• Journal of Pharmaceutical Investigation
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• v.30 no.1
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• pp.33-37
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• 2000

One of the methods to increase the solubility of a drug is to use complexation with a cyclodextrin. Due to the hydrophobic nature of the interior cavity of the cyclodextrin, it has been known that undissociated lipophilic drugs can be included within the cyclodextrin by hydrophobic interaction. Recently, inclusion of hydrophilic or dissociated form of a drug has been investigated. In this study, the synergism of pH and complexation with $hydroxypropy-{\beta}-cyclodextrin\;(HP\;{\beta}\;CD)$ to increase the solubility of two oxicam derivatives was investigated. In addition, the effect of partition coefficient of dissociated and undissociated form of the drug on the extent of complexation with HP ${\beta}$ CD was studied. The solubility was measured by equilibrium solubility method. The solubility of tenoxicam and piroxicam increased exponentially with an increase in solution pH above the pKa of the drug in the presence and absence of HP ${\beta}$ CD. The solubility of the drugs increased linearly as a function of HP ${\beta}CD$ concentration at fixed pH. Although the stability constant of ionized species is less than that of the unionized species, the concentration of the ionized drug complex is greater than that of the unionized drug complex due to higher concentration of ionized species at pH 7.3.

• Child Health Nursing Research
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• v.23 no.2
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• pp.199-206
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• 2017

Purpose: The purpose of this study was to explore perception of the clinical learning environment, resilience and perfectionism in relation to practice burnout and to identify factors influencing practice burnout in student nurses. Methods: A descriptive correlational study was conducted. The participants were 313 student nurses from three universities in B and U city. Data were analyzed using t-test, ANOVA, Pearson correlation coefficient, $Scheff{\acute{e}}s$ test and multiple regression analysis. Results: Mean score for practice burnout in student nurses was 2.92 out of 5 points. Practice burnout explained 44.7% of the variance in perfectionism (${\beta}=.245$, p<.001), satisfaction with college life (${\beta}=.232$, p<.001), resilience (${\beta}=-.228$, p<.001), clinical learning environment (${\beta}=-.193$, p<.001), satisfaction with major (${\beta}=.180$, p=.001), practical relationships with peers (${\beta}=.128$, p=.005), and satisfaction with clinical practice (${\beta}=.124$, p=.039). Conclusion: Research results suggest that the important variable for student nurses' practice burnout is perfectionism. Therefore education is needed to develop strategies to manage perfectionism and reduce practice burnout.

• The Journal of Korean Academic Society of Nursing Education
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• v.22 no.2
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• pp.210-219
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• 2016

Purpose: The purpose of this study was to contribute to career counseling and career guidance for nursing students by examining students' career decision-making styles and career decision levels and the relationship between self-efficacy and career decision-making styles and career decision levels. Methods: A descriptive survey design was used and data were collected using questionnaires from a sample of 469 nursing students. The data were analyzed using frequencies means, Kruskal-Wallis test, Pearson correlation coefficient, and multiple regression analysis with SPSS 21.0. Results: Career decision level had a significant correlation with self-efficacy and decision-making styles. Self-efficacy (${\beta}=.143$, p<.001), type of decision-making styles rational type (${\beta}=.180$, p<.001), intuitive type (${\beta}=.137$, p<.001), dependent type (${\beta}=-.236$, p<.001) and sex (${\beta}=-.086$, p=.023), school grades (${\beta}=.086$, p=.033), and satisfaction of nursing major (${\beta}=.209$, p<.001) were significant predictors of career decision level. Conclusion: It is necessary to develop effective career support programs according to type of decision-making styles, sex, school grades, motivation to improve nursing students' self-efficacy and satisfaction in the nursing major.

• Journal of the Korean Chemical Society
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• v.36 no.4
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• pp.517-522
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• 1992

The reaction of ${\beta}$-picoline with substituted benzoyl chlorides has been studied by means of conductometry under various pressures in acetonitrile. From the values of pseudo-first order and second order rate constants, the activation parameters (${\Delta}V{\neq}$, ${\Delta}{\beta}{\neq}$, ${\Delta}H{\neq}$, ${\Delta}S{\neq}$ and ${\Delta}G{\neq}$) and the pressure dependence of Hammett ${\rho}$ value were studied. The activation volume, the activation compressibility coefficient and the activation entropy were all negative. By increasing pressure the rate constant and Hammett ${\rho}$ value were increased, and the reaction mechanism was proceed in bond formation favored.

