• Biomolecules & Therapeutics
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• 제28권6호
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• pp.519-526
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• 2020

Methamphetamine (MA) is one of the most commonly abused drugs in the world by illegal drug users. Addiction to MA is a serious public health problem and effective therapies do not exist to date. It has also been reported that behavior induced by psychostimulants such as MA is related to histone deacetylase (HDAC). MeBib is an HDAC6 inhibitor derived from a benzimidazole scaffold. Many benzimidazole-containing compounds exhibit a wide range of pharmacological activity. In this study, we investigated whether HDAC6 inhibitor MeBib modulates the behavioral response in MA self-administered rats. Our results demonstrated that the number of active lever presses in MA self-administered rats was reduced by pretreatment with MeBib. In the hippocampus of rats, we also found MA administration promotes GluN2B, an NMDA receptor subunit, expression, which results in sequential activation of ERK/CREB/BDNF pathway, however, MeBib abrogated it. Collectively, we suggest that MeBib prevents the MA seeking response induced by MA administration and therefore, represents a potent candidate as an MA addiction inhibitor.

• International Journal of Aeronautical and Space Sciences
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• 제17권2호
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• pp.260-267
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• 2016

The design process of blended inlet body (BIB) for the preliminary design of a near-space high supersonic unmanned aerial vehicle (HSUAV) is presented. The mass flow rate and cowl area of inlet at a design point are obtained according to the cruise condition of the HSUAV. A mixed-compression axisymmetric supersonic inlet section with a fixed geometry reasonably matching the high supersonic cruise state is created by using the inviscid theory of aerodynamics. The inlet section is optimized and used as a baseline section for the BIB design. Three BIB concepts for the HSUAV are proposed, and their internal aerodynamic characteristics of inlet are evaluated using Euler computational fluid dynamics (Euler CFD) solver. The preferred concept is identified, in which the straight leading edge of the baseline HSUAV configuration is modified into the convex leading edge to accommodate the inlet and meet the requirements of the cowl area to capture the sufficient air flow. The total recovery of inlet for the preferred BIB concept and the aerodynamic characteristics of the modified HSUAV configuration are verified using Navier-Stokes computational fluid dynamics (NS CFD) solver. The validation indicates that the preferred BIB concept can meet both the requirements of the inlet and aerodynamic performance of the HSUAV.

• 한국연초학회지
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• 제15권1호
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• pp.90-97
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• 1993

1. Average moisture content of tobacco in BIB silo was about 19: 1% until 4hours conditioned time, and then moisture variation of tobacco after 2hr conditioned was very small. 2. Application of mathematical model for ordering system. 1) The constant K in the exponential equation varies inversely with both relative humidity and equilibrium moisture. 2) Time needed to order blending tobacco leaves with standard moisture from bulking and blending silo was 4 hours. 3) Reconstituted tobacco sheet had higher moisture absorption ratio than Oriental and Burley tobacco. 4) For minimize of conditioning time in BIB silo, the values of K and Mo given in this study can be used in equation(1) to calculate moisture absorption ratio and optimum conditioning time. 3. Average moisture content and water activity of conditioned tobacco for 4 hours in BIB silo was about 20% and 0.65. In this condition. microbial life will inhibite 4. Physical properties of conditioned tobacco in bulking and blending silo for 4hours was virtually no change.

• 월간포장계
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• 통권64호
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• pp.102-103
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• 1998

• 품질경영학회지
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• 제44권4호
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• pp.799-811
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• 2016

Purpose: The conjoint analyst in marketing are interested in detecting whether there exist synergy or antagonistic effects between two attributes. In the cases where attributes have two or three levels, we research on the design of survey questionnaire to estimate all the main effect and as many two factor interaction effects as possible. Methods: We consider the balanced incomplete block (BIB) mixed level factorial design $2^f{\times}3^g$ or fractional factorial design. To reduce the number of questions in a questionnaire, we propose the balanced incomplete block mixed level design with minimum aberration which is generated by implementing proc factex in SAS. Also, we propose using two or three level BIB factorial design instead of mixed level designs by transforming three level attributes into two attributes of two levels and two level attribute into three level attribute by using dummy level technique. Results: We propose three methods for designing survey questionnaire where the block and design generators are found with practical number of questions in a questionnaire. By analyzing all the respondents survey data generated by the simulation study, we find the proper model and do the concepts optimization. Conclusion: The proposed methods of designing survey questionnaires seem to perform well in the sense that the proper model, and then the optimal concept is found in a case study where all the respondents survey data are generated by the simulation study.

