• 제목/요약/키워드: BiSI

검색결과 522건 처리시간 0.032초

GSTP1, ERCC1 and ERCC2 Polymorphisms, Expression and Clinical Outcome of Oxaliplatin-based Adjuvant Chemotherapy in Colorectal Cancer in Chinese Population

  • Li, Hui-Yan;Ge, Xin;Huang, Guang-Ming;Li, Kai-Yu;Zhao, Jing-Quan;Yu, Xi-Miao;Bi, Wen-Si;Wang, Yu-Lin
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권7호
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    • pp.3465-3469
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    • 2012
  • Aim: Platinum agents have shown to be effective in the treatment of colorectal cancer. We assessed whether single nucleotide polymorphisms (SNPs) in GSTP1, ERCC1 Asn118Asn and ERCC2 Lys751Gln might predict the overall survival in patients receiving oxaliplatin-based chemotherapy in a Chinese population. Methods: SNPs of GSTP1, ERCC1 Asn118Asn and ERCC2 Lys751Gln in 335 colorectal cancer patients were assessed using TaqMan nuclease assays. Results: At the time of final analysis on Nov. 2011, the median follow-up period was 37.7 months (range from 1 to 60 months). A total of 229 patients died during follow-up. Our study showed GSTP1 Val/Val (HR=0.44, 95% CI=0.18-0.98), ERCC1 C/C (HR=0.20, 95% CI=0.10-0.79) and ERCC2 G/G (HR=0.48, 95% CI=0.19-0.97) to be significantly associated with better survival of colorectal cancer. GSTP1 Val/Val, ERCC1 C/C and ERCC2 G/G were also related to longer survival among patients with colon cancer, with HRs (95% CIs) of 0.41 (0.16-0.91), 0.16 (0.09-0.74) and 0.34 (0.16-0.91), respectively. Conclusion: GSTP1, GSTP1, ERCC1 Asn118Asn and ERCC2 Lys751Gln genotyping might facilitate tailored oxaliplatin-based chemotherapy for colorectal cancer patients.

한국산 灰重石鑛의 광물학적, 지화학적 연구 및 그의 探査에의 이용 (The Mineralogical and Geochemical Study on Korean Scheelites and its Application to the Ore Prospecting)

  • So, Chil-Sup;Park, Maeng-Eon
    • 자원환경지질
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    • 제12권2호
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    • pp.79-93
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    • 1979
  • 한반도 내에 부존되고 있는 중적광상들은 세 주요한 Metallousenetic Epoch (Pre-Cambrian E., Jurassic-early Cretaceous E., 및 late Cretaceous-early Tertiary E.)에 생성되었고 성인으로 열수작용과 접촉교대작용에 기인된다고 보고되었다. 이중 12개 광상(달성, 산내, 일광, 상동, 대화, 월악, 복수, 옥방, 쌍전, 홍성, 삼봉, 청양)을 본 연구의 대상으로 택하고 각 지역에서 채취한 표품중 모두 25개 시료에 대하여 지화학적 실험을 수행하였다. 즉 각 분쇄된 시료 (-80+120mesh)는 super panner, 중액, isodynamic separator, UV lamp를 이용한 물리적인 처리과정을 거쳐 최종으로 입체현미경 하에서 단체분리된 후 Jarrell-Ash 1.5m Grating Spectrometer를 이용하여 본 연구대상 시료로 개발한 Spectrochemical method (Carrier: NaCl, Internal standard: $La_2O_3$)로 정량 분석되었다. 본 연구에서 밝혀낸 국내 회중석 광내에 함유되는 희유 윈소의 종류는 모두 Al, Bi, Fe, Si, Mn, Pb, Mg, Sn, Mo, Cu, Sr, Cr, Y, Ag, Ti, Ni, As, Yb의 18개 원소이며, 이들은 각각의 절대적 및 상대적인 함량과 각 광화작용의 시기, 광상의 성인, 모암, 각 원소의 mobility 그리고 회중석광의 형광색 및 육안색과 비교 검토되었다. 본 연구의 결과로 회중석광이 정출되는 과정에서 유사한 지질환경의 물리화학적인 여건이 이루어지면 그 내에 함유되는 몇 성분원소들의 화학적인 특성은 매우 유사성을 보여주는 typochemical habit를 가짐을 알 수 있었다. 본 연구에서 밝혀진 한국산 회중석 광내의 희유성분(稀有成分)으로서 Y, Mn, Sr 원소들의 Geochemical mobility의 특성(特性)은 앞으로 회중석광의 심도탐광을 위하여 고려되어야하고, 더욱 연구개발되어야 할 것이다. 또한 상기 회중석 광내의 물리적 및 화학적으로 결합되어 있는 불순물의 희유성분들은 선광 제련 파정에서 금속성분의 추출농집공정(工程)에 유용한 자료가 될 것이다.

