• Asian Pacific Journal of Cancer Prevention
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• v.15 no.4
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• pp.1589-1595
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• 2014

Objective: Forkhead box C2 (FOXC2) is a member of the winged helix/forkhead box (Fox) family of transcription factors. It has been suggested to regulate tumor vasculature, growth, invasion and metastasis, although it has not been studied in cervical cancer. Here, we analyzed FOXC2 expression in cervical tissues corresponding to different stages of cervical cancer development and examined its correlation with clinicopathological characteristics. In addition, we examined the effects of targeting FOXC2 on the biological behavior of human cervical cancer cells. Methods: The expression of FOXC2 in normal human cervix, CIN I-III and cervical cancer was examined by immunohistochemistry and compared among the three groups and between cervical cancers with different pathological subtypes. Endogenous expression of FOXC2 was transiently knocked down in human Hela and SiHa cervical cells by siRNA, and cell viability and migration were examined by scratch and CCK8 assays, respectively. Results: In normal cervical tissue the frequency of positive staining was 25% (10/40 cases), with a staining intensity (PI) of $0.297{\pm}0.520$, in CIN was 65% (26/40cases), with a PI of $3.00{\pm}3.29$, and in cancer was 91.8% (68/74 cases), with a PI of $5.568 {\pm}3.449$. The frequency was 100% in adenocarcinoma (5/5 cases) and 91.3% in SCCs (63/69 cases). The FOXC2 positive expression rate was 88.5% in patients with cervical SCC stage I and 100% in stage II, showing significant differences compared with normal cervix and CIN. With age, pathologic differentiation degree and tumor size, FOXC2 expression showed no significant variation. On transient transfection of Hela and SiHa cells, FOXC2-siRNA inhibition rates were 76.2% and 75.7%; CCK8 results showed reduced proliferation and relative migration (in Hela cells from $64.5{\pm}3.16$ to $49.5{\pm}9.24$ and in SiHa cells from $60.1{\pm}3.05$ to $44.3{\pm}3.98$) (P < 0.05). Conclusion: FOXC2 gene expression increases with malignancy, especially with blood vessel hyperplasia and invasion degree. Targeted silencing was associated with reduced cell proliferation as well as invasion potential.

• Korean Journal of Head & Neck Oncology
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• v.8 no.2
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• pp.72-81
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• 1992

Thyroid cancer, the most common cancer of endocrine neoplasms, has tremendous variation in tumor biologic behavior. There is no consensus about treatment mode to prevent recurrences despite of recent advance in understanding characteristics of thyroid cancer. So, we have made a clinical analysis and follow-up study of recurred 27 cases among 189 cases treated under the diagnosis of thyroid carcinoma in the department of surgery, Chonnam University Hospital from February, 1982 to February, 1992 to clarify our experience about the characteristics of recurred thyroid cancer. The results were as follow: According to the pathological classification of recurred thyroid cancer, recurrence rate was 11.6% in papillary carcinoma, 15.6% in follicular carcinoma, 37.5% in medullary carcinoma, 66.7% in undifferentiated carcinoma, respectively, and the mean recurrence rate of thyroid cancer was 14.3%. The recurrence rate according to age was 28.6% in 8th decade and 17.9% in 4th decade. The recurrence rate according to sex was not singificant(15.6% in male: 14% in female). The mean period to relapse was 4 years 6 months in papillary carcinoma, 2 years 5 months in follicular carcinoma, 2 years 1 months in medullary carcinoma, 2 years 6 months in undifferentiated carcinoma. The recurrence rate according to previous operating methods, such as performing lymph node dissection or not, mode of thyridectomy, type of lymph node dissection was statisfically non-specific. Common recurrent sites of papillary and follicular carcinoma was cervical lymph node and remained thyroid tissue. Medullary and undifferentiated carcinoma was noted in multiregional or systemic involvement Reoperation was performed with complete resection of recurred or metastatic mass, such as radical neck dissection or mass extirpation from involved organs as possible. The postoperative complications were 2 cases of horseness, and 1 case with hematoma, transient hypocalcemia, wound infection, and pulmonary insufficency, respectively. 5-year survival rate was 85.5% in papillary carcinoma, 66.7% in follicular carcinoma. 50% in medullary carcinoma, and 50% in undifferentiated carcinoma. We concluded that recurrence in thyroid cancer give a reconsideration to previous conservative therapy and more extensive surgical procedures for thyroid cancer including lymphatic dissection are recommanded to prevent recurrences in selected cases if possible.