• 한국식생활문화학회지
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• 제35권1호
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• pp.55-64
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• 2020

This study on the importance and satisfaction of selection attributes for customers using Michelin restaurants. The survey was conducted on 309 respondents who had visited and used restaurants by classifying the Michelin restaurants into starred restaurants and Bib Gourmand restaurants. The data was collected and the frequency analysis, t-test verification, and IPA analysis were performed using the SPSS 25.0 statistical program. The results of the study examined the difference between the importance and satisfaction of the choice of starred restaurants. Overall, the importance was higher than satisfaction. The importance of hygiene and cleanliness was recognized by many customers that the expectation for the overall Starred restaurants was very high. Bib Gourmand, showed that the importance was higher than satisfaction. In terms of importance and satisfaction, the taste of food is the most important and the satisfaction is high. Comparing the IPA analysis of the attributes of 1) hygiene and cleanliness, food quality, convenience, and facade of food, 2) service professionalism and variety of menus, 3) food price, atmosphere and amount, and 4) the attitude and kindness of the employees were shown. This study has great significance in providing practical basic data for the management of domestic Michelin restaurants.

• Journal of the Korean Statistical Society
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• 제11권1호
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• pp.1-11
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• 1982

Srivastava and Anderson(1970) illustrate a method of obtaining Balanced (but not orthogonal) Resolution $IV^*$ designs starting with a BIB design. The incidence matrix of a BIB design with parameters (v, b, r, k, and $\lambda$) is utilized to obtain Balanced Resolution $IV^*$ designs with m factors and n=2b runs, where $m \leq v$. In this paper, the same idea is extended to the case of PBIB designs to obtain Partially Balanced Resolution $IV^*$ designs. In the designs obtained here the variances are balanced and the covariances are partially balanced with respect to the main effects. A proof of this property of Partially Balanced Resoultion $IV^*$ designs is given. The efficiency of Partially Balanced Resolution $IV^*$ designs is also considered and examples of Partially Balanced Resoultion $IV^*$ designs are included.

• 천문학논총
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• 제32권1호
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• pp.351-353
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• 2017

To realize large-format compact array detectors covering a wide far-infrared wavelength range up to 200 µm, we have been developing Blocked-Impurity-Band (BIB) type Ge detectors with the room-temperature surface-activated wafer bonding technology provided by Mitsubishi Heavy Industries. We fabricated various types of $p^+-i$ junction devices which possessed a BIB-type structure, and evaluated their spectral response curves using a Fourier transform spectrometer. From the Hall effect measurement, we also obtained the physical characteristics of the $p^+$ layers which constituted the $p^+-i$ junction devices. The overall result of our measurement shows that the $p^+-i$ junction devices have a promising applicability as a new far-infrared detector to cover a wavelength range of $100-200{\mu}m$.

• 복합신소재구조학회지
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• 제7권1호
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• pp.25-30
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• 2016

• 응용통계연구
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• 제12권1호
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• pp.253-260
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• 1999

이어진 블록계획 중에서 대칭 균형된 불완비 블록계획(Symmetrical Balanced Incomplete Block Design : SBIBD)을 이용하여 n-ary를 블록 완전이면교배(Complete Diallel Cross : CDC)계획을 설계하였다. 처리 수와 반복 수가 고정된 경우, 이렇게 설계된 계획이 균형된 불완비 블록계획을 이용해서 설계한 계획들 중에서 가장 효율이 높은 계획임을 보인다.