005)   DOI   ScienceOn
36 G. P. Mitchell, C. A. Mirkin, and R. L. Letsinger, J. Am. Chem. Soc., 121, 8122 (1999)   DOI   ScienceOn
37 P. S. Chowdhury, P. Ghosh, and A. Patra, J. Lumines., 124, 327 (2007)   DOI   ScienceOn
38 Q. Wang, Y. C. Kuo, Y. Wang, G. Shin, C. Ruengruglikit, and Q. Huang, J. Phys. Chem. B, 110, 16860 (2006)   DOI   ScienceOn
39 J. Lovric, S. J. Cho, F. M. Winnik, and D. Maysinger, Chem. Biol., 12, 1227 (2005)   DOI   ScienceOn