• Archives of Pharmacal Research
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• 제17권1호
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• pp.54-55
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• 1994

• 한국음향학회지
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• 제36권6호
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• pp.387-393
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• 2017

베타 사이클로덱스트린(${\beta}$-Cyclodextrin, ${\beta}$-CD)(호스트)과 벤조산 유도체(게스트)의 수용액에 대하여 $25^{\circ}C$, 광대역 주파수영역(0.2 MHz ~ 50 MHz)에서 초음파 흡수계수를 측정하여 호스트와 게스트의 복합체 형성반응의 속도론적 연구를 행하였다. 특히 본 연구에서는 1 MHz이하의 초음파 흡수측정이 중요하다. ${\beta}$-CD와 벤조산 유도체의 상호작용에 의한 초음파 완화는 수 MHz영역에서 단일 완화현상의 전형적인 스펙트럼을 보였다. 단일완화현상의 원인은 ${\beta}$-CD와 벤조산 유도체의 복합체 형성반응에 의한 화학평행의 혼란상태에 의한것으로 해석하였다. 게스트 농도에 따른 완화주파수의 의존성으로부터 붕괴 속도상수($k_b=7.48{\times}10^6M^{-1}s^{-1}$), 평형상수($K=68.6M^{-1}$)를 결정하였다. 그리고 파장당 최대흡수치의 의존성으로부터 반응에 의한 표준체적변화(${\Delta}V=10.6{\times}10^{-6}m^3mol^{-1}$)를 구하였다. 또한 게스트 분자의 소수성 그룹이 복합체의 안정성에 중요한 역할을 하는 것을 알았다.

• 한국응용과학기술학회지
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• 제11권1호
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• pp.53-60
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• 1994

The Synthesis of azobenzene containing long chain fatty acid and poly vinyl alcohol by esterification reaction($C_{n}-Azo-PVA$) was optimized, starting from P-(P'-hydroxy phenyl azo)-benzoic acid and the product of reaction containing azobenzene chromophores was investigated by ultraviolet spectrophotometery in toluene solvent at room temperature. In addition, UV absorption spectra of Langmmuir Blodggett (LB) film deposited on quartz plate have been measured and the structure of these compounds were ascertained by means of Ultraviolet and FT-IR. Recrystallization of reaction product in the solvent results the experimental yield obtained about 22.27% P-(P'-octadecyloxy phenyl azo)-benzoic acid-poly vinyl alcohol. Long chain azobenzene derivative-poly vinyl alcohols are induced phtoisomerization by u, v, and visible light irradiation. The LB film of azobenzene containing long chain fatty acids($C_{18}-Azo-PVA$) are possible of being applied to functional molecular devices such as photomemory and light switching.

• Natural Product Sciences
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• 제5권3호
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• pp.134-137
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• 1999

The chloroform extract of Pulicaria gnaphalodes yielded flavonoids (1-2), sesquiterpenoid (3), sterol (4), benzoic acid derivative (5) and fatty acids (6-7). Their structures were elucidated with the aid of NMR spectroscopy. The described compounds have not been reported so far from this source.

• 미생물학회지
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• 제54권1호
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• pp.18-23
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• 2018

히말라야산의 동토에서 발견된 Preussia sp.로부터 신규 벤조산 유도체 benzyl 2,4-di(benzyloxy)benzoate (1)와 6개의 알려진 화합물들(2-7)이 분리되었다. 신규물질 및 다른 화합물들의 구조는 1D-와 2D NMR실험 및 문헌값과의 비교에 의하여 결정되었다. 화합물 2-7은 동 속 및 Sporormiaceae과에서 처음으로 얻어졌다. 분리된 물질들은 쥐의 대식세포 RAW 264.7 cells에서 lipopolysaccharide (LPS) 처리에 의하여 유도된 nitric oxide (NO)의 생성량 억제를 측정하였다. 화합물 1번과 2번은 100 mg/ml의 농도로 처리했을 때 LPS에 의하여 유도된 NO 생성량을 각각 50.7% 및 88.5%까지 억제하는 것을 보였다.

