• 생약학회지
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• 제22권1호
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• pp.13-17
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• 1991

Dimethyltectorigenin, irisflorentin, muningin and iristectorigenins A and B were isolated from the rhizomes of Belamcanda chinensis.

• Archives of Pharmacal Research
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• 제14권4호
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• pp.357-358
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• 1991

Two flavonoids were isolated from the rhizomes of Belamcanda chinensis and identified as kanzakiflavove-2 and 2R:3R-dihydrokaempferol-7-methylether, respectively.

• 생약학회지
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• 제20권4호
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• pp.219-222
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• 1989

Tectorigenin, irigenin, their glucosides and 5,3'-dihydroxy-4',5'-dimethoxy-6,7-methylenedioxyisoflavone were isolated from the rhizomes of Belamcanda chinensis.

• 생약학회지
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• 제24권4호
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• pp.309-312
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• 1993

A new method for separation and quantitative determination of isoflavone glucosides in rhizomes of Belamcanda chinensis (Iridaceae) by high performance liquid chromatography was elaborated. A reverse-phase system with a Spheri-5 RP-18 column using MeOH:HOAc:$H_2O$(24 : 5 : 71) as a mobile phase was developed. The isoflavonoids were detected at 268 nm and the analysis was successfully carried out within 15 min.

• Natural Product Sciences
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• 제10권2호
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• pp.89-91
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• 2004

Six components were isolated from the $CH_2Cl_2$ fraction of Belamcanda chinensis rhizome by open column chromatography. Their structures were elucidated as ${\beta}-sitosterol$ (1), apocynin (2), decursin (3), iristectorigenin A (4), irigenin (5) and tectorigenin (6) by spectral analysis. Among these compounds, decursin (3) was isolated for the first time from a plant of the family Iridaceae.

• Food Science and Biotechnology
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• 제14권1호
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• pp.39-41
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• 2005

Four compounds were isolated from the rhizome of Belamcanda chinensis (Iridaceae) by repeated column chromatography and were elucidated as iristectorigenin A, irigenin, tectorigenin and tectoridin by spectral analysis. The estrogenic activity of these isoflavones was tested using Ishikawa cells. Irigenin, tectorigenin and tectoridin were highly estrogenic ($EC_{50}\;=\;0.75$, 0.42 and $0.81\;{\mu}g/ml$, respectively), while iristectorigenin A exhibited weak estrogenic activity ($EC_{50}{\geq}4\;{\mu}g/ml$).

• Archives of Pharmacal Research
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• 제27권2호
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• pp.184-188
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• 2004

The present study was carried out to clarify whether tectorigenin and tectoridin isolated from the rhizomes of Belamcanda chinensis (Iridaceae) inhibit hepatic damage induced by carbon tetrachloride ($CCl_4$)-intoxication in rats by the experimental methods in vitro and in vivo. Tectorigenin and tectoridin exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by $CCl_4$-intoxication in rats, as well as in a lipid peroxidation causing a significant decrease in malondialdehyde (MDA) production by thiobarbituric acid (TBA)-reactant assay. Both compounds also showed strong increase in the antioxidant enzymes such as hepatic cytosolic superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-px) activities in $CCl_4$-intoxicated rats. These results suggested that tectorigenin and tectoridin isolated from the rhizomes of B. chinensis possess not only the antioxidative, but also the hepatoprotective activities in $CCl_4$ -intoxicated rats.

• 한국콘텐츠학회논문지
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• 제19권1호
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• pp.242-255
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• 2019

이 연구는 34종의 천연 식물 추출물을 이용하여 치주염 원인균 Actinobacillus actinomycetemcomitans와 Prevotella intermedia에 대한 항균효과를 조사하였다. 이에 본 연구는 치주염 원인균에 대한 천연 식물 추출물의 항균효과를 연구하고자 유기용매 추출물을 이용하여 생육저지활성을 측정하고, 시료 추출물의 최소생육저해농도(Minimum Inhibition Concentration, MIC)를 측정한다. 1차적으로 34종의 각 천연 식물 추출물을 에탄올로 추출하여 디스크 확산법(disk diffusion method)을 이용하여 각 추출물의 생육저지환(clear zone, mm)의 크기를 측정한 결과 나복자, 목통, 백작약, 사간, 선복화, 어성초, 연교, 진교, 천련자, 황금, (천)황련, 황백, 해동피 등 13종에서 천연 식물 추출물이 치주염의 원인균인 A. actinomycetemcomitans에 대해서 생육저지 활성을 나타내었다. P. intermedia의 경우, 나복자, (일)당귀, 목통, 사간, 선복화, 어성초, 육계, 자완, 천련자, 황금, (천)황련, 황백, 해동피 등 13종에서 생육저지 활성을 나타내었다. A. actinomycetemcomitans에 대해서는 사간, 육계, 해동피, 황백, (천)황련에서 항균효과가 나타났다. (천)황련은 A. actinomycetemcomitans의 모든 유기용매 분획에서 가장 우수한 생육저지 활성을 나타내었다. P. intermedia는 사간, 육계, 천련자, 황백, 황련에서 생육저지 활성이 나타났다.

• Natural Product Sciences
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• 제13권2호
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• pp.101-104
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• 2007

Four isoflavones including tectorigenin (1), irisflorentin (2), irigenin (3), and tectoridin (4) have been isolated from the 70% EtOH extract of Belamcanda chinensis rhizome. The evaluation for protective effect of compounds 1-4 against glutamate-induced cytotoxicity in hippocampal HT22 cell line was conducted. Compound 1 showed significant protective effect with an EC$_{50}$ value of 67.25 ${\pm}$ 1.2 ${\mu}$M, whereas compounds 2-4 were inactive. These results suggest that compound 1 may possess the neuroprotective activity against oxidative cellular injures.

• Archives of Pharmacal Research
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• 제25권3호
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• pp.306-312
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• 2002

Aldose reductase, the key enzyme of the polyol pathway, is known to play important roles in the diabetic complication. The inhibitors of aldose reductase, therefore, would be potential agents for the prevention of diabetic complications. To evaluate active principles for the inhibition of aldose reductase from the rhizomes of Belamcanda chinensis, twelve phenolic compounds were isolated and tested for their effects on rat lens aldose reductase. As a result, isoflavones such as tectorigenin, irigenin and their glucosides were found to show a strong aldose reductase inhibition. Tectoridin and tectorigenin, exhibited the highest aldose reductase inhibitory potency, their $IC_{50}$ values, being $1.08{\times}10^{-6}{\;}M{\;}and{\;}1.12{\times}10^{-6}{\;}M$, respectively, for DL-glyceraldehyde as a substrate. Both compounds, when administered orally at 100 mg/kg for 10 consecutive days to streptozotocin-induced diabetic rats, caused a significant inhibition of sorbitol accumulation in the tissues such as lens, sciatic nerves and red blood cells. Tectorigenin showed a stronger inhibitory activity than tectoridin. From these results, it is suggested that tectorigenin is attributed to be a promising compound for the prevention and/or treatment of diabetic complications.