Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
권호 표지

The analgesic mechanism of Acupuncturing at $ST_{36}$ in the abdominal pain of the mouse

족삼리 침자극의 복통 억제기전 연구

  • Lim, Hyung-Taeck (Research group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute, Kyung Hee University) ;
  • Park, Hi-Joon (Research group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute, Kyung Hee University) ;
  • Jang, Ji-Ryeon (Research group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute, Kyung Hee University) ;
  • Choi, Il-Hwan (Research group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute, Kyung Hee University) ;
  • Lee, Seok-Chan (Environment and Process Technology Division, Korea Institute of Science and Technology) ;
  • Kim, Dae-Soo (Environment and Process Technology Division, Korea Institute of Science and Technology) ;
  • Shin, Hee-Sup (Environment and Process Technology Division, Korea Institute of Science and Technology) ;
  • Lim, Sa-Bi-Na (Research group of Pain and Neuroscience in Vision 2000 Project, East-West Medical Research Institute, Kyung Hee University)
  • 임형택 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀) ;
  • 박히준 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀) ;
  • 장지련 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀) ;
  • 최일환 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀) ;
  • 이석찬 (한국과학기술연구원 생체과학연구부) ;
  • 김대수 (한국과학기술연구원 생체과학연구부) ;
  • 신희섭 (한국과학기술연구원 생체과학연구부) ;
  • 임사비나 (경희대학교 동서의학연구소 경희비젼 2000 통증 및 신경의학연구팀)
  • Published : 2004.06.27
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Abstract

Objective : Acupuncture has been used for treatment of numerous disorders, especially for pain control in Oriental Medicine. However, the mechanism of pain control by acupuncture was not clear until now. This study was performed to prove analgesic mechanism of acupuncture treatment at acupoint $ST_{36}$ by observing the changes of abdominal pain and c-Fos expression in the thalamus. Methods : Abdominal pain was induced by acetic acid, and the changes of writhing reflex after acupuncture treatment on $ST_{36}$ and non-acupoints were measured. c-Fos immunohistochemistry was also performed to study the changes of the neuronal activity in the thalamus. Results : The writhing reflex decrease significantly after acupuncturing at $ST_{36}$ compared with control group(p<0.05). The changes of the writhing reflex by non-acupoint acupuncture treatment also showed significant decrease compared with control group(p<0.05). c-Fos expression in the thalamus, especially periventricular part was significantly decreased after acupuncturing as $ST_{36}$ compared with control groups(p<0.05). Conclusion : This study shows that the acupuncture has the analgesic effect in the abdominal pain induced by acetic acid and the thalamus might be a important area for this mechanism.

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