• 대한교통학회지
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• 제28권1호
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• pp.135-142
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• 2010

본 연구는 현재 국내 BIS에서 버스도착시간 및 정류소간 통행시간 산정을 위해 개별노선단위로 적용하고 있는 버스 도착시간 추정 모형의 한계점을 제시하고, 이를 극복하기 위한 방안으로 버스의 진행 방향과 정류소 구간을 고려한 노선그룹단위 버스도착시간 및 구간통행시간 추정 알고리즘을 제시하였다. 서울시 BMS에서 수집되는 버스 운행자료를 활용하여 본 연구에서 제시된 모형의 신뢰성과 적정성을 평가하였다. 모형의 검증은 서울시에서 운행 중인 간선버스 노선 중 서대문역${\rightarrow}$독립문역 구간을 운행하는 노선을 대상으로 하였으며, 서울역방향(직진), 충정로방향(좌회전), 광화문방향(우회전) 등 버스노선을 진행방향과 구간별로 그룹화하여 모형에 적용하였다. 모형의 비교평가를 위해 RMSE를 효과척도로 하여 기존 개별노선단위 모형과 본 연구에서 제시한 노선그룹단위 모형을 비교한 결과, 관측 값의 개수가 4인 경우 구간별 평균 14.8, 관측 값의 개수가 5인 경우 구간별 평균 16.8의 차이로 본 연구에서 제시한 노선그룹단위 버스도착시간 및 정류소간 통행시간 추정모형이 기존 모형보다 우수한 것으로 분석되었다.

• Korean Journal of Acupuncture
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• 제21권2호
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• pp.69-79
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• 2004

Objective : Acupuncture has been used for treatment of numerous disorders, especially for pain control in Oriental Medicine. However, the mechanism of pain control by acupuncture was not clear until now. This study was performed to prove analgesic mechanism of acupuncture treatment at acupoint $ST_{36}$ by observing the changes of abdominal pain and c-Fos expression in the thalamus. Methods : Abdominal pain was induced by acetic acid, and the changes of writhing reflex after acupuncture treatment on $ST_{36}$ and non-acupoints were measured. c-Fos immunohistochemistry was also performed to study the changes of the neuronal activity in the thalamus. Results : The writhing reflex decrease significantly after acupuncturing at $ST_{36}$ compared with control group(p<0.05). The changes of the writhing reflex by non-acupoint acupuncture treatment also showed significant decrease compared with control group(p<0.05). c-Fos expression in the thalamus, especially periventricular part was significantly decreased after acupuncturing as $ST_{36}$ compared with control groups(p<0.05). Conclusion : This study shows that the acupuncture has the analgesic effect in the abdominal pain induced by acetic acid and the thalamus might be a important area for this mechanism.

• 한국식품과학회지
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• 제40권6호
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• pp.696-701
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• 2008

이 연구의 목적은 더덕 및 도라지 에틸아세테이트 분획물(CLEA나 PGEA)이 다양한 항산화 시스템을 가동시켜 sodium nitroprusside(SNP)에 의해 유도된 산화적 스트레스에 대항하여 세포를 보호해 줄 수 있을지 연구하는 것이다. 0.5 mM의 SNP를 HepG2 세포주에 24시간 동안 노출시켰을 때 세포 생존율이 감소하였으나, CLEA와 PGEA 천처리에 의해 SNP 노출에 의한 세포 생존율 감소가 저해되었다. 또한 항산화 시스템들 발현에 미치는 CLEA와 PGEA의 영향을 RT-PCR로 알아보았다. Catalase, glucose-6-phosphate dehydrogenase(G6PD) 그리고 metallothionein (MT)-1A mRNA 수준이 CLEA를 세포에 24시간 동안 처리한 후 증가하였고, Mn superoxide dismutase, catalase, G6PD, MT-1A 와 MT-2A mRNA 수준이 PGEA 처리에 의해 증가하였다. 우리는 CLEA와 PGEA가 아마 다양한 항산화 시스템들을 증가시키는 간접적인 항산화 효과를 나타내며, 이들 효과들이 산화적 스트레스로부터 세포를 보호해 줄 것이라 추정하였다.

