• Journal of Korean Neurosurgical Society
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• v.59 no.2
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• pp.161-164
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• 2016

Few preoperative extrapontine myelinolysis (EPM) cases with pituitary adenoma have been reported. No such case had long follow-up to see the outcome of EPM. We reported a 38-year-old man complaining of nausea, malaise and transient loss of consciousness who was found to have severe hyponatremia. Neurologic deficits including altered mental status, behavioral disturbances, dysarthria and dysphagia developed despite slow correction of hyponatremia. Endocrine and imaging studies revealed hypopituitarism, nonfunctional pituitary macroadenoma and extrapontine myelinolysis. Transsphenoidal surgery was performed after three weeks of supportive therapy, when neurological symptoms improved significantly. The patient recovered function completely 3 months after surgery. Our case indicates that outcome of EPM can be good even with prolonged periods of severe neurologic impairment.

• Journal of Korean society of Dental Hygiene
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• v.14 no.6
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• pp.961-966
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• 2014

Objectives: The purpose of the study was to investigate the classes of humanities and social sciences in the public health curricula. Methods: Data were collected through online received from 329 public health curricula from July to August, 2014. Categorized are introduction, management of hospital, medical health law, and ethics, patient psychology, others(communication, behavioral science, administration). The data were analyzed by a descriptive analyses and ${\chi}^2$-test(SPSS 12.0). Results: As a result of evaluate the classes of humanities and social sciences in the public health curriculum, 86.0% of department of occupational therapy, 71.4% of department of radiological technology and 72.6% of department of dental hygiene established more 4 classes. 92.1% of department physical therapy and 64.9% of department medical technology established more 5 credits. Numbers and credits of courses showed no differences by educational system. Conclusions: Humanities and social sciences are not popularly introduced in the most departments of public health sciences. Humanities and social sciences are very important and necessary for training competent future professionals in the public health sciences. So this study will provide the basic data for the introduction of humanities and social sciences in the public health curricula.

• Nutritional Sciences
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• v.8 no.2
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• pp.133-139
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• 2005

Objective: The purpose of this study was to determine serum antioxidant nutrients and the relationship between serum antioxidants and risks of chronic diseases in obese Korean children Methods: Normal weight Korean school children (0=170), mean age of 11.5$\pm$1.5, and obese (body fat mass > $28\%$) children (0=176), mean age of 11.0$\pm$1.8, were recruited Fat mass ($\%$) was determnined by Bioelectrical Impedance (BEI), and body mass index (BMI) was calculated Fasting blood was collected to measure serum antioxidant nutrients, vitamin A, vitamin E and zinc. Serum lipid profiles including total cholesterol (TC), high density cholesterol (HDL) and triglyceride (TG), and blood glucose, glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPI) were also determined. Differences in serum blood measurements between obese and normal children were assessed by independent t test. Pearson's correlation analysis was used to determine the relationship between variables. Results: Blood glucose, GPT, total cholesterol, and triglycerides concentrations were significantly higher among obese boys, compared to normal boys (p<005). Significantly lower concentrations of serum vitamin E, after adjustment for TG and TC, was shown in obese boys (0.26 mg/mg) and obese girls (0.31 mg/mg), compared to normal boys (0.36 mg/mg) and girls (0.38 mg/mg) (p<0.05). Fat mass ($\%$) was negatively con-elated with serum vitamin A and vitamin E. Conclusion: Obese Korean children showed insufficient serum vitamin E concentration and increased risk for diabetes, atherosclerosis, and liver disease. Since lower vitamin E concentration was negatively con-elated with atherogenic index, improved vitamin E status in children may decrease the risk of atherosclerosis later in life.

• Journal of Nutrition and Health
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• v.45 no.2
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• pp.170-180
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• 2012

This study was conducted to identify factors influencing Health/Functional Foods (HFFs) consumption for women in their 20's based on social cognitive theory. A total of 295 subjects participated in this study and were divided into two groups based on the experience of HFF use. This study compared their personal, environmental and behavioral factors which influence the consumption of HFFs. With regard to personal factors, the expected effectiveness for HFFs was higher in the user group than the nonuser group. For the environmental factors, the subjects' use of HFFs was critically affected by the use of HFFs regarding the family members. In terms of behavioral factors, there were no significant differences between the two groups. For the user group, it was observed that their use of HFFs was closely related to when their interests for health was high and the family's use of HFF was high. On the other hands, for the nonuser group, there were less people around them using HFFs than the user group and they did not feel that HFFs were necessary. Since non-experts including parents and close acquaintances critically affected the HFF ingestion of the subjects, it is essential to educate all citizens as well as HFFs consumers about HFFs information.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7309-7316
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• 2014