• The Journal of Korean Academy of Sensory Integration
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• v.7 no.1
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• pp.1-12
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• 2009

Objective : This study is to verify effect of a sensory integration (SI) intervention on sensory processing of children with sensory modulation disorder (SMD), and to explore how the SI intervention affect play, socialization, occupational performance and occupational satisfaction of those children. Method : Five children with developmental disabilities living in metropolitan were diagnosed as SMD by the Sensory History Interview (SHI) and Short Sensory Profile (SSP). The SMD children undergone the 48 sessions of 50 min intervention twice in a week for six months and took the Revised Knox Preschool Play Scale(RKPPS), Social maturity test, Canadian Occupational Performance Measure(COPM), and Japanese Sensory Inventory Revised(JSI-2) before- and after the intervention. The result data analyzed by the Wilcoxon matched-pair signed rank test. Results : All data of post-intervention differed significantly; RKPPS(Z=-2.023, p=.043), Social maturity test(Z=-2.023, p=.043); occupational performance(Z=-2.023, p=.043); satisfaction(Z=-2.032, p=.042); and tactile system of JSI-2(Z=-2.032, p=.042). Conclusions : The results advocate that sensory integration intervention is effective in improving tactile processing, play, socialization, occupational performance, and occupational satisfaction of child with SMD. It is found that sensory integration intervention improves not only one's occupational performance but also underlying components of the performance. In order to generalize this conclusion, further studies need to be done with more number of subjects and consideration of environmental factors. Striving for more reliable and valid methods of data collection is also suggested.

• Journal of Music and Human Behavior
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• v.11 no.2
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• pp.19-39
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• 2014

This study investigated whether a song psychotherapy based on the change stages of alcohol addiction impacted the change readiness of alcoholics. The song psychotherapy intervention consists of six activities (listening to a song, singing, songwriting, song sharing, lyrics analysis, and discussion and analysis of a song), which considers the change stages of alcohol addiction. A total of 64 inpatients diagnosed with alcoholism were randomly assigned to either the control (n = 33) or experimental group (n = 31). The experimental group took part in the intervention program for 45 minutes twice a week for 6 weeks (total of 12 sessions). The intervention effect was evaluated with SOCRATES-K. The results showed that the SOCRATES-K score significantly increased by 14.6% (p < .001) for the experimental group, whereas it remained almost unchanged (0.8% increase, p = .141) in the control group. For subcategory scales, the experimental group showed the highest increase in the ambivalence factor, followed by the recognition and taking-steps factors. Meanwhile, no significant changes in all three scales were found in the control group. Therefore, the song psychotherapy intervention based on the change stages of alcohol addiction was found to significantly increase the change readiness of alcoholics.

• Journal of Music and Human Behavior
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• v.14 no.2
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• pp.45-70
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• 2017

The purpose of this study was to validate the Korean version of RESPECT-Music, which measures personal, social and cultural function of music, and to examine the correlation between the measured RESPECT data and the data measured from other scales for emotions. A survey was conducted with two separate groups of undergraduate students. Exploratory factor analysis with sample A (N=212) and confirmatory factor analysis and correlation analyses with sample B (N=296) were conducted. The result of exploratory factor analysis generated 10 factors as influential factors in music use, which was the similar results to the original scale: background, values, focus, dancing, family bonding, cultural identity, political attitudes, venting, emotional expression and social bonding. In the confirmatory factor analysis, this 35-item measurement was found to obtain adequate internal consistency and reliability. In addition, the correlations were found with other scales measuring emotional adjustment. Specifically, RESPECT showed a positive correlation with scales for positive affect, reappraisal, negative mood regulation and repair. Among the generated factors as music function, dancing was highly correlated with emotional adjustment, while political attitudes was negatively correlated with emotional adjustment. The results indicate that music use in our everyday lives is intercorrelated with the intrapersonal and interpersonal motives and emotional adjustment, while the function of music that influences cultural identity was not associated with the level of emotional adjustment. Implications for future studies were also suggested.

• Journal of Music and Human Behavior
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• v.2 no.1
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• pp.47-65
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• 2005

One of important goals for early childhood music learning program is to build a positive attitude toward music. Positive attitude toward music is a basic condition on effective music education for all ages of children including early childhood. Although scholars realize such importance of positive music attitude, much research for creating educational environment to foster a positive music attitude has not been performed. Edwin E. Gordon who found a music learning theory for early childhood emphasized the importance of enriched musical environment. Very young children should be provided best quality of music in an interactive way. Audie's important method of education is to provide young children with a variety of musical activities containing the materials in the ordinary life. Through this method, children accept music as close as friends who are always beside themselves, which naturally builds a solid foundation for audiation for children.

