• 대한의용생체공학회:의공학회지
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• 제44권4호
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• pp.225-241
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• 2023

The study empirically analyzed the differences in industry distribution and innovation activity performance in the metropolitan and non-metropolitan areas of Korea's bio companies, which are highlighted as future growth engines. The main innovation activities of the bio industry, which are focused on science and technology and expressed with high uncertainty, were analyzed, centering on human resources, technology cooperation, and investment promotion. As a result of the analysis, the biomedical industry in the metropolitan area was found to have a high proportion, and bio foods, bio-based chemicals, and energy industries in the non-metropolitan area, respectively. Moreover, the innovation activity performances differed between the two regions. In particular, the notable characteristics included human resources, investment promotion, and technical cooperation with medical institutions in the metropolitan area with a high proportion of biomedical industries, and technology personnel exchange and cooperation with private research institutions in the non-metropolitan area, which has a high proportion of bio foods, bio-based chemicals, and energy industries. This study is significant in that it is the first study to compare and analyze the performance of innovative activities based on the distribution of industries in the bio-industry, focusing on human resources, technology cooperation, and investment promotion. In addition, after investigating the distribution status and competitiveness of the domestic bio-industry by region, it will analyze the status and characteristics of the domestic bio-industry and present policy implications to implement relevant promotion policy more efficiently.

• 대한기계학회논문집 C: 기술과 교육
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• 제5권1호
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• pp.23-52
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• 2017

바이오융합 및 의료기기 산업은 의학과 전기, 전자, 기계, 재료 등 공학이 융합되는 다학제간 응용기술 산업분야이다. 바이오 융합 및 의료기기를 이용해 인간의 삶의 질 향상을 목표로 하고 있으며 제품에 대한 인지도와 브랜드 파워가 매우 중요한 산업이다. 그러나, 자본/기술 의존형 산업으로 제품의 개발부터 생산까지 소요되어지는 기간이 길고 개별 제품의 시장 규모가 작고 수명주기가 짧다고 할 수 있다. 따라서 연구개발에 대한 지속적인 투자가 요구되어지는 산업으로 국가적인 차원에서 바이오벤처 기업들을 위해 기술적 지원, 제도적 뒷받침, 인력 양성 등의 산업생태계 전반을 활성화하고자 하는 노력이 필요하다.

• 한국해양바이오학회지
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• 제13권1호
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• pp.20-27
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• 2021

Ironically, marine bioresource production in Chungnam Province is the second-largest in the country. The province's marine bioresource production puts its lack of a marine bioindustry in the spotlight despite the region's favorable conditions to produce representative value-added and (ultra) high value-added products such as neutraceutical and/or pharmaceutical function. This juxtaposition is to be expected, as there are no institutions for training professionals in the field of marine biology or in the fisheries industry in the West Sea area. The unique features of the region require individuals with specialized training who have been educated in accordance with regional development and the specificity of the region. Recently, however, a plan has been initiated at the national level to foster the growth of the marine biology industry in the Chungnam Province on Korea's west coast. This plan includes increasing funds to the marine biology market to 1.2 trillion by 2030. If the Chungnam region wants to successfully revitalize the marine biology industry and put the increased funds to efficient use, it must first establish various research and (business) development (R&(B)D) plans regarding local marine biology infrastructures and marine biology programs at local universities. It must also focus on training specialists to protect, maintain, and develop the region's marine bio-resources to increase the growth of the region's bioindustry.

• Advances in Traditional Medicine
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• 제10권4호
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• pp.288-293
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• 2010

Lindera erythrocarpa Makino (LE) is widely distributed on Jeju Island, where it has been used for various traditional therapies. Effects of a crude extract of LE were examined in rats with obesity induced by a high-fat diet (HFD). Anti-obesity effects were followed in rats receiving orally administered vehicle, 100mg/kg extract, or 250 mg/kg LE extract, for 56 days. LE extract (250 mg/kg) suppressed increases in body weight and epididymal fat, with amelioration of fatty changes in the liver. Additionally, serum levels of alanine aminotransferase, aspartate aminotransferase, and total cholesterol were significantly decreased compared with those of vehicle-treated groups (p < 0.05). These results suggest that oral administration of LE extract reduced rat obesity induced by HFD, possibly through the reduction of fat accumulation.

• 기술혁신학회지
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• 제16권3호
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• pp.839-860
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• 2013

본 연구는 대표적인 지식기반산업인 생명의료산업의 첨단의료복합단지 조성정책을 대상으로 하여 정책형성과정을 분석하고자 한다. 첨단의료복합단지는 다양한 분석요소와 속성들을 내포하고 있기 때문에 국내외 정치적 경제적 사회적 환경변화에 따른 정책형성과정을 Kingdon(1984, 1995, 2003)의 '정책흐름모형'을 적용하여 분석하였다. 2005년 8월 의료산업선진화위원회가 출범한 시기에서 2008년 3월 '첨단의료복합단지특별법'이 제정되기까지 정책형성 과정을 대상으로 하였다. 분석결과 첨단 의료산업분야의 정책형성 과정은 여러 요인들과 정책흐름들이 간여되어 있으며, 특히 정책의제가 정부의제로 공식화되는 법제화의 과정은 정책선도자 뿐만 아니라 다양한 이해관계자의 역동적인 역할에 의하여 진행된다는 점을 조명하였다.