• 대한한의학회지
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• 제31권2호
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• pp.91-108
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• 2010

Background & Objective: The aim of this study was to investigate the effect of P. radix on the inflammatory related gene expression in IL-$1{\beta}$-stimulated primary human gingival fibroblast using Whole Transcript Sense Target (WT-ST). Method: Human gingival fibroblast was incubated with P. radix [100 or $200\;{\mu}g/ml$], and IL-$1{\beta}$ [$1ng/m{\ell}$] added an hour later. After 24h, total RNA was extracted using RNeasy Mini Kit and the whole gene expression patterns were performed using WT-ST Labeling $Assay^{(R)}$. Result: In the DEG results, 782 genes were up-regulated in the IL-$1{\beta}$-treated group as compared to control and among those, 43 genes were associated with inflammation. 981 genes were down-regulated after treatment with IL-$1{\beta}$ and of those 7 genes were associated with inflammation. 1439 genes were up-regulated after treatment with P. radix plus IL-$1{\beta}$-treated when compared to IL-$1{\beta}$-treated alone group and 1225 genes were down-regulated in the same condition. Among the down-regulated genes, 5 were associated with inflammation- and inhibitor genes such as GDF15 and LIF. In the analysis of the P. radix plus IL-$1{\beta}$-treated group, the most significant pathways were the cytokine-cytokine receptor interaction, toll-like receptor signaling, JAK-STAT signaling and tyrosine metabolism. The gene expression patterns in the P. radix $200{\mu}g/m{\ell}$ plus IL-$1{\beta}$-treated group appear to be more involved in the metabolism-related pathways than in the $100{\mu}g/m{\ell}$ plus IL-$1{\beta}$-treated group. Conclusion & Discussion: By microarray analysis of gene expression data, we are able to identify gene expression patterns associated with not only anti-inflammation effect but also transcription function of P. radix.

• Journal of Acupuncture Research
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• 제18권5호
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• pp.33-42
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• 2001

Objective : To evaluate the effect of treatment for Rheumatoid arthritis by using Bee-venom Acupuncture that is well known for anti-inflammatory effect and function of activating immune system. Methods : Evaluated the result of Bee-venom Acupuncture treatment twice in a week for patients who diagnosised as rheumatoid arthritis by 7 criteria of US Rheumatism Academy. Results : 1. If you see the distribution chart, sexual rate of male and female was 1:2.75 and age distribution shows as age ascend it shows high. 2. If you see the duration distribution, it shows chronic tendency in order of more than 6 months (59.5%), 2 to 5 months, and 1 month. 3. If you see the invaded region distribution, it shows chronic tendency in order of finger(17 cases), wrist joint(16 cases), knee joint(16 cases), ankle joint(10 cases), elbow joint(8 cases), shoulder joint(7 cases), feet(7 cases), hip joint(5 cases), low back(3 cases) and neck(2 cases). 4. If you see the result of duration distribution treatment, the improvement index is rising in order of within a month, 2 to 5 months, and over 6 months. So it shows that it has good result of treatment within a month. 5. If you see the invaded region, it shows high improvement index in order of low back, hop joint, shoulder joint, wrist joint, feet, knee joint, finger, elbow joint, ankle joint and neck. 6. If you see the result of morning stiffness time before treatment, it shows good effect of treatment in order of 2-3hrs, 30min.-an hr, an hr to 2hrs, and 0-30min. 7. If you see the patients satisfaction after Bee-venom Acupuncture treatment, Excellent is 6 cases, Good is 7 cases, and Moderate 2 cases. Conclusions : It will have greater treatment effect if herbal medicine, moxibustion, and acupuncture are used together as patients whole body condition and symptoms with Bee-venom Acupuncture for rheumatoid arthritis that is chronic inflammatory disease.

