Browse > Article
http://dx.doi.org/10.7845/kjm.2018.7085

Chemical constituents from the culture filtrate of a Himalayan soil fungus, Preussia sp. and their anti-inflammatory activity  

Youn, Ui Joung (Division of Life Sciences, Korea Polar Research Institute, KIOST)
Seo, Seung Suk (Division of Life Sciences, Korea Polar Research Institute, KIOST)
Yim, Jung Han (Division of Life Sciences, Korea Polar Research Institute, KIOST)
Kim, Il Chan (Division of Life Sciences, Korea Polar Research Institute, KIOST)
Han, Se Jong (Division of Life Sciences, Korea Polar Research Institute, KIOST)
Publication Information
Korean Journal of Microbiology / v.54, no.1, 2018 , pp. 18-23 More about this Journal
Abstract
A new naturally occurring benzoic acid derivative, benzyl 2,4-di(benzyloxy)benzoate (1) and six known compounds (2-7) were isolated from the fungus, Preussia sp. found in frozen soil of the Himalaya Mountain. The structures of the new compound, together with the known compounds were determined by 1D-and 2D-NMR experiments, as well as comparison with published values. In addition, to the best of our knowledge, the known compounds 2-7 were isolated for the first time from the genus Preussia and the family Sporormiaceae. The isolates were evaluated for cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells in vitro. Compounds 1 and 2 inhibited NO production by 50.7% and 88.5% at a concentration of 100 mg/ml, respectively.
Keywords
Preussia sp.; Sporormiaceae; benzoic acid derivative; diketopiperazine; nitric oxide;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Arx von, J.A. and Van der Aa, H.A. 1987. Spororminula tenerifae gen. et sp. nov. Mycol. Soc. 89, 117-120.   DOI
2 Chen, X., Shi, Q., Lin, G., Guo, S., and Yang, J. 2009. Spirobisnaphthalene analogs from the endophytic fungus Preussia sp. J. Nat. Prod. 72, 1712-1715.   DOI
3 Du, L., Robles, A.J., King, J.B., Mooberry, S.L., and Cichewicz, R.H. 2014. Cytotoxic dimeric epipolythiodiketopiperazines from the ascomycetous fungus Preussia typharum. J. Nat. Prod. 77, 1459-1466.   DOI
4 Guarro, J., Abdullah, S.K., Gene, J., and Al-Saadoon, A.H. 1997. A new species of Preussia from submerged plant debris. Mycol. Res. 101, 305-308.   DOI
5 Kawada, M., Someno, T., Inoue, H., Ohba, S., Masuda, T., Kato, T., and Ikeda, D. 2010. NBRI16716A, a new antitumor compound against human prostate cancer cells, produced by Perisporiopsis melioloides Mer-f16716. J. Antibiot. 63, 319-323.   DOI
6 Kitajima, J., Ishikawa, T., Tanaka, T., and Ida, Y. 1999. Water-soluble constituents of fennel. IX. Glucides and nucleosides. Chem. Pharm. Bull. 47, 988-992.   DOI
7 Krasnoff, S.B., Keresztes, I., Donzelli, B.G.G., and Gibson, D.M. 2014. Metachelins, mannosylated and N-oxidized coprogen-type siderophores from Metarhizium robertsii. J. Nat. Prod. 77, 1685-1692.   DOI
8 Lee, B.H. and Pan, T.M. 2013. Dimerumic acid, a novel antioxidant identified from Monascus-fermented products exerts chemoprotective effects: Mini review. J. Funct. Foods 5, 2-9.   DOI
9 Mapperson, R.R., Kotiw, M., Davis, R.A., and Dearnaley, J.D. 2014. The diversity and antimicrobial activity of Preussia sp. endophytes isolated from Australian dry rainforests. Curr. Microbiol. 68, 30-37.   DOI
10 Moncada, S., Palmer, R.M.J., and Higgs, E.A. 1991. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43, 109-142.
11 Saladino, R., Crestini, C., Neri, V., Ciciriello, F., Costanzo, G., and Mauro, E.D. 2006. Origin of informational polymers: The concurrent roles of formamide and phosphates. Chembiochem 7, 1707-1714.   DOI
12 Talontsi, F.M., Lamshoft, M., Douanla-Meli, C., Kouam, S.F., and Spiteller, M. 2014. Antiplasmodial and cytotoxic dibenzofurans from Preussia sp. harboured in Enantia chlorantha Oliv. Fitoterapia 93, 233-238.   DOI
13 Tang, F., Wang, Y., and Hou, A.J. 2014. Total syntheses of Nigrasin I and Kuwanon C. Tetrahedron 70, 3963-3970.   DOI
14 Arenal, F., Platas, G., and Pelaez, F. 2004. Variability of spore length in some species ofthe genus Preussia (Sporormiella). Mycotaxon 89, 137-151.
15 Tseng, W.T., Hsu, Y.W., and Pan, T.M. 2016. Neuroprotective effects of dimerumic acid and deferricoprogen from Monascus purpureus NTU 568-fermented rice against 6-hydroxydopamine-induced oxidative stress and apoptosis in differentiated pheochromocytoma PC-12 cells. Pharm. Biol. 54, 1434-1444.   DOI
16 Uemoto, H., Tsuda, M., and Kobayashi, J. 1999. Mukanadins A-C, new bromopyrrole alkaloids from marine sponge Agelas nakamurai. J. Nat. Prod. 62, 1581-1583.   DOI
17 Yamashiro, J., Shiraishi, S., Fuwa, T., and Horie T. 2008. Dimerumic acid protected oxidative stress-induced cytotoxicity in isolated rat hepatocytes. Cell Biol. Toxicol. 24, 283-290.   DOI
18 Anggard, E. 1994. Nitric oxide: mediator, murderer, and medicine. Lancet 343, 1199-1206.   DOI