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압축재 포설에 따른 매설관거의 하중저감 효과 평가 (A Study of Load Reduction Effect on Conduits Using Compressible Inclusion)

  • 김진만;최봉혁;조삼덕;주태성;김호비;이종화
    • 한국지반신소재학회논문집
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    • 제2권2호
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    • pp.3-11
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    • 2003
  • 지중매설구조물에 작용하는 수직하중 저감기법인 유도 고랑형 기법은 관거 상단의 내부토체에 압축성이 큰 재료(점토, 이토, 지푸라기 등)를 뒤채움함으로서 다짐된 지반인 외부토체에 대해 상대적으로 하향 침하하는 변위를 유발시킴으로써 발생되는 아칭효과에 의해 하중을 저감시키는 기법이다. 그러나, 기존의 유도 고랑형 기법은 상대적 변위를 유발시키기 위한 압축재인 점토, 이토, 지푸라기 등이 현장의 품질관리차원에서 관리가 어렵다는 문제점을 가지고 있다. 최근의 관련 연구 경향은 압축재로서 재료 관리가 용이한 대체 재료의 개발과 EPS 블록의 활용성 검증 등에 초점이 모아 지고 있는 실정이다. 본 논문에서는 연성강관의 포설 효과, EPS 블록 포설 형태, 연성강관의 직경 등을 변화인자로 한 일련의 실험을 통하여 연성관 및 EPS 블록 포설에 따른 수직하중 저감 효과와 매커니즘을 분석하고, 현장적용에 필요한 최적 단면 및 설계 시 적용되는 환산하중계수(K')을 제시하고자 한다.

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한국산 가막사리속(국화과)의 미기록 귀화식물: 왕도깨비바늘 (First record of Bidens subalternans DC. var. subalternans (Asteraceae-Heliantheae) from Korea)

  • 김선유;윤석민;홍석표
    • 식물분류학회지
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    • 제42권2호
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    • pp.178-183
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    • 2012
  • 부산광역시 금정구와 경상북도 경산시 진량읍 및 대구광역시 북구에서 채집된 한국산 국화과의 미기록 귀화식물인 Bidens subalternans DC. var. subalternans을 확인하여 보고한다. 본 분류군은 잎은 1회 우상복엽으로 깊게 갈라지며, 소엽은 너비가 좁은 피침형이고, 통상화는 4갈래, 수과는 장타원형으로 한국산 가막사리속 다른 분류군들과 구분이 된다. 국명은 식물체가 대형(특히, 잎 크기)임을 고려하여, '왕도깨비바늘'로 신칭하였다. 한국산 가막사리속 분류군에 대한 검색표를 제시하였다.

한국 미기록 귀화식물: 민털비름(비름과) (A newly naturalized species in Korea: Amaranthus powellii S. Watson (Amaranthaceae))

  • 박용호;박수현;유기억
    • 식물분류학회지
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    • 제44권2호
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    • pp.132-135
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    • 2014
  • 한반도 미기록 귀화식물인 민털비름(Amaranthus powellii S. Watson)을 경기도 의정부시 자일동에서 발견하였다. 본 종은 미국 남서부와 멕시코 북부 원산으로 현재 전세계 온대지역에 널리 귀화된 상태이다. 본 종은 근연분류군인 가는털비름(A. patulus Bertol.)과 긴털비름(A. hybridus L.)에 비해 잎은 넓은 침형, 능형 또는 피침형으로 화피편의 길이가 서로 다르고 뚜렷한 녹색의 중앙맥이 없으며 열매가 주두쪽으로 올라가면서 서서히 좁아지는 특징으로 구별된다. 국명은 가는털비름, 긴털비름, 털비름(A. retroflexus L.)과 유사하나 줄기와 잎에 털이 현저히 적은 특징을 바탕으로 '민털비름'이라 하였다. 본 분류군의 외부형태적 특징에 대한 기재, 사진, 도해 그리고 근연분류군과의 검색표 등을 제시하였다.

