Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Lindera erythrocarpa Makino extract reduces obesity induced by high-fat diet in rats

  • Ahn, Mee-Jung (Department of Anatomy, College of Medicine, Jeju National University) ;
  • Yang, Won-Jun (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Kang, So-Hi (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Kang, Min-Chul (Bio-industry Development center) ;
  • Ko, Ryeo-Kyeong (Bio-industry Development center) ;
  • Kim, Gi-Ok (Bio-industry Development center) ;
  • Shin, Tae-Kyun (Department of Veterinary Anatomy, College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
  • Received : 2010.09.15
  • Accepted : 2010.12.06
  • Published : 2010.12.31
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Abstract

Lindera erythrocarpa Makino (LE) is widely distributed on Jeju Island, where it has been used for various traditional therapies. Effects of a crude extract of LE were examined in rats with obesity induced by a high-fat diet (HFD). Anti-obesity effects were followed in rats receiving orally administered vehicle, 100mg/kg extract, or 250 mg/kg LE extract, for 56 days. LE extract (250 mg/kg) suppressed increases in body weight and epididymal fat, with amelioration of fatty changes in the liver. Additionally, serum levels of alanine aminotransferase, aspartate aminotransferase, and total cholesterol were significantly decreased compared with those of vehicle-treated groups (p < 0.05). These results suggest that oral administration of LE extract reduced rat obesity induced by HFD, possibly through the reduction of fat accumulation.

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