Background: While many researchers often use a theoretical framework for mammogram repeat interventions, it seems they do not apply an identified mediation analysis method. The aim of this study was to determine the mediators of mammogram replication behavior in two tailored interventions for non-adherent Iranian women. Materials and Methods: A sample population of 184 women over 50 years old in Sanandaj, Iran, was selected for an experiment. Participants were randomly allocated into one of the three conditions: 1) an intervention based on the Health Belief Model (HBM) 2) an intervention based on an integration of the HBM and selected constructs from the Theory of Planned Behavior (TPB), and 3) a control group. Constructs were measured before the intervention, and after a 6-month follow-up. Results: Perceived self-efficacy, behavioral control, and subjective norms were recognized as mediators in the HBM and selected constructs from the TPB intervention. Perceived susceptibility, severity, barriers, self-efficacy and behavioral control met the criteria for mediation in the HBM intervention. Conclusions: This study was successful in establishing mediation in a sample of women. Our findings enrich the literature on mammography repeat, indicating key intervention factors, and relegating redundant ones in the Iranian populations. The use of strategies to increase mammography repeat, such HBM and TPB constructs is suggested to be important for maintaining a screening behavior, once the behavior has been adopted.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.305-310
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• 2016

Background: Given the association between drinking hot tea and the risk of esophageal squamous cell carcinoma, this study was designed to determine the effectiveness of an educational campaign based on the Theory of Planned Behavior (TPB) in reducing hot tea consumption among a sample of Iranian female students. Materials and Methods: In this quasi-experimental study, 130 primary-school female students in Salas Babajani, Kermanshah, Iran were randomly selected. A two-month campaign based on TPB constructs was developed and conducted for the intervention group. Combined mass media approaches (such as posters, pamphlet, and brochure) with small group and individual activities were used to transfer the campaign messages. Also, five 40-minute instructional sessions for the students and one session for their parents and teachers were held. The hot tea consumption, attitude, subjective norms, perceived behavioral control and no intention to drink hot tea were variables which were measured at baseline and again after 4 weeks. Results: There was a significant improvement in the perceived behavioral control and intention to drink no hot tea variables in the intervention group as compared to the control group following the campaign. In addition, significant reductions were found for the hot tea consumption and favorable attitude toward drinking hot tea in the intervention group as compared to the control group. Conclusions: Conducting educational campaigns based on TPB variables may reduce hot tea consumption among Iranian students.

• International Journal of Computer Science & Network Security
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• v.21 no.3
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• pp.219-228
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• 2021

The adoption of new technology in any organization will represent change, and such change needs user acceptance for its successful implementation. Saudi Arabian health centers are no exception; therefore, the current study will investigate the adoption of new technology, namely that of virtual reality (VR), within health centers in Saudi Arabia and specifically in Riyadh City. This study explores the current state of VR technology adoption, factors that influence such adoption, and the extent of this technology's efficiency when it is used for vaccinating children. The data were collected from two samples: workers in vaccination clinics who responded to a survey and a group of children who participated in the VR technology experiment. The current study proposed a model based on the unified theory of acceptance and use of technology 2 (UTAUT2), with the addition of two variables: personal innovativeness and satisfaction. The results indicated that the respondents' perceptions regarding the health centers' infrastructure in terms of adopting VR were moderate. Among the factors affecting VR adoption, satisfaction, personal innovativeness, and behavioral intention were identified as vastly influential factors. From the eight hypotheses, six were found to be supported, with their factors significantly influencing behavioral intention with regard to VR technology adoption. Besides, the experiment concerning the use of VR technology on children verified the technique's high efficiency in terms of providing pain management and fear removal. These findings support the continuity of VR technology use, expand its future application fields, and integrate this study into the literature on technology acceptance models for VR adoption, as limited studies have covered this topic; consequently, this will benefit future research in this field.

