• 한국광학회:학술대회논문집
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• 한국광학회 2008년도 하계학술발표회 논문집
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• pp.309-310
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• 2008

Polymer optical waveguides are fabricated with high-index materials deposited to strengthen exciations of evanescent field whose birefringence is utilized for optical sensing. Optical sensing properties are examined as a function of time, using different types of analyte solutions to extract noise-free signal induced by evanescent field birefringence. It is observed that sensing signal can be free of initial noise that may obscure real signal recognition, when glycerol is used for sensing characterization, due to slow accumulation process following adsorption of analyte material onto the sensing surface of the waveguide.

• Coupled systems mechanics
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• 제10권1호
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• pp.21-38
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• 2021

This work is an attempt to design a dynamic model for a non local bio-thermoelastic medium with diffusion. The system of governing equations are formulated in terms of displacement vector field, chemical potential and the tissue temperature in the context of non local dual phase lag (NL DPL) theories of heat conduction and mass diffusion. Based on this considered model, we study the fundamental solution and propagation of plane harmonic waves in tissues. In order to analyze the behavior of the NL DPL model, we construct basic theorem in the terms of elementary function which determine the existence of three longitudinal and one transverse wave. The effects of various parameters on the characteristics of waves i.e., phase velocity and attenuation coefficients are elaborated by plotting various figures of physical quantities in the later part of the paper.

• 한국전자통신학회논문지
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• 제8권4호
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• pp.619-629
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• 2013

이 연구는 20대 여대생들을 대상으로 세 가지 균형조절 훈련(Aqua, Bio-feedback, Trampolin)이 정적 균형 능력과 시각, 전정각, 고유수용감각 등의 감각요소에 미치는 효과를 비교하기 위해 아쿠아 훈련군(10명), 바이오피드백 훈련군(10명), 트램폴린 훈련군(9명)으로 무작위 할당한 후 각 군별로 주 3회, 회당 30분간의 운동 프로그램을 6주간 진행하면서 3주후, 6주후에 Tetrax portable multiple system을 이용하여 안정성지수를 측정하고, 근전도 중앙주파수값을 이용하여 산출한 근전도 균형점수를 반복측정된 자료의 분산분석 및 Wilcoxon의 부호순위 검정 등을 이용하여 비교 분석한 결과를 종합해 볼 때, 바이오피드백 훈련은 세 가지 감각기능을 고루 향상시키며 아울러 감각기능 간의 협응성 또한 향상시키는 것으로 판단되며, 아쿠아 훈련은 전정기능을 집중적으로 강화시키는 것으로 보인다.

• KSBB Journal
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• 제26권6호
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• pp.483-490
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• 2011

Bioactive peptides (BAP) showed excellent cosmetic activity than bio-materials such as caffeic acid (CA), gallic acid (GA), and nicotinic acid (NA). Caffeoyl tripeptide-1 (CT-1) is a BAP that is stabilized with Gly-His-Lys (GHK) tripeptide and CA by using Fmoc solid phase peptide synthesis. Digalloyl tetrapeptide-19 (DT-19) is stabilized by combining Lys-Glu-Cys-Gly with GA and nicotinoyl tripeptide-1 (NT-1) is synthesized by GHK and NA. According to experiments, CT-1 has an excellent anti-oxidant function even with a very small amount of 10 ppm CT-1. DT-19's tyrosinase inhibition activity has the better effect of about 28.57% in 0.01% and 33.33% in 0.005% of concentration and about 7.89% in 0.001% concentration than vitamin-C. In addition, NT-1 is safer than the NA. Almost BAPs like pal-KTTKS, acetyl hexapeptide, and copper tripeptide-1 have the anti-wrinkle effect while DT-19 and NT-1 are applicable for potential BAPs focused on the whitening effect. The three kinds of BAPs like CT-1, DT-19, and NT-1 consisting of amino acids are safe to the skin, and have more excellent stability than bio-materials which are found to be unstable and cause skin irritation. Due to the high biological activity of BAP in the field of skin care, its utilization will increase constantly.

• 구강회복응용과학지
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• 제25권4호
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• pp.431-436
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• 2009

심한 치조골 흡수를 동반한 III급 악골 관계 환자의 총의치 제작의 경우 안정적이고 지속적인 교합을 제공하는 치료계획을 세워야 한다. 불리한 치관 대 치근 비와 임상적 동요도가 관찰되는 하악 잔존치를 고정하여 사용함으로써 환자의 불편감을 줄이고 시간적, 경제적으로 효율적인 치료를 제공할 수 있다. 본 증례에서는 상악 편악 무치악 환자의 기능적인 하악 운동과 조화로운 총의치 균형 교합을 이루기 위해 T-Scan System을 이용하였다.

• Genomics & Informatics
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• 제11권2호
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• pp.76-82
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• 2013

Over the past decade or so, dramatic developments in our ability to experimentally determine the content and function of genomes have taken place. In particular, next-generation sequencing technologies are now inspiring a new understanding of bacterial transcriptomes on a global scale. In bacterial cells, whole-transcriptome studies have not received attention, owing to the general view that bacterial genomes are simple. However, several recent RNA sequencing results are revealing unexpected levels of complexity in bacterial transcriptomes, indicating that the transcribed regions of genomes are much larger and complex than previously anticipated. In particular, these data show a wide array of small RNAs, antisense RNAs, and alternative transcripts. Here, we review how current transcriptomics are now revolutionizing our understanding of the complexity and regulation of bacterial transcriptomes.