• Kyungpook Mathematical Journal
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• v.53 no.1
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• pp.13-23
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• 2013

In this present work, the authors obtain Fekete-Szeg$\ddot{o}$ inequality for certain normalized analytic function $f(z)$ defined on the open unit disk for which $$\frac{{\lambda}{\beta}z^3(L(a,c)f(z))^{{\prime}{\prime}{\prime}}+(2{\lambda}{\beta}+{\lambda}-{\beta})z^2(L(a,c)f(z))^{{\prime}{\prime}}+z(L(a,c)f(z))^{{\prime}}}{{\lambda}{\beta}z^2(L(a,c)f(z))^{{\prime}{\prime}}+({\lambda}-{\beta})z(L(a,c)f(z))^{\prime}+(1-{\lambda}+{\beta})(L(a,c)f(z))}\;(0{\leq}{\beta}{\leq}{\lambda}{\leq}1)$$ lies in a region starlike with respect to 1 and is symmetric with respect to the real axis. Also certain applications of the main result for a class of functions defined by Hadamard product (or convolution) are given. As a special case of this result, Fekete-Szeg$\ddot{o}$ inequality for a class of functions defined through fractional derivatives are obtained.

• Kyungpook Mathematical Journal
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• v.46 no.1
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• pp.19-29
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• 2006

In this paper, we obtain some inequalities similar to Hilbert type. Some new inequalities are also given.

• Korean Journal of Animal Reproduction
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• v.16 no.4
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• pp.377-385
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• 1993

This study was taken to examine correlationships between ehdocrine changes such as estradiol-17$\beta$, progesterone, T4 and T3 and serum components concentrations of female Oreochromis niloticus living in 0$\textperthousand$, 10$\textperthousand$, 20$\textperthousand$, and 30$\textperthousand$ salt concentrations, respectively. The results obtained in these experiments were summarized as follows. Correlation coefficients of serum albumin and thyroxine were ＋0.907 and ＋0.611 in 10$\textperthousand$ and 20$\textperthousand$, respectively. In 30$\textperthousand$ salinity, serum BUN and other 3 kinds of hormones showed all negative correlation coefficients. Correlation coefficients of serum estradiol-17$\beta$ with calcium and cholesterol in 20$\beta$ were ＋0.624, ＋0.733, respectively. Correlation coefficient between serum triglycerides and thyroxine in 30$\beta$ was ＋0.989.

• Communications for Statistical Applications and Methods
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• v.1 no.1
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• pp.102-111
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• 1994

We Propose a method of sensitivity analysis in latent root regression analysis (LRRA). For this purpose we derive the quantities ${\beta\limits^\wedge \;_{LRR}}^{(1)}$, which correspond to the theoretical influence function $I(x, y \;;\;\beta\limits^\wedge \;_{LRR})$ for the regression coefficient ${\beta\limits^\wedge}_{LRR}$ based on LRRA. We give a numerical example for illustration and also investigate numerically the relationship between the estimated values of ${\beta\limits^\wedge \;_{LRR}}^{(1)}$ with the values of the other measures called sample influence curve(SIC) based on the recomputation for the data with a single observation deleted. We also discuss the comparision among the results of LRRA, ordinary least square regression analysis (OLSRA) and ridge regression analysis(RRA).

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 2000.11a
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• pp.115-121
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• 2000

The contaminant seperation performance of fitters has been widely investigated for many years. However, most of the proposed filter assessment techniques have proven disappointing for practical use. Although the Multipass (Beta) Filtration test method (ISO 4572) provides valuable information in assessing fi ters, it has a limitation on evaluating the increasing family of low-flow and high Beta filters. The limitation stems from two main sources: the over simplified theoretical model and the inherently complicated procedure in analysis of data. Hence a new advanced filtration theory, the Beta Prime developed on a draw-down test basis is applied to predict field operating characteristics of a filter for tractor hydraulic systems in this study.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2001.05c
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• pp.15-18
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• 2001

The composites were fabricated 61 vol% $\beta$-SiC and $39vol%TiB_2$ powders with the liquid forming additives of 8, 12, 16wt% $Al_2O_3+Y_2O_3$ by hot pressing at $1730^{\circ}C$ and subsequent pressed annealing and pressureless annealing at $1750^{\circ}C$ for 4 hours to form YAG. The result of phase analysis of composites by XRD revealed $\alpha$-SiC(6H), $TiB_2$, and YAG($Al_5Y_3O_{12}$) crystal phase. The relative density of composites were increased with increasing $Al_2O_3+Y_2O_3$ contents. The fracture toughness showed the highest value of $7.77MPa{\cdot}m^{1/2}$ for composites added with 12wt% $Al_2O_3+Y_2O_3$ additives at room temperature. The electrical resistivity and the resistance temperature coefficient showed the lowest of $7.3{\times}10^{-4}{\Omega}{\cdot}cm$ and $3.8{\times}10^{-3}/^{\circ}C$, respectively, for composite added with 12wt% $Al_2O_3+Y_2O_3$ additives at room temperature. The electrical resistivity of the composites was all positive temperature coefficient resistance(PTCR) in the temperature range of $25^{\circ}C$ to $700^{\circ}C$.