• Journal of Microbiology and Biotechnology
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• 제31권8호
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• pp.1079-1087
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• 2021

Gentisic acid (GA), a benzoic acid derivative present in various food ingredients, has been shown to have diverse pharmaceutical activities such as anti-carcinogenic, antioxidant, and hepatoprotective effects. In this study, we used a co-culture system to investigate the mechanisms of the anti-inflammatory and anti-adipogenic effects of GA on macrophages and adipocytes, respectively, as well as its effect on obesity-related chronic inflammation. We found that GA effectively suppressed lipopolysaccharide-stimulated inflammatory responses by controlling the production of nitric oxide and pro-inflammatory cytokines and modulating inflammation-related protein pathways. GA treatment also inhibited lipid accumulation in adipocytes by modulating the expression of major adipogenic transcription factors and their upstream protein pathways. Furthermore, in the macrophage-adipocyte co-culture system, GA decreased the production of obesity-related cytokines. These results indicate that GA possesses effective anti-inflammatory and anti-adipogenic activities and may be used in developing treatments for the management of obesity-related chronic inflammatory diseases.

• Bulletin of the Korean Chemical Society
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• 제34권2호
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• pp.460-464
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• 2013

Single-chain variable fragments of antibodies (scFv) specific to 2,4-dinitrotoluene (DNT) were isolated from a phage library displaying synthetic human scFv fragments with 6 diversified complementary determining regions (CDRs). A DNT derivative that contained an extended amine group was synthesized and conjugated to the NHS-group that was linked to magnetic beads. Phages specific to the immobilized DNT derivatives were isolated from the library after 4 rounds of sequential binding and elution processes. The displayed scFv fragments from the isolated phages showed consensus CDR sequences. One DNT-specific scFv was expressed in E. coli and purified using Ni-affinity chromatography. The purified DNT-specific scFv binds specifically to the immobilized DNT-derivative with $K_D$ value of $6.0{\times}10^{-7}$ M. The scFv and DNT interaction was not disrupted by the addition of 4-nitrotoluene or benzoic acid. These data demonstrate that the screened scFv from the phage displayed library could be used for selective and sensitive detection of explosives such as TNT.

• Bulletin of the Korean Chemical Society
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• 제33권6호
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• pp.1939-1944
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• 2012

Benzoyloxy benzophenone derivatives were prepared in 3 steps including DCC coupling, Fries rearrangement and esterification from benzoic acids in 24-89% total yields. Among the prepared 12 benzophenone analogues 1a-1l, the compound 1b having three chloro groups at the para position showed maximum inhibitory effects of ICAM-1 expression but, 1a which have no substituents at all showed no inhibitory activity. This study provides the evidences that benzoyloxy benzophenone derivative, 1b may exert its anti-inflammatory activity by suppressing IFN-${\gamma}$-induced ICAM-1 expression.

• Bulletin of the Korean Chemical Society
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• 제28권5호
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• pp.791-794
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• 2007

A new azocalix[4]arene, 5,14,17,23-tetra[(2-benzoic acid)(azo)phenyl] calix[4]arene (2), has been prepared by hydrolysis of its ester derivative and characterized by 1H NMR, IR, UV-Vis spectroscopy and elemental analysis. Based on UV spectral changes, we found that 2 exhibits Pb2+ ion selectivity. In basic media, Pb2+ forms a 1:1 complex with the ligand. Beer's law is obeyed in the range of 2.0 × 10?6 ? 2.4 × 10?5 mol L?1 of Pb2+. The molar absorptivity (ε ) of 2-Pb2+ complex is 1.89 × 104 L mol?1 cm?1 at 440 nm, and the detection limit is 1.6 × 10?6 mol L?1.

• 미생물학회지
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• 제52권4호
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• pp.415-420
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• 2016

북극 유래 박테리아인 Pseudomonas aeruginosa 균주의 대사산물에 대한 화학적 연구는 벤조산 유도체 6번을 포함하여, 두 개의 diketopiperazine 1과 2, 두 개의 phenazine alkaloid 3과 4, indole carbaldehyde 5번을 분리하였다. 화합물들의 구조는 1D 과 2D NMR, 및 MS 기법들과 기존 보고된 문헌 값 과의 비교에 의하여 동정되었다. 분리된 화합물들 중 5번과 6번은 북극 척지해 해수의 P. aeruginosa로 부터 처음으로 보고 되었다. 대사산물들 1-6의 항균 활성은 Staphylococcus aureus과 and Candida albicans에 대하여 측정하였다.