• Biomolecules & Therapeutics
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• 제31권3호
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• pp.276-284
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• 2023

Sinapic acid (SA) is a phenolic acid that is widely distributed in fruits and vegetables, which has various bioactivities, such as antidiabetic, anticancer and anti-inflammatory functions. Over-activated microglial is involved in the development progress of neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. The objective of this study was to investigate the effect of SA in microglia neuroinflammation models. Our results demonstrated that SA inhibited secretion of the nitric oxide (NO) and interleukin (IL)-6, reduced the expression of inducible nitric oxide synthase (iNOS) and enhanced the release of IL-10 in a dose-dependent manner. Besides, our further investigation revealed that SA attenuated the phosphorylation of AKT and MAPK cascades in LPS-induced microglia. Consistently, oral administration of SA in mouse regulated the production of inflammation-related cytokines and also suppressed the phosphorylation of MAPK cascades and AKT in the mouse cerebral cortex. These results suggested that SA may be a possible therapy candidate for anti-inflammatory activity by targeting the AKT/MAPK signaling pathway.

• Journal of Microbiology and Biotechnology
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• 제12권4호
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• pp.603-609
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• 2002

DFA IV is di-D-fructose-2,6':6,2'-dianhydride, consisting of two fructose residues. It can be enzymatically synthesized from levan by levan fructotransferase, and can be used for mineral absorption. Understanding of the structure and composition of levan is important to obtain high-level production of DFA IV. A bacterial strain, Pseudomonas aurantiaca 5-4380, was identified to produce low-branched levan, and the levansucrase gene (lsch) from this bacterium was found to be composed of 1,275 Up coding for a protein of 424 amino acids, with an estimated molecular weight of 47 kDa. The bacterial levansucrase gene was expressed in Escherichia coli DH5${\alpha}$ by its own promoter and lac promoter. The recombinant levansucrase was produced in soluble form with 170U of levansucrase activity from 1-ml E. coii culture broth. The expressed enzyme from the clone showed similar biochemical properties, such as size of active levansucrase, degree of branching, and optimum temperature, with P.aurantiaca 5-4380 levansucrase.

• 대한의용생체공학회:의공학회지
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• 제31권5호
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• pp.375-384
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• 2010

The purpose of this study is to determine whether there is a correlation between the segmental bio-impedance measurement with the frequency modulations and the life-style disease of obesity. An obesity is not simply the factor for estimating the life-style disease of obesity, but also the risk factor occurring. There are many methods (BMI, WHR, Waist, CT, DEXA, BIA, etc.) for measuring a degree of obesity; the bio-impedance measurement is more economic and more effective than others. The physical examination, the blood test, the medical imaging diagnosis and the bio-impedancemeasurementswithmultiple frequencies for each body parts have been conducted for 77 people. The estimated value has been calculated through a segmental bio-impedance model based on multi-frequency that was created to reflect the highest correlation by analyzing correlation with linear regression analysis method for the measured bio-impedance and the risk factors. Then we compared with the clinical diagnosis. In case of high level cholesterol, low HDL-C and high LDL-C for life-style disease, the sensitivity is 80~100%and the specificity is 83~100%. This study has shown conclusively that bio-impedance can be a possible predictor to analyze the disease risk rate of population and individual health maintenance. And also the multi-frequency segmental bio-impedance can be used as early predictor to estimate the life-style disease of obesity.

• 한국산업융합학회 논문집
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• 제25권3호
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• pp.443-449
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• 2022

In this study, in order to improve the disadvantages of the environmental error of the infusion set that performs infusion therapy in the existing clinical practice and to maximize the user's convenience by miniaturizing the existing infusion pump system, the structure of the muscle pump of the human vein was imitated. As a double check valve method, a method for preventing the backflow of fluid and discharging a constant fluid in one direction by external pressure was proposed. The proposed bio-mimic muscle pump uses a check valve that controls the flow of fluid in one direction and a silicone tube with elasticity, and a chamber is constructed. A peristaltic pump for applying intermittent pressure to the tube chamber was constructed using a multi-cam structure roller. In order to verify the performance of the proposed pump, optimization was performed while changing the number of multi-cam rollers and adjusting the speed of the roller driving motor, and the reproducibility of the instantaneous discharge amount and the continuous discharge amount of the pump was compared and tested. The performance of the muscle pump proposed in this study was verified through experiments that it can inject up to 1L of fluid within 12 hours, and that it is possible to inject the fluid with an accuracy of ±0.1ml. Real-time monitoring of the fluid injection volume through the bio-mimic muscle pump proposed in this study not only increases the convenience of the administrator, but also provides a precise fluid administration environment to more patients at a low cost, and additionally applies bubble detection and occlusion detection technology If so, it is believed that a safer medical environment can be provided to patients.

• 한국응용과학기술학회지
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• 제38권6호
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• pp.1433-1444
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• 2021

본 연구는 코로나 시대이후로 가속화된 뷰티분야의 4차 산업들과 융합으로 산업에서 요구되는 실무능력을 교육하기 위한 교육과정 개발을 목적으로 진행되었다. 여러 문헌의 탐색적 조사와 전문가의견을 수렴한 결과 뷰티산업은 앞으로 단일 아이템 또는 서비스 제공이 아닌 의료, 바이오, ICT, 인공지능 기술 등이 결합된 개인맞춤형 서비스 제공 산업으로 분야가 확장될 것으로 분석되었다. 분석 내용을 바탕으로 전통적인 뷰티산업에서 요구하는 기본 직무 능력 외에 갖추어야 할 디지털 활용능력을 추가하여 교육과정을 구성하고 과목을 도출하였다. 코로나 이후의 시대는 4차 산업혁명을 기반으로 다양한 산업의 변화를 가져올 것이며 이러한 변화에 대응하여 뷰티산업의 발전과 지속가능성을 위한 인재 개발을 위해 대학에서는 산업의 변화에 항상 주목해야 할 것이다.