Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Toxicological Evaluation of Medicinal Plants Used for Herbal Drugs (III) -Cytotoxicity and Antitumor Activities Against Glioma(9 ASK)-

한국산 생약의 약리작용 및 독성연구 (제3보) -세포독성 및 Glioma(9 ASK)에 대한 항암작용-

  • Chang, Il-Moo (Natural Products Research Institute, Seoul National University) ;
  • Chi, Hyung-Joon (Natural Products Research Institute, Seoul National University)
  • Published : 1982.06.30
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Abstract

Thirtyfour species of Korean medicinal plants which have been frequently used in oriental herb prescriptions were evaluated on their cytotoxicity and potential antitumor activities against AC glioma(9 ASK) in vitro. Dose of $100{\mu}g/ml$ of plant extracts appeared to exhibit slight cytotoxicity. Seven plant extracts, Aralia continentalis(Araliaceae), Lycium chinensis(Solanaceae), Epimedium koreanum(Berberidaceae), Platyodon grandiflorium(Campanulaceae), Pleuropterus multiflorus(Polygonaceae), Rheum undulatun(Polygonaceae) and Scutellaria baicalensis(Laminaceae), exhibited significant reversal$(51{\sim}90%)$ of astrocyte formation into original neuroglial cells' morphology through the prescreen tests.

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