• 생약학회지
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• 제19권2호
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• pp.93-96
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• 1988

Three flavonoids were isolated from Epimedium koreanum and identified as quercetin(1), $anhydroicaritin-3-O-{\alpha}-rhamnoside(2)$ and icariin(3) by spectroscopic methods. The former two compounds are the first isolation from this plant.

• 한국자원식물학회지
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• 제11권1호
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• pp.22-29
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• 1998

Korean folk medicine "Ggaenggaengipul" has beenused to dlear heat and treat chronic childfood mutitional impairment, diarrhea, jaundice, haemorrhoid, inflammation, anepithymia, nausea and egestion .The crude drug often used as a supstitute for the more expensive "Huang Lian " (황연) in Korea and China. With regard to the botainicla origic of " Ggaenggaenigipul" , it has never been studied pharmacognostically. To clarify botanical origin of " Ggaenggaegipul" , the morphological and anatomicla characteristics of the leaves, petiole, rhizoma, and radix of Jeffersonia dubia BENTH were studied.

• Natural Product Sciences
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• 제12권1호
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• pp.19-23
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• 2006

Berberis chitria (family Berberidaceae) has a close affinity with B. aristata, used in traditional systems of medicine as a drug 'Daruharidra' for skin disease, jaundice, affection of eyes, and rheumatism. Keeping this in view, in the present study attempts have been made to identify marker characters of B. chitria in order to differentiate the two species. Some of the diagnostic features of the root are patches of pericyclic fibre, pitted sclerieds and berberine containing cells and heterocyclic medullary rays. Besides, the physicochemical characters such as total ash; acid insoluble ash; alcohol and water soluble extractive; tannins; sugar and starch percentages has shown variations. The percentage of berberine as berberine hydrochloride was also calculated through HPTLC densitometric method and it was found little higher than B. aristata and B. asiatica i.e. 3.16%. Thus, this species can be utilized as a possible substitute to Daruharidra.

• 생약학회지
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• 제13권2호
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• pp.55-61
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• 1982

Thirtyfour species of Korean medicinal plants which have been frequently used in oriental herb prescriptions were evaluated on their cytotoxicity and potential antitumor activities against AC glioma(9 ASK) in vitro. Dose of $100{\mu}g/ml$ of plant extracts appeared to exhibit slight cytotoxicity. Seven plant extracts, Aralia continentalis(Araliaceae), Lycium chinensis(Solanaceae), Epimedium koreanum(Berberidaceae), Platyodon grandiflorium(Campanulaceae), Pleuropterus multiflorus(Polygonaceae), Rheum undulatun(Polygonaceae) and Scutellaria baicalensis(Laminaceae), exhibited significant reversal$(51{\sim}90%)$ of astrocyte formation into original neuroglial cells' morphology through the prescreen tests.

• Natural Product Sciences
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• 제13권1호
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• pp.27-32
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• 2007

Berberis tinctoria (Berberidaceae), commonly known as Nilgiri Barberry is a common allied species to B. aristata, used in India Traditional Systems of Medicine by the name of 'Daruharidra' for skin disease, jaundice, affection of eyes, and rheumatism. Keeping this in view, in the present study attempts have been made to identify marker characters of B. tinctoria. Some of the diagnostic features of the root are patches of pericyclic fibre, pitted sclerieds, crystals, berberine containing cells and heterocyclic medullary rays. Besides, the physicochemical characters such as total ash; acid insoluble ash; alcohol and water soluble extractive; tannins; sugar and starch percentages has also shown some variations. The percentage of berberine as berberine hydrochloride was also calculated through HPTLC densitometric method and it was found almost similar to B. aristata, B. asiatica and B. chitria i.e. 3.36%. Thus it can be explored as a possible source of substitute to B.aristata.

• 생약학회지
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• 제20권1호
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• pp.21-24
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• 1989

A new method for quantitative determination of icariin in Epimedii Herba by high performance liquid chromatography was established. A reversed-phase system with $a\;{\mu}Bondapak\;C_{18}$ column using methanol in water(15% to 70%, gradient elution) as a mobile phase was developed. Icariin and spinosin as an internal reference were detected at 350 nm and the analysis was successfully carried out within 30 min.