• 한국구조물진단유지관리공학회 논문집
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• 제15권6호
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• pp.118-126
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• 2011

본 연구의 목적은 전단경간비에 따른 합성지하벽의 거동을 실험적으로 연구하고 유한요소해석 프로그램인 ADINA를 활용하여 합성지하벽 (Composite Basement Wall, CBW)의 비선형 거동의 예측이다. 특히 각 층 바닥 부근과 같이 콘크리트가 압축응력상태일 때의 합성벽의 거동을 연구하였다. 특히 강재와 콘크리트가 접촉되는 부분의 모델링 방법에 따른 해석방법의 적합성을 검토하고자 하였다. 콘크리트 벽체부분이 압축응력상태에 있는 합성지하벽의 거동을 이해하기 위하여 합성지하벽에 대한 실험을 실시하고 ADINA 프로그램을 이용하여 유한요소해석을 실시하였다. 해석의 편의를 위하여, 철근은 별도의 독립 요소로 모델링하지 않고, 콘크리트에 등분포되어 콘크리트와 함께 거동하는 것으로 하고 모든 요소는 소성거동을 표현하기 위하여 이선형 모델로 하였다. 강재와 콘크리트의 접촉면과 관련해서는 접촉면의 연결조건에 따라, AGO, SEGO-T 그리고 SEGO-NT로 모델링하여 해석을 실시한 뒤 각 조건에 따른 응력흐름과 집중정도를 관찰하고 그 결과를 실험결과와 비교하였다. 연구결과, 합성지하벽은 전단경간비가 비록 1에 가깝더라도, 강재의 소성변형에 의해 충분히 연성적인 거동을 보이는 것으로 나타났으며, 이와 같은 거동을 묘사하기 위하여 ADINA 프로그램을 이용하여 콘크리트와 강재 및 스터드볼트의 비선형특성을 고려하고 접촉면 요소로서 강재와 콘크리트의 접합면을 모델링하여 해석한 결과 접촉면연결과 모든 절점공유 옵션을 사용한 모델을 적용할 경우, 실험결과와 근사한 예측이 가능한 것으로 나타났다.

• 디자인학연구
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• 제19권2호
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• pp.91-98
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• 2006

제품의 융합과 그 사용 환경의 복잡화로 인하여 다양한 감각을 활용해서 제품과 교감하는 다중 인터페이스의 필요성이 제기되고 있다. 전통적이고 일반적인 정보의 습득에는 시각이 압도적으로 많이 활용되었으나 디지털 네트워크 기술을 기반으로 발달할 미래 정보 사회에서는 보다 편리하고 합리적인 제품의 사용을 위하여 다양한 감각의 활용이 요구될 것이다. 정보 전달에 있어서 시각과 더불어 점차적으로 활용 가능성이 높아지고 있는 청각은 그 쓰임새가 더욱 넓어지고 또한 다양한 방식으로 발전될 것이다. 이러한 배경을 바탕으로 본 연구에서는 정보의 전달에서 사용되는 문자언어와 음성언어의 특성과 그에 대한 반응에 있어서 남성과 여성의 차이점의 비교분석에 관한 연구가 수행되었다. 이를 위하여 일단 언어를 구성하는 여러 가지 요소에 대한 문헌자료의 연구를 수행하였다. 이어서 시각과 청각의 특성을 검토한 후 선행 연구를 기반으로 하여 적절한 실험이 설계 및 수행되었다. 수행된 실험은 객관적인 분석방법을 통하여 실험 결과가 검토되었다. 금번 연구의 결과로는 첫째, 문자언어에 대한 반응 시간이 음성언어에 대한 그것보다 짧다는 것, 둘째 각 자극에 대한 반응에 있어서 남녀간의 차이가 존재한다는 것, 셋째, 시각이 청각에 비하여 선택적인 측면에서 절대적 우위를 점하지 못한다는 점등을 들 수 있다. 이번 연구를 기반으로 하여 보다 다양한 감각에 대한 폭 넓은 연구 방법의 개발이 필요할 것으로 사료된다.

• 정신신체의학
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• 제24권2호
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• pp.157-164
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• 2016

Objectives : The objective of this study was to investigate the characteristics of language profiles according to whether or not Korean children with autism spectrum disorder(ASD) also have ADHD, and to examine the relationship with executive function. Methods : Participants in the study were boys with ADHD aged 6 to 11 years who visited the clinic from January 2012 to December 2013. In this study, 25 boys with ASD were included, and completed scales included the Korean version of Autism Diagnostic Interview-Revised(K-ADI-R), Korean version of Autism Diagnostic Observation Schedule(K-ADOS), Korean ADHD Rating Scale(K-ARS), and Korean-Conners' Parent Rating Scale(K-CPRS). They also completed neuropsychological tests and assessed language profiles. Patients were categorized into two groups(with ADHD and without ADHD). T-test and Multivariate analysis of covariance (MANCOVA) was used for analysis. Results : Statistically, no difference was found in receptive and expressive language ability between the ASD groups with and without ADHD. However, a lower score in Test of Problem solving(TOPS) was observed for ASD with ADHD than for ASD without ADHD, with problem solving and finding cues showing significant differences. Conclusions : These findings suggest that language profiles in the ASD group without ADHD could be similar to those in the ASD group with ADHD, but comorbid ADHD could lead to more difficulty in linguistic ability for problem solving and could be related with executive function of the frontal lobe.