• Biomolecules & Therapeutics
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• v.22 no.5
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• pp.406-413
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• 2014

to valproic acid (VPA) during pregnancy produces ASD-like core behavioral phenotypes as well as hyperactivity in offspring both in human and experimental animals, which makes it a plausible model to study ASD-related neurobiological processes. In this study, we examined the effects of two of currently available attention defecit hyperactivity disorder (ADHD) medications, methylphenidate (MPH) and atomoxetine (ATX) targeting dopamine and norepinephrine transporters (DAT and NET), respectively, on hyperactive behavior of prenatally VPA-exposed rat offspring. In the prefrontal cortex of VPA exposed rat offspring, both mRNA and protein expression of DAT was increased as compared with control. VPA function as a histone deacetylase inhibitor (HDACi) and chromatin immunoprecipitation experiments demonstrated that the acetylation of histone bound to DAT gene promoter was increased in VPA-exposed rat offspring suggesting epigenetic mechanism of DAT regulation. Similarly, the expression of NET was increased, possibly via increased histone acetylation in prefrontal cortex of VPA-exposed rat offspring. When we treated the VPA-exposed rat offspring with ATX, a NET selective inhibitor, hyperactivity was reversed to control level. In contrast, MPH that inhibits both DAT and NET, did not produce inhibitory effects against hyperactivity. The results suggest that NET abnormalities may underlie the hyperactive phenotype in VPA animal model of ASD. Profiling the pharmacological responsiveness as well as investigating underlying mechanism in multiple models of ASD and ADHD may provide more insights into the neurobiological correlates regulating the behavioral abnormalities.

• Journal of Life Science
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• v.26 no.2
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• pp.181-189
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• 2016

The aim of this study was to identify the effects of dithiopyr (DTP), a herbicide, on behavior in zebrafish. The toxicity of DTP has rarely been investigated in fish. In the present study, zebrafish were exposed to different concentrations of DTP in the range of 10-20 μM for 48 h in a test container, in order to measure the value of median lethal concentrations (LC₅₀). Behavioral experiments were performed, including the novel tank test (NTT) and the open field test (OFT), to assess stress responses or locomotion. After exposure to the DTP solution at a sublethal concentration of 2.5–10 μM for 6 min, the behavior of the zebrafish was observed for 6 min. In the acute toxicity test, the LC₅₀ value of DTP showed as 14.49 μM in the zebrafish. The NTT showed that the duration of immobility and the velocity were significantly increased by exposure at a concentration of 5 μM of DTP, compared with a control group (p<0.05). However, compared with the control group, DTP significantly decreased the distance moved and the frequency at the top of the tank, and significantly increased the turn angle and duration at the bottom, in a concentration-dependent manner (p<0.05). In addition, in the OFT, exposure to DTP significantly decreased the distance moved and velocity compared with the control group (p<0.05). Exposure to DTP also significantly increased the duration of immobility, the turn angle, and the meandering movement, in a concentration-dependent manner (p<0.05). Further, exposure to DTP at a low concentration elevated whole-body cortisol levels in the zebrafish. The results of this study thus suggest that DTP induces a toxic response and negative effects on behavior and the endocrine system in zebrafish.

• Brain Tumor Research and Treatment
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• v.6 no.2
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• pp.73-77
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• 2018

Germinoma is the most common type of intracranial germ cell tumors (GCTs). Pineal gland and suprasellar region are the most frequent sites of central nervous system (CNS) involvement. Intracranial masses caused by Langerhans cell histiocytosis (LCH) mimics features of CNS GCTs. LCH frequently involve spine and is the most common cause of vertebra plana in children. A 15-year-old boy presented with progressing symptoms of polydipsia, polyuria, general headache, nausea and severe back pain. Brain MRI showed brain tumor with simultaneous involvement of suprasellar region and pineal gland. An excisional biopsy of suprasellar mass was done. The pathologic assessment confirmed the diagnosis of germinoma. Patient's treatment continued accordingly. A spine MRI, done due to persistent backache, showed a vertebra plana. We reevaluated the primary diagnosis suspecting LCH. Germinoma of CNS was confirmed and a biopsy of vertebral lesion resulted in hemangioma. Thus we report a case of CNS germinoma with co-occurrence of vertebra plana. We emphasized the importance of histopathologic diagnosis of pineal/suprasellar masses and primary investigation of other CNS regions including spine for possible metastasis or comorbidities.