• Journal of Music and Human Behavior
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• v.2 no.1
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• pp.67-85
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• 2005

The purpose of this study was to investigate the effect of music listening, autogenic training, and music-assisted autogenic training on the quality of life, physiological and psychological relaxation responses, and daily living in a population of migraine patients. Forty migraine patients, ranging 20 to 60 years, were referred to the researcher by their physicians and participated in the study. A convenience control-group pretest-posttest design was employed. The participants were randomly assigned to one of four groups: music listening (ML), autogenic training (AT), music-assisted autogenic training (MAT), or a control group participants, with n = 10 participants per group. The participants in experimental groups received four 30-minute sessions with an assigned treatment, once a week during a 4-week experiment period. The participants in the control group continued their regular medical treatment as prescribed by the doctor without receiving any other relaxation treatment. However, they were still aware of the research and their responsibilities for the study. The Migraine Assessment (MIDAS) and Migraine-Specific Quality of Life (MSQOL) questionnaire were used to investigate a migraine patients' quality of life collected before and after the 4-week experiment for all subjects. The physiological and psychological relaxation responses of migraine patients were measured by relaxation levels and forehead temperature recorded before and after each treatment session for the participants in three treatment conditions. The effect of the relaxation treatments on daily living of migraine patients was examined through the frequency and intensity of migraine headaches, and the amount of medication taken for migraine headaches during the 4-week experiment as recorded in participants' diary for all participants. The results found significant differences from pre- to posttest on the MIDAS, MSQOL, and relaxation levels while no significant was found among the groups. The analysis of forehead temperature showed no significant difference from pre- to posttest and among the groups. A one-way ANOVA was performed on the frequency, intensity, and amount of medication taken for migraine headaches during the 4-week experiment period. While results yielded no significant difference among the groups, the data indicate that the participants in the three treatment groups reported fewer migraine headaches, lower degrees of headache intensity, and less medication taken for migraine headaches than participants in the control group. A conclusion drawn from this study is that music listening itself as a relaxation treatment, or as an adjunct to other relaxation techniques can be effective in the treatment of migraine headaches.

• Journal of Music and Human Behavior
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• v.2 no.1
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• pp.17-33
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• 2005

Music has a vital meaning in peoples' lives, mostly as a communication medium for thoughts and feelings. Because music is nonthreatening and nonjudgmental, its viability works for everyone. The purpose of this research is firstly to compare the effectiveness of existing social rehabilitation program and music integrated social rehabilitation program for people with mental retardation. Secondly, the study purported to find out if the music integrated social rehabilitation program was effective, then how various musical activities can assist communication and expression, and further assist social interactions among the people with mental retardation. The data were collected using Emotions Assessment Tool, Social Skills Assessment, and Skills development in Music were used. Also, verbal contents, voices, gestures, nonverbal expressions were observed and analyzed. As the result, it is shown that the music integrated social rehabilitation program has enhanced communicative and expressive skills of adults with mental retardation, and further improved social interactive skills. This implies that music had positive effects to the mental patients on their social relationship activities, than the program without music integration. The results support previous findings that music can be an effective communicative and expression tool.

• Journal of Music and Human Behavior
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• v.12 no.1
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• pp.43-64
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• 2015

This study investigated the effects of song discussion on depression and rehabilitation motivation in stroke patients. Older adults with chronic stroke participated in this study: nine for the experimental group and eight for the control group. The experimental group was divided into three subgroups and participated in 12 sessions over 6 weeks. Target lyrics were selected by the investigator among popular songs from the participants' young adulthood. The song-based discussion was facilitated to address issues targeted at supportive, insight-focused, or reconstructive stage. The control group was provided with delayed intervention. At pre and posttest, the short form of Geriatric Depression Scale and the Rehabilitation Motivation Scale were measured. The experimental group showed significantly decreased depression and significantly increased rehabilitation motivation (p < .01), while the control group showed no significant changes. Positive changes were also observed in all subcategories of rehabilitation motivation in the experimental group, particularly in significantly increased task-oriented motivation and decreased amotivation. This study suggests that song discussion will be effectively applied in rehabilitative settings to address psychological issues of older adults with stroke.

• Journal of Music and Human Behavior
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• v.12 no.1
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• pp.23-42
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• 2015

This study investigated the harmonic preference of children and adolescents depending on age and musical training. A total of 684 primary and secondary school students participated in this study. For this study, a four-measure melody was composed and constructed in four levels of harmonic complexity, determined by the rate of nonharmonic notes used and immediacy of harmonic resolution. Participants rated the degree of their perceived complexity and their preferences after listening to each musical stimulus. Ratings from the participants were analyzed in terms of the effect of age and the length of musical training. The results showed that younger students demonstrated little to no change in their preference regardless of the complexity level. Middle and high school students showed significantly decreased preference with increased harmonic complexity. High school students with more musical instrument training perceived changes in harmonic complexity more sensitively and showd higher level of optimal complexity. Younger students was affected by musical training relatively less than older students. This study presents the baseline data to be considered when determining the appropriate level of harmonic complexity for music appreciation of young population.