• Natural Product Sciences
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• 제7권4호
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• pp.102-106
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• 2001

Berberis aristata (family Berberidaceae), known as 'Daruharidra' in Ayurvedic system of medicine, is an important medicinal plant used extensively for treating a variety of ailments in various systems of indigenous medicine. Being an important medicinal plant it is being adulterated and in the absence of any pharmacognostic information it is very difficult to check the adulteration. The present study was therefore, carried out to provide the requisite pharmacognostic details. Morphological, anatomical and phytochemical aspects of B. aristata were carried out. Diagnostic features of B. aristata root were identified and characterized from the above investigations and presented in the present communication. Some of the diagnostic features of the root drug noted from the anatomical study are patches of pericyclic fibre, pitted sclerieds, berberine containing cells and heterocyclic medullary rays. HPTLC analysis showed three distinct bands of which berberine was identified as the major constituents. The $R_f$. value of other bands was also calculated.

• Advances in Traditional Medicine
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• 제10권3호
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• pp.184-190
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• 2010

Berberis lycium (family Berberidaceae) has a close affinity with B. aristata, used in India Traditional Systems of Medicine as a drug 'Daruharidra' for skin disease, jaundice, affection of eyes, and rheumatism. Various species of Berberis are being sold in India herbal drug market. During the market surveillance of different herbal drug markets of India, it was observed that almost all the markets either comprise of Berberis lycium or Berberis asiatica. Keeping this in view, in the present study attempts have been made to identify marker characters of this potent species.

• 한국환경생태학회지
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• 제15권4호
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• pp.293-318
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• 2002

As one of the botanical hot spots of the Korean peninsula, the vascular plant species in the areas of Taebaeksan, Hambaeksan, Geumdaebong(Peak) and Maebongsan were summarized as 694 taxa, 89 families, 302 genus, 579 species. 102 varieties and 13 forms. Based on the list of rare and endangered plants from the Forest Research Institute and the Ministry of Environment, 22 species were recorded in the studied areas: Thuja koraiensis(Cupressaceae), Arisaema heterophyllum(Araceae), Disporum ovale(Liliaceae), Tricyrtis dialata(Liliaceae), Lilium distichum(Liliaceae), Anemone koraiensis(Ranunculaceae), Rodgersia podophylla(Saxifragaceae), Rosa marretii(Rosaceae), Viola diamantica(Violaceae), Viola albida(Violaceae), Echinopanax horridum(Araliaceae), Acanthopanax chiisannensis(Araliaceae), Lysimachia coreana(Prinmulaceae), Syringa velutina var. kamibayashii, Halenia corniculata(Gentianaceae), Partrinia saniculaefolia(Valerianaceae), Adenophora grandiflora(Campanulaceae), Cacalia pseudo-taimingasa(Compositae) Iris odaesanensis(Iridaceae), Leontice microrhyncha(Berberidaceae), Rpdgersia tabularis(Saxifragaceae), and Acanthopanax sentico년(Araliaceae), Among them the four species were recorded from the list of the Ministry of Environment. As most of the species were recorded from the mountain-trails, the long-term habitat monitoring for the species is required .

• 생약학회지
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• 제54권2호
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• pp.66-71
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• 2023

Ethyl acetate (EA) soluble fraction of the Berberis amurensis (Berberidaceae) methanol extract showed the potent DPPH radical scavenging activity through Caenorhabditis elegans model system. The EA fraction was measured for the activity of superoxide dismutase (SOD), catalase, and oxidative stress tolerance by using C. elegans along with reactive oxygen species (ROS) level. In addition, SOD-3 expression was conducted using a transgenic strain (CF1553) to confirm that the regulation of the stress response gene is responsible for the increased stress tolerance of C. elegans treated by the EA fraction. As a result, the EA soluble fraction of B. amurensis increased SOD and catalase activity, and decreased ROS accumulation in a dose-dependent manner. Furthermore, the EA fraction-treated CF1553 worm showed higher SOD-3::GFP intensity than the control worm.