E-band low-noise amplifier MMIC with impedance-controllable filter using SiGe 130-nm BiCMOS technology

  • Chang, Woojin;Lee, Jong-Min;Kim, Seong-Il;Lee, Sang-Heung;Kang, Dong Min
    • ETRI Journal
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    • 제42권5호
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    • pp.781-789
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    • 2020
  • In this study, an E-band low-noise amplifier (LNA) monolithic microwave integrated circuit (MMIC) has been designed using silicon-germanium 130-nm bipolar complementary metal-oxide-semiconductor technology to suppress unwanted signal gain outside operating frequencies and improve the signal gain and noise figures at operating frequencies. The proposed impedance-controllable filter has series (Rs) and parallel (Rp) resistors instead of a conventional inductor-capacitor (L-C) filter without any resistor in an interstage matching circuit. Using the impedance-controllable filter instead of the conventional L-C filter, the unwanted high signal gains of the designed E-band LNA at frequencies of 54 GHz to 57 GHz are suppressed by 8 dB to 12 dB from 24 dB to 26 dB to 12 dB to 18 dB. The small-signal gain S21 at the operating frequencies of 70 GHz to 95 GHz are only decreased by 1.4 dB to 2.4 dB from 21.6 dB to 25.4 dB to 19.2 dB to 24.0 dB. The fabricated E-band LNA MMIC with the proposed filter has a measured S21 of 16 dB to 21 dB, input matching (S11) of -14 dB to -5 dB, and output matching (S22) of -19 dB to -4 dB at E-band operating frequencies of 70 GHz to 95 GHz.

SMAD4 Controls Cancer Cell Metabolism by Regulating Methylmalonic Aciduria Cobalamin Deficiency (cbl) B Type

  • Song, Kyoung;Lee, Hun Seok;Jia, Lina;Chelakkot, Chaithanya;Rajasekaran, Nirmal;Shin, Young Kee
    • Molecules and Cells
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    • 제45권6호
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    • pp.413-424
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    • 2022
  • Suppressor of mothers against decapentaplegic homolog (SMAD) 4 is a pluripotent signaling mediator that regulates myriad cellular functions, including cell growth, cell division, angiogenesis, apoptosis, cell invasion, and metastasis, through transforming growth factor β (TGF-β)-dependent and -independent pathways. SMAD4 is a critical modulator in signal transduction and functions primarily as a transcription factor or cofactor. Apart from being a DNA-binding factor, the additional SMAD4 mechanisms in tumor suppression remain elusive. We previously identified methyl malonyl aciduria cobalamin deficiency B type (MMAB) as a critical SMAD4 binding protein using a proto array analysis. This study confirmed the interaction between SMAD4 and MMAB using bimolecular fluorescence complementation (BiFC) assay, proximity ligation assay (PLA), and conventional immunoprecipitation. We found that transient SMAD4 overexpression down-regulates MMAB expression via a proteasome-dependent pathway. SMAD4-MMAB interaction was independent of TGF-β signaling. Finally, we determined the effect of MMAB downregulation on cancer cells. siRNA-mediated knockdown of MMAB affected cancer cell metabolism in HeLa cells by decreasing ATP production and glucose consumption as well as inducing apoptosis. These findings suggest that SMAD4 controls cancer cell metabolism by regulating MMAB.

