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http://dx.doi.org/10.7845/kjm.2016.6058

Isolation of secondary metabolites from an Arctic bacterium, Pseudomonas aeruginosa and their antimicrobial activities  

Youn, Ui Joung (Division of Life Sciences, Korea Polar Research Institute, KIOST)
Kim, Min Ju (Division of Life Sciences, Korea Polar Research Institute, KIOST)
Han, Se Jong (Division of Life Sciences, Korea Polar Research Institute, KIOST)
Yim, Jung Han (Division of Life Sciences, Korea Polar Research Institute, KIOST)
Publication Information
Korean Journal of Microbiology / v.52, no.4, 2016 , pp. 415-420 More about this Journal
Abstract
Chemical study of an Arctic bacterium, Pseudomonas aeruginosa (Pseudomonadaceae) led to the isolation of two diketopiperazines 1 and 2, two phenazine alkaloids 3 and 4, and an indole carbaldehyde 5, along with a benzoic acid derivative 6. The structures of the compounds were confirmed by 1D and 2D NMR, and MS experiments, as well as by comparison of their data with published values. Among the isolates, compounds 5 and 6 were isolated for the first time from P. aeruginosa of the seawater of Arctic Chuckchi Sea. Antimicrobial activities of compounds 1‒6 against a Staphylococcus aureus and Candida albicans were evaluated.
Keywords
Pseudomonas aeruginosa; antimicrobial activity; diketopiperazine; phenazine; Pseudomonadaceae;
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