• Asian-Australasian Journal of Animal Sciences
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• 제32권8호
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• pp.1145-1152
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• 2019

Objective: Mulberry (Morus alba L.) is a cultivated shrub grown widely in the sub-tropical and tropical areas. It has been shown that mulberry leaf contains high levels of protein while having polyphenols as phytonutrients. Therefore, it is important to conduct an experiment to assess potential toxic level from mulberry on behavior, blood hematological and coagulation parameter using Sprague-Dawley (SD) rats. Methods: Both male and female SD rats were given an intragastric administration of respective treatments of mulberry leaf intakes (control, low and high levels). Parameters of feed intake, hematological and coagulation of blood parameters, as well as liveweight changes were taken during the 7 d of adaptation, 28 d of treatment exposure, and 14 d of recovery periods, respectively. All treatment data were statistically analyzed using analysis of variance of SPSS17.0 for Windows Statistical Software following the Randomized complete block design with sex as a block. Results: Most of the parameters of the physical symptoms of the SD rats, were not significantly different (p>0.05) when compared with that of the control group. Those which remain unchanged in each dose group were, body weight (BW) gain, feed intake, the hematology and coagulation indexes. Although, there were a few individual indicators that were abnormal, but the overall physiological appearance of the rats were normal. Conclusion: Results under this experiment revealed that most hematological and coagulation parameters of the SD rats in both male and female were normal, although the weight gain of female rats in high-dose group was significantly reduced than those of the male rats. Under this study, the use of mulberry leaf up to 2 g/kg BW did not result in abnormal phenomenon in the SD rats. These findings would offer useful information for further in vivo feeding trials in animals to extensively use of mulberry leaf to improve animal production, particularly in P.R. China.

• Animal Bioscience
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• 제35권7호
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• pp.999-1009
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• 2022

Objective: To improve the feeding value of rice straw (RS), this study evaluated the potential of rice straw fermented with Pleurotus sajor-caju (FRS) as dairy goat feed. Methods: Spent Pleurotus sajor-caju mushroom substrate was used as fungi inoculum to break the lignocellulose linkage of rice straw, which was solid-fermented at 25℃ to 30℃ for 8 weeks. The ruminal degradation of pangolagrass hay (PG), FRS, and RS were measured in situ for 96 hours in three dry Holstein cows, respectively. Effect of fungi fermented RS on milking performance was studied in feeding trials. A total of 21 Alpine goats a trial were divided into 3 groups: a control group in which PG accounted for 15% of the diet dry matter, and FRS or RS was used to replace the PG in the control group. Goats were fed twice a day under two 28-day trial in individual pens. Meanwhile, a 3×3 Latin square trial (14 days/period) was conducted to study the rumen digestion of three diets by using three fistulated dry goats. Rumen contents were collected for metabolite analyses every one to three hours on the last two days. Results: In situ study showed that fermentation could elevate the rumen degradable fraction and effective degradability of RS (p<0.05). Effective degradability of FRS dry matter was significantly increased from 29.5% of RS to 41.7%. Lactating trial results showed that dry matter intake and milk yield in the PG group and FRS group were similar and higher than those in RS group (p<0.05). The concentration of propionic acid and total volatile fatty acid in the RS group tended to be lower than those in PG group (p<0.10). There were no differences in rumen pH value and ammonia nitrogen level among the groups tested. Conclusion: Fermentation of rice straw by spent Pleurotus sajor-caju mushroom substrate could substantially enhance its feeding value to be equivalent to PG as an effective fiber source for dairy goat. The fermented rice straw is recommended to account for 15% in diet dry matter.