• Journal of Ginseng Research
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• 제46권3호
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• pp.408-417
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• 2022

Background: Korean Red Ginseng extract (KRGE) has been used as a health supplement and herbal medicine. Astrocytes are one of the key cells in the central nervous system (CNS) and have bioenergetic potential as they stimulate mitochondrial biogenesis. They play a critical role in connecting the brain vasculature and nerves in the CNS. Methods: Brain samples from KRGE-administered mice were tested using immunohistochemistry. Treatment of human brain astrocytes with KRGE was subjected to assays such as proliferation, cytotoxicity, Mitotracker, ATP production, and O₂ consumption rate as well as western blotting to demonstrate the expression of proteins related to mitochondria functions. The expression of hypoxia-inducible factor-1α (HIF-1α) was diminished utilizing siRNA transfection. Results: Brain samples from KRGE-administered mice harbored an increased number of GFAP-expressing astrocytes. KRGE triggered the proliferation of astrocytes in vitro. Enhanced mitochondrial biogenesis induced by KRGE was detected using Mitotracker staining, ATP production, and O₂ consumption rate assays. The expression of proteins related to mitochondrial electron transport was increased in KRGE-treated astrocytes. These effects were blocked by HIF-1α knockdown. The factors secreted from KRGE-treated astrocytes were determined, revealing the expression of various cytokines and growth factors, especially those related to angiogenesis and neurogenesis. KRGE-treated astrocyte conditioned media enhanced the differentiation of adult neural stem cells into mature neurons, increasing the migration of endothelial cells, and these effects were reduced in the background of HIF-1α knockdown. Conclusion: Our findings suggest that KRGE exhibits prophylactic potential by stimulating astrocyte mitochondrial biogenesis through HIF-1α, resulting in improved neurovascular function.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2003년도 제3회 국제심포지움 및 학술대회
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• pp.82-82
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• 2003

Offspring have been produced from somatic cells in a number of species. This biotechnology introduced a new phenomenon in reprogramming and differentiation of somatic cell, namely totipotency. However, birth of oversized calves and perinatal abnormalities such as increased gestation length, lack of spontaneous parturition, higher incidence of dystocia, and reduced perinatal viability of offspring are frequently observed in pregnancies of cloned bovine fetuses. Disturbance of feto-placenta has been proposed as likely causes for abnomal growth. However. Little is known the mechanism responsible for the perinatal problems. Therefore, we focused on gestation length in somatic cell nuclear recipient cows. To solve this issues, placental tissues of control and cloned bovine were obtained by a cesarean section (C-section) before 5 days of paturition. Total RNA from control and cloned bovine placenta was extractd by TRIzol reagent. GeneFishing DEG kits (Seegene) were used to identify differentially expression genes. Total RNA (3 ug) were synthesized by M-MLV reverse transcriptase (200 u/ul) with 10 uM dT-annealing control primer (ACP1) at 42C for 90 min. Then, first-strand cDNA (50 ng) was amplified using the 5 uM arbitary ACP (1-20) and 10 uM dT-ACP2 primers. Some specific expression genes were amplified, Now, we are cloning and sequencing. These finding strongly can be support to solve the problems for parturition delay in nuclear transfer cows, suggest that placenta specific proteins are key indicators for the aberration of gestation and placental function in cows.

• Journal of Microbiology and Biotechnology
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• 제15권4호
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• pp.909-912
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• 2005

In the course of screening for selective growth inhibitors against the mycelial form of Candida albicans, we isolated a Streptomyces sp. A6792 from soils. The inhibitor was isolated from the above bacterium and identified through several spectral analyses with UV and mass spectrophotometries, and various NMR. The compound was determined to be a macrocyclic dilactone antibiotic, IKD-8344 (molecular weight: 844, molecular formula: $C_{48}H_{76}O_{12}$). The compound selectively inhibited the growth of mycelial form of C. albicans with an MIC of 6.25 ${\mu}g/ml$. It also exhibited strong inhibitory effect preferentially on the mycelial form of various Candida spp. including C. krusei, C. tropicalis, and C. lusitaniae, with MICs ranging from 1.56 to 25 ${\mu}g$/ml. Furthermore, the compound showed no significant toxicity against SPF ICR mice up to 60 mg/kg. These results suggest that IKD-8344 is a useful lead compound for the development of novel antifungal agents, based on the preferential growth inhibition against Candida spp.

• Journal of Biosystems Engineering
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• 제33권2호
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• pp.101-105
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• 2008

Some physical properties of rapeseed such as geometric properties (linear dimensions, sphericity, seed volume, surface area) and gravimetric properties (the mass of one thousand seeds, bulk density) were analyzed at five levels of moisture content of 10.03, 14.91, 20.07, 25.06 and 30.12% (w.b.). The physical properties of rapeseed were evaluated as a function of seed moisture content. In the moisture range, when the moisture content increase, sphericity decreased from 0.946 to 0.927, and geometric mean diameter, seed volume and surface area increased from 2.17 to 2.31 mm, 5.58 to $6.88 \;mm^3$ and 14.76 to $16.77\;mm^2$ respectively. Mass of one thousand seeds increased from 5.04 to 6.46 g. Bulk density decreased from 579.3 to $549.2\;kg/m^3$ due to swelling of the seed.