150kW급 수소연료전지 차량용 DC/DC 컨버터 개발 및 실차모사 실험 (Development of DC/DC Converters and Actual Vehicle Simulation Experiment for 150 kW Class Fuel-cell Electric Vehicle)

  • 김선주;정현주;최세완;조준호;전유종;박준성;윤혜성
    • 전력전자학회논문지
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    • 제27권1호
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    • pp.26-32
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    • 2022
  • This paper proposes a power system that includes a 120k W fuel cell DC-DC converter (FDC) and 30 kW bidirectional DC-DC converter (BHDC) for a 150 kW fuel-cell vehicle. With a high DC link voltage of 800 V, the efficiency and power density of the power electronic components are improved. Through the modular design of FDC and BHDC, electric components are shared, resulting in reduced mass production costs. The switching frequency of 30 kHz of full SiC devices and optimal design of coupled inductor reduce the volume, achieving a power density of 8.3 kW/L. Furthermore, a synergetic operation strategy using variable limiter control of FDC and BHDC was proposed to efficiently operate the fuel cell vehicle considering the fuel cell stack efficiency according to the load. Finally, the performance of the prototype was verified by Highway Fuel Economy Driving Schedule testing, EMI test, and the linked operation between FDC and BHDC. The full load efficiencies of the FDC and BHDC prototypes are 98.47% and 98.74%, respectively.

Radiation parameterizations and optical characterizations for glass shielding composed of SLS waste glass and lead-free materials

  • Thair Hussein Khazaalah;Iskandar Shahrim Mustafa ;M.I. Sayyed
    • Nuclear Engineering and Technology
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    • 제54권12호
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    • pp.4708-4714
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    • 2022
  • The novelty in the present search, the Soda-Lime-Silica (SLS) glass waste to prepare free lead glass shielding was used in order to limit the accumulation of glass waste, which requires extensive time to decompose. This also saves on the consumption of pure SiO2, which is a finite resource. Furthermore, the combining of BaO with Bi2O3 into a glass network leads to increased optical properties and improved attenuation. The UV-Visible Spectrophotometer was used to investigate the optical properties and the radiation shielding properties were reported for current glass samples utilizing the PhysX/PDS online software. The optical property results indicate that when BaO content increases in glass structure, the Urbach energy ΔE, and refractive index n increases while the energy optical band gap Eopt decreases. The result of the metallisation criteria (M) revealed that the present glass samples are nonmetallic (insulators). Furthermore, the radiation shielding parameter findings suggest that when BaO was increased in the glass structure, the linear attenuation coefficient and effective atomic number (Zeff) rose. But the half-value layer HVL declined as the BaO concentration grew. According to the research, the glass samples are non-toxic, transparent to visible light, and efficient radiation shielding materials. The Ba5 sample is considered the best among all the samples due to its higher attenuation value and lower HVL and MFP values, which make it a suitable candidate as transparent glass shield shielding.

Elemental characteristics of sialoliths extracted from a patient with recurrent sialolithiasis

  • Buyanbileg Sodnom-Ish;Mi Young Eo;Kezia Rachellea Mustakim;Yun Ju Cho;Soung Min Kim
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • 제50권2호
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    • pp.94-102
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    • 2024
  • The exact mechanism of sialolith formation has yet to be determined. Recurrence of sialolithiasis is rare, affecting only 1%-10% of patients. The current study presents a case of recurrent stones that occurred twice on the right submandibular gland 6 months postoperative and 7 months after reoperation in a 48-year-old female patient. The stones were analyzed using histology, scanning electron microscopy, energy dispersive spectroscopy, and transmission electron microscopy (TEM). The first stone showed a three-layered structure with a poorly mineralized peripheral multilayered zone, highly mineralized middle layer, and the central nidus. The stones were composed of Ca, C, O, Cu, F, N, P, Si, Zn, and Zr. In TEM, compact bi-layered bacterial cell membrane was found on the peripheral layer and the central nidus of the stone as well as exosomes in the central nidus. The results demonstrated the essential components of sialolith formation, including bacteria, inflammatory exosomes, and exfoliated salivary epithelial cells that cooperatively underwent the pathogenetic progresses of central nidus formation, induction of compact zone calcification of the middle layer, and repeated subsequent deposition in the peripheral multilayer zone. The rapid recurrence could have resulted from residual pieces of a sialolith acting as the nidus of bacterial infection.