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Antioxidant Activities of Isoflavones from the Rhizomes of Belamcanda chinensis on Carbon Tetrachloride-Induced Hepatic Injury in Rats  

Jung, Sang-Hoon (Natural Products Research Institute, College of Pharmacy, Seoul National University, Natural Products Research Center, Korea Institute of Science and Technology)
Lee, Yeon-Sil (Seokwon Life Science Research Institute)
Lim, Soon-Sung (Silver Biotechnology Research Center, Hallym University)
Lee, Sanghyun (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Shin, Kuk-Hyun (Natural Products Research Institute, College of Pharmacy, Seoul National University, Seokwon Life Science Research Institute)
Kim, Yeong-Shik (Natural Products Research Institute, College of Pharmacy, Seoul National University)
Publication Information
Archives of Pharmacal Research / v.27, no.2, 2004 , pp. 184-188 More about this Journal
Abstract
The present study was carried out to clarify whether tectorigenin and tectoridin isolated from the rhizomes of Belamcanda chinensis (Iridaceae) inhibit hepatic damage induced by carbon tetrachloride ($CCl_4$)-intoxication in rats by the experimental methods in vitro and in vivo. Tectorigenin and tectoridin exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by $CCl_4$-intoxication in rats, as well as in a lipid peroxidation causing a significant decrease in malondialdehyde (MDA) production by thiobarbituric acid (TBA)-reactant assay. Both compounds also showed strong increase in the antioxidant enzymes such as hepatic cytosolic superoxide dismutase (SOD), catalase and glutathione peroxidase (GSH-px) activities in $CCl_4$-intoxicated rats. These results suggested that tectorigenin and tectoridin isolated from the rhizomes of B. chinensis possess not only the antioxidative, but also the hepatoprotective activities in $CCl_4$ -intoxicated rats.
Keywords
Belamcanda chinensis; lridaceae; Tectorigenin; Tectoridin; Carbon tetrachloride; Antioxidant activeity;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
Times Cited By Web Of Science : 16  (Related Records In Web of Science)
Times Cited By SCOPUS : 18
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1 Beckman, K. B. and Ames, B. N., The free radical theory of aging matures. Physiol. Rev., 78, 547-581 (1998)   PUBMED
2 Buege, J. A. and Aust, S. D., Microsomal lipid peroxidation. Method Enzymol., 52, 302-306 (1978)   DOI   PUBMED
3 Burk, R. F., Nishiki, K., Lawrence, R. A, and Chance, B., Peroxide removal by selenium-dependent and selenium-independent glutathione peroxidases in hemoglobin free per-fused rat liver. J. Biol. Chem., 253, 43-46 (1978)   PUBMED
4 Kim, Y. P, Yamada, M., Lim, S. S., Lee, S. H., Ryu, N., Shin, K. H., and Ohuchi, K., Inhibition by tectorigenin and tectoridin of prostaglandin $E_{2}$ production and cyclooxygenase-2 induction in rat peritoneal macrophages. Biochim. Biophys. Acta, 10, 399-407 (1999)
5 Kumaravelu, P., Dakshinamoorthy, D. P., Subramaniam, S., Devaraj, H., and Devaraj, N. S., Effect of eugenol on drug-metabolizing enzymes of carbon tetrachloride-intoxicated rat liver. Biochem. Pharmacol., 49,1 703-1707 (1995)
6 Kubow, S., Toxicity of dietary lipid peroxidation products. Trends Food Sci. Tech., 1,67-71 (1990)   DOI
7 Lowry, O. H., Posenbrough, N. N., Farr, A. L., and Randall, R. J., Protein measurement with the folin phenol reagent. J. Biol. Chem., 193, 265-275 (1951)   PUBMED
8 Park, K. Y., Jung, G. O., Choi, J. W., Lee, K. T., and Park, H. J., Potent antimutagenic and their anti-lipid peroxidative effect of kaikasaponin III and tectorigenin from the flower of Pueraria thunbergiana. Arch. Pharm. Res., 25, 320-324 (2002)   DOI   ScienceOn
9 Rigo, A and Rotilio, G., Simultaneous determination of super-oxide dismutase and catalase in biological materials by polarography. Anal. Biol. chem., 81, 157-166 (1977)   DOI   ScienceOn
10 Wei, H., Bowen, R., Cai, Q., Bames, S., and Wang, Y, Anti-oxidant and antipromotional effects of the soybean isoflavone genistein. Proc. Soc. Exp. Biol. Med., 208, 124-130 (1995).   DOI
11 Pike, J. and Chandra, R. K., Effect of vitamin and trace element supplementation on immune indices in healthy elderly. Int. J. Vitamin Nutr. Res., 65, 117-120 (1995)
12 Lee, K. T., Sohn, I. C., Kim, D. H., Choi, J. W., Kwon, S. H., and Park, H. J., Hypoglycemic and hypolipidemic effects of tecto-rigenin and kaikasaponin III in the streptozotocin-induced diabetic rat and their antioxidant activity in vitro. Arch. Pharm. Res., 23, 461-466 (2000)   DOI   ScienceOn
13 Ito, H., Onoue, S., and Yoshida, T., Isoflavonoids from Belamcanda chinensis. Chem. Pharm. Bull., 49, 1229-1231 (2001)   DOI   ScienceOn
14 Cross, C. E., Oxygen radicals and human disease. Ann. Intem. Med., 107,526-545 (1987).   DOI   PUBMED   ScienceOn
15 Kovacic, P. and Jacintho, J. D., Mechanisms of carcinogenesis: focus on oxidative stress and electron transfer. Curr. Med. Chem., 8, 773-796 (2001)   DOI   PUBMED   ScienceOn
16 Jung, S. H., Lee, Y S., Lee, S., Lim, S. S., Kim, Y S., Ohuchi, K., and Shin, K. H., Anti- angiogenic and anti-tumor activities of isoflavonoids from the rhizomes of Belamcanda chinensis. Planta Med., 69, 617-622 (2003)   DOI   ScienceOn
17 Recknagel, R. O., Glende Jr, E. A., Dolak, J. A., and Waller, R. L., Mechanisms of carbon tetrachloride toxicity. Pharmacol. Therapeut., 43, 139-154 (1989)   DOI   ScienceOn
18 Brar, S. S., Kennedy, T. P., Sturrock, A. B., Huecksteadt, T. P, Quinn, M. T., Murphy, T. M., Chitano, P., and Hoidal, J. R., NADPH oxidase promotes NF-kB activation and proliferation in human airway smooth muscle. Am. J. Physiol. Lung Cell Mol. Physiol., 282, L782-L795 (2002)
19 Reitman, S. and Frankel, S., A chlorotrimetric method for the determination of sGOT and sGPT Am. J. Clin. Pathol., 28, 56-63 (1957)   PUBMED
20 McCord, J. M. and Fridovich, I., Superoxide dismutase: An enzymatic function for erythrocuprein (hemocoprein). J. Biol. Chem., 244, 6049-6055 